1,135 research outputs found
Ordering dynamics of the driven lattice gas model
The evolution of a two-dimensional driven lattice-gas model is studied on an
L_x X L_y lattice. Scaling arguments and extensive numerical simulations are
used to show that starting from random initial configuration the model evolves
via two stages: (a) an early stage in which alternating stripes of particles
and vacancies are formed along the direction y of the driving field, and (b) a
stripe coarsening stage, in which the number of stripes is reduced and their
average width increases. The number of stripes formed at the end of the first
stage is shown to be a function of L_x/L_y^\phi, with \phi ~ 0.2. Thus,
depending on this parameter, the resulting state could be either single or
multi striped. In the second, stripe coarsening stage, the coarsening time is
found to be proportional to L_y, becoming infinitely long in the thermodynamic
limit. This implies that the multi striped state is thermodynamically stable.
The results put previous studies of the model in a more general framework
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Impact of Hypothyroidism and Heart Failure on Hospitalization Risk.
BackgroundPrior studies suggest that the relationship between hypothyroidism and mortality is dependent on underlying cardiovascular risk. Little is known about the association of hypothyroidism with hospitalization risk, and how these associations are modified by cardiovascular status.MethodsThis study examined the association of thyroid status, defined by serum thyrotropin (TSH), with hospitalization risk among patients who received care at a large university-based tertiary care center between 1990 and 2015. Thyroid status was categorized as hypothyroidism versus euthyroidism (TSH >4.7 vs. 0.3-4.7 mIU/L, respectively). The relationship between thyroid status and hospitalization risk stratified by cardiovascular status was examined using multivariable Cox models.ResultsAmong 52,856 patients who met eligibility criteria, 49,791 (94.2%) had euthyroidism and 3065 (5.8%) had hypothyroidism. In analyses stratified by congestive heart failure (CHF) status, compared to euthyroidism, hypothyroidism was associated with higher risk of hospitalization in those with CHF but slightly lower risk in those without CHF (adjusted hazard ratio [aHRs] = 1.86 [confidence interval (CI) 1.17-2.94] and HR = 0.95 [CI 0.92-0.99], respectively; p = 0.006). In sensitivity analyses accounting for death as a competing event, underlying coronary artery disease modified the hypothyroidism-hospitalization relationship, such that stronger associations were observed among those with versus without coronary artery disease. In competing risk analyses, hypothyroidism was associated with higher versus lower risk of hospitalization among those with versus without cerebrovascular disease, respectively.ConclusionsHypothyroidism is associated with higher hospitalization risk among patients with underlying cardiovascular disease. Future studies are needed to determine whether correction of thyroid status with replacement therapy ameliorates hospitalization risk in this population
Tri-critical behavior in rupture induced by disorder
We discover a qualitatively new behavior for systems where the load transfer
has limiting stress amplification as in real fiber composites. We find that the
disorder is a relevant field leading to tri--criticality, separating a
first-order regime where rupture occurs without significant precursors from a
second-order regime where the macroscopic elastic coefficient exhibit power law
behavior. Our results are based on analytical analysis of fiber bundle models
and numerical simulations of a two-dimensional tensorial spring-block system in
which stick-slip motion and fracture compete.Comment: Revtex, 10 pages, 4 figures available upon reques
Direct Geometric Probe of Singularities in Band Structure
The band structure of a crystal may have points where two or more bands are
degenerate in energy and where the geometry of the Bloch state manifold is
singular, with consequences for material and transport properties. Ultracold
atoms in optical lattices have been used to characterize such points only
indirectly, e.g., by detection of an Abelian Berry phase, and only at
singularities with linear dispersion (Dirac points). Here, we probe
band-structure singularities through the non-Abelian transformation produced by
transport directly through the singular points. We prepare atoms in one Bloch
band, accelerate them along a quasi-momentum trajectory that enters, turns, and
then exits the singularities at linear and quadratic touching points of a
honeycomb lattice. Measurements of the band populations after transport
identify the winding numbers of these singularities to be 1 and 2,
respectively. Our work opens the study of quadratic band touching points in
ultracold-atom quantum simulators, and also provides a novel method for probing
other band geometry singularities
Structure of eukaryotic purine/H(+) symporter UapA suggests a role for homodimerization in transport activity
The uric acid/xanthine H(+) symporter, UapA, is a high-affinity purine transporter from the filamentous fungus Aspergillus nidulans. Here we present the crystal structure of a genetically stabilized version of UapA (UapA-G411VΔ1-11) in complex with xanthine. UapA is formed from two domains, a core domain and a gate domain, similar to the previously solved uracil transporter UraA, which belongs to the same family. The structure shows UapA in an inward-facing conformation with xanthine bound to residues in the core domain. Unlike UraA, which was observed to be a monomer, UapA forms a dimer in the crystals with dimer interactions formed exclusively through the gate domain. Analysis of dominant negative mutants is consistent with dimerization playing a key role in transport. We postulate that UapA uses an elevator transport mechanism likely to be shared with other structurally homologous transporters including anion exchangers and prestin
Twenty five years after KLS: A celebration of non-equilibrium statistical mechanics
When Lenz proposed a simple model for phase transitions in magnetism, he
couldn't have imagined that the "Ising model" was to become a jewel in field of
equilibrium statistical mechanics. Its role spans the spectrum, from a good
pedagogical example to a universality class in critical phenomena. A quarter
century ago, Katz, Lebowitz and Spohn found a similar treasure. By introducing
