Prospectus, November 7, 1984

KROHN MOVES FORWARD IN HER QUEST FOR LIFE…WE\u27LL MISS YOU; Veterans Day-1984; PC Happenings; Programs aid parents of pre-schoolers; Speaking Cobras take 4th; Classic presented in Parkland Theatre; Medicare workshop gives assistance; Talent auditions for \u2785 season for Busch Gardens; McDermott enjoys helping students gain knowlegde; Did You Know...; Classifieds; Creative Corner...especially for you!; Doom Story...the end draws near; Its over way before its over; Trial; I Love...; i\u27m content; divorces; self destruction; Pointless; Forty and Proud; anonymous; No More; my prison; the invisible wall; Dear Church street,; ?Blessing?; The Torch Bearers; these rooms; Still There; Koontz strikes again; Field plays greatest role; Elton John reborn; Creativity flowers in adverse conditions; Look out Belleville...here we come, and we bad!!!; Hard work pays off for Deany, Edwards; Workshop on memory disorders; Urbanek\u27s defense spearheads Hit Men to IM championship; Four Cobras advance to Nationalshttps://spark.parkland.edu/prospectus_1984/1005/thumbnail.jp

Prospectus, April 24, 1985

https://spark.parkland.edu/prospectus_1985/1011/thumbnail.jp

Prospectus, November 14, 1984

YOUR COURAGE, DEDICATION AND SACRIFICES ARE NOT FORGOTTEN; Parkland Veterans Honored; Women Veterans receive deserved recognition; Landslide of volunteers hoped for; Recognition needed all year; Blood Drive November; Best Sellers in the Library; PC Happenings; Original performance at Parkland; How to Live to be 1000 is retirees topic; Gallery hosts touring exhibit; EMT refresher workshop scheduled; Parkland, GM cooperate; Student job prospects look great; Man on Street...Question: Did you vote on Tuesday, and whatever you answer, why?; Creative Corner...especially for you!; Doom story...The cataclysm begins; Fluffy White Clouds; Nursing on a psychiatric floor; Ember of Empathy; With Feeling; Hurry Monday!; Contradiction versus deception; the eve of destruction; Homo Sapiens; Essence; Straub has not even begun to hit his stride; Good music sometimes underrated; Anothe Bowie hit; Classifieds; Britter\u27s Knights devastate USA Adidas 113-55 in opener; Lady Cobras finish spectacular season with 39-9-1 clipping; Knights down Nonames 100-30; Cobra cagers have flexibility and depth for \u2784-\u2785 campaign; Stater, Phillips supply one-two punch for Cobrashttps://spark.parkland.edu/prospectus_1984/1004/thumbnail.jp

Constructive approach to limiting periodic orbits with exponential and power law dynamics

In dynamical systems limit cycles arise as a result of a Hopf bifurcation, after a control parameter has crossed its critical value. In this study we present a constructive method to produce dissipative dynamics which lead to stable periodic orbits as time grows, with predesigned transient dynamics. Depending on the construction method a) the limiting orbit can be a regular circle, an ellipse or a more complex closed orbit and b) the approach to the limiting orbit can follow an exponential law or a power law. This technique allows to design nonlinear models of dynamical systems with desired (exponential or power law) relaxation properties.Comment: 17 pages, 6 figure

A novel asynchronous access method with binary interfaces

© 2008 Silva et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution Licens

Development of a complex intervention to test the effectiveness of peer support in type 2 diabetes

