Impaired decidual natural killer cell regulation of vascular remodelling in early human pregnancies with high uterine artery resistance

During human pregnancy, natural killer (NK) cells accumulate in the maternal decidua, but their specific roles remain to be determined. Decidual NK (dNK) cells are present during trophoblast invasion and uterine spiral artery remodelling. These events are crucial for successful placentation and the provision of an adequate blood supply to the developing fetus. Remodelling of spiral arteries is impaired in the dangerous pregnancy complication pre-eclampsia. We studied dNK cells isolated from pregnancies at 9-14 weeks' gestation, screened by uterine artery Doppler ultrasound to determine resistance indices which relate to the extent of spiral artery remodelling. dNK cells were able to promote the invasive behaviour of fetal trophoblast cells, partly through HGF. Cells isolated from pregnancies with higher resistance indices were less able to do this and secreted fewer pro-invasive factors. dNK cells from pregnancies with normal resistance indices could induce apoptotic changes in vascular smooth muscle and endothelial cells in vitro, events of importance in vessel remodelling, partly through Fas signalling. dNK cells isolated from high resistance index pregnancies failed to induce vascular apoptosis and secreted fewer pro-apoptotic factors. We have modelled the cellular interactions at the maternal-fetal interface and provide the first demonstration of a functional role for dNK cells in influencing vascular cells. A potential mechanism contributing to impaired vessel remodelling in pregnancies with a higher uterine artery resistance is presented. These findings may be informative in determining the cellular interactions contributing to the pathology of pregnancy disorders where remodelling is impaired, such as pre-eclampsia. Copyright © 2012 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd

Cosmological implications of the KATRIN experiment

The upcoming Karlsruhe Tritium Neutrino (KATRIN) experiment will put unprecedented constraints on the absolute mass of the electron neutrino, \mnue. In this paper we investigate how this information on \mnue will affect our constraints on cosmological parameters. We consider two scenarios; one where \mnue=0 (i.e., no detection by KATRIN), and one where \mnue=0.3eV. We find that the constraints on \mnue from KATRIN will affect estimates of some important cosmological parameters significantly. For example, the significance of $n_s<1$ and the inferred value of $\Omega_\Lambda$ depend on the results from the KATRIN experiment.Comment: 13 page

Forecasting neutrino masses from galaxy clustering in the Dark Energy Survey combined with the Planck Measurements

We study the prospects for detecting neutrino masses from the galaxy angular power spectrum in photometric redshift shells of the Dark Energy Survey (DES) over a volume of 20 (Gpc/h)^3 combined with the Cosmic Microwave Background (CMB) angular fluctuations expected to be measured from the Planck satellite. We find that for a Lambda-CDM concordance model with 7 free parameters in addition to a fiducial neutrino mass of M_nu = 0.24 eV, we recover from DES &Planck the correct value with uncertainty of +- 0.12 eV (95 % CL), assuming perfect knowledge of the galaxy biasing. If the fiducial total mass is close to zero, then the upper limit is 0.11 eV (95 % CL). This upper limit from DES &Planck is over 3 times tighter than using Planck alone, as DES breaks the parameter degeneracies in a CMB-only analysis. The analysis utlilizes spherical harmonics up to 300, averaged in bin of 10 to mimic the DES sky coverage. The results are similar if we supplement DES bands (grizY) with the VISTA Hemisphere Survey (VHS) near infrared band (JHK). The result is robust to uncertainties in non-linear fluctuations and redshift distortions. However, the result is sensitive to the assumed galaxy biasing schemes and it requires accurate prior knowledge of the biasing. To summarize, if the total neutrino mass in nature greater than 0.1eV, we should be able to detect it with DES &Planck, a result with great importance to fundamental Physics.Comment: Submitted to MNRAS, 9 pages, 10 figure

Constraining New Physics with a Positive or Negative Signal of Neutrino-less Double Beta Decay

We investigate numerically how accurately one could constrain the strengths of different short-range contributions to neutrino-less double beta decay in effective field theory. Depending on the outcome of near-future experiments yielding information on the neutrino masses, the corresponding bounds or estimates can be stronger or weaker. A particularly interesting case, resulting in strong bounds, would be a positive signal of neutrino-less double beta decay that is consistent with complementary information from neutrino oscillation experiments, kinematical determinations of the neutrino mass, and measurements of the sum of light neutrino masses from cosmological observations. The keys to more robust bounds are improvements of the knowledge of the nuclear physics involved and a better experimental accuracy.Comment: 23 pages, 3 figures. Minor changes. Matches version published in JHE

