Prospects for Observations of Pulsars and Pulsar Wind Nebulae with CTA

The last few years have seen a revolution in very-high gamma-ray astronomy (VHE; E>100 GeV) driven largely by a new generation of Cherenkov telescopes (namely the H.E.S.S. telescope array, the MAGIC and MAGIC-II large telescopes and the VERITAS telescope array). The Cherenkov Telescope Array (CTA) project foresees a factor of 5 to 10 improvement in sensitivity above 0.1 TeV, extending the accessible energy range to higher energies up to 100 TeV, in the Galactic cut-off regime, and down to a few tens GeV, covering the VHE photon spectrum with good energy and angular resolution. As a result of the fast development of the VHE field, the number of pulsar wind nebulae (PWNe) detected has increased from one PWN in the early '90s to more than two dozen firm candidates today. Also, the low energy threshold achieved and good sensitivity at TeV energies has resulted in the detection of pulsed emission from the Crab Pulsar (or its close environment) opening new and exiting expectations about the pulsed spectra of the high energy pulsars powering PWNe. Here we discuss the physics goals we aim to achieve with CTA on pulsar and PWNe physics evaluating the response of the instrument for different configurations.Comment: accepted for publication in Astroparticle Physic

Convergent evolution of pregnancy-specific glycoproteins in human and horse

Pregnancy-specific glycoproteins (PSGs) are members of the carcinoembryonic antigen cell adhesion molecule (CEACAM) family that are secreted by trophoblast cells. PSGs may modulate immune, angiogenic and platelet responses during pregnancy. Until now, PSGs are only found in species that have a highly invasive (hemochorial) placentation including humans, mice and rats. Surprisingly, analyzing the CEACAM gene family of the horse, which has a non-invasive epitheliochorial placenta, with the exception of the transient endometrial cups, we identified equine CEACAM family members that seem to be related to PSGs of rodents and primates. We identified seven genes that encode secreted PSG-like CEACAMs. Phylogenetic analyses indicate that they evolved independently from an equine CEACAM1-like ancestor rather than from a common PSG-like ancestor with rodents and primates. Significantly, expression of PSG-like genes (CEACAM44, CEACAM48, CEACAM49 and CEACAM55) was found in non-invasive as well as invasive trophoblast cells such as purified chorionic girdle cells and endometrial cup cells. Chorionic girdle cells are highly invasive trophoblast cells that invade the endometrium of the mare where they form endometrial cups and are in close contact with maternal immune cells. Therefore, the microenvironment of invasive equine trophoblast cells has striking similarities to the microenvironment of trophoblast cells in hemochorial placentas, suggesting that equine PSG-like CEACAMs and rodent and primate PSGs have undergone convergent evolution. This is supported by our finding that equine PSG-like CEACAM49 exhibits similar activity to certain rodent and human PSGs in a functional assay of platelet–fibrinogen binding. Our results have implications for understanding the evolution of PSGs and their functions in maternal–fetal interactions

X-ray spectral curvature of High Frequency Peaked BL Lacs: a predictor for the TeV flux

Most of the extragalactic sources detected at TeV energies are BL Lac objects. They belong to the subclass of "high frequency peaked BL Lacs" (HBLs) exhibiting spectral energy distributions with a lower energy peak in the X-ray band; this is widely interpreted as synchrotron emission from relativistic electrons. The X-ray spectra are generally curved, and well described in terms of a log-parabolic shape. In a previous investigation of TeV HBLs (TBLs) we found two correlations between their spectral parameters. (1) The synchrotron peak luminosity L_p increases with its peak energy E_p; (2) the curvature parameter b decreases as E_p increases. The first is consistent with the synchrotron scenario, while the second is expected from statistical/stochastic acceleration mechanisms for the emitting electrons. Here we present an extensive X-ray analysis of a sample of HBLs observed with XMM-Newton and SWIFT but undetected at TeV energies (UBLs), to compare their spectral behavior with that of TBLs. Investigating the distributions of their spectral parameters and comparing the TBL X-ray spectra with that of UBLs, we develop a criterion to select the best HBLs candidates for future TeV observations.Comment: 25 pages, 6 figures, Astrophysical Journal publishe

Studies of active galactic nuclei with CTA

In this paper, we review the prospects for studies of active galactic nuclei (AGN) using the envisioned future Cherenkov Telescope Array (CTA). This review focuses on jetted AGN, which constitute the vast majority of AGN detected at gamma-ray energies. Future progress will be driven by the planned lower energy threshold for very high energy (VHE) gamma-ray detections to ~10 GeV and improved flux sensitivity compared to current-generation Cherenkov Telescope facilities. We argue that CTA will enable substantial progress on gamma-ray population studies by deepening existing surveys both through increased flux sensitivity and by improving the chances of detecting a larger number of low-frequency peaked blazars because of the lower energy threshold. More detailed studies of the VHE gamma-ray spectral shape and variability might furthermore yield insight into unsolved questions concerning jet formation and composition, the acceleration of particles within relativistic jets, and the microphysics of the radiation mechanisms leading to the observable high-energy emission. The broad energy range covered by CTA includes energies where gamma-rays are unaffected from absorption while propagating in the extragalactic background light (EBL), and extends to an energy regime where VHE spectra are strongly distorted. This will help to reduce systematic effects in the spectra from different instruments, leading to a more reliable EBL determination, and hence will make it possible to constrain blazar models up to the highest energies with less ambiguity.Comment: invited review article, 15 pages, 9 figures, Astroparticle Physics, Special Issue on Physics with the Cherenkov Telescope Array, in pres

