Investigation of the Heating Processes and Temperature Field of the Frequency-controlled Asynchronous Engine Based on Mathematical Models

The study of the temperature field of the engine for non-stationary modes is done. A numerical simulation of a non-stationary thermal process using dynamic EHD, the characteristic of the rate of rise of temperatures is done. An increase in the temperature of individual parts in the idle interval, when the power of heat release is significantly reduced, is established, and the reverse of the heat flow through the air gap is established. It is shown that the EHD method, in contrast to the FEM, is self-sufficient, which determines its practical value. In various parts of the speed control range in the implementation of various laws of regulation. At the same time, the main electrical, magnetic and additional losses associated with the fundamental voltage harmonics (FVH), and mechanical losses, as well as additional electrical and magnetic losses associated with the higher voltage harmonics, change. When using serial asynchronous engines as frequency-controlled. Permissible under the conditions of heating power is significantly reduced by the power of serial engines. Depending on the synchronous speed, the reduction is from 10 % to 20 %. Given the additional overheating due to higher voltage harmonics, as well as the deterioration of the cooling conditions when adjusting the rotational speed "down" from the nominal, it seems very relevant

Development and research of the stamp for cutting of a rolled stock with a differentiated clamp

The work aims to develop and research a stamp with a differentiated clamp of a rolled stock for cutting by shear. A new stamp design with a differentiated clamp of the rolled stock has been developed. In terms of their technical and economic indicators, these stamps meet or exceed the modern samples of similar punch tools. At the same time, in the process of vertical cutting, a constant position of the rolled stock axis is ensured. The transmission of force to the clamp through the rolled stock is excluded. The stamp design ensures its sufficiently high rigidity and relatively small overall dimensions. Based on the analysis of the mathematical model of a stamp with a differentiated clamp, the effective angles of force transmission to the clamp and the cutting of the rolled stock between the stamp parts have been established. The resulting model was used to optimize the angles of force transfer to the clamp, and the cutting rolled stock, respecting the force from the side of a buffer and the minimum required press force. At the same time, the vertical stroke of the moving parts is reduced, the overall dimensions of the stamp are decreased, and the buffer also has a minimum size. To reduce the required force of the press, it is necessary to reduce the value of a frictional slipping coefficient by using antifriction materials on contact surfaces and ensuring good lubrication conditions. The results of the conducted experiments confirm the adequacy of the mathematical model. The value of the required force on the press slide available from experiments is slightly higher than the values obtained by the developed analytical model. The results of the stamp implementation show that: the stamps are efficient and reliable in exploitation; the quality of the cutoff workpieces corresponds to the quality indicators of the workpieces cut on similar modern equipment

Design, Synthesis and Pharmacological Evaluation of Novel C2,C3-Quinoxaline Derivatives as Promising Anxiolytic Agents

A new series of quinoxaline derivatives, 2a–4b, were synthesized and their anxiolytic potential was evaluated in vivo using elevated plus maze (EPM), open field (OF) and light-dark box (LDB) techniques. According to the results of the EPM, four active compounds were found in 2a, 2b, 2c, 4b. Their anxiolytic properties were confirmed in terms of LDB and the most active was compound 2b. In the OF, only 2c had an influence on the locomotor activity of the rodents. Thus, the most promising substance was determined; this was 2b, which has the structure of 2-(2-{[3-(4-tert-butylphenyl)quinoxaline-2-yl]methyl}-4,5-dimethoxyphenyl)-N-methylethan-1-amine hydrochloride. The obtained data were analyzed with the pharmacophore feature prediction approach, which made it possible to compare the structures of the studied compounds with the reference drug diazepam, and to determine the contribution of pharmacophores to the manifestation of the activity under study. ADMET analysis was carried out for compound 2b and the acute oral toxicity of this substance was also tested in vivo. As a result of the study, a promising compound with a high anxiolytic effect and low level of toxicity 2b was found, which is of interest for further preclinical study of its properties

Synthesis, Structure, Spectral-Luminescent Properties, and Biological Activity of Chlorine-Substituted <i>N</i>-[2-(Phenyliminomethyl)phenyl]-4-methylbenzenesulfamide and Their Zinc(II) Complexes

New azomethine compounds of 2-(N-tosylamino)benzaldehyde or 5-chloro-2-(N-tosylamino)benzaldehyde and the corresponding chlorine-substituted anilines, zinc(II) complexes based on them have been synthesized. The structures of azomethines and their complexes were determined by elemental analysis, IR, 1H NMR, X-ray spectroscopy, and X-ray diffraction. It is found that all ZnL2 complexes have a tetrahedral structure according to XAFS and X-ray diffraction data. The photoluminescent properties of azomethines and zinc complexes in methylene chloride solution and in solid form have been studied. It is shown that the photoluminescence quantum yields of solid samples of the complexes are an order of magnitude higher compared to the solutions and range from 11.34% to 48.3%. The thermal properties of Zn(II) complexes were determined by thermal gravimetric analysis (TGA) and differential scanning calorimetry. The TGA curves of all the compounds suggest their high thermal stability up to temperatures higher than 290 °C. The electrochemical properties of all complexes were investigated by the cyclic voltammetry method. The multilayered devices ITO/PEDOT:PSS/NPD/Zn complex/ TPBI/LiF/Al with wide electroluminescence (EL) color range spanning the range from bluish-green (494 nm) to green (533 nm) and the high values of brightness, current and power efficiency were fabricated. The biological activity of azomethines and zinc complexes has been studied. In the case of complexes, the protistocidal activity of the zinc complex with azomethine of 5-chloro-2-(N-tosylamino)benzaldehyde with 4-chloroaniline was two times higher than the activity of the reference drug toltrazuril

Novel Hybrid Benzoazacrown Ligand as a Chelator for Copper and Lead Cations: What Difference Does Pyridine Make

A synthetic procedure for the synthesis of azacrown ethers with a combination of pendant arms has been developed and the synthesized ligand, characterized by various techniques, was studied. The prepared benzoazacrown ether with hybrid pendant arms and its complexes with copper and lead cations were studied in terms of biomedical applications. Similarly to a fully acetate analog, the new one binds both cations with close stability constants, despite the decrease in both constants. The calculated geometry of the complexes correlate with the data from X-ray absorption and NMR spectroscopy. Coordination of both cations differs due to the difference between the ionic radii. However, these chelation modes provide effective shielding of cations in both cases, that was shown by the stability of their complexes in the biologically relevant media towards transchelation and transmetallation

Neuropsychiatric symptoms in Alzheimer\u27s disease: Past progress and anticipation of the future

Neuropsychiatric symptoms (NPS) in Alzheimer\u27s disease (AD) are widespread and disabling. This has been known since Dr. Alois Alzheimer\u27s first case, Frau Auguste D., presented with emotional distress and delusions of infidelity/excessive jealousy, followed by cognitive symptoms. Being cognizant of this, in 2010 the Alzheimer\u27s Association convened a research roundtable on the topic of NPS in AD. A major outcome of the roundtable was the founding of a Professional Interest Area (PIA) within the International Society to Advance Alzheimer\u27s Research and Treatment (ISTAART). The NPS-PIA has prepared a series of documents that are intended to summarize the literature and provide more detailed specific recommendations for NPS research. This overview paper is the first of these living documents that will be updated periodically as the science advances. The overview is followed by syndrome-specific synthetic reviews and recommendations prepared by NPS-PIA workgroups on depression, apathy, sleep, agitation, and psychosis. © 2013 The Alzheimer¢s Association. All rights reserved