Pediatricians and nutritionists knowledge about treatment of cow milk allergy in infants

OBJECTIVE: Evaluate the knowledge of pediatricians and nutritionists regarding the exclusion diet of cow milk and derivates, with emphasis on questions related to the nutrition of children submitted to such diet. METHODS: Cross-sectional study that enrolled pediatricians (n=53) and nutritionists (n=29) from public hospitals in São Paulo, Brazil, during 2005. Data was collected through self-administered questionnaires. RESULTS: The age of the professionals varied from 21 to 50 years old. Regarding professional experience, 41.2% were graduated for less than five years and 91.6% had a specialization course, masters and/or PhD degree. The vast majority of professionals (97.5%) confirmed that they regularly evaluated the diet of children that needed exclusion of cow milk. However, only 48% of the professionals conducted a more detailed evaluation of the diet, including calculations of food ingestion. Only 38.7% of the professionals compared child s food ingestion with some recommended pattern. Recommendations for daily ingestion of calcium by children up to the age of 36 months were properly mentioned by 22% of the pediatricians and 60.7% of the nutritionists (p=0.001). Inadequate cow milk substitute products were recommended by 66% of the pediatricians and by 48.3% of the nutritionists. Regarding labels of industrialized products, 81.6% of the pediatricians and 96.4% of the nutritionists advised the parents to look for all terms that could indicate the presence of cow milk protein. CONCLUSIONS: Pediatricians and nutritionists made conceptual errors in their main recommendations regarding the treatment of cow milk protein allergy.OBJETIVO: Avaliar o conhecimento de pediatras e nutricionistas sobre a dieta de exclusão do leite de vaca e seus derivados, com ênfase em questões relacionadas à nutrição da criança. MÉTODOS: Estudo transversal descritivo, do qual participaram pediatras (n=53) e nutricionistas (n=29), vinculados a hospitais públicos do Município de São Paulo, no ano de 2005. Os dados foram coletados por questionário auto-administrado. RESULTADOS: A idade dos profissionais variou de 21 a 50 anos. Quanto ao tempo de graduação, 41,2% eram formados a menos de cinco anos e 91,6% possuíam especialização, mestrado e/ou doutorado. A maioria (97,5%) afirmou avaliar a dieta de crianças submetidas à exclusão do leite de vaca, entretanto, somente 48% o faziam de forma mais detalhadas, incluindo o cálculo da ingestão alimentar. Apenas 38,7% comparam a ingestão alimentar da criança com algum padrão de recomendação. A recomendação diária da ingestão de cálcio para crianças com até 36 meses foi corretamente assinalada por 22% dos pediatras e 60,7% dos nutricionistas (p=0,001). Produtos não adequados como substitutos do leite de vaca seriam recomendados por 66% dos pediatras e 48,3% dos nutricionistas. Com relação à leitura de rótulos de produtos industrializados, 81,6% dos pediatras e 96,4% dos nutricionistas orientam os pais a ler todos os termos que indicam a presença das proteínas do leite de vaca. CONCLUSÕES: Os pediatras e nutricionista demonstraram erro conceitual no que se refere às principais recomendações terapêuticas na alergia às proteínas do leite de vaca.Universidade Federal de São Paulo (UNIFESP)UNIFESPUNIFESPSciEL

X-ray Group and cluster mass profiles in MOND: Unexplained mass on the group scale

Although very successful in explaining the observed conspiracy between the baryonic distribution and the gravitational field in spiral galaxies without resorting to dark matter (DM), the modified Newtonian dynamics (MOND) paradigm still requires DM in X-ray bright systems. Here, to get a handle on the distribution and importance of this DM, and thus on its possible form, we deconstruct the mass profiles of 26 X-ray emitting systems in MOND, with temperatures ranging from 0.5 to 9 keV. Initially we compute the MOND dynamical mass as a function of radius, then subtract the known gas mass along with a component of galaxies which includes the cD galaxy with $M/L_K=1$. Next we test the compatibility of the required DM with ordinary massive neutrinos at the experimental limit of detection ($m_{\nu}=2$ eV), with density given by the Tremaine-Gunn limit. Even by considering that the neutrino density stays constant and maximal within the central 100 or 150 kpc (which is the absolute upper limit of a possible neutrino contribution there), we show that these neutrinos can never account for the required DM within this region. The natural corollary of this finding is that, whereas clusters (T \ga 3 keV) might have most of their mass accounted for if ordinary neutrinos have a 2 eV mass, groups (T \lsim 2 keV) cannot be explained by a 2 eV neutrino contribution. This means that, for instance, cluster baryonic dark matter (CBDM, Milgrom 2007) or even sterile neutrinos would present a more satisfactory solution to the problem of missing mass in MOND X-ray emitting systems.Comment: 13 pages, 8 figures, 1 table, accepted in MNRA

