A visibilidade de Pabllo Vittar na mídia

O presente trabalho tem como tema A visibilidade de Pabllo Vittar na mídia. Ao considerar o atual contexto político do Brasil, que é o país com maior número de transexuais e transgêneros assassinados do mundo, torna-se imprescindível abordar essa temática na universidade. Embasado em um referencial teórico relacionado a questões de gênero e à história da arte drag, e com a realização de uma análise de conteúdo no que tange o crescimento da drag queen Pabllo Vittar na mídia, a amplitude do alcance de seu trabalho e o impacto disso para o movimento LGBTQ+, o trabalho tem como objetivo analisar a parceria entre Pabllo Vittar e outros artistas. O intuito é trazer visibilidade ao movimento LGBTQ+ e chamar atenção para o crescimento da arte drag no Brasil e no mundo. Percebe-se o início de uma mudança no pensamento da sociedade através da presença de uma drag queen em tantos canais do meio digital. Conclui-se ainda que o preconceito e a intolerância são muito significativos e que ainda há um longo caminho a ser percorrido

Drenaje peritoneal permanente en paciente con mesotelioma metástasico: ganancia en calidad de vida en paciente oncológica

We present the case of a 63-year-old female patient diagnosed with stage IV epithelial mesothelioma. During the progressive evolution of his illness, frequent evacuation paracentesis was required with regular visits to the Emergency Department. Given the situation, in September 2016, the Radiology and Pneumology Service of the PleurX® catheter was placed in the peritoneal cavity, at the level of the right iliac fossa. The patient presented good tolerance, without needing more paracentesis in the emergency room, and with great benefit in their quality of life.Presentamos el caso de una paciente, mujer de 63 años diagnosticada de mesotelioma epiteliode estadío IV. Durante la evolución progresiva de su enfermedad, fue precisando paracentesis evacuadoras frecuentes con correspondientes visitas habituales al servicio de Urgencias. Dada la situación, en Septiembre de 2016 se procedió a colocación por parte del Servicio de Radiología y Neumología de catéter PleurX® en cavidad peritoneal, a nivel de fosa ilíaca derecha. La paciente presentó buena tolerancia, sin necesidad de más paracentesis en urgencias, y con gran beneficio en su calidad de vida

Understanding the Role of Electronic Effects in CO on the Pt-Sn Alloy Surface via Band Structure Measurements

Using angle-resolved photoemission spectroscopy, we show direct evidence for charge transfer between adsorbed molecules and metal substrates, i.e., chemisorption of CO on Pt(111) and Pt-Sn/Pt(111) 2 x 2 surfaces. The observed band structures show a unique signature of charge transfer as CO atoms are adsorbed, revealing the roles of specific orbital characters participating in the chemisorption process. As the coverage of CO increases, the degree of charge transfer between CO and Pt shows a clear difference to that of Pt-Sn. With comparison to density functional theory calculation results, the observed distinct features in the band structure are interpreted as back-donation bonding states formed between the Pt molecular orbital and the 2 pi orbital of CO. Furthermore, the change in the surface charge concentration, measured from the Fermi surface area, shows that the Pt surface has a larger charge concentration change than the Pt-Sn surface upon CO adsorption. The differences between Pt and Pt-Sn surfaces are due to the effect of Pt-Sn intermetallic bonding on the interaction of CO with the surface

Evolutionary genomics of Staphylococcus aureus reveals insights into the origin and molecular basis of ruminant host adaptation

