122 research outputs found
WSRT Observations of radio-sources in the galactic plane near L= 54-degrees
A radio continuum map of a 1°5 X 1°5 region in the galactic plane nearl = 54° is presented at 49 cm with a resolution of 100 arcsec X 200 arcsec. The shell source G 54.4 - 0.3 has the characteristics of a supernova remnant while the second large ring structure G 53.9 + 0.3 is a Hn ring consisting of W 52 and several small-diameter thermal sources. One of the twelve small-diameter sources (G 54.73 + 0.61) has a spectral indexâ -1.6
The evolution of rotating stars
First, we review the main physical effects to be considered in the building
of evolutionary models of rotating stars on the Upper Main-Sequence (MS). The
internal rotation law evolves as a result of contraction and expansion,
meridional circulation, diffusion processes and mass loss. In turn,
differential rotation and mixing exert a feedback on circulation and diffusion,
so that a consistent treatment is necessary.
We review recent results on the evolution of internal rotation and the
surface rotational velocities for stars on the Upper MS, for red giants,
supergiants and W-R stars. A fast rotation is enhancing the mass loss by
stellar winds and reciprocally high mass loss is removing a lot of angular
momentum. The problem of the ``break-up'' or -limit is critically
examined in connection with the origin of Be and LBV stars. The effects of
rotation on the tracks in the HR diagram, the lifetimes, the isochrones, the
blue to red supergiant ratios, the formation of W-R stars, the chemical
abundances in massive stars as well as in red giants and AGB stars, are
reviewed in relation to recent observations for stars in the Galaxy and
Magellanic Clouds. The effects of rotation on the final stages and on the
chemical yields are examined, as well as the constraints placed by the periods
of pulsars. On the whole, this review points out that stellar evolution is not
only a function of mass M and metallicity Z, but of angular velocity
as well.Comment: 78 pages, 7 figures, review for Annual Review of Astronomy and
Astrophysics, vol. 38 (2000
CCAAT/enhancer binding proteins in normal mammary development and breast cancer
CCAAT/enhancer binding proteins (C/EBPs) are a family of leucine zipper, transcription factors that bind to DNA as homodimers and heterodimers. They regulate cellular proliferation, differentiation and apoptosis in the mammary gland. Multiple protein isoforms, including truncated, dominant negatives, are generated by translation of the C/EBPÎČ transcript or via proteolytic cleavage of the full-length C/EBPÎČ protein. Gene deletion of individual C/EBP family members has demonstrated an essential role for C/EBPÎČ in normal mammary development, while transgenic and overexpression studies provide evidence that the dominant-negative C/EBPÎČ-liver-enriched inhibitory protein isoform induces proliferation in mammary epithelial cells. Mounting evidence suggests that alterations in the ratio of the C/EBPÎČ-liver-enriched inhibitory protein isoform and the C/EBPÎČ-liver-enriched activating protein isoform may play a role in the development of breast cancer. This review will consequently focus on C/EBP actions in normal mammary development and on the emerging data that supports a role in breast cancer
Individual Human Brain Areas Can Be Identified from Their Characteristic Spectral Activation Fingerprints
The human brain can be parcellated into diverse anatomical areas. We investigated whether rhythmic brain activity in these areas is characteristic and can be used for automatic classification. To this end, resting-state MEG data of 22 healthy adults was analysed. Power spectra of 1-s long data segments for atlas-defined brain areas were clustered into spectral profiles (âfingerprintsâ), using k-means and Gaussian mixture (GM) modelling. We demonstrate that individual areas can be identified from these spectral profiles with high accuracy. Our results suggest that each brain area engages in different spectral modes that are characteristic for individual areas. Clustering of brain areas according to similarity of spectral profiles reveals well-known brain networks. Furthermore, we demonstrate task-specific modulations of auditory spectral profiles during auditory processing. These findings have important implications for the classification of regional spectral activity and allow for novel approaches in neuroimaging and neurostimulation in health and disease
Workersâ Health Surveillance in the Meat Processing Industry: Work and Health Indicators Associated with Work Ability
Mechanochemical modeling of dynamic microtubule growth involving sheet-to-tube transition
Microtubule dynamics is largely influenced by nucleotide hydrolysis and the
resultant tubulin configuration changes. The GTP cap model has been proposed to