a seemingly trivial modification to the Ising lattice gas, they took it into
the vast realms of non-equilibrium statistical mechanics. An abundant variety
of unexpected behavior emerged and caught many of us by surprise. We present a
brief review of some of the new insights garnered and some of the outstanding
puzzles, as well as speculate on the model's role in the future of
non-equilibrium statistical physics.Comment: 3 figures. Proceedings of 100th Statistical Mechanics Meeting,
Rutgers, NJ (December, 2008
The role of E1-E2 interplay in multiphonon Coulomb excitation
In this work we study the problem of a charged particle, bound in a
harmonic-oscillator potential, being excited by the Coulomb field from a fast
charged projectile. Based on a classical solution to the problem and using the
squeezed-state formalism we are able to treat exactly both dipole and
quadrupole Coulomb field components. Addressing various transition amplitudes
and processes of multiphonon excitation we study different aspects resulting
from the interplay between E1 and E2 fields, ranging from classical dynamic
polarization effects to questions of quantum interference. We compare exact
calculations with approximate methods. Results of this work and the formalism
we present can be useful in studies of nuclear reaction physics and in atomic
stopping theory.Comment: 10 pages, 6 figure
Modelling charge self-trapping in wide-gap dielectrics: Localization problem in local density functionals
We discuss the adiabatic self-trapping of small polarons within the density
functional theory (DFT). In particular, we carried out plane-wave
pseudo-potential calculations of the triplet exciton in NaCl and found no
energy minimum corresponding to the self-trapped exciton (STE) contrary to the
experimental evidence and previous calculations. To explore the origin of this
problem we modelled the self-trapped hole in NaCl using hybrid density
functionals and an embedded cluster method. Calculations show that the
stability of the self-trapped state of the hole drastically depends on the
amount of the exact exchange in the density functional: at less than 30% of the
Hartree-Fock exchange, only delocalized hole is stable, at 50% - both
delocalized and self-trapped states are stable, while further increase of exact
exchange results in only the self-trapped state being stable. We argue that the
main contributions to the self-trapping energy such as the kinetic energy of
the localizing charge, the chemical bond formation of the di-halogen quasi
molecule, and the lattice polarization, are represented incorrectly within the
Kohn-Sham (KS) based approaches.Comment: 6 figures, 1 tabl
Changes in synaptic transmission and protein expression in the brains of adult offspring after prenatal inhibition of the kynurenine pathway
During early brain development, N-methyl-d-aspartate (NMDA) receptors are involved in cell migration, neuritogenesis, axon guidance and synapse formation, but the mechanisms which regulate NMDA receptor density and function remain unclear. The kynurenine pathway of tryptophan metabolism includes an agonist (quinolinic acid) and an antagonist (kynurenic acid) at NMDA receptors and we have previously shown that inhibition of the pathway using the kynurenine-3-monoxygenase inhibitor Ro61-8048 in late gestation produces rapid changes in protein expression in the embryos and effects on synaptic transmission lasting until postnatal day 21 (P21). The present study sought to determine whether any of these effects are maintained into adulthood. After prenatal injections of Ro61-8048 the litter was allowed to develop to P60 when some offspring were euthanized and the brains removed for examination. Analysis of protein expression by Western blotting revealed significantly reduced expression of the GluN2A subunit (32%) and the morphogenetic protein sonic hedgehog (31%), with a 29% increase in the expression of doublecortin, a protein associated with neurogenesis. No changes were seen in mRNA abundance using quantitative real-time polymerase chain reaction. Neuronal excitability was normal in the CA1 region of hippocampal slices but paired-pulse stimulation revealed less inhibition at short interpulse intervals. The amount of long-term potentiation was decreased by 49% in treated pups and recovery after low-frequency stimulation was delayed. The results not only strengthen the view that basal, constitutive kynurenine metabolism is involved in normal brain development, but also show that changes induced prenatally can affect the brains of adult offspring and those changes are quite different from those seen previously at weaning (P21). Those changes may be mediated by altered expression of NMDAR subunits and sonic hedgehog
Cyclin E overexpression sensitizes triple negative breast cancer to Wee1 kinase Inhibition
Purpose: Poor prognosis in triple-negative breast cancer (TNBC) is due to an aggressive phenotype and lack of biomarker-driven targeted therapies. Overexpression of cyclin E and phosphorylated-CDK2 are correlated with poor survival in TNBC patients, and the absence of CDK2 desensitizes cells to inhibition of Wee1 kinase, a key cell cycle regulator. We hypothesize that cyclin E expression can predict response to therapies, which include the Wee1 kinase inhibitor, AZD1775. Experimental Design: Mono and combination therapies with AZD1775 were evaluated in TNBC cell lines and multiple patient derived xenograft (PDX) models with different cyclin E expression profiles. The mechanism(s) of cyclin E-mediated replicative stress were investigated following cyclin E induction or CRISPR/Cas9 knockout by a number of assays in multiple cells lines. Results: Cyclin E overexpression (1) is enriched in TNBCs with high recurrence rates, (2) sensitizes TNBC cell lines and PDX models to AZD1775, (3) leads to CDK2-dependent activation of DNA replication stress pathways and (4) increases Wee1 kinase activity. Moreover, treatment of cells with either CDK2 inhibitors or carboplatin leads to transient transcriptional induction of cyclin E (in cyclin E-low tumors) and result in DNA replicative stress. Such drug mediated cyclin E induction in TNBC cells and PDX models sensitizes them to AZD1775 in a sequential treatment combination strategy. Conclusions: Cyclin E is a potential biomarker of response (1) for AZD1775 as monotherapy in cyclin E high TNBC tumors and (2) for sequential combination therapy with CDK2 inhibitor or carboplatin followed by AZD1775 in cyclin E low TNBC tumors
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