Prospects for a Dark Matter annihilation signal towards the Sagittarius dwarf galaxy with ground based Cherenkov telescopes

Dwarf galaxies are widely believed to be among the best targets for indirect dark matter searches using high-energy gamma rays; and indeed gamma-ray emission from these objects has long been a subject of detailed study for ground-based atmospheric Cherenkov telescopes. Here, we update current exclusion limits obtained on the closest dwarf, the Sagittarius dwarf galaxy, in light of recent realistic dark matter halo models. The constraints on the velocity-weighted annihilation cross section of the dark matter particle are of a few 10$^{-23}$ cm$^{3}$s$^{-1}$ in the TeV energy range for a 50 h exposure. The limits are extrapolated to the sensitivities of future Cherenkov Telescope Arrays. For 200 h of observation time, the sensitivity at 95% C.L. reaches 10$^{-25}$ cm$^{3}$s$^{-1}$. Possible astrophysical backgrounds from gamma-ray sources dissembled in Sagittarius dwarf are studied. It is shown that with long-enough observation times, gamma-ray background from millisecond pulsars in a globular cluster contained within Sagittarius dwarf may limit the sensitivity to dark matter annihilations.Comment: 12 pages, 5 figures, 2 tables, accepted for publication in Ap

Hybrid Optical Switching for Data Center Networks

Current data centers networks rely on electronic switching and point-to-point interconnects.When considering future data center requirements, these solutions will raise issues in terms of flexibility, scalability, performance, and energy consumption. For this reason several optical switched interconnects, which make use of optical switches and wavelength division multiplexing (WDM), have been recently proposed. However, the solutions proposed so far suffer from low flexibility and are not able to provide service differentiation. In this paper we introduce a novel data center network based on hybrid optical switching (HOS). HOS combines optical circuit, burst, and packet switching on the same network. In this way different data center applications can be mapped to the optical transportmechanism that best suits their traffic characteristics. Furthermore, the proposed HOS network achieves high transmission efficiency and reduced energy consumption by using two parallel optical switches. We consider the architectures of both a traditional data center network and the proposed HOS network and present a combined analytical and simulation approach for their performance and energy consumption evaluation. We demonstrate that the proposed HOS data center network achieves high performance and flexibility while considerably reducing the energy consumption of current solutions

Dark Matter and Fundamental Physics with the Cherenkov Telescope Array

The Cherenkov Telescope Array (CTA) is a project for a next-generation observatory for very high energy (GeV-TeV) ground-based gamma-ray astronomy, currently in its design phase, and foreseen to be operative a few years from now. Several tens of telescopes of 2-3 different sizes, distributed over a large area, will allow for a sensitivity about a factor 10 better than current instruments such as H.E.S.S, MAGIC and VERITAS, an energy coverage from a few tens of GeV to several tens of TeV, and a field of view of up to 10 deg. In the following study, we investigate the prospects for CTA to study several science questions that influence our current knowledge of fundamental physics. Based on conservative assumptions for the performance of the different CTA telescope configurations, we employ a Monte Carlo based approach to evaluate the prospects for detection. First, we discuss CTA prospects for cold dark matter searches, following different observational strategies: in dwarf satellite galaxies of the Milky Way, in the region close to the Galactic Centre, and in clusters of galaxies. The possible search for spatial signatures, facilitated by the larger field of view of CTA, is also discussed. Next we consider searches for axion-like particles which, besides being possible candidates for dark matter may also explain the unexpectedly low absorption by extragalactic background light of gamma rays from very distant blazars. Simulated light-curves of flaring sources are also used to determine the sensitivity to violations of Lorentz Invariance by detection of the possible delay between the arrival times of photons at different energies. Finally, we mention searches for other exotic physics with CTA.Comment: (31 pages, Accepted for publication in Astroparticle Physics

A unifying mathematical framework for experimental TCR-pMHC kinetic constants

Receptor binding and triggering are central in Immunology as T cells activated through their T cell receptors (TCR) by protein antigens orchestrate immune responses. In order to understand receptor-ligand interactions, many groups working with different experimental techniques and assays have generated a vast body of knowledge during the last decades. However, in recent years a type of assays, referred to as two-dimensional or membrane-to-membrane, has questioned our current understanding of the role of different kinetic constants (for instance, on- versus off-rate constants) on TCR-ligand interaction and subsequent T cell activation. Here we present a general mathematical framework that provides a unifying umbrella to relate fundamental and effective (or experimentally determined) kinetic constants, as well as describe and compare state-of-the-art experimental methods. Our framework is able to predict the correlations between functional output, such as 1/EC50, and effective kinetic constants for a range of different experimental assays (in two and three dimensions). Furthermore, our approach can be applied beyond Immunology, and serve as a “translation method” for the biochemical characterization of receptor-ligand interactions