Ultra-fine dark matter structure in the Solar neighbourhood

The direct detection of dark matter on Earth depends crucially on its density and its velocity distribution on a milliparsec scale. Conventional N-body simulations are unable to access this scale, making the development of other approaches necessary. In this paper, we apply the method developed in Fantin et al. 2008 to a cosmologically-based merger tree, transforming it into a useful instrument to reproduce and analyse the merger history of a Milky Way-like system. The aim of the model is to investigate the implications of any ultra-fine structure for the current and next generation of directional dark matter detectors. We find that the velocity distribution of a Milky Way-like Galaxy is almost smooth, due to the overlap of many streams of particles generated by multiple mergers. Only the merger of a 10^10 Msun analyse can generate significant features in the ultra-local velocity distribution, detectable at the resolution attainable by current experiments.Comment: 9 pages, 6 figures, accepted for publication in MNRA

Key anthropometric variables associated with front-crawl swimming performance in youth swimmers: an allometric approach

This is an accepted manuscript of an article published by Lippincott, Williams & Wilkins/National Strength and Conditioning Association in Journal of Strength and Conditioning Research on 07/02/2020, available online: 10.1519/JSC.0000000000003491 The accepted version of the publication may differ from the final published version.Sammoud, S, Negra, Y, Chaabene, H, Bouguezzi, R, Attia, A, Granacher, U, Younes, H, and Nevill, AM. Key anthropometric variables associated with front-crawl swimming performance in youth swimmers: an allometric approach. J Strength Cond Res XX(X): 000-000, 2020-This study aimed to establish key anthropometric characteristics (e.g., optimal body height, limb-segment length, and girth/breadth ratios) related to 100-m front-crawl performance in young swimmers. In total, 74 swimmers (boys [n = 41; age: 18.1 ± 3.5 years]; girls [n = 33; age: 15.9 ± 3.1 years]) participated in this study. We adopted a multiplicative allometric log-linear regression model to identify key anthropometric characteristics associated with 100-m front-crawl swimming performance. The main outcomes indicated that length ratio = ([height/leg length]), foot length and ankle girth, biacromial breadth, and % of body fat were associated with 100-m front-crawl mean swimming speed performance. These findings highlight the importance of assessing anthropometric characteristics in young front-crawl swimmers for talent identification and development.Published versio

Targeting NF-κB signaling cascades of glioblastoma by a natural benzophenone, garcinol, via in vitro and molecular docking approaches

Glioblastoma multiforme (GBM) is regarded as the most aggressive form of brain tumor delineated by high cellular heterogeneity; it is resistant to conventional therapeutic regimens. In this study, the anti-cancer potential of garcinol, a naturally derived benzophenone, was assessed against GBM. During the analysis, we observed a reduction in the viability of rat glioblastoma C6 cells at a concentration of 30 µM of the extract (p < 0.001). Exposure to garcinol also induced nuclear fragmentation and condensation, as evidenced by DAPI-stained photomicrographs of C6 cells. The dissipation of mitochondrial membrane potential in a dose-dependent fashion was linked to the activation of caspases. Furthermore, it was observed that garcinol mediated the inhibition of NF-κB (p < 0.001) and decreased the expression of genes associated with cell survival (Bcl-XL, Bcl-2, and survivin) and proliferation (cyclin D1). Moreover, garcinol showed interaction with NF-κB through some important amino acid residues, such as Pro275, Trp258, Glu225, and Gly259 during molecular docking analysis. Comparative analysis with positive control (temozolomide) was also performed. We found that garcinol induced apoptotic cell death via inhibiting NF-κB activity in C6 cells, thus implicating it as a plausible therapeutic agent for GBM

Elective Cancer Surgery in COVID-19-Free Surgical Pathways During the SARS-CoV-2 Pandemic: An International, Multicenter, Comparative Cohort Study.

PURPOSE: As cancer surgery restarts after the first COVID-19 wave, health care providers urgently require data to determine where elective surgery is best performed. This study aimed to determine whether COVID-19-free surgical pathways were associated with lower postoperative pulmonary complication rates compared with hospitals with no defined pathway. PATIENTS AND METHODS: This international, multicenter cohort study included patients who underwent elective surgery for 10 solid cancer types without preoperative suspicion of SARS-CoV-2. Participating hospitals included patients from local emergence of SARS-CoV-2 until April 19, 2020. At the time of surgery, hospitals were defined as having a COVID-19-free surgical pathway (complete segregation of the operating theater, critical care, and inpatient ward areas) or no defined pathway (incomplete or no segregation, areas shared with patients with COVID-19). The primary outcome was 30-day postoperative pulmonary complications (pneumonia, acute respiratory distress syndrome, unexpected ventilation). RESULTS: Of 9,171 patients from 447 hospitals in 55 countries, 2,481 were operated on in COVID-19-free surgical pathways. Patients who underwent surgery within COVID-19-free surgical pathways were younger with fewer comorbidities than those in hospitals with no defined pathway but with similar proportions of major surgery. After adjustment, pulmonary complication rates were lower with COVID-19-free surgical pathways (2.2% v 4.9%; adjusted odds ratio [aOR], 0.62; 95% CI, 0.44 to 0.86). This was consistent in sensitivity analyses for low-risk patients (American Society of Anesthesiologists grade 1/2), propensity score-matched models, and patients with negative SARS-CoV-2 preoperative tests. The postoperative SARS-CoV-2 infection rate was also lower in COVID-19-free surgical pathways (2.1% v 3.6%; aOR, 0.53; 95% CI, 0.36 to 0.76). CONCLUSION: Within available resources, dedicated COVID-19-free surgical pathways should be established to provide safe elective cancer surgery during current and before future SARS-CoV-2 outbreaks

Elective cancer surgery in COVID-19-free surgical pathways during the SARS-CoV-2 pandemic: An international, multicenter, comparative cohort study

PURPOSE As cancer surgery restarts after the first COVID-19 wave, health care providers urgently require data to determine where elective surgery is best performed. This study aimed to determine whether COVID-19–free surgical pathways were associated with lower postoperative pulmonary complication rates compared with hospitals with no defined pathway. PATIENTS AND METHODS This international, multicenter cohort study included patients who underwent elective surgery for 10 solid cancer types without preoperative suspicion of SARS-CoV-2. Participating hospitals included patients from local emergence of SARS-CoV-2 until April 19, 2020. At the time of surgery, hospitals were defined as having a COVID-19–free surgical pathway (complete segregation of the operating theater, critical care, and inpatient ward areas) or no defined pathway (incomplete or no segregation, areas shared with patients with COVID-19). The primary outcome was 30-day postoperative pulmonary complications (pneumonia, acute respiratory distress syndrome, unexpected ventilation). RESULTS Of 9,171 patients from 447 hospitals in 55 countries, 2,481 were operated on in COVID-19–free surgical pathways. Patients who underwent surgery within COVID-19–free surgical pathways were younger with fewer comorbidities than those in hospitals with no defined pathway but with similar proportions of major surgery. After adjustment, pulmonary complication rates were lower with COVID-19–free surgical pathways (2.2% v 4.9%; adjusted odds ratio [aOR], 0.62; 95% CI, 0.44 to 0.86). This was consistent in sensitivity analyses for low-risk patients (American Society of Anesthesiologists grade 1/2), propensity score–matched models, and patients with negative SARS-CoV-2 preoperative tests. The postoperative SARS-CoV-2 infection rate was also lower in COVID-19–free surgical pathways (2.1% v 3.6%; aOR, 0.53; 95% CI, 0.36 to 0.76). CONCLUSION Within available resources, dedicated COVID-19–free surgical pathways should be established to provide safe elective cancer surgery during current and before future SARS-CoV-2 outbreaks

Assessment of CFD turbulence models for free surface flow simulation and 1-D modelling for water level calculations over a broad-crested weir floodway

Floodways, where a road embankment is permitted to be overtopped by flood water, are usually designed as broad-crested weirs. Determination of the water level above the floodway is crucial and related to road safety. Hydraulic performance of floodways can be assessed numerically using 1-D modelling or 3-D simulation using computational fluid dynamics (CFD) packages. Turbulence modelling is one of the key elements in CFD simulations. A wide variety of turbulence models are utilized in CFD packages; in order to identify the most relevant turbulence model for the case in question, 96 3-D CFD simulations were conducted using Flow-3D package, for 24 broad-crested weir configurations selected based on experimental data from a previous study. Four turbulence models (one-equation, k-ε, RNG k-ε, and k-ω) ere examined for each configuration. The volume of fluid (VOF) algorithm was adopted for free water surface determination. In addition, 24 1-D simulations using HEC-RAS-1-D were conducted for comparison with CFD results and experimental data. Validation of the simulated water free surface profiles versus the experimental measurements was carried out by the evaluation of the mean absolute error, the mean relative error percentage, and the root mean square error. It was concluded that the minimum error in simulating the full upstream to downstream free surface profile is achieved by using one-equation turbulence model with mixing length equal to 7% of the smallest domain dimension. Nevertheless, for the broad-crested weir upstream section, no significant difference in accuracy was found between all turbulence models and the one-dimensional analysis results, due to the low turbulence intensity at this part. For engineering design purposes, in which the water level is the main concern at the location of the flood way, the one-dimensional analysis has sufficient accuracy to determine the water level

Three-Dimensional Numerical Investigations of the Flow Pattern and Evolution of the Horseshoe Vortex at a Circular Pier during the Development of a Scour Hole

In the current study, a three-dimensional CFD model is utilized to investigate the variation of the flow structure and bed shear stress at a single cylindrical pier during scour development. The scour development is presented by seven solidified geometries of the scour hole, collected during previous experimental work at different scour stages. Different turbulence models are evaluated and the (k-ω) model is chosen due to its relative accuracy in capturing the flow oscillation and vortex shedding at the pier downstream side with personal computer computational and storage resources. The numerical results are verified against dimensionless parameters from different previous experimental works. This research describes in detail the flow structure and bed shear stress variations through seven stages of the scour hole development. The dimensionless area-averaged circulation coefficient (Ψi) is developed to evaluate the changes in the vortex strength through the scouring process by eliminating the calculation area effect. It was concluded that the circulation in the (Y) direction is the main driving factor in the development of the scour hole more than the circulation in the (X) direction. The ratio between the horseshoe vortex (HV) mean size and the scouring depth (DV/dS) in addition to the location of the maximum bed shear stress are investigated during different stages of the scour development

DEMAND FOR TOBACCO (CIGARETTE), AND THE EFFECT OF CUSTOMS RAISING UPON IT IN SAUDI ARABIA

This study has estimated the demand for cigarette in Saudi Arabia by using two independent variables, namely, real retail price of cigarette and real per capita income. Three econometric models were used to estimate the demand functions and compare their results to choose the best model. These models were: Linear, Logarithmic, and Semi-Logarithmic. Using time-series data (1980-1994), the regression results indicated that all models explained over 90 percent of the variation in the quantity of consumed cigarette in Saudi Arabia. The Semi-Logarithmic model outperformed the other models on economic and statistical grounds. The estimated price and income elasticities of cigarette were (-1.40) and (0.25), respectively in the semi-logarithmic model. This means that an imposition of an importation tax of 50 percent of the value of imports will lead to a decrease in cigarette consumption in the year 2000 by one third of the consumption without taxes. Finally, the study shows that the demand for cigarette to be price elastic and this policy makers to put the import policies for tobacco in futur

Evaluation of CMORPH, PERSIANN-CDR, CHIRPS V2.0, TMPA 3B42 V7, and GPM IMERG V6 Satellite Precipitation Datasets in Arabian Arid Regions

Rainfall depth is a crucial parameter in water resources and hydrological studies. Rain gauges provide the most reliable point-based rainfall estimates. However, they do not have a proper density/distribution to provide sufficient rainfall measurements in many areas, especially in arid regions. To evaluate the adequacy of satellite datasets as an alternative to the rain gauges, the Kingdom of Saudi Arabia (KSA) is selected for the current study as a representative of the arid regions. KSA occupies most of the Arabian Peninsula and is characterized by high variability in topographic and climatic conditions. Five satellite precipitation datasets (SPDSs)—CMORPH, PERSIANN-CDR, CHIRPS V2.0, TMPA 3B42 V7, and GPM IMERG V6—are evaluated versus 324 conventional rain-gauges’ daily precipitation measures. The evaluation is conducted based on nine quantitative and categorical metrics. The evaluation analysis is carried out for daily, monthly, yearly, and maximum yearly records. The daily analysis revealed a low correlation for all SPDSs (0.8). Accordingly, in arid regions, the use of daily SPDSs in rainfall estimation will lead to high uncertainty in the obtained results. The best performance for all statistical metrics was found at 500–750 m altitudes in the central and northern parts of the study area for all satellites except minor anomalies. CMORPH dataset has the lowest centered root mean square error (RMSEc) for all analysis periods with the best results in the monthly analyses