23 research outputs found
Elective Cancer Surgery in COVID-19-Free Surgical Pathways During the SARS-CoV-2 Pandemic: An International, Multicenter, Comparative Cohort Study.
- Author
- Aawsaj Y.
- Abad Gurumeta A.
- Abad-Motos A.
- Abate E.
- Abatini C.
- Abbadessa F.
- Abbas A. M.
- Abbassi-Ghadi N.
- Abbott D.
- Abbott T.
- Abd Elazeem H. A. S.
- Abdalla M.
- Abdallah M.
- Abdel Al S.
- Abdel Jalil R.
- Abdeldayem H.
- Abdelkader Salama I.
- Abdelkarem M. M.
- Abdelkarim M.
- Abdelmajeed A.
- Abdelrahman A.
- Abdelrahman S.
- Abdelsamed A.
- Abdou M.
- Abdulkareem A.
- Abdulwahed E.
- Abdur-Rahman L.
- Abel M. K.
- Abellan M.
- Aboelkassem Ibrahim A.
- Abosamak N. E.
- Abou Chaar M. K.
- Abou-Khalil J.
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- Abreu Da Silva A.
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- Aderombi A.
- Adeyeye A.
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- Aggarwal A.
- Aghayeva A.
- Agilinko J.
- Agnes A.
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- Agoston P.
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- Agresta F.
- Aguado H.
- Aguilar Gonzalez M.
- Aguzzoli L.
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- J Clin Oncol
- Publication date
- 01/01/2020
- Field of study
Get PDFPURPOSE: As cancer surgery restarts after the first COVID-19 wave, health care providers urgently require data to determine where elective surgery is best performed. This study aimed to determine whether COVID-19-free surgical pathways were associated with lower postoperative pulmonary complication rates compared with hospitals with no defined pathway. PATIENTS AND METHODS: This international, multicenter cohort study included patients who underwent elective surgery for 10 solid cancer types without preoperative suspicion of SARS-CoV-2. Participating hospitals included patients from local emergence of SARS-CoV-2 until April 19, 2020. At the time of surgery, hospitals were defined as having a COVID-19-free surgical pathway (complete segregation of the operating theater, critical care, and inpatient ward areas) or no defined pathway (incomplete or no segregation, areas shared with patients with COVID-19). The primary outcome was 30-day postoperative pulmonary complications (pneumonia, acute respiratory distress syndrome, unexpected ventilation). RESULTS: Of 9,171 patients from 447 hospitals in 55 countries, 2,481 were operated on in COVID-19-free surgical pathways. Patients who underwent surgery within COVID-19-free surgical pathways were younger with fewer comorbidities than those in hospitals with no defined pathway but with similar proportions of major surgery. After adjustment, pulmonary complication rates were lower with COVID-19-free surgical pathways (2.2% v 4.9%; adjusted odds ratio [aOR], 0.62; 95% CI, 0.44 to 0.86). This was consistent in sensitivity analyses for low-risk patients (American Society of Anesthesiologists grade 1/2), propensity score-matched models, and patients with negative SARS-CoV-2 preoperative tests. The postoperative SARS-CoV-2 infection rate was also lower in COVID-19-free surgical pathways (2.1% v 3.6%; aOR, 0.53; 95% CI, 0.36 to 0.76). CONCLUSION: Within available resources, dedicated COVID-19-free surgical pathways should be established to provide safe elective cancer surgery during current and before future SARS-CoV-2 outbreaks
Elective cancer surgery in COVID-19-free surgical pathways during the SARS-CoV-2 pandemic: An international, multicenter, comparative cohort study
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- Publication venue
- 'American Society of Clinical Oncology (ASCO)'
- Publication date
- 01/01/2021
- Field of study
