Few-mode field quantization for multiple emitters

The control of the interaction between quantum emitters using nanophotonic structures holds great promise for quantum technology applications, while its theoretical description for complex nanostructures is a highly demanding task as the electromagnetic (EM) modes form a high-dimensional continuum. We here introduce an approach that permits a quantized description of the full EM field through a small number of discrete modes. This extends the previous work in ref. (I. Medina, F. J. García-Vidal, A. I. Fernández-Domínguez, and J. Feist, "Few-mode field quantization of arbitrary electromagnetic spectral densities,"Phys. Rev. Lett., vol. 126, p. 093601, 2021) to the case of an arbitrary number of emitters, without any restrictions on the emitter level structure or dipole operators. The low computational demand of this method makes it suitable for studying dynamics for a wide range of parameters. We illustrate the power of our approach for a system of three emitters placed within a hybrid metallodielectric photonic structure and show that excitation transfer is highly sensitive to the properties of the hybrid photonic-plasmonic mode

Formación práctica con especial valor a la innovación y a la libertad de maniobra

En este trabajo se expone el modelo de prácticas de empresa destinadas a alumnos de las titulaciones de grado desarrollado de la Escuela Politécnica Superior y enfocadas en tecnologías de la información y las comunicaciones. El objetivo de dichas prácticas es la adquisición por parte del alumnado de competencias básicas para el trabajo en equipo como son la cooperación, la responsabilidad, la iniciativa, la toma de decisiones y liderazgo. Este modelo está influenciado por otros trabajos pioneros donde se premia la creatividad, innovación y la motivación entre los trabajadores. Potenciando este trabajo en equipo, facilitaremos la adaptación de nuestros estudiantes al mundo laboral, además de complementar formación individual que durante sus años de estudio han desarrollado. Los técnicos y profesores participantes en la red han desarrollado actividades que fomentan estos objetivos así como indicadores que nos han permitido evaluar el grado de consecución de objetivos

Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase.

Obesity-associated insulin resistance plays a central role in type 2 diabetes. As such, tyrosine phosphatases that dephosphorylate the insulin receptor (IR) are potential therapeutic targets. The low-molecular-weight protein tyrosine phosphatase (LMPTP) is a proposed IR phosphatase, yet its role in insulin signaling in vivo has not been defined. Here we show that global and liver-specific LMPTP deletion protects mice from high-fat diet-induced diabetes without affecting body weight. To examine the role of the catalytic activity of LMPTP, we developed a small-molecule inhibitor with a novel uncompetitive mechanism, a unique binding site at the opening of the catalytic pocket, and an exquisite selectivity over other phosphatases. This inhibitor is orally bioavailable, and it increases liver IR phosphorylation in vivo and reverses high-fat diet-induced diabetes. Our findings suggest that LMPTP is a key promoter of insulin resistance and that LMPTP inhibitors would be beneficial for treating type 2 diabetes

Prevalence of Hyperuricemia and Its Association with Cardiovascular Risk Factors and Subclinical Target Organ Damage

The role of uric acid levels in the cardiovascular continuum is not clear. Our objective is to analyze the prevalence of hyperuricemia (HU) and its association with cardiovascular risk factors (CVRF), subclinical target organ damage (sTOD), and cardiovascular diseases (CVD). We evaluated the prevalence of HU in 6.927 patients included in the baseline visit of the IBERICAN study. HU was defined as uric acid levels above 6 mg/dL in women, and 7 mg/dL in men. Using adjusted logistic regression models, the odds ratios were estimated according to CVRF, sTOD, and CVD. The prevalence of HU was 16.3%. The risk of HU was higher in patients with pathological glomerular filtration rate (aOR: 2.92), heart failure (HF) (aOR: 1.91), abdominal obesity (aOR: 1.80), hypertension (HTN) (aOR: 1.65), use of thiazides (aOR: 1.54), left ventricular hypertrophy (LVH) (aOR: 1.36), atrial fibrillation (AFIB) (aOR: 1.29), and albuminuria (aOR: 1.27). On the other hand, being female (aOR: 0.82) showed a reduced risk. The prevalence of HU was higher in men, in patients presenting CVRF such as HTN and abdominal obesity, and with co-existence of LVH, atrial fibrillation (AFIB), HF, and any form of kidney injury. These associations raise the possibility that HU forms part of the early stages of the cardiovascular continuum. This may influence its management in Primary Healthcare because the presence of HU could mean an increased CV risk in the patients