Phenotypic biotyping has traditionally been used to differentiate bacteria occupying distinct ecological niches such as host species. For example, the capacity of Staphylococcus aureus from sheep to coagulate ruminant plasma, reported over 60 years ago, led to the description of small ruminant and bovine S. aureus ecovars. The great majority of small ruminant isolates are represented by a single, widespread clonal complex (CC133) of S. aureus, but its evolutionary origin and the molecular basis for its host tropism remain unknown. Here, we provide evidence that the CC133 clone evolved as the result of a human to ruminant host jump followed by adaptive genome diversification. Comparative whole-genome sequencing revealed molecular evidence for host adaptation including gene decay and diversification of proteins involved in host-pathogen interactions. Importantly, several novel mobile genetic elements encoding virulence proteins with attenuated or enhanced activity in ruminants were widely distributed in CC133 isolates, suggesting a key role in its host-specific interactions. To investigate this further, we examined the activity of a novel staphylococcal pathogenicity island (SaPIov2) found in the great majority of CC133 isolates which encodes a variant of the chromosomally encoded von Willebrand-binding protein (vWbp(Sov2)), previously demonstrated to have coagulase activity for human plasma. Remarkably, we discovered that SaPIov2 confers the ability to coagulate ruminant plasma suggesting an important role in ruminant disease pathogenesis and revealing the origin of a defining phenotype of the classical S. aureus biotyping scheme. Taken together, these data provide broad new insights into the origin and molecular basis of S. aureus ruminant host specificity.This work was funded by grant BB/D521222/1 from the Biotechnology and Biological Sciences Research Council (to J.R.F.). The Bacterial Microarray Group at St Georges is funded by The Wellcome Trust

Early mobilisation in critically ill COVID-19 patients: a subanalysis of the ESICM-initiated UNITE-COVID observational study

Background Early mobilisation (EM) is an intervention that may improve the outcome of critically ill patients. There is limited data on EM in COVID-19 patients and its use during the first pandemic wave. Methods This is a pre-planned subanalysis of the ESICM UNITE-COVID, an international multicenter observational study involving critically ill COVID-19 patients in the ICU between February 15th and May 15th, 2020. We analysed variables associated with the initiation of EM (within 72 h of ICU admission) and explored the impact of EM on mortality, ICU and hospital length of stay, as well as discharge location. Statistical analyses were done using (generalised) linear mixed-effect models and ANOVAs. Results Mobilisation data from 4190 patients from 280 ICUs in 45 countries were analysed. 1114 (26.6%) of these patients received mobilisation within 72 h after ICU admission; 3076 (73.4%) did not. In our analysis of factors associated with EM, mechanical ventilation at admission (OR 0.29; 95% CI 0.25, 0.35; p = 0.001), higher age (OR 0.99; 95% CI 0.98, 1.00; p ≤ 0.001), pre-existing asthma (OR 0.84; 95% CI 0.73, 0.98; p = 0.028), and pre-existing kidney disease (OR 0.84; 95% CI 0.71, 0.99; p = 0.036) were negatively associated with the initiation of EM. EM was associated with a higher chance of being discharged home (OR 1.31; 95% CI 1.08, 1.58; p = 0.007) but was not associated with length of stay in ICU (adj. difference 0.91 days; 95% CI − 0.47, 1.37, p = 0.34) and hospital (adj. difference 1.4 days; 95% CI − 0.62, 2.35, p = 0.24) or mortality (OR 0.88; 95% CI 0.7, 1.09, p = 0.24) when adjusted for covariates. Conclusions Our findings demonstrate that a quarter of COVID-19 patients received EM. There was no association found between EM in COVID-19 patients' ICU and hospital length of stay or mortality. However, EM in COVID-19 patients was associated with increased odds of being discharged home rather than to a care facility. Trial registration ClinicalTrials.gov: NCT04836065 (retrospectively registered April 8th 2021)

Technological properties of concrete blocks made with rice husk ashes suited for pavements