interpret the stabilizing mechanism of microtubule growth from the view of
hydrolysis effects. Besides, the microtubule growth involves the closure of a
curved sheet at its growing end. The curvature conversion also helps to
stabilize the successive growth, and the curved sheet is referred to as the
conformational cap. However, there still lacks theoretical investigation on the
mechanical-chemical coupling growth process of microtubules. In this paper, we
study the growth mechanisms of microtubules by using a coarse-grained molecular
method. Firstly, the closure process involving a sheet-to-tube transition is
simulated. The results verify the stabilizing effect of the sheet structure,
and the minimum conformational cap length that can stabilize the growth is
demonstrated to be two dimers. Then, we show that the conformational cap can
function independently of the GTP cap, signifying the pivotal role of
mechanical factors. Furthermore, based on our theoretical results, we describe
a Tetris-like growth style of microtubules: the stochastic tubulin assembly is
regulated by energy and harmonized with the seam zipping such that the sheet
keeps a practically constant length during growth.Comment: 23 pages, 7 figures. 2 supporting movies have not been uploaded due
to the file type restriction
The COGs (context, object, and goals) in multisensory processing
Our understanding of how perception operates in real-world environments has been substantially advanced by studying both multisensory processes and âtop-downâ control processes influencing sensory processing via activity from higher-order brain areas, such as attention, memory, and expectations. As the two topics have been traditionally studied separately, the mechanisms orchestrating real-world multisensory processing remain unclear. Past work has revealed that the observerâs goals gate the influence of many multisensory processes on brain and behavioural responses, whereas some other multisensory processes might occur independently of these goals. Consequently, other forms of top-down control beyond goal dependence are necessary to explain the full range of multisensory effects currently reported at the brain and the cognitive level. These forms of control include sensitivity to stimulus context as well as the detection of matches (or lack thereof) between a multisensory stimulus and categorical attributes of naturalistic objects (e.g. tools, animals). In this review we discuss and integrate the existing findings that demonstrate the importance of such goal-, object- and context-based top-down control over multisensory processing. We then put forward a few principles emerging from this literature review with respect to the mechanisms underlying multisensory processing and discuss their possible broader implications
The elegans of spindle assembly
The Caenorhabditis elegans one-cell embryo is a powerful system in which to study microtubule organization because this large cell assembles both meiotic and mitotic spindles within the same cytoplasm over the course of 1Â h in a stereotypical manner. The fertilized oocyte assembles two consecutive acentrosomal meiotic spindles that function to reduce the replicated maternal diploid set of chromosomes to a single-copy haploid set. The resulting maternal DNA then unites with the paternal DNA to form a zygotic diploid complement, around which a centrosome-based mitotic spindle forms. The early C. elegans embryo is amenable to live-cell imaging and electron tomography, permitting a detailed structural comparison of the meiotic and mitotic modes of spindle assembly
Modelling Z â ÏÏ processes in ATLAS with Ï-embedded Z â ΌΌ data
This paper describes the concept, technical realisation and validation of a largely data-driven method to model events with ZâÏÏ decays. In ZâΌΌ events selected from proton-proton collision data recorded at âs=8 TeV with the ATLAS experiment at the LHC in 2012, the Z decay muons are replaced by Ï leptons from simulated ZâÏÏ decays at the level of reconstructed tracks and calorimeter cells. The Ï lepton kinematics are derived from the kinematics of the original muons. Thus, only the well-understood decays of the Z boson and Ï leptons as well as the detector response to the Ï decay products are obtained from simulation. All other aspects of the event, such as the Z boson and jet kinematics as well as effects from multiple interactions, are given by the actual data. This so-called Ï-embedding method is particularly relevant for Higgs boson searches and analyses in ÏÏ final states, where ZarrowÏÏ decays constitute a large irreducible background that cannot be obtained directly from data control samples. In this paper, the relevant concepts are discussed based on the implementation used in the ATLAS Standard Model HâÏÏ analysis of the full datataset recorded during 2011 and 2012
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