Infinite All-Layers Simple Foldability

We study the problem of deciding whether a crease pattern can be folded by simple folds (folding along one line at a time) under the infinite all-layers model introduced by [Akitaya et al., 2017], in which each simple fold is defined by an infinite line and must fold all layers of paper that intersect this line. This model is motivated by folding in manufacturing such as sheet-metal bending. We improve on [Arkin et al., 2004] by giving a deterministic $O(n)$-time algorithm to decide simple foldability of 1D crease patterns in the all-layers model. Then we extend this 1D result to 2D, showing that simple foldability in this model can be decided in linear time for unassigned axis-aligned orthogonal crease patterns on axis-aligned 2D orthogonal paper. On the other hand, we show that simple foldability is strongly NP-complete if a subset of the creases have a mountain-valley assignment, even for an axis-aligned rectangle of paper

Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins

Statins effectively lower LDL cholesterol levels in large studies and the observed interindividual response variability may be partially explained by genetic variation. Here we perform a pharmacogenetic meta-analysis of genome-wide association studies (GWAS) in studies addressing the LDL cholesterol response to statins, including up to 18,596 statin-treated subjects. We validate the most promising signals in a further 22,318 statin recipients and identify two loci, SORT1/CELSR2/PSRC1 and SLCO1B1, not previously identified in GWAS. Moreover, we confirm the previously described associations with APOE and LPA. Our findings advance the understanding of the pharmacogenetic architecture of statin response

New genetic loci link adipose and insulin biology to body fat distribution.

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms

Scalable, repeatable, and contention-free parallelization of traffic simulation

Thesis: M. Eng., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, 2018.This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.Cataloged from student-submitted PDF version of thesis.Includes bibliographical references (pages 85-86).Tripod is a project funded by ARPA-E and partly carried on by the Intelligent Transportation Systems (ITS) Lab at MIT that aims to promote more energy efficient travel options by offering commuters incentives to make smart travel choices. These incentives depend on the current network state, and the ability to estimate the state of a given road network in real time is crucial. It relies on the DynaMIT system to determine what these incentives ought to be in order to optimize traffic flow on the network. Developed by the ITS lab, DynaMIT uses simulation to compute the current network state, predict its state in the future and, by extension, compute the incentives to travelers that optimize the global energy gain. While DynaMIT is able to do this effectively within smaller areas, it is unable to simulate traffic for the Greater Boston Area, or GBA, due to the scale of the network. The goal of this thesis is to scale the DynaMIT system so that it is less affected by network sizes. First, we outline a custom, lightweight profiling tool that is able to better track down the problems with scalability; next, we build off of previous work to address design errors that slow serial execution time; and finally, we implement a novel way to parallelize traffic simulation that avoids the race conditions and concurrency issues generally associated with such systems.by Cordelia Avery.M. Eng

Risk of posterior capsular rupture during phacoemulsification cataract surgery in eyes with previous intravitreal antivascular endothelial growth factor injections

Purpose: To investigate if previous intravitreal anti vascular endothelial growth factor (VEGF) injections are a predictor for posterior capsule rupture (PCR) during phacoemulsification cataract surgery. Setting: National Health Service: Whipps Cross University Hospital Eye Treatment Centre. District General, London, United Kingdom Design: Single centre, retrospective, electronic medical record (EMR) database study with univariate analysis. Methods: EMR (Medisoft) was used to extract data for eyes undergoing phacoemulsification surgery between 01.08.16 to 01.01.18. Patient demographics, indication for intravitreal therapy, treatment type, number of previous intravitreal injections (IVI), diabetic status, surgeon grade and operative complications were included as variables for analysis. Results: Data was available for 4047 cataract operations. Of these, 108 had undergone previous anti-VEGF IVI treatment. Three eyes were noted to have pre-operative PC trauma and were excluded from the final analysis. The logistic regression analysis after exclusion of the eyes with pre-existing damage to the PC confirmed that prior anti-VEGF IVI treatment was associated with an increased risk of PCR when compared to the non IVI group (9.26% vs 1.88%, p<0.0001). There is a dose dependent relationship between the number of anti-VEGF injections and the likelihood of PCR. Conclusions: Previous intravitreal anti-VEGF injections are significantly correlated with an increased risk of surgical PCR despite the absence of visible structural damage to the PC pre-operatively