Get PDFPURPOSE As cancer surgery restarts after the first COVID-19 wave, health care providers urgently require data to determine where elective surgery is best performed. This study aimed to determine whether COVID-19–free surgical pathways were associated with lower postoperative pulmonary complication rates compared with hospitals with no defined pathway. PATIENTS AND METHODS This international, multicenter cohort study included patients who underwent elective surgery for 10 solid cancer types without preoperative suspicion of SARS-CoV-2. Participating hospitals included patients from local emergence of SARS-CoV-2 until April 19, 2020. At the time of surgery, hospitals were defined as having a COVID-19–free surgical pathway (complete segregation of the operating theater, critical care, and inpatient ward areas) or no defined pathway (incomplete or no segregation, areas shared with patients with COVID-19). The primary outcome was 30-day postoperative pulmonary complications (pneumonia, acute respiratory distress syndrome, unexpected ventilation). RESULTS Of 9,171 patients from 447 hospitals in 55 countries, 2,481 were operated on in COVID-19–free surgical pathways. Patients who underwent surgery within COVID-19–free surgical pathways were younger with fewer comorbidities than those in hospitals with no defined pathway but with similar proportions of major surgery. After adjustment, pulmonary complication rates were lower with COVID-19–free surgical pathways (2.2% v 4.9%; adjusted odds ratio [aOR], 0.62; 95% CI, 0.44 to 0.86). This was consistent in sensitivity analyses for low-risk patients (American Society of Anesthesiologists grade 1/2), propensity score–matched models, and patients with negative SARS-CoV-2 preoperative tests. The postoperative SARS-CoV-2 infection rate was also lower in COVID-19–free surgical pathways (2.1% v 3.6%; aOR, 0.53; 95% CI, 0.36 to 0.76). CONCLUSION Within available resources, dedicated COVID-19–free surgical pathways should be established to provide safe elective cancer surgery during current and before future SARS-CoV-2 outbreaks
Outcomes from elective colorectal cancer surgery during the SARS-CoV-2 pandemic
- Author
- 14 | COVIDSurg COllabOratIVe Tzovaras G. (General University Hospital of Larissa)
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- Cassinotti E. (Fondazione IRCCS Ca’ Granda – Ospedale Maggiore Policlinico di Milano)
- Castellammare di Stabia)
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- Pereira R.
- Pereira Rodrigues A.
- Perez D.
- Perez Gonzalez M.
- Pergolini I. Reim D. (Klinikum Rechts der Isar TUM School of Medicine)
- Perivoliotis K.
- Peros G. (Kantonsspital Winterthur). Turkey: Aghayeva A.
- Perotto L. O.
- Perra T.
- Persiani R.
- Pertile D.
- Petrillo A.
- Petropoulos K.
- Peyroteo M.
- Pezzuto A. P.
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- Phillips E.
- Picardo A. L.
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- Picón Rodríguez R.
- Pieniowski E. (Stockholm South General Hospital)
- Piessen G.
- Pieve Emanuele (Mi))
- Pina S.
- Pinto J. Tojal A. (Centro Hospitalar Tondela-Viseu)
- Pipitone Federico N. S. (Edoardo Agnelli)
- Pisani Ceretti A. (ASST Santi Paolo E. Carlo)
- Pisanu A.
- Pizarro M. J.
- Pizzini P. (Ospedale Maggiore di Lodi)
- Pla Marti V. (Hospital Clínico Universitario de Valencia)
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- Podda M. (Cagliari University Hospital)
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- Popoola A. (University of Ilorin Teaching Hospital). Pakistan: Jamal A.
- Porcu A.
- Portinari M.
- Posadas-Trujillo O. E.
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- Provozina A. (Immanuel Kant Baltic Federal University
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- Ramcharan S.
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- Razafindrahita J. B.
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- Rega D.
- Regional Clinical Hospital)
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- Ribeiro R.
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- Rice D.
- Richards T.
- Ridgway P. F.
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- Riley C.
- Rimonda R.
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- Rodimov S.
- Rodrigo V. S. D. (District General Hospital Chilaw)
- Rodriguez J. L.
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- Rose J.
- Roslani A. C. (University Malaya Medical Centre). Mexico: Buerba G. A.
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- Rottoli M.
- Roy Mahapatra S.
- Royle T.
- Rozzano (Mi) and Humanitas University
- Rubio-Perez I.
- Ruivo A.
