29 research outputs found
Mycosis Fungoides Associated with Kaposi\u27s Sarcoma, T-cell Rich B-cell Lymphoma, and T cell Lymphoma with Angioimmunoblastic Features
A patient with mycosis fungoides (MF), Kaposi\u27s sarcoma, T-cell B-cell rich lymphoma and T-cell lymphoma with angioimmunoblastic features is described. The appearance of multiple malignancies in this patient may have been caused by previous exposure to radiation in the Chernobyl accident and/or systemic chemotherapy for the initial T-cell B-cell rich lymphoma which he underwent.</p
An Uncommon Presentation of Darier-White Disease with Hystrix-like Palmoplantar Keratoderma
Darier-White disease is a relatively common autosomal dominant
genodermatosis caused by mutation in the ATP2A2 gene. It is characterized by
multiple warty papules coalescing into plaques in the seborrheic areas and by
specific histological skin changes. Palm and sole involvement in Darier-White
disease is usually mild, mainly featuring discrete and small keratotic papules. We
present a unique case of Darier-White disease presenting with a diffuse, mutilating
hystrix-like palmoplantar keratoderma
An Uncommon Presentation of Darier-White Disease with Hystrix-like Palmoplantar Keratoderma
Darier-White disease is a relatively common autosomal dominant
genodermatosis caused by mutation in the ATP2A2 gene. It is characterized by
multiple warty papules coalescing into plaques in the seborrheic areas and by
specific histological skin changes. Palm and sole involvement in Darier-White
disease is usually mild, mainly featuring discrete and small keratotic papules. We
present a unique case of Darier-White disease presenting with a diffuse, mutilating
hystrix-like palmoplantar keratoderma
FOXP3 Predicts Response to Treatment in Mycosis Fungoid
Background: The role of the T-regulatory cells (Tregs) marker forkhead box Protein
3 (FOXP3) in mycoses fungoides (MF) pathogenesis is unclear and the results of
previous studies are inconclusive.
Objective: We aimed at ascertaining the possibility that FOXP3 expression may
serve to predict MF stage and response to therapy.
Patients and methods: Immunohistochemistry staining for FOXP3 was performed
on 30 skin biopsies from patients with MF, and FOXP3 expression level was quantitatively
graded. Disease stage, progression, and response to treatment were determined
based on clinical and imaging evidence, and association with FOXP3 expression
was assessed.
Results: FOXP3 expression in the dermis correlated with poor response to treatment
(P=0.047). A negative non-significant relationship between epidermal FOXP3
expression and clinical stage severity was observed (P=0.17).
Conclusions: Dermal FOXP3 expression in MF lesions could be used to predict response
to treatment in patients with MF
Passive scalar turbulence in high dimensions
Exploiting a Lagrangian strategy we present a numerical study for both
perturbative and nonperturbative regions of the Kraichnan advection model. The
major result is the numerical assessment of the first-order -expansion by
M. Chertkov, G. Falkovich, I. Kolokolov and V. Lebedev ({\it Phys. Rev. E},
{\bf 52}, 4924 (1995)) for the fourth-order scalar structure function in the
limit of high dimensions 's. %Two values of the velocity scaling exponent
have been considered: % and . In the first case, the
perturbative regime %takes place at , while in the second at , %in agreement with the fact that the relevant small parameter %of the
theory is . In addition to the perturbative results, the
behavior of the anomaly for the sixth-order structure functions {\it vs} the
velocity scaling exponent, , is investigated and the resulting behavior
discussed.Comment: 4 pages, Latex, 4 figure
Epidermolytic Ichthyosis Sine Epidermolysis
Epidermolytic ichthyosis (EI) is a rare disorder of cornification caused by mutations in KRT1 and KRT10, encoding two suprabasal epidermal keratins. Because of the variable clinical features and severity of the disease, histopathology is often required to correctly direct the molecular analysis. EI is characterized by hyperkeratosis and vacuolar degeneration of the upper epidermis, also known as epidermolytic hyperkeratosis, hence the name of the disease. In the current report, the authors describe members of 2 families presenting with clinical features consistent with EI. The patients were shown to carry classical mutations in KRT1 or KRT10, but did not display epidermolytic changes on histology. These observations underscore the need to remain aware of the limitations of pathological features when considering a diagnosis of EI
Measurement of jet fragmentation into charged particles in pp and PbPb collisions at sqrt(s[NN]) = 2.76 TeV
Jet fragmentation in pp and PbPb collisions at a centre-of-mass energy of
2.76 TeV per nucleon pair was studied using data collected with the CMS
detector at the LHC. Fragmentation functions are constructed using
charged-particle tracks with transverse momenta pt > 4 GeV for dijet events
with a leading jet of pt > 100 GeV. The fragmentation functions in PbPb events
are compared to those in pp data as a function of collision centrality, as well
as dijet-pt imbalance. Special emphasis is placed on the most central PbPb
events including dijets with unbalanced momentum, indicative of energy loss of
the hard scattered parent partons. The fragmentation patterns for both the
leading and subleading jets in PbPb collisions agree with those seen in pp data
at 2.76 TeV. The results provide evidence that, despite the large parton energy
loss observed in PbPb collisions, the partition of the remaining momentum
within the jet cone into high-pt particles is not strongly modified in
comparison to that observed for jets in vacuum.Comment: Submitted to the Journal of High Energy Physic