The Cluster Lensing and Supernova Survey with Hubble (CLASH): Strong Lensing Analysis of Abell 383 from 16-Band HST WFC3/ACS Imaging

We examine the inner mass distribution of the relaxed galaxy cluster Abell 383 in deep 16-band HST/ACS+WFC3 imaging taken as part of the CLASH multi-cycle treasury program. Our program is designed to study the dark matter distribution in 25 massive clusters, and balances depth with a wide wavelength coverage to better identify lensed systems and generate precise photometric redshifts. This information together with the predictive strength of our strong-lensing analysis method identifies 13 new multiply-lensed images and candidates, so that a total of 27 multiple-images of 9 systems are used to tightly constrain the inner mass profile, $d\log \Sigma/d\log r\simeq -0.6\pm 0.1$ (r<160 kpc). We find consistency with the standard distance-redshift relation for the full range spanned by the lensed images, 1.01<z<6.03, with the higher redshift sources deflected through larger angles as expected. The inner mass profile derived here is consistent with the results of our independent weak-lensing analysis of wide-field Subaru images, with good agreement in the region of overlap. The overall mass profile is well fitted by an NFW profile with M_{vir}=(5.37^{+0.70}_{-0.63}\pm 0.26) x 10^{14}M_{\odot}/h and a relatively high concentration, c_{vir}=8.77^{+0.44}_{-0.42}\pm 0.23, which lies above the standard c-M relation similar to other well-studied clusters. The critical radius of Abell 383 is modest by the standards of other lensing clusters, r_{E}\simeq16\pm2\arcsec (for z_s=2.55), so the relatively large number of lensed images uncovered here with precise photometric redshifts validates our imaging strategy for the CLASH survey. In total we aim to provide similarly high-quality lensing data for 25 clusters, 20 of which are X-ray selected relaxed clusters, enabling a precise determination of the representative mass profile free from lensing bias. (ABRIDGED)Comment: 15 pages, 14 figures, 2 tabels; V3 matches the submitted version later published in Ap

CLASH: New Multiple-Images Constraining the Inner Mass Profile of MACS J1206.2-0847

We present a strong-lensing analysis of the galaxy cluster MACS J1206.2-0847 ($z$=0.44) using UV, Optical, and IR, HST/ACS/WFC3 data taken as part of the CLASH multi-cycle treasury program, with VLT/VIMOS spectroscopy for some of the multiply-lensed arcs. The CLASH observations, combined with our mass-model, allow us to identify 47 new multiply-lensed images of 12 distant sources. These images, along with the previously known arc, span the redshift range 1\la z\la5.5, and thus enable us to derive a detailed mass distribution and to accurately constrain, for the first time, the inner mass-profile of this cluster. We find an inner profile slope of $d\log \Sigma/d\log \theta\simeq -0.55\pm 0.1$ (in the range [1\arcsec, 53\arcsec], or 5\la r \la300 kpc), as commonly found for relaxed and well-concentrated clusters. Using the many systems uncovered here we derive credible critical curves and Einstein radii for different source redshifts. For a source at $z_{s}\simeq2.5$, the critical curve encloses a large area with an effective Einstein radius of \theta_{E}=28\pm3\arcsec, and a projected mass of $1.34\pm0.15\times10^{14} M_{\odot}$. From the current understanding of structure formation in concordance cosmology, these values are relatively high for clusters at $z\sim0.5$, so that detailed studies of the inner mass distribution of clusters such as MACS J1206.2-0847 can provide stringent tests of the $\Lambda$CDM paradigm.Comment: 7 pages, 1 table, 4 figures; submitted to ApJ Letters; V3: minor correction