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- Ruiz Soriano M.
- Ruiz-Marín M.
- Russ J.
- Rutegård M. (Umea University Hospital). Switzerland: Arigoni M.
- Rutherford D.
- Ruzzenente A.
- Ryan M. (University Hospital Waterford/University College Cork). Italy: Macina S. (ASST Mantua)
- Ryan É. (University Hospital Galway)
- Ryska O. (Royal Lancaster Infirmary)
- Río Lafuente F. D.
- Saad M. M.
- Saafan T.
- Saavedra J.
- Sabah)
- Sabratha)
- Sabry A.
- Saeed S.
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- Sagnotta A. (Ospedale San Filippo Neri)
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- Salem H.
- Salgado-Nesme N.
- Salimoğlu S.
- Salindera S.
- Sallam I.
- Samih A.
- Samir Abdelaal A.
- Samison L. H. (Joseph Ravoahangy Andrianavalona Hospital). Malaysia: Hamdan K. H.
- Samkari A.
- Sammarco G.
- Sammour T. (Royal Adelaide Hospital)
- Sampaio da Nóvoa Gomes Miguel I. I. (Centro Hospitalar Universitário do Algarve – Unidade de Portimão)
- Sampietro G. M. (Ospedale di Rho – ASST Rhodense)
- San Francisco (UCSF))
- Sanchez Cabezudo Noguera F.
- Sanchez Gonzalez J.
- Sanchez Jimenez R.
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- Sanchon L.
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- Santanach C.
- Santarrufina Martinez S.
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- Sarantitis I.
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- Sarjanoja E. (Länsi-Pohja Central Hospital)
- Sarma D. R.
- Sarre C. (Instituto Nacional de Ciencias Médicas y Nutrición ‘Salvador Zubirán’). Morocco: Amrani L.
- Sartarelli L.
- Sarveswaran J.
- Sasapu K. (Diana Princess of Wales Hospital Grimsby)
- Sasia D.
- Saudí S. (Hospital Universitario Miguel Servet)
- Sauvain M. (Pourtales Neuchatel Hospital)
- Sauvat F. (CHU Réunion). Romania: Bezede C.
- Savković N.
- Sayyed R. (Patel Hospital)
- Scabini S.
- Scalabre A. (Chu Saint Etienne)
- Scanu A. M. (Cliniche San Pietro
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- Schineis C. (Charité University Medicine
- Schizas D.
- Schlesinger N.
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- Scott L. (Pinderfields Hospital)
- Scotton G. (St Moritz Hospital)
- Scrima O.
- Sechenov Medical State University)
- Seebah K.
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- Seguin-Givelet A.
- Sehgal T.
- Selmani J.
- Semina E. (Moscow Research and Educational Center
- Senossi O.
- Serevina O. L.
- Serralta de Colsa D. (Infanta Sofía University Hospital)
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- Seymour Z. (Ysbyty Gwynedd). USA: Haynes A.
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- Sgrò A.
- Shah J. (North Manchester General Hospital)
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- Shah Z. A.
- Shaikh I.
- Shaikh S.
- Sharabiany S. (Amsterdam UMC
- Sharma P. (Aberdeen Royal Infirmary)
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- Sheridan K.
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- Sherif A. E. (National Liver Institute
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- Shokuhi P.
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- Sibilla M. G.
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- Silva M.
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- Silveira Nunes I.
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- Soriero D. (IRCCS Ospedale Policlinico San Martino)
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- Soto Montesinos C. (Fundació Althaia – Xarxa Assistencial Universitària de Manresa)
- Souadka A. (Institut National d’Oncologie
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- Spartalis E.
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- Subhi M. T. (Alkhadra Hospital)
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- Subramaniam S. (Queen Elizabeth Hospital and Universiti Malaysia Sabah
- Sundaram Venkatesan G. (Glan Clwyd Hospital)
- Suszták N. (Szent Borbála Kórház). India: Bhat G. A.
- Sutherland A. (Coffs Harbour Health Campus)
- Swinson B. (Royal Brisbane and Women’s Hospital). Austria: Messner F.
