The difficulties in identifying and grafting an intramuscular coronary artery

Myocardial bridging involves tunnelling of one of the coronary arteries through the myocardium, resulting in what are known as intramyocardial coronaries. While most patients with intramyocardial coronary vessels are asymptomatic, there is evidence that myocardial bridging may be the cause of sudden death. Given the low detection rate on coronary angiography, myocardial bridging may complicate coronary artery bypass grafting (CABG). This case report discusses a 72-year-old gentleman who underwent CABG, during which an undiagnosed intramuscular left anterior descending (LAD) coronary artery was found. With only the tapering end of the LAD visible at the apex of the heart, a small incision was made at this site and a 1mm probe inserted. At the uppermost reach of the probe the tip was felt to point superficial and therefore a second more proximal incision was performed. The left internal thoracic artery (LITA) was than successfully anastomosed with the proximal arteriotomy and a length of saphenous vein was used for anastomosis with the distal arteriotomy where the probe was originally inserted. The patient was discharged home 5 days post operatively.peer-reviewe

A Deep Space Network Portable Radio Science Receiver

The Radio Science Receiver (RSR) is an open-loop receiver installed in NASA s Deep Space Network (DSN), which digitally filters and records intermediate-frequency (IF) analog signals. The RSR is an important tool for the Cassini Project, which uses it to measure perturbations of the radio-frequency wave as it travels between the spacecraft and the ground stations, allowing highly detailed study of the composition of the rings, atmosphere, and surface of Saturn and its satellites

Efecto de mezcla de grasa, albedo de maracuyá (passiflora edulis.) var. flavicarpa y aceite de girasol (helianthus annuus) sobre la capacidad de retención de agua, color textura y aceptabilidad general de hamburguesas de carne de vacuno (bos taurus)

En la presente investigación se evaluó el efecto de las mezclas de grasa de cerdo, albedo de maracuyá y aceite de girasol (0 – 100%) sobre la capacidad de retención de agua, el color (L*, a* y b*), textura instrumental y aceptabilidad general de hamburguesas de carne de vacuno. Se aplicó un diseño de mezclas simplex reticular con centroide ampliado bajo la metodología de superficie de respuesta, con la finalidad de obtener el modelo matemático adecuado para representar el comportamiento de las variables en estudio y establecer la combinación óptima estimada de los factores que permita optimizar las variables respuesta. Existió efecto significativo (p<0.05) de las mezclas grasa de cerdo, albedo de maracuyá y aceite de girasol sobre la textura y la aceptabilidad general. Caso contrario ocurrió para las variables capacidad de retención de agua y color. El modelo matemático cúbico especial representó el comportamiento de la textura instrumental y el modelo cuadrático el de la aceptabilidad general, con valores de coeficientes de determinación R2 de 0.96 y 0.87, respectivamente. La combinación óptima estimada de grasa de cerdo al 90.31%, albedo de maracuyá al 6.58% y aceite de girasol al 3.11%, permitió optimizar las variables respuesta: aceptabilidad general con mayor calificación de 6.89 (valor aproximado a 7 = calificación de “Me agrada moderadamente”) y adecuada textura instrumental de 2.67 N, en hamburguesas de carne de vacuno.The effect of the mixtures of pork fat, passion fruit albedo and sunflower oil (0 100%) on the water holding capacity, color (L*, a* y b*), instrumental texture and overall acceptability of beef burgers, was evaluated. The reticular simplex mixtures design with expanded centroid under the methodology of response surface was used in order to obtain the appropriate mathematical model to represent the behavior of the variables under study and to establish the optimal combination of predicted factors for optimizing it. A significant (p<0.05) effect of the mixtures of pork fat, passion fruit albedo and sunflower oil on the fiber texture and overall acceptability was found. The opposite was true for water retention capacity and color properties. The special cubic mathematical model represented the behavior of the instrumental texture and the quadratic model was followed for the general acceptability, with values of coefficients of determination R2 of 0.96 and 0.87, respectively. The predicted optimal combination was: pork fat 90.31%; passion fruit albedo 6.58% and sunflower oil 3.11%; this mixture allowed to optimize the response variables: overall acceptability score greater than 6.89 (approximate value 7 = rating ""I like it moderately""), adequate texture and 2.67 N instrumental in beef burgers

AS RETÓRICAS DO DIREITO

O presente artigo propõe um modelo classificatório dos ambientes retóricos que compõem a retórica jurídica em sentido amplo. Partindo de referenciais teóricos como a tripartição retórica de Ottmar Ballweg e a retórica do inconsciente de Vital Brazil, chega-se a conclusão que a praxis jurídica e a realização do direito são ambientados por três retóricas que ocupam tanto o espaço da real constituição linguística do sistema social do direito, como o espaço do simbólico em um contexto de interpretância de uma hermenêutica intersubjetiva do sujeito-operador do direito, podendo influenciar, direta e indiretamente, na condução da problemática da realização do direito: a retórica jurídica strictu sensu, a retórica gnoseológica e a retórica subjetiva do sujeito-operador do direito

