Context Aware Drivers' Behaviour Detection System for VANET

Wireless communications and mobile computing have led to the enhancement of, and improvement in, intelligent transportation systems (ITS) that focus on road safety applications. As a promising technology and a core component of ITS, Vehicle Ad hoc Networks (VANET) have emerged as an application of Mobile Ad hoc Networks (MANET), which use Dedicated Short Range Communication (DSRC) to allow vehicles in close proximity to communicate with one another, or to communicate with roadside equipment. These types of communication open up a wide range of potential safety and non-safety applications, with the aim of providing an intelligent driving environment that will offer road users more pleasant journeys. VANET safety applications are considered to represent a vital step towards improving road safety and enhancing traffic efficiency, as a consequence of their capacity to share information about the road between moving vehicles. This results in decreasing numbers of accidents and increasing the opportunity to save people's lives. Many researchers from different disciplines have focused their research on the development of vehicle safety applications. Designing an accurate and efficient driver behaviour detection system that can detect the abnormal behaviours exhibited by drivers (i.e. drunkenness and fatigue) and alert them may have an impact on the prevention of road accidents. Moreover, using Context-aware systems in vehicles can improve the driving by collecting and analysing contextual information about the driving environment, hence, increasing the awareness of the driver while driving his/her car. In this thesis, we propose a novel driver behaviour detection system in VANET by utilising a context-aware system approach. The system is comprehensive, non-intrusive and is able to detect four styles of driving behaviour: drunkenness, fatigue, reckless and normal behaviour. The behaviour of the driver in this study is considered to be uncertain context and is defined as a dynamic interaction between the driver, the vehicle and the environment; meaning it is affected by many factors and develops over the time. Therefore, we have introduced a novel Dynamic Bayesian Network (DBN) framework to perform reasoning about uncertainty and to deduce the behaviour of drivers by combining information regarding the above mentioned factors. A novel On Board Unit (OBU) architecture for detecting the behaviour of the driver has been introduced. The architecture has been built based on the concept of context-awareness; it is divided into three phases that represent the three main subsystems of context-aware system; sensing, reasoning and acting subsystems. The proposed architecture explains how the system components interact in order to detect abnormal behaviour that is being exhibited by driver; this is done to alert the driver and prevent accidents from occurring. The implementation of the proposed system has been carried out using GeNIe version 2.0 software to construct the DBN model. The DBN model has been evaluated using synthetic data in order to demonstrate the detection accuracy of the proposed model under uncertainty, and the importance of including a large amount of contextual information within the detection process

Deserting the Practice of the Promotion of Virtue and the Prevention of Vice: Causes and Remedies in the Light of the Qur’an and the Sunnah

This research paper is concerned with the study of the causes underlying the desertion of the practice of promoting virtue and preventing vice and with their remedies in the light of the Qur’an and the Sunnah. It aims to enhance the practice and its impact on security at large. It seeks to achieve its aim through identifying the most significant obstacles and doubts contributing to the spread of vice among people in great numbers. The spread of vice can be attributed to ignorance, emulation of capricious elites and self-delusion. Having identified and discussed the obstacles and doubts in the light of the standards of the Qur’an and the Sunnah, the paper attempts to analyze them academically, supporting the analysis with evidences from Hadith and Qur’an specialists and from statements of credible imams. The paper follows a deductive approach. The most important conclusions of the paper are as follows: the Prophet was evidently concerned with the practice of promoting virtue and combating vice; the desertion of the practice has disastrous consequences and leads to the destruction of communities; strong faith helps overcome the obstacles to the practice; and the ulama stress the basic requirement of the heart’s rejection of abominable acts. The research recommends that the practice be strongly enhanced, and that related obstacles and doubts be studied at all levels of educational curricula and courses in simple and comprehensible ways

Interference Mitigation Using Uplink Power Control in 5G Relay-Based Heterogeneous Networks