- Syed W. A. S.
- Syllaios A.
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- Sánchez del Pueblo C.
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- Sánchez- Pernaute A.
- Sánchez- Rubio M.
- Sánchez-García S.
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- Taibi A. (Chu Limoges)
- Talal El-Abur I.
- Talwar R. (Luton and Dunstable University Hospital)
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- Tanal M.
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- Tartaglia D. (Azienda Ospedaliero Universitaria Pisana)
- Tasis N. (Athens Naval and Veterans Hospital)
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- Tebala G. D.
- Teixeira J. (Centro Hospitalar Universitário do Algarve – Unidade de Faro)
- Teixeira M. (Centro Hospitalar do Tamega e Sousa)
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- Testa V. (Santa Croce E. Carle Hospital
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- Tezas S. (Furness General Hospital)
- Thaha M.
- Thanapal M. R. (Hospital Kuala Lumpur)
- Theodosopoulos T.
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- Thulasiraman S. V.
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- TU Dresden)
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- Uludağ S. S.
- Umair M.
- Universiti Sains Malaysia)
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- Università di Ferrara)
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- Velidedeoglu M.
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- Vervoort D.
- Vescio G. (University ‘Magna Graecia’ of Catanzaro)
- Vezakis A. (Aretaieion Hospital)
- Videira J. F. (IPO Porto). Réunion: Kassir R.
- Vieira B. (Centro Hospitalar de Trás-Os-Montes e Alto Douro
- Vieira Caroço T. (IPO Coimbra)
- Vieira Paiva Lopes A. C. (Hospital de Torres Vedras – Centro Hospitalar do Oeste)
- Vignali A. (San Raffaele Scientific Institute
- Vigorita V. (Álvaro Cunqueiro Hospital)
- Vijayan D. (Queen Elizabeth Hospital Birmingham)
- Villalabeitia Ateca I. (Hospital Universitario Cruces)
- Vimalachandran D. (Countess of Chester Hospital)
- Viswanath Y. K. S. (James Cook University Hospital)
- Vitali A. (Ospedale San Giovanni di Dio)
- Vitone L. (Royal Blackburn Hospital)
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- Von Papen M.
- Vovola F. (Ospedali Riuniti Azienda Ospedaliera Universitaria Foggia)
- Vucic N.
- Vázquez Fernández A. (Hospital Clínico Universitario de Valladolid)
- Wadham B. (The University Hospital of South Manchester)
- Walkes K. (Queen Elizabeth Hospital). Belgium: Flamey N.
- Wani R. (Sher-I-Kashmir Institute of Medical Sciences)
- Waqar S. H. (Pakistan Institute of Medical Sciences). Poland: Major P. (Jagiellonian University Medical College). Portugal: Azevedo C.
- Warren O. (Chelsea and Westminster Hospital)
- Watson L. J. (Sunderland Royal Hospital)
- Watson N. (King’s Mill Hospital)
- Weitz J.
- Welsch T. (Carl-Gustav-Carus University Hospital
- Werner J. (LMU Klinikum Campus Innenstadt)
- Westwood E. (James Paget University NHS Foundation Trust Hospital)
- Whelan M. (Tallaght University Hospital)
- Whitmore H. (Torbay and South Devon NHS Trust)
- Wilkin R. J. W. (South Warwickshire NHS Foundation Trust)
- Wilkins A. (Hull University Teaching Hospitals NHS Trust)
- Williams G. (Royal Gwent Hospital)
- Williams K. (St George’s Hospital)
- Wilson M. (Forth Valley Royal Hospital)
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- Wong M.
- Worku D. (Queens Medical Centre)
- Wullschleger M. (Gold Coast University Hospital)
- Xavier R. G.
- Xenaki S.
- Xynos E. (University Hospital of Heraklion Crete and Interclinic Hospital of Crete). Hong Kong: Futaba K.
- Yang W.
- Yassin N. (Royal Wolverhampton NHS Trust)
- Ye G.
- Yesantharao P.