Plataforma de aprendizaje Kahoot para la mejora de la enseñanza en diferentes grados del área de ciencias de la salud

La plataforma Kahoot es un sistema de respuesta personal o en grupo basado en el juego que transforma la clase en una competición entre los participantes. El objetivo de este proyecto ha sido utilizarla en las clases presenciales de distintas asignaturas del área de Ciencias de la Salud, como una nueva herramienta atractiva y accesible para los estudiantes, que permita una mejora del proceso de enseñanza-aprendizaje

Lugar(es)

Catálogo de la exposición colectiva celebrada en la sala de exposiciones de la Facultad de Bellas Artes de la Universidad Complutense de Madrid entre el 14 y el 30 de enero de 201

A Theoretical Perspective on Molecular Polaritonics

In the past decade, much theoretical research has focused on studying the strong coupling between organic molecules (or quantum emitters, in general) and light modes. The description and prediction of polaritonic phenomena emerging in this light-matter interaction regime have proven to be difficult tasks. The challenge originates from the enormous number of degrees of freedom that need to be taken into account, both in the organic molecules and in their photonic environment. On one hand, the accurate treatment of the vibrational spectrum of the former is key, and simplified quantum models are not valid in many cases. On the other hand, most photonic setups have complex geometric and material characteristics, with the result that photon fields corresponding to more than just a single electromagnetic mode contribute to the light-matter interaction in these platforms. Moreover, loss and dissipation, in the form of absorption or radiation, must also be included in the theoretical description of polaritons. Here, we review and offer our own perspective on some of the work recently done in the modeling of interacting molecular and optical states with increasing complexityThis work has been funded by the European Research Council through Grant ERC-2016-StG-714870 and by the Spanish Ministry for Science, Innovation, and Universities−Agencia Estatal de Investigación through grants RTI2018-099737-BI00, PCI2018-093145 (through the QuantERA program of the European Commission), and CEX2018-000805-M (through the María de Maeztu program for Units of Excellence in R&D). We also acknowledge financial support from the Proyecto Sinérgico CAM 2020 Y2020/TCS-6545 (NanoQuCo-CM) of the Community of Madri

Uso de la rapamicina y derivados para el tratamiento de la tripanosomiasis africana

[EN] Use of a composition that comprises a TbTOR-inhibiting agent, rapamycin or any of the salts, prodrugs, derivatives or analogues thereof, for the preparation of a drug to prevent and treat African trypanosomiasis.[ES] Uso de una composición que comprende un agente inhibidor de TbTOR, la rapamicina o cualquiera de sus sales, profármacos, derivados o análogos, para la elaboración de un medicamento para la prevención o el tratamiento de Ia tripanosomiasis africana.Peer reviewedConsejo Superior de Investigaciones Científicas (España)A1 Solicitud de patentes con informe sobre el estado de la técnic

Target of rapamycin (TOR) kinase in Trypanosoma brucei : an extended family

The complex life cycle of Trypanosoma brucei provides an excellent model system to understand signalling pathways that regulate development. We described previously the classical functions of TOR (target of rapamycin) 1 and TOR2 in T. brucei. In a more recent study, we described a novel TOR kinase, named TOR4, which regulates differentiation from the proliferative infective form to the quiescent form. In contrast with TOR1 loss-of-function, down-regulation of TOR4 triggers an irreversible differentiation process through the development of the insect pre-adapted quiescent form. TOR4 governs a signalling pathway distinct from those controlled by the conventional TOR complexes TORC1 and TORC2. Depletion of TOR4 induces all well-known characteristics of the quiescent developmental stage in trypanosomes, including expression of the PAD (proteins associated with differentiation) surface proteins and transcriptional down-regulation of the VSG (variant surface glycoprotein) gene. TOR4 kinase forms a structurally and functionally distinct complex named TORC4. TOR4 associates with LST8 (lethal with sec-13 protein 8) and other factors including an armadillo-domain-containing protein and the major vault protein, which probably serves as a scaffold for this kinase. Research in T. brucei, a protozoan parasite that diverged from the eukaryotic tree early in evolution, may help to uncover new functions of TOR kinases