Heterogeneous network (HetNet) is an attractive solution for future cellular networks with high data rate and coverage requirements. In HetNets, small cells such as micro cells, pico cells, femto cells and relay node (RN) are added to the network of macro cells in the same region. A large number of low power RNs produces new cell edges with significant intra-cell and inter-cell interferences. In the uplink (UL) scenarios of time-division based HetNets with RN, the user equipment (UE) desired signal may be interfered by the transmissions of the co-channel UEs during the first time slot and by the transmissions of the co-channel UEs or RNs during the second time slot. The interference caused by the RNs may significantly degrade the UE signal. UL transmission power control (PC) is essential for mitigating interference and, as a result, enhancing the cell edge and overall system performance. This research proposes a PC algorithm in order to mitigate the UL interference in 5g relay-based HetNets. This research also investigates the UL performance of HetNets when PC is applied at the RNs. Simulation results indicate that UL PC at the RNs greatly reduces average interference and improves average UL signal-to-interference-plus-noise ratio (SINR) and average UL end-to-end throughput compared to the situation in which UL PC is not implemente

Study of Shoot Tip Necrosis Problems of Fegra Fig (Ficus palmata Forssk.) In Vitro in Saudi Arabia

This work studied the micropropagation of fegra fig (F. palmata Forssk.) during which we experienced the incidence of shoot-tip necrosis (STN). STN was evident during the shoot elongation stage, which was regenerated on Murashige and Skoog (MS) medium supplemented with 2 mg/L 6-benzylaminopurine. To alleviate SNT, we conducted a series of experiments and supplemented the medium with calcium chloride (40, 80, and 120 mg/L), ascorbic acid (50, 100, and 150 mg/L), silver nitrate (1, 2, and 3 mg/L), and boric acid (9.3, 12.4, and 15.5 mg/L). Results showed that all the treatments controlled STN at varying levels, and supplementation of medium with 3 mg/L silver nitrate reduced the incidence of STN from 80% to 24%. The regenerated shoots were rooted on the same medium with incubation of cultures in the dark for 3 weeks and subsequent 4 weeks of incubation under 16/8-hour light/dark photoperiod. The growth parameters (number of shoots and roots, length of the main shoot and root, fresh and dry weights), photosynthetic pigments (chlorophylls and carotenoids), and relative water content of plantlets were restored with the application of 3 mg/L silver nitrate to the medium. Incubation of cultures initially in the dark followed by 16/8-hour light incubation facilitated axillary shoot elongation. On the basis of our findings, it is recommended to culture the regenerated axillary shoots of fegra fig onto MS medium containing 3% sucrose, 1.5 mg/L activated charcoal, and 3 mg/L silver nitrate to manage STN effectively

Pyridylpiperazine-based carbodithioates as urease inhibitors: synthesis and biological evaluation

The urease enzyme is recognized as a valuable therapeutic agent for treating the virulent Helicobacter pylori bacterium because of its pivotal role in aiding the colonization and growth of the bacterium within the gastric mucosa. In order to control the harmful consequences of bacterial infections, urease inhibition presents itself as a promising and effective approach. The current research aimed to synthesize pyridylpiperazine-based carbodithioate derivatives 5a–5n and 7a–7n that could serve as potential drug candidates for preventing bacterial infections through urease inhibition. The synthesized carbodithioate derivatives 5a–5n and 7a–7n were explored to assess their ability to inhibit the urease enzyme after their structural explication by gas chromatography–mass spectrometry (GC-MS). In the in vitro evaluation with thiourea as a standard drug, it was observed that all the synthesized compounds exhibited significant inhibitory activity compared to the reference drug. Among the compounds tested, 5j (bearing an o-tolyl moiety) emerged as the most effective inhibitor, displaying strong urease inhibition with an IC50 value of 5.16 ± 2.68 μM. This IC50 value is notably lower than that of thiourea (23 ± 0.03 μM), indicating the significantly most potent potential of inhibition. In molecular docking of 5j within the active site of urease, numerous noteworthy interactions were identified

Interdisciplinary Cooperation Between Medical Secretary Technicians and Pharmacist

An evaluation was conducted to determine whether or not a pharmacy technician is capable of providing assistance with the functions of a pharmacist-driven osteoporosis management service that are linked to patient screening and documentation. Evidence suggests that a healthcare provider and pharmacy technician are able to accurately identify whether or not a patient is a candidate for intervention by a pharmacist and collect clinical information to aid the establishment of a care plan. The involvement of pharmacists and medical secretaries in patient care has been shown to improve results, including a reduction in adverse drug events and medication errors, an increase in the appropriateness of prescription use, and an improvement in patient understanding of their drugs

Effect of Matricaria aurea essential oils on biofilm development, virulence factors and quorum sensing-dependent genes of Pseudomonas aeruginosa

Abstract: The emergence of drug-resistant microorganisms presents a substantial global public health threat. The increase in pathogens resistant to commonly prescribed antibiotics underscores the urgent requirement to explore alternative treatment strategies. This study adopts a novel approach by harnessing natural resources, specifically essential oils (EO), to combat bacterial pathogenicity. The primary aim of this research was to analyze the chemical composition of the aerial part of the Matricaria aurea (M. aureas) EO and evaluate its potential for inhibiting quorum sensing (QS) and disrupting biofilm formation in Pseudomonas aeruginosa (P. aeruginosa). The gas chromatography-mass spectrometry (GCMS) analysis unveiled that α-bisabolol oxide A constituted the predominant portion, comprising 64.8% of the total, with β-bisabolene at 6.3% and α-farnesene at 4.8% following closely behind. The antibiofilm efficacy was observed at concentrations of 0.3, 0.15, and 0.08 mg/mL, demonstrating negligible effects on cell viability. Furthermore, the EO from M. aurea effectively inhibited the formation of P. aeruginosa biofilms by diminishing aggregation, hydrophobicity, and swarming motility. Significantly, the EO treatment resulted in a conspicuous decrease in the production of pyocyanin, rhamnolipid, and extracellular polymeric substances (EPS), along with a reduction in the enzymatic activity of protease and chitinase. The EO effectively hindered QS by disrupting QS mechanisms, resulting in a marked decline in the secretion of N-Acyl homoserine lactone (AHL) molecules and the expression of phazA1 and aprA genes. This investigation offers compelling evidence supporting the potential of M. aurea EO as a promising therapeutic candidate for addressing infectious diseases induced by biofilm formation

Two new sponge species (Demospongiae: Chalinidae and Suberitidae) isolated from hyperarid mangroves of Qatar with notes on their potential antibacterial bioactivity.

This study presents the taxonomic description of two new sponge species that are intimately associated with the hyperarid mangrove ecosystem of Qatar. The study includes a preliminary evaluation of the sponges' potential bioactivity against pathogens. Chalinula qatari sp. nov. is a fragile thinly encrusting sponge with a vivid maroon colour in life, often with oscular chimneys and commonly recorded on pneumatophores in the intertidal and shallow subtidal zone. Suberites luna sp. nov. is a massive globular-lobate sponge with a greenish-black colour externally and a yellowish orange colour internally, recorded on pneumatophores in the shallow subtidal zone, with large specimens near the seagrass ecosystem that surrounds the mangrove. For both species, a drug extraction protocol and an antibacterial experiment was performed. The extract of Suberites luna sp. nov. was found to be bioactive against recognized pathogens such as Staphylococcus epidermidis, Staphylococcus aureus and Enterococcus faecalis, but no bioactive activity was recorded for Chalinula qatari sp. nov. This study highlights the importance of increasing bioprospecting effort in hyperarid conditions and the importance of combining bioprospecting with taxonomic studies for the identification of novel marine drugs.QNRF/URE

Impact of opioid-free analgesia on pain severity and patient satisfaction after discharge from surgery: multispecialty, prospective cohort study in 25 countries

Background: Balancing opioid stewardship and the need for adequate analgesia following discharge after surgery is challenging. This study aimed to compare the outcomes for patients discharged with opioid versus opioid-free analgesia after common surgical procedures.Methods: This international, multicentre, prospective cohort study collected data from patients undergoing common acute and elective general surgical, urological, gynaecological, and orthopaedic procedures. The primary outcomes were patient-reported time in severe pain measured on a numerical analogue scale from 0 to 100% and patient-reported satisfaction with pain relief during the first week following discharge. Data were collected by in-hospital chart review and patient telephone interview 1 week after discharge.Results: The study recruited 4273 patients from 144 centres in 25 countries; 1311 patients (30.7%) were prescribed opioid analgesia at discharge. Patients reported being in severe pain for 10 (i.q.r. 1-30)% of the first week after discharge and rated satisfaction with analgesia as 90 (i.q.r. 80-100) of 100. After adjustment for confounders, opioid analgesia on discharge was independently associated with increased pain severity (risk ratio 1.52, 95% c.i. 1.31 to 1.76; P < 0.001) and re-presentation to healthcare providers owing to side-effects of medication (OR 2.38, 95% c.i. 1.36 to 4.17; P = 0.004), but not with satisfaction with analgesia (beta coefficient 0.92, 95% c.i. -1.52 to 3.36; P = 0.468) compared with opioid-free analgesia. Although opioid prescribing varied greatly between high-income and low- and middle-income countries, patient-reported outcomes did not.Conclusion: Opioid analgesia prescription on surgical discharge is associated with a higher risk of re-presentation owing to side-effects of medication and increased patient-reported pain, but not with changes in patient-reported satisfaction. Opioid-free discharge analgesia should be adopted routinely

The global burden of adolescent and young adult cancer in 2019 : a systematic analysis for the Global Burden of Disease Study 2019

Background In estimating the global burden of cancer, adolescents and young adults with cancer are often overlooked, despite being a distinct subgroup with unique epidemiology, clinical care needs, and societal impact. Comprehensive estimates of the global cancer burden in adolescents and young adults (aged 15-39 years) are lacking. To address this gap, we analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019, with a focus on the outcome of disability-adjusted life-years (DALYs), to inform global cancer control measures in adolescents and young adults. Methods Using the GBD 2019 methodology, international mortality data were collected from vital registration systems, verbal autopsies, and population-based cancer registry inputs modelled with mortality-to-incidence ratios (MIRs). Incidence was computed with mortality estimates and corresponding MIRs. Prevalence estimates were calculated using modelled survival and multiplied by disability weights to obtain years lived with disability (YLDs). Years of life lost (YLLs) were calculated as age-specific cancer deaths multiplied by the standard life expectancy at the age of death. The main outcome was DALYs (the sum of YLLs and YLDs). Estimates were presented globally and by Socio-demographic Index (SDI) quintiles (countries ranked and divided into five equal SDI groups), and all estimates were presented with corresponding 95% uncertainty intervals (UIs). For this analysis, we used the age range of 15-39 years to define adolescents and young adults. Findings There were 1.19 million (95% UI 1.11-1.28) incident cancer cases and 396 000 (370 000-425 000) deaths due to cancer among people aged 15-39 years worldwide in 2019. The highest age-standardised incidence rates occurred in high SDI (59.6 [54.5-65.7] per 100 000 person-years) and high-middle SDI countries (53.2 [48.8-57.9] per 100 000 person-years), while the highest age-standardised mortality rates were in low-middle SDI (14.2 [12.9-15.6] per 100 000 person-years) and middle SDI (13.6 [12.6-14.8] per 100 000 person-years) countries. In 2019, adolescent and young adult cancers contributed 23.5 million (21.9-25.2) DALYs to the global burden of disease, of which 2.7% (1.9-3.6) came from YLDs and 97.3% (96.4-98.1) from YLLs. Cancer was the fourth leading cause of death and tenth leading cause of DALYs in adolescents and young adults globally. Interpretation Adolescent and young adult cancers contributed substantially to the overall adolescent and young adult disease burden globally in 2019. These results provide new insights into the distribution and magnitude of the adolescent and young adult cancer burden around the world. With notable differences observed across SDI settings, these estimates can inform global and country-level cancer control efforts. Copyright (C) 2021 The Author(s). Published by Elsevier Ltd.Peer reviewe