BACKGROUND: Diabetes is a chronic illness which requires the individual to assume responsibility for their own care with the aim of maintaining glucose and blood pressure levels as close to normal as possible. Traditionally self management training for diabetes has been delivered in a didactic setting. In recent times alternatives to the traditional delivery of diabetes care have been investigated, for example, the concept of peer support which emphasises patient rather than professional domination. The aim of this paper is to describe the development of a complex intervention of peer support in type 2 diabetes for a randomised control trial in a primary care setting. METHODS: The Medical Research Council (MRC) framework for the development and evaluation of complex interventions for randomised control trials (RCT) was used as a theoretical guide to designing the intervention. The first three phases (Preclinical Phase, Phase 1, Phase 2) of this framework were examined in depth. The Preclinical Phase included a review of the literature relating to type 2 diabetes and peer support. In Phase 1 the theoretical background and qualitative data from 4 focus groups were combined to define the main components of the intervention. The preliminary intervention was conducted in Phase 2. This was a pilot study conducted in two general practices and amongst 24 patients and 4 peer supporters. Focus groups and semi structured interviews were conducted to collect additional qualitative data to inform the development of the intervention. RESULTS: The four components of the intervention were identified from the Preclinical Phase and Phase 1. They are: 1. Peer supporters; 2. Peer supporter training; 3. Retention and support for peer supporters; 4. Peer support meetings. The preliminary intervention was implemented in the Phase 2. Findings from this phase allowed further modeling of the intervention, to produce the definitive intervention. CONCLUSION: The MRC framework was instrumental in the development of a robust intervention of peer support of type 2 diabetes in primary care. TRIAL REGISTRATION: Current Controlled Trials ISRCTN42541690

Beyond gene-disease validity: capturing structured data on inheritance, allelic requirement, disease-relevant variant classes, and disease mechanism for inherited cardiac conditions

Background: As the availability of genomic testing grows, variant interpretation will increasingly be performed by genomic generalists, rather than domain-specific experts. Demand is rising for laboratories to accurately classify variants in inherited cardiac condition (ICC) genes, including secondary findings. // Methods: We analyse evidence for inheritance patterns, allelic requirement, disease mechanism and disease-relevant variant classes for 65 ClinGen-curated ICC gene-disease pairs. We present this information for the first time in a structured dataset, CardiacG2P, and assess application in genomic variant filtering. // Results: For 36/65 gene-disease pairs, loss of function is not an established disease mechanism, and protein truncating variants are not known to be pathogenic. Using the CardiacG2P dataset as an initial variant filter allows for efficient variant prioritisation whilst maintaining a high sensitivity for retaining pathogenic variants compared with two other variant filtering approaches. // Conclusions: Access to evidence-based structured data representing disease mechanism and allelic requirement aids variant filtering and analysis and is a pre-requisite for scalable genomic testing

The state of the Martian climate

60°N was +2.0°C, relative to the 1981–2010 average value (Fig. 5.1). This marks a new high for the record. The average annual surface air temperature (SAT) anomaly for 2016 for land stations north of starting in 1900, and is a significant increase over the previous highest value of +1.2°C, which was observed in 2007, 2011, and 2015. Average global annual temperatures also showed record values in 2015 and 2016. Currently, the Arctic is warming at more than twice the rate of lower latitudes

Potent Innate Immune Response to Pathogenic Leptospira in Human Whole Blood

Background: Leptospirosis is caused by pathogenic spirochetes of the genus Leptospira. The bacteria enter the human body via abraded skin or mucous membranes and may disseminate throughout. In general the clinical picture is mild but some patients develop rapidly progressive, severe disease with a high case fatality rate. Not much is known about the innate immune response to leptospires during haematogenous dissemination. Previous work showed that a human THP-1 cell line recognized heat-killed leptospires and leptospiral LPS through TLR2 instead of TLR4. The LPS of virulent leptospires displayed a lower potency to trigger TNF production by THP-1 cells compared to LPS of non-virulent leptospires. Methodology/Principal Findings: We investigated the host response and killing of virulent and non-virulent Leptospira of different serovars by human THP-1 cells, human PBMC's and human whole blood. Virulence of each leptospiral strain was tested in a well accepted standard guinea pig model. Virulent leptospires displayed complement resistance in human serum and whole blood while in-vitro attenuated non-virulent leptospires were rapidly killed in a complement dependent manner. In vitro stimulation of THP-1 and PBMC's with heat-killed and living leptospires showed differential serovar and cell type dependence of cytokine induction. However, at low, physiological, leptospiral dose, living virulent complement resistant strains were consistently more potent in whole blood stimulations than the corresponding non-virulent complement sensitive strains. At higher dose living virulent and non-virulent leptospires were equipotent in whole blood. Inhibition of different TLRs indicated that both TLR2 and TLR4 as well as TLR5 play a role in the whole blood cytokine response to living leptospires. Conclusions/Significance: Thus, in a minimally altered system as human whole blood, highly virulent Leptospira are potent inducers of the cytokine response