Producción académica y desempeño docente en una universidad privada de la región San Martín – Perú, 2021

La presente investigación tuvo como objetivo, Determinar la relación entre producción académica y desempeño docente en la escuela de Derecho de una Universidad privada de la región San Martín – Perú, 2021. El tipo de investigación básica, con diseño no experimental, la población y muestra estuvo conformada 80 docentes; la técnica la encuesta y el instrumento, el cuestionario. Los resultados del nivel de la producción académica fueron medio con un 47,5 %. El nivel de las dimensiones de la producción académica que más destaca fue las publicaciones, con un 60 % en un nivel bajo, El nivel de desempeño docente fue bueno con el 90 %. El nivel de dimensiones del desempeño docente que más resalta fue la del dominio tecnológico, con un 86.25 %también fue bueno. Se concluyó que, no existe relación entre la producción académica y el desempeño docente en la Escuela de Derecho de una universidad privada de la región San Martín – Perú, 2021. Mediante el análisis estadístico del coeficiente de correlación de Rho de Spearman se alcanzó el 0,064 y una significancia bilateral de 0,570 siendo mayor que 0,05; por lo que, se acepta la H0 y rechaza la hipótesis alterna

Propuesta de implementación de un modelo para la evaluación de la calidad del producto de software para una empresa consultora TI

El presente trabajo de investigación tiene como objetivo el estudio de la línea de servicio de Certificación de Software de la empresa consultora TI y requiere resolver la problemática en la evaluación de los productos de desarrollo de software que impactan directamente en el cumplimiento de sus SLA, generando grandes pérdidas económicas. En el análisis cuantitativo, se identificó que existen inadecuadas técnicas para la evaluación con un impacto en el cumplimiento de los umbrales definidos en cada SLA, lo cual ha generado grandes pérdidas económicas en los últimos años por penalización. Ante esta situación caótica, se propone la implementación de un modelo de evaluación de calidad del producto de Software, la cual propone lineamientos de acuerdo con estándares y prácticas internacionales para la evaluación de la calidad, ayudando a incrementar la calidad de sus productos y la satisfacción del cliente, debido que se evidencia pérdidas económicas que se están incrementando anualmente. En este trabajo de investigación se hace una revisión general de los estándares de evaluación de calidad de producto de Software, se realiza una evaluación del cumplimiento de la norma ISO/IEC 25010 en la empresa y se propone un plan de mejora. Como conclusión, se recomienda la ejecución de la propuesta de implementación como apoyo estratégico al cumplimiento de los objetivos estratégicos de la empresa, reduciendo el riesgo de pérdidas económicas e incrementar la capacidad para ejecutar nuevas STD (Solicitudes Técnicas de Desarrollo), que permitirá a la empresa ser más rentable y brindar un servicio de mejor calidad.The following work of research has as main subject the study of the software certification service line from the consulting TI company and requires solving the problematic in the evaluation of software development products that has a direct impact in the fulfillment of their SLA, generating large economic losses. In the quantitative analysis, it was identified there are inadequate techniques for the evaluation with an impact of the fulfillment of the thresholds defined on each SLA, which has generated large economic losses in the last year due to penalty. Given this chaotic situation, the implementation of a software product quality evaluation model is proposed, which provides guidelines in accordance with international standards and practices for the evaluation of quality, helping to increase the quality of its products and customer satisfaction, because there is evidence of economic losses that are increasing annually. In this research work a general review of the existing software product quality evaluation standards is made, an evaluation of compliance of the ISO/IEC 25010 norm in the company will be carried out and an improvement plan will be proposed. In conclusion, the implementation of the proposal is recommended as strategic support for the fulfillment of the strategic objectives of the company, reducing the risk of economic losses and increasing the capacity to execute new STD (Technical Development Requests), which will allow the company to be more profitable and provide a better quality service.Trabajo de investigació

Rare coding variants and X-linked loci associated with age at menarche.

More than 100 loci have been identified for age at menarche by genome-wide association studies; however, collectively these explain only ∼3% of the trait variance. Here we test two overlooked sources of variation in 192,974 European ancestry women: low-frequency protein-coding variants and X-chromosome variants. Five missense/nonsense variants (in ALMS1/LAMB2/TNRC6A/TACR3/PRKAG1) are associated with age at menarche (minor allele frequencies 0.08-4.6%; effect sizes 0.08-1.25 years per allele; P<5 × 10(-8)). In addition, we identify common X-chromosome loci at IGSF1 (rs762080, P=9.4 × 10(-13)) and FAAH2 (rs5914101, P=4.9 × 10(-10)). Highlighted genes implicate cellular energy homeostasis, post-transcriptional gene silencing and fatty-acid amide signalling. A frequently reported mutation in TACR3 for idiopathic hypogonatrophic hypogonadism (p.W275X) is associated with 1.25-year-later menarche (P=2.8 × 10(-11)), illustrating the utility of population studies to estimate the penetrance of reportedly pathogenic mutations. Collectively, these novel variants explain ∼0.5% variance, indicating that these overlooked sources of variation do not substantially explain the 'missing heritability' of this complex trait.UK sponsors (see article for overseas ones): This work made use of data and samples generated by the 1958 Birth Cohort (NCDS). Access to these resources was enabled via the 58READIE Project funded by Wellcome Trust and Medical Research Council (grant numbers WT095219MA and G1001799). A full list of the financial, institutional and personal contributions to the development of the 1958 Birth Cohort Biomedical resource is available at http://www2.le.ac.uk/projects/birthcohort. Genotyping was undertaken as part of the Wellcome Trust Case-Control Consortium (WTCCC) under Wellcome Trust award 076113, and a full list of the investigators who contributed to the generation of the data is available at www.wtccc.org.uk ... The Fenland Study is funded by the Wellcome Trust and the Medical Research Council, as well as by the Support for Science Funding programme and CamStrad. ... SIBS - CRUK ref: C1287/A8459 SEARCH - CRUK ref: A490/A10124 EMBRACE is supported by Cancer Research UK Grants C1287/A10118, C1287/A16563 and C1287/A17523. Genotyping was supported by Cancer Research - UK grant C12292/A11174D and C8197/A16565. Gareth Evans and Fiona Lalloo are supported by an NIHR grant to the Biomedical Research Centre, Manchester. The Investigators at The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust are supported by an NIHR grant to the Biomedical Research Centre at The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust. Ros Eeles and Elizabeth Bancroft are supported by Cancer Research UK Grant C5047/A8385. ... Generation Scotland - Scottish Executive Health Department, Chief Scientist Office, grant number CZD/16/6. Exome array genotyping for GS:SFHS was funded by the Medical Research Council UK. 23andMe - This work was supported in part by NIH Award 2R44HG006981-02 from the National Human Genome Research Institute.This is the final version of the article. It first appeared from NPG via http://dx.doi.org/10.1038/ncomms875

Mining Environmental Liability and Its in Situ Treatment with Calcium Oxide for Zinc Removal

Mining environmental liabilities have negative effects on human health, the ecosystem and property. This study was conducted at the Cercapuquio Mining Environmental Liability (MEL) in the district of Chongos Alto. The wastewater analysis was conducted at Universidad Continental and data were obtained on metal content and hydrogen potential. This investigation revealed that the Cercapuquio MEL wastewater had a higher concentration of zinc, 9,916 mg/L, and the pH level was 7.53 (alkaline), which is why this effluent exceeds the maximum permissible limit of the annual average. A neutralizing reagent was also prepared by recycling eggshells, calcined at 1000 °C for 40 min, obtaining quicklime with 61.30% calcium oxide (CaO). For wastewater treatment, the quicklime obtained in neutralizing solution was used, which, when applied to the effluent, had the effect of lowering the zinc concentration from 9.916 mg/L to 0.051 mg/L and the pH from 7.53 to 10.36. The average zinc removal achieved in the effluent is 96%

Social Distancing and COVID-19: Factors Associated With Compliance With Social Distancing Norms in Spain

This article describes patterns of compliance with social distancing measures among the Spanish population during the coronavirus disease-2019 (COVID-19) pandemic. It identifies several factors associated with higher or lower compliance with recommended measures of social distancing. This research is part of a 67-country study, titled the International COVID-19 study on Social & Moral Psychology, in which we use a Spanish dataset. Participants were residents in Spain aged 18 or above. The sample comprises 1,090 respondents, weighted to be representative of the Spanish population. Frequencies, correlations, bivariate analysis, and six models based on hierarchical multiple regressions were applied. The main finding is that most Spaniards are compliant with established guidelines of social distance during the pandemic (State of Alarm, before May 2020). Variables associated more with lower levels of compliance with these standards were explored. Six hierarchical multiple regression models found that compliance with social distance measures has a multifactorial explanation (R 2 between 20.4 and 49.1%). Sociodemographic factors, personal hygiene patterns, and the interaction between personal hygiene patterns and the support for political measures related to the coronavirus brought significant effects on the regression models. Less compliance was also associated with beliefs in some specific conspiracy theories with regard to COVID-19 or general conspiracy mentality (Conspiracy Mentality Questionnaire, CMQ), consumption patterns of traditional mass media (television, paper newspapers, magazines, and radio) and modern means to get informed (online digital newspapers, blogs, and social networks), political ideology, vote, trust in institutions, and political identification. Among the future lines of action in preventing the possible outbreak of the virus, we suggest measures to reinforce trust in official information, mainly linked to reducing the influence of disinformation and conspiracy theories parallel to the pandemic