Hittitology today: Studies on Hittite and Neo-Hittite Anatolia in Honor of Emmanuel Laroche’s 100th Birthday

Il y a 100 ans, Emmanuel Laroche voyait le jour. Savant à la fois passionné de linguistique indo-européenne et d’Antiquité, il marqua durablement l’hittitologie par ses nombreuses contributions dans des domaines aussi variés que l’histoire des religions proche-orientales, la philologie cunéiforme ou encore la grammaire du hittite, du louvite et du hourrite. Ce colloque organisé en l’honneur de son centenaire a été l’occasion de faire le point sur les avancées de l’hittitologie actuelle, avancées auxquelles il participa tout au long de sa vie et qui se poursuivent après lui. Les axes thématiques qui sont abordés dans ce volume sont ceux qu’Emmanuel Laroche développa de son vivant, à savoir la linguistique des langues anatoliennes, la philologie et l’épigraphie cunéiforme et hiéroglyphique, les religions de l’Anatolie hittite et néo-hittite, l’histoire et la géographie historique, mais aussi l’archéologie proche-orientale, domaine qu’Emmanuel Laroche côtoya de près. Ajoutons à ces domaines celui de l’historiographie qui illustre, entre autres choses, l’impact des travaux d’Emmanuel Laroche dans l’hittitologie d’aujourd’hui.100 years ago, Emmanuel Laroche was born. As a scholar who was fascinated both by Indo-European Linguistics and Ancient Near Eastern and Classical Studies, he had a durable impact on Hittitology through his numerous contributions. His publications dealt with History of Near Eastern Religions, Cuneiform Philology, and Hittite, Luwian, and Hurrian grammar, among many other topics. This conference was organized in honor of his 100th birthday. Its aim was to discuss the recent developments in Hittitology, the ones to whom Emmanuel Laroche contributed and the ones which occurred after his time. The following themes are dealt with in this volume: Anatolian Linguistics, Cuneiform and Hieroglyphic Philology and Epigraphy, Religions of Bronze and Early Iron Age Anatolia, History and Historical Geography of Asia Minor, but also Near Eastern Archaeology, as Emmanuel Laroche was also very close to this discipline. Let us add to those fields Historiography which illustrates, among other things, the impact of Emmanuel Laroche’s work on today’s Hittitology

The Confidence Database

Understanding how people rate their confidence is critical for the characterization of a wide range of perceptual, memory, motor and cognitive processes. To enable the continued exploration of these processes, we created a large database of confidence studies spanning a broad set of paradigms, participant populations and fields of study. The data from each study are structured in a common, easy-to-use format that can be easily imported and analysed using multiple software packages. Each dataset is accompanied by an explanation regarding the nature of the collected data. At the time of publication, the Confidence Database (which is available at https://osf.io/s46pr/) contained 145 datasets with data from more than 8,700 participants and almost 4 million trials. The database will remain open for new submissions indefinitely and is expected to continue to grow. Here we show the usefulness of this large collection of datasets in four different analyses that provide precise estimations of several foundational confidence-related effects

Silica nanoparticle-covered Graphene Oxide as solid-phase extraction sorbent coupled with FAAS for the determination of some of heavy metals in water sample

The current study portrays a dispersive solid-phase extraction as a silica nanoparticle-covered Graphene Oxide(GO-SiO2) synthesised with some modification as in the literature and developed removal/preconcentration method for selective extraction of some heavy metal in water samples. Flame atomic absorption spectrophotometry (FAAS) was used to measure in optimum conditions for the proposed method. Field emission scanning electron microscope (FESEM) and X-beam diffraction (XRD) were utilised for the characterisation of solid phase. The developed method presents high surface areas for sorption capacity and a low amount of solid phase. The removal percentage was performed at approximately 100% with pH 4 to 10 for all metal ions. According to validation results under the optimised method, the limits of detection (LODs) and quantification (LOQs) were found in the range of 5.8–23.0 µg L−1 and 16.0 − 38.1 µg L−1, respectively. The developed method was applied by using certified reference material (BCR 715) for trueness, which observed high relative recovery with lower than 11.8% relative error except for Pb and Cd. The comparison between the experimental results and the certified reference material indicated that the accuracy of the method is higher than 90%. The proposed method was effectively practised for five water samples with standard addition. © 2020 Informa UK Limited, trading as Taylor & Francis Group

The association of hematologic inflammatory markers with atherogenic index in type 2 diabetic retinopathy patients

Müberra Akdoğan,1 Yasemin Ustundag-Budak,2 Kagan Huysal2 1Department of Ophtalmology, 2Department of Clinical Laboratory, Yüksek İhtisas Education and Research Hospital, Bursa, Turkey Background: Atherogenic dyslipidemia is particularly common in people with type 2 diabetes (DM2). Platelets from patients with DM2 have increased reactivity and baseline activation. The aim of the present study is to evaluate the relationship between atherogenic index and hematologic inflammatory markers and to evaluate the relationship between these parameters and associated variables in diabetic retinopathy (DR) patients. Methods: The medical records of all patients admitted to the eye clinic between January and December 2014 were evaluated systematically. Laboratory parameters of 278 outpatients with DM2 diagnosed after the age of 30 years and 107 healthy subjects were analyzed. Results: The DM2 + DR group consisted of 120 patients (47 males and 73 females; mean age 59.8±9.2 years). The DM2 without DR group consisted of 158 patients (59 males and 99 females; mean age 57.3±12.2 years). Mean platelet volume, platelet distribution width (PDW), platelet–lymphocyte (P/L) ratio, triglycerides, and atherogenic index were higher in DM2 patients than in control patients, but there was no difference between the DM2 + DR and the DM2 without DR groups. Only P/L ratio was different in the DM2 + DR patients compared to the DM2 without DR patients. Hemoglobin A1c levels correlated very weakly with the mean platelet volume, PDW, P/L ratio, and the red cell distribution width. The atherogenic index was very weakly correlated with the P/L ratio, PDW, and red cell distribution width. Conclusion: Dyslipidemia-induced inflammation contributes to pathological processes that lead to retinopathy in DR patients. Keywords: type 2 diabetes mellitus, diabetes complications, platelets, erythrocyte indices, triglyceride

What is the Best Way to Diagnose Possible Asthma Patients with Negative Bronchodilator Reversibility Tests?

Buket Ba&scedil;a Akdo&gbreve;an, Ilkay Koca Kalkan, Gözde Köycü Buhari, Özlem Özdedeo&gbreve;lu, Hale Ate&scedil;, Kurtulu&scedil; Aksu, Ferda Öner Erkekol Department of Chest Diseases, Division of Immunology and Allergy, University of Health Sciences Ataturk Chest Diseases and Chest Surgery Education and Research Hospital, Ankara, TurkeyCorrespondence: Buket Ba&scedil;a Akdo&gbreve;an, Department of Chest Diseases, Division of Immunology and Allergy, University of Health Sciences Ataturk Chest Diseases and Chest Surgery Education and Research Hospital, Incirlist, No: 57 Floor:3, 34147 Bakirkoy/Istanbul, Ankara, Turkey, Tel +90 5053518861 ; +90 850 4339393, Email [email protected]: The best method and strategy for the diagnosis of asthma remains unclear, especially in patients with negative bronchodilator reversibility test (BDRT). In our study, we aimed to investigate the diagnostic yield of peak expiratory flow (PEF) variability for this patient group.Methods: A total of 50 patients with suspected asthma, all with negative BDR test, were included in the study. Demographic information and symptoms were recorded and PEF variability was monitored for 2 weeks. Metacolinbronchial provocation test (mBPT) was performed. Asthma was diagnosed when PEF variability ≥ 20% and/or positive mBPT was observed.Results: 30 of 50 patients were diagnosed with asthma. After 1 month, 17 patients were evaluated for treatment outcomes. The sensitivity and specificity of PEF variability for different cut-off values (≥ 20%, > 15% and > 10%) were 61.5– 83.3, 88.5– 62.5 and 100– 16.7, respectively. One of the most important findings of our study was the absence of variable airflow limitation or airway hyper reactivity in 39% patients with a previous diagnosis of asthma. Multiple logistic regression analysis revealed that a low baseline FEF25-75 value was an independent predictive factor for the diagnosis of asthma (p= 0.05).Conclusion: The most efficient diagnostic test for asthma is still unclear due to many factors. Our study is one of the few studies on this subject. Although current diagnostic recommendations generally recommend a PEF variability of 10% for the diagnosis of asthma, this threshold may not be appropriate for the BDR-negative patient group. Our results suggest using a threshold value of < 15% for PEF variability when excluding asthma and ≥ 20% when confirming the diagnosis of asthma in patients with clinically suspected but unproven reversibility. Furthermore, FEF25-75 is considered to be an important diagnostic parameter that should be included in diagnostic recommendations for asthma.Keywords: diagnosis of asthma, reversibility, peak expiratory flow (PEF) variability, bronchial challenge test, forced expiratory flow (25-75%

Klinik Olarak Aşikar Kardiyovasküler Hastalığı Ya Da Geleneksel Ateroskleroz Risk Faktörü Bulunmayan Psöriatik Artritli Hastalarda Subklinik Aterosklerozun Değerlendirilmesi

Scopu

Diagnostic utility of oxidative and non-oxidative markers for spontaneous bacterial peritonitis in non-malign ascites

Objective: In this study, we aimed to investigate the diagnostic availability of oxidant and antioxidant parameters in ascites for spontaneous bacterial peritonitis (SBP). Material and methods: This study was carried out between July and October 2018 with 25 patients with SBP and 24 patients without SBP. Patients with acute infection, those taking vitamin supplements and antioxidant medication, smoking and drinking alcohol, and patients without ascites culture were excluded from the study. Results: In patients with SBP compared those without SBP median paraoxonase (3.1 vs 15.6; p <0.001), median stimulated paraoxonase (12.6 vs 53.1; p <0.001), median arylesterase (769,9 vs 857,5; p = 0,003) and median catalase (10 vs 22,2; p = 0,003) were found to be lower and median myeloperoxidase (8.1 vs 1.1; p <0.001) were found to be higher. There was a positive correlation between paraoxonase levels and stimulated paraoxonase levels, arylesterase levels and catalase levels, there was a negative correlation between paraoxonase levels and myeloperoxidase levels. Paraoxonase levels 3.7 and lower, stimulated paraoxonase levels 25.8 and lower, arylesterase levels 853.4 and lower, catalase levels 11.8 and lower and myeloperoxidase levels 2.7 and more predicted the the presence of SBP with high specificity and high sensitivity. Paraoxonase and stimulated paraoxo-nase levels were found to have superior performance in predicting the presence of SBP compared to arylesterase levels (p <0.05). Conclusion: In this study it was shown that paraoxonase, stimulated paraoxonase, arylesterase, catalase and myeloperoxidase activities can be used for the diagnosis and severity of SBP. © 2020, Universa Press. All rights reserved