Considering the importance of recycling agricultural waste, such as the one originated from the utilization of the rice husk as source of energy, the rice husk ashes (RHA), in this study it was researched the use of RHA on the production of concrete blocks for pavements, seeking to obtain an alternative product for companies of the branch. The ash used had its origin in the burning of the rice husk at a temperature of 550ºC and it was characterized concerning moisture levels, carbon levels and granulometry. Due to its granulometry, the RHA was inserted in substitution to the medium thick sand, in the percentages of 5% and 10%, in mass. In search for reality in production, the concrete blocks with and without the RHA were made by a company of such branch, existing in Pelotas, RS, and they were tested regarding water absorption levels, void ratio, mechanical resistance to compression and abrasion resistance. Besides that, it was also verified the effects of adding RHA on the final tonality of the block, aiming the possibility of reducing the use of inorganic dye (pigments) and a possible cost reduction of this aspect. The result showed to be possible to attain blocks with RHA with the proposed quantities, but only the blocks with 5% replacement met the ABNT NBR 9781:2013 requirements.Sem bolsaConsiderando a importância da reciclagem de resíduos agrícolas, tais como o originado pelo aproveitamento da casca de arroz como fonte de energia, a cinza de casca de arroz (CCA), no presente trabalho pesquisou-se o emprego da CCA na produção de blocos de concreto para pavimentos, buscando obter um produto alternativo para empresas do ramo. A cinza utilizada tem origem na queima da casca de arroz à temperatura em torno de 550ºC e foi caracterizada quanto ao teor de umidade, teor de carbono e granulometria. Em função de sua granulometria, a CCA foi inserida em substituição ao agregado miúdo, a areia média, nos percentuais de 5% e 10%, em massa. Na busca por uma realidade de produção, os blocos de concreto sem e com CCA foram fabricados por uma empresa do ramo existente em Pelotas, RS, e testados quanto ao teor de absorção de água, índice de vazios, resistência à compressão e resistência à abrasão. Além disto, também, verificou-se o efeito da adição da CCA na tonalidade final do bloco, visando a possibilidade de redução do uso de corantes (pigmentos) inorgânicos e uma possível redução de custo nesse aspecto. O resultado mostrou ser possível a obtenção de blocos com CCA nas quantidades propostas de 5% e 10% de substituição, mas que somente os blocos com 5% de substituição atenderam as exigências da ABNT NBR 9781:2013

A Systematic Review and Meta-Analysis

Funding: The Regional Health Administration of Lisbon and Tagus Valley funded Dr. Maria’s salary and had no role in the study design, data collection, analysis or writing of this article. The present publication was funded by Fundação Ciência e Tecnologia, IP national support through CHRC (UIDP/04923/2020)The ongoing chronic use of hydroxychloroquine or chloroquine (HCQ/CQ) in rheumatic patients might impact their outcomes after a SARS-CoV-2 infection. Therefore, we sought to assess the mortality in rheumatic patients with chronic HCQ/CQ use who developed a COVID-19 infection through a comparison between individuals chronically using HCQ/CQ with those not taking these drugs. We performed a systematic review and meta-analysis of studies on PubMed, Embase, and Cochrane Central. We included full-length reports, prospective observational cohorts, and clinical trials of adult patients (aged ≥ 18 years) who were diagnosed with a COVID-19 infection. Case studies, case series, letters, comments, and editorials were excluded. The main outcome was all-cause mortality. This study is registered with PROSPERO (CRD42022341678). We identified 541 studies, of which 20 studies were included, comprising 236,997 patients. All-cause mortality was significantly lower in patients with prior chronic use of HCQ/CQ compared to those with no previous usage (OR 0.76; 95% CI 0.62–0.94; p = 0.01). There was a considerably lower incidence of hospitalization among patients with chronic HCQ/CQ use compared to their counterparts without HCQ/CQ usage (OR 0.80; 95% CI 0.65–0.99; p = 0.04). All-cause mortality and hospitalization were significantly lower in rheumatic patients with chronic HCQ/CQ use who developed a COVID-19 infection.publishersversionpublishe

Understanding the Role of Electronic Effects in CO on the Pt-Sn Alloy Surface via Band Structure Measurements

Using angle-resolved photoemission spectroscopy, we show direct evidence for charge transfer between adsorbed molecules and metal substrates, i.e., chemisorption of CO on Pt(111) and Pt-Sn/Pt(111) 2 x 2 surfaces. The observed band structures show a unique signature of charge transfer as CO atoms are adsorbed, revealing the roles of specific orbital characters participating in the chemisorption process. As the coverage of CO increases, the degree of charge transfer between CO and Pt shows a clear difference to that of Pt-Sn. With comparison to density functional theory calculation results, the observed distinct features in the band structure are interpreted as back-donation bonding states formed between the Pt molecular orbital and the 2 pi orbital of CO. Furthermore, the change in the surface charge concentration, measured from the Fermi surface area, shows that the Pt surface has a larger charge concentration change than the Pt-Sn surface upon CO adsorption. The differences between Pt and Pt-Sn surfaces are due to the effect of Pt-Sn intermetallic bonding on the interaction of CO with the surface.11Nsciescopu