- Yetkin S. G. (Sisli Hamidiye Etfal Training and Research Hospital)
- Yeşilyurt D. (University of Health Sciences Tepecik Training and Research Hospital)
- Yiallourou A. (Nicosia General Hospital). Czechia: Martinek L.
- Yıldırım A.
- Yildiz A. (Yildirim Beyazit University Yenimahalle Training and Research Hospital). Uganda: Lule H.
- Young R. (York Teaching Hospitals NHS Trust)
- Yousof E. A. (Assiut University Hospital)
- Youssef M. (Norfolk and Norwich University Hospital)
- Yurttas C. (University Hospital Tuebingen)
- Yánez C. (Royo Villanova)
- Yüksel E. (Kocaeli University Teaching Hospital)
- Zafar S. N. (University of Wisconsin)
- Zakaria A. D.
- Zakaria Z. (School of Medical Sciences and Hospital
- Zambon M. (Policlinico Umberto I Sapienza University of Rome)
- Zanus G. (Ca’ Foncello Treviso – DISCOG – Università di Padova)
- Zegarac M. (Institute for Oncology and Radiology of Serbia)
- Zelić M. (University Hospital Center Rijeka)
- Zengin A. K. (Istanbul Universty – Cerrahpaşa Medical Faculty)
- Zerbib P. (CHU Lille)
- Zervas K.
- Zese M. (Santa Maria degli Angeli Hospital ULSS 5 – Adria)
- Zhang H. (Concord Repatriation General Hospital)
- Zizzo M. (Azienda Unità Sanitaria Locale – IRCCS di Reggio Emilia)
- Zografos C. (Laiko University Hospital)
- Zorrilla Ortúzar J. (Hospital General Universitario Gregorio Marañón)
- Zourntou S. (General Hospital of Larissa ‘Koutlimpaneio and Triantafylleio’)
- Zubaidi A. M. (King Saud University). Serbia: Aleksić L.
- Ângelo M.
- Çelebi F.
- Çolak E.
- Öfner D. (Medical University of Innsbruck)
- Öhlberger L.
- Özçelık M. F.
- Öğücü H.
- Überrück L.
- Ćoza I.
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2020
- Field of study
Get PDFThis study aimed to describe the change in surgical practice and the impact of SARS-CoV-2 on mortality after surgical resection of colorectal cancer during the initial phases of the SARS-CoV-2 pandemic
Burnout among surgeons before and during the SARS-CoV-2 pandemic: an international survey
- Author
- Abbas Ahmed Hosam Eldin Hasan
- Abbas Ghanem
- Abbas Hazem
- Abbatini Francesca
- Abdalbakheet Duaa
- Abdallah Emad
- Abdelazim Tarek
- Abdelaziz Nabil Yassin Tammam
- Abdelglil Momen
- Abdelhalim Ahmed
- Abdelhalim Mostafa Mohammed
- Abdelhamid Ahmed
- Abdelhamid Mohamed Sayed
- Abdelkhalik Morsi Mohamed Morsi
- Abdellatif Ahmed
- Abdelmageed Mohammed Elkassaby
- Abdelmaksoud Mohamed
- Abdelmohsen Ahmed
- Abdelmomen Ahmed Ezzat Elghrieb
- Abdelmoneim Ibrahim Tharwat Mohamed
- Abdelmonem Mohamed Ahmed
- Abdelmotaleb Hussien Ali
- Abdelrafee Ahmed
- Abdelrasheed Sayed
- Abdelsayed Emad Fahim
- Abdo Nael
- Abdulatef Shehab Ahmed Ali
- Abdullah Alqahtani Ali
- Abdulrahman Chadi
- Abdur-Rahman Lukman
- Abduraboh Abdullah Fayez
- Abed Ali Ibrahim Eldawy
- Abiodun Azeez Lateef
- Abiyere Henry
- Aboelmagid Hamdy Haggag Ebrahim
- Abolnasr Khaled Samir
- Abosi-Appeadu Kessewa
- Abouelnagah Galal
- Abozeid Ahmad Mahmoud
- Abozeid Mahmoud
- Abualkhair Wael
- Abualnaja Yousra
- