318 research outputs found
Association Between Direct-to-Consumer Advertising and Testosterone Testing and Initiation in the United States, 2009-2013
Testosterone initiation increased substantially in the United States from 2000 to 2013, especially among men without clear indications. Direct-to-consumer advertising (DTCA) also increased during this time
Contributors to life satisfaction in parents of an adult child with Down syndrome [Conference Abstract]
Aim: This study investigated: (1) concurrent relationships between measures of family life and parental satisfaction with life in parents of an adult with Down syndrome and (2) influence of early family functioning on current parental satisfaction. Method: Sixty-two families were interviewed using a semi-structured interview, and responded to a series of questionnaires related to family functioning when their child with Down syndrome was between 7 and 15 years. Fifteen years later parents were asked to provide data on their current situation, including mental health, and satisfaction and difficulties with respect to care-giving in relation to their adult child. Results: Over half the families provided data to the second phase of the study. Life circumstances were appreciably worse for a small group of families than had been the case 15 years previously; however, these changes were generally unrelated to their parenting role. Overall, parents reported experiencing satisfaction from their care-giving role and did not report high levels of difficulties emanating from this role. Conclusions: Most parents demonstrated good levels of personal functioning, although there was a small group for whom this was not the case. Earlier functioning did not make a strong contribution to current levels of life satisfaction
Fecal Contamination of Shallow Tubewells in Bangladesh Inversely Related to Arsenic
The health risks of As exposure due to the installation of millions of shallow tubewells in the Bengal Basin are known, but fecal contamination of shallow aquifers has not systematically been examined. This could be a source of concern in densely populated areas with poor sanitation because the hydraulic travel time from surface water bodies to shallow wells that are low in As was previously shown to be considerably shorter than for shallow wells that are high in As. In this study, 125 tubewells 6−36 m deep were sampled in duplicate for 18 months to quantify the presence of the fecal indicator Escherichia coli. On any given month, E. coli was detected at levels exceeding 1 most probable number per 100 mL in 19−64% of all shallow tubewells, with a higher proportion typically following periods of heavy rainfall. The frequency of E. coli detection averaged over a year was found to increase with population surrounding a well and decrease with the As content of a well, most likely because of downward transport of E. coli associated with local recharge. The health implications of higher fecal contamination of shallow tubewells, to which millions of households in Bangladesh have switched in order to reduce their exposure to As, need to be evaluated
Management of oral secretions in neurological disease.
Sialorrhoea is a common and problematic symptom that arises from a range of neurological conditions associated with bulbar or facial muscle dysfunction. Drooling can significantly affect quality of life due to both physical complications such as oral chapping, and psychological complications such as embarrassment and social isolation. Thicker, tenacious oral and pharyngeal secretions may result from the drying management approach to sialorrhoea. The management of sialorrhoea in neurological diseases depends on the underlying pathology and severity of symptoms. Interventions include anticholinergic drugs, salivary gland-targeted radiotherapy, salivary gland botulinum toxin and surgical approaches. The management of thick secretions involves mainly conservative measures such as pineapple juice as a lytic agent, cough assist, saline nebulisers and suctioning or mucolytic drugs like carbocisteine. Despite a current lack of evidence and variable practice, management of sialorrhoea should form a part of the multidisciplinary approach needed for long-term neurological conditions
Genome-wide meta-analysis implicates mediators of hair follicle development and morphogenesis in risk for severe acne
Acne vulgaris is a highly heritable common, chronic inflammatory disease of the skin for which five genetic risk loci have so far been identified. Here, we perform a genome-wide association study of 3823 cases and 16,144 controls followed by meta-analysis with summary statistics from a previous study, with a total sample size of 26,722. We identify 20 independent association signals at 15 risk loci, 12 of which have not been previously implicated in the disease. Likely causal variants disrupt the coding region of WNT10A and a P63 transcription factor binding site in SEMA4B. Risk alleles at the 1q25 locus are associated with increased expression of LAMC2, in which biallelic loss-of-function mutations cause the blistering skin disease epidermolysis bullosa. These findings indicate that variation affecting the structure and maintenance of the skin, in particular the pilosebaceous unit, is a critical aspect of the genetic predisposition to severe acne
Cross sections and double-helicity asymmetries of midrapidity inclusive charged hadrons in p+p collisions at sqrt(s)=62.4 GeV
Unpolarized cross sections and double-helicity asymmetries of
single-inclusive positive and negative charged hadrons at midrapidity from p+p
collisions at sqrt(s)=62.4 GeV are presented. The PHENIX measurements for 1.0 <
p_T < 4.5 GeV/c are consistent with perturbative QCD calculations at
next-to-leading order in the strong coupling constant, alpha_s. Resummed pQCD
calculations including terms with next-to-leading-log accuracy, yielding
reduced theoretical uncertainties, also agree with the data. The
double-helicity asymmetry, sensitive at leading order to the gluon polarization
in a momentum-fraction range of 0.05 ~< x_gluon ~< 0.2, is consistent with
recent global parameterizations disfavoring large gluon polarization.Comment: PHENIX Collaboration. 447 authors, 12 pages, 5 figures, 5 tables.
Submitted to Physical Review
Inclusive cross section and single-transverse-spin asymmetry for very forward neutron production in polarized p+p collisions at sqrt(s)=200 GeV
The energy dependence of the single-transverse-spin asymmetry, A_N, and the
cross section for neutron production at very forward angles were measured in
the PHENIX experiment at RHIC for polarized p+p collisions at sqrt(s)=200 GeV.
The neutrons were observed in forward detectors covering an angular range of up
to 2.2 mrad. We report results for neutrons with momentum fraction of x_F=0.45
to 1.0. The energy dependence of the measured cross sections were consistent
with x_F scaling, compared to measurements by an ISR experiment which measured
neutron production in unpolarized p+p collisions at sqrt(s)=30.6--62.7 GeV. The
cross sections for large x_F neutron production for p+p collisions, as well as
those in e+p collisions measured at HERA, are described by a pion exchange
mechanism. The observed forward neutron asymmetries were large, reaching
A_N=-0.08+/-0.02 for x_F=0.8; the measured backward asymmetries, for negative
x_F, were consistent with zero. The observed asymmetry for forward neutron
production is discussed within the pion exchange framework, with interference
between the spin-flip amplitude due to the pion exchange and nonflip amplitudes
from all Reggeon exchanges. Within the pion exchange description, the measured
neutron asymmetry is sensitive to the contribution of other Reggeon exchanges
even for small amplitudes.Comment: 383 authors, 16 pages, 18 figures, 6 tables. Submitted to Phys. Rev.
D. Plain text data tables for the points plotted in figures for this and
previous PHENIX publications are (or will be) publicly available at
http://www.phenix.bnl.gov/papers.htm
Inclusive cross section and double helicity asymmetry for pi^0 production in p+p collisions at sqrt(s) = 62.4 GeV
The PHENIX experiment presents results from the RHIC 2006 run with polarized
proton collisions at sqrt(s) = 62.4 GeV for inclusive pi^0 production at
mid-rapidity. Unpolarized cross section results are measured for transverse
momenta p_T = 0.5 to 7 GeV/c. Next-to-leading order perturbative quantum
chromodynamics calculations are compared with the data, and while the
calculations are consistent with the measurements, next-to-leading logarithmic
corrections improve the agreement. Double helicity asymmetries A_LL are
presented for p_T = 1 to 4 GeV/c and probe the higher range of Bjorken_x of the
gluon (x_g) with better statistical precision than our previous measurements at
sqrt(s)=200 GeV. These measurements are sensitive to the gluon polarization in
the proton for 0.06 < x_g < 0.4.Comment: 387 authors from 63 institutions, 10 pages, 6 figures, 1 table.
Submitted to Physical Review D. Plain text data tables for the points plotted
in figures for this and previous PHENIX publications are (or will be)
publicly available at http://www.phenix.bnl.gov/papers.htm
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Measurement of Bottom versus Charm as a Function of Transverse Momentum with Electron-Hadron Correlations in p+p Collisions at sqrt(s)=200 GeV
The momentum distribution of electrons from semi-leptonic decays of charm and
bottom for mid-rapidity |y|<0.35 in p+p collisions at sqrt(s)=200 GeV is
measured by the PHENIX experiment at the Relativistic Heavy Ion Collider (RHIC)
over the transverse momentum range 2 < p_T < 7 GeV/c. The ratio of the yield of
electrons from bottom to that from charm is presented. The ratio is determined
using partial D/D^bar --> e^{+/-} K^{-/+} X (K unidentified) reconstruction. It
is found that the yield of electrons from bottom becomes significant above 4
GeV/c in p_T. A fixed-order-plus-next-to-leading-log (FONLL) perturbative
quantum chromodynamics (pQCD) calculation agrees with the data within the
theoretical and experimental uncertainties. The extracted total bottom
production cross section at this energy is \sigma_{b\b^bar}= 3.2
^{+1.2}_{-1.1}(stat) ^{+1.4}_{-1.3}(syst) micro b.Comment: 432 authors, 6 pages text, 3 figures. Submitted to Phys. Rev. Lett.
Plain text data tables for the points plotted in figures for this and
previous PHENIX publications are (or will be) publicly available at
http://www.phenix.bnl.gov/papers.htm
Cold Nuclear Matter Effects on J/psi Yields as a Function of Rapidity and Nuclear Geometry in Deuteron-Gold Collisions at sqrt(s_NN) = 200 GeV
We present measurements of J/psi yields in d+Au collisions at sqrt(s_NN) =
200 GeV recorded by the PHENIX experiment and compare with yields in p+p
collisions at the same energy per nucleon-nucleon collision. The measurements
cover a large kinematic range in J/psi rapidity (-2.2 < y < 2.4) with high
statistical precision and are compared with two theoretical models: one with
nuclear shadowing combined with final state breakup and one with coherent gluon
saturation effects. To remove model dependent systematic uncertainties we also
compare the data to a simple geometric model. We find that calculations where
the nuclear modification is linear or exponential in the density weighted
longitudinal thickness are difficult to reconcile with the forward rapidity
data.Comment: 449 authors from 66 institutions, 6 pages, 3 figures. Submitted to
Physical Review Letters. Plain text data tables for the points plotted in
figures for this and previous PHENIX publications are (or will be) publicly
available at http://www.phenix.bnl.gov/papers.htm
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