Vom "Ob" zum "Wie" - bedarfsorientierte Angebote für den Studienbeginn

Der Übergang von Schule zu Hochschule verläuft unbefriedigend, wenn die Passung von Studieninteresse und Fähigkeiten der Studienanfänger_innen mit den Anforderungen des Studiums nicht optimal ist. An der Universität Jena werden ein Online Self-Assessment und ein lernbezogenes Beratungsangebot, aufbauend auf einer multimethodischen Bedarfsanalyse, entwickelt. Erste Ergebnisse zeigen den Zusammenhang von unrealistischen Erwartungen, geringer Studienzufriedenheit und erhöhter Abbruchneigung. Lernbezogene Präventionsstrategien hängen negativ mit erlebter Belastung durch Lernschwierigkeiten zusammen. Der Artikel stellt Ergebnisse der Bedarfsanalyse und die entstehenden Unterstützungsangebote vor

Olfactory Performance as an Indicator for Protective Treatment Effects in an Animal Model of Neurodegeneration

Background: Neurodegenerative diseases are often accompanied by olfactory deficits. Here we use a rare neurovisceral lipid storage disorder, Niemann–Pick disease C1 (NPC1), to illustrate disease-specific dynamics of olfactory dysfunction and its reaction upon therapy. Previous findings in a transgenic mouse model (NPC1-/-) showed severe morphological and electrophysiological alterations of the olfactory epithelium (OE) and the olfactory bulb (OB) that ameliorated under therapy with combined 2-hydroxypropyl-ß-cyclodextrin (HPßCD)/allopregnanolone/miglustat or HPßCD alone.Methods: A buried pellet test was conducted to assess olfactory performance. qPCR for olfactory key markers and several olfactory receptors was applied to determine if their expression was changed under treatment conditions. In order to investigate the cell dynamics of the OB, we determined proliferative and apoptotic activities using a bromodeoxyuridine (BrdU) protocol and caspase-3 (cas-3) activity. Further, we performed immunohistochemistry and western blotting for microglia (Iba1), astroglia (GFAP) and tyrosine hydroxylase (TH).Results: The buried pellet test revealed a significant olfactory deterioration in NPC1-/- mice, which reverted to normal levels after treatment. At the OE level, mRNA for olfactory markers showed no changes; the mRNA level of classical olfactory receptor (ORs) was unaltered, that of unique ORs was reduced. In the OB of untreated NPC1-/- mice, BrdU and cas-3 data showed increased proliferation and apoptotic activity, respectively. At the protein level, Iba1 and GFAP in the OB indicated increased microgliosis and astrogliosis, which was prevented by treatment.Conclusion: Due to the unique plasticity especially of peripheral olfactory components the results show a successful treatment in NPC1 condition with respect to normalization of olfaction. Unchanged mRNA levels for olfactory marker protein and distinct olfactory receptors indicate no effects in the OE in NPC1-/- mice. Olfactory deficits are thus likely due to central deficits at the level of the OB. Further studies are needed to examine if olfactory performance can also be changed at a later onset and interrupted treatment of the disease. Taken together, our results demonstrate that olfactory testing in patients with NPC1 may be successfully used as a biomarker during the monitoring of the treatment

Assessing human and environmental pressures of global land-use change 2000-2010

Global land is turning into an increasingly scarce resource. We here present a comprehensive assessment of co-occuring land-use change from 2000 until 2010, compiling existing spatially explicit data sources for different land uses, and building on a rich literature addressing specific land-use changes in all world regions. This review systematically categorizes patterns of land use, including regional urbanization and agricultural expansion but also globally telecoupled land-use change for all world regions. Managing land-use change patterns across the globe requires global governance. Here we present a comprehensive assessment of the extent and density of multiple drivers and impacts of land-use change. We combine and reanalyze spatially explicit data of global land-use change between 2000 and 2010 for population, livestock, cropland, terrestrial carbon and biodiversity. We find pervasive pressure on biodiversity but varying patterns of gross land-use changes across world regions. Our findings enable a classification of land-use patterns into three types. The 'consumers' type, displayed in Europe and North America, features high land footprints, reduced direct human pressures due to intensification of agriculture, and increased reliance on imports, enabling a partial recovery of terrestrial carbon and reducing pressure on biodiversity. In the 'producer' type, most clearly epitomized by Latin America, telecoupled land-use links drive biodiversity and carbon loss. In the 'mover' type, we find strong direct domestic pressures, but with a wide variety of outcomes, ranging from a concurrent expansion of population, livestock and croplands in Sub-Saharan Africa at the cost of natural habitats to strong pressure on cropland by urbanization in Eastern Asia. In addition, anthropogenic climate change has already left a distinct footprint on global land-use change. Our data- and literature-based assessment reveals region-specific opportunities for managing global land-use change. © 2019 The Author(s)

Association of Forced Vital Capacity with the Developmental Gene <i>NCOR2</i>

Background Forced Vital Capacity (FVC) is an important predictor of all-cause mortality in the absence of chronic respiratory conditions. Epidemiological evidence highlights the role of early life factors on adult FVC, pointing to environmental exposures and genes affecting lung development as risk factors for low FVC later in life. Although highly heritable, a small number of genes have been found associated with FVC, and we aimed at identifying further genetic variants by focusing on lung development genes. Methods Per-allele effects of 24,728 SNPs in 403 genes involved in lung development were tested in 7,749 adults from three studies (NFBC1966, ECRHS, EGEA). The most significant SNP for the top 25 genes was followed-up in 46,103 adults (CHARGE and SpiroMeta consortia) and 5,062 chi

Genome-wide association analysis identifies six new loci associated with forced vital capacity

Forced vital capacity (FVC), a spirometric measure of pulmonary function, reflects lung volume and is used to diagnose and monitor lung diseases. We performed genome-wide association study meta-analysis of FVC in 52,253 individuals from 26 studies and followed up the top associations in 32,917 additional individuals of European ancestry. We found six new regions associated at genome-wide significance (P < 5 × 10−8) with FVC in or near EFEMP1, BMP6, MIR129-2–HSD17B12, PRDM11, WWOX and KCNJ2. Two loci previously associated with spirometric measures (GSTCD and PTCH1) were related to FVC. Newly implicated regions were followed up in samples from African-American, Korean, Chinese and Hispanic individuals. We detected transcripts for all six newly implicated genes in human lung tissue. The new loci may inform mechanisms involved in lung development and the pathogenesis of restrictive lung disease

Vom "Ob" zum "Wie" - bedarfsorientierte Angebote für den Studienbeginn

Der Übergang von Schule zu Hochschule verläuft unbefriedigend, wenn die Passung von Studieninteresse und Fähigkeiten der Studienanfänger_innen mit den Anforderungen des Studiums nicht optimal ist. An der Universität Jena werden ein Online Self-Assessment und ein lernbezogenes Beratungsangebot, aufbauend auf einer multimethodischen Bedarfsanalyse, entwickelt. Erste Ergebnisse zeigen den Zusammenhang von unrealistischen Erwartungen, geringer Studienzufriedenheit und erhöhter Abbruchneigung. Lernbezogene Präventionsstrategien hängen negativ mit erlebter Belastung durch Lernschwierigkeiten zusammen. Der Artikel stellt Ergebnisse der Bedarfsanalyse und die entstehenden Unterstützungsangebote vor

Vom "Ob" zum "Wie" - bedarfsorientierte Angebote für den Studienbeginn

Der Übergang von Schule zu Hochschule verläuft unbefriedigend, wenn die Passung von Studieninteresse und Fähigkeiten der Studienanfänger_innen mit den Anforderungen des Studiums nicht optimal ist. An der Universität Jena werden ein Online Self-Assessment und ein lernbezogenes Beratungsangebot, aufbauend auf einer multimethodischen Bedarfsanalyse, entwickelt. Erste Ergebnisse zeigen den Zusammenhang von unrealistischen Erwartungen, geringer Studienzufriedenheit und erhöhter Abbruchneigung. Lernbezogene Präventionsstrategien hängen negativ mit erlebter Belastung durch Lernschwierigkeiten zusammen. Der Artikel stellt Ergebnisse der Bedarfsanalyse und die entstehenden Unterstützungsangebote vor

Mechanical Characterization of Handball Shoes Using Biomechanical Load Spectrums

AbstractThe purpose of this paper was to mechanically characterize handball shoes using biomechanical evaluated load spectrums. In the first step a biomechanical study with 15 experienced amateur handball players was conducted. Within this study the kinematics and kinetics of three typical handball activities, namely sprint, feint and jump shot, were evaluated using an optoelectronic measurement system and a force plate. After determining typical biomechanical load spectrums for handball activities from the collected data, in a second step a sample of nine handball shoes size UK 8 were mechanically tested to characterize their cushioning properties

Fachdidaktik und Fachunterricht

Koch-Priewe B, Köker A, Störtländer JC. Fachdidaktik und Fachunterricht. In: Harring M, Rohlfs C, Gläser-Zikuda M, eds. Handbuch Schulpädagogik. Münster: Waxmann; 2018: 418-426

Fachunterricht und Fachdidaktik

Koch-Priewe B, Köker A, Störtländer JC. Fachunterricht und Fachdidaktik. In: Harring M, Rohlfs C, Gläser-Zikuda M, eds. Handbuch Schulpädagogik. 2. aktualisierte und erweiterte. Münster / New York: Waxmann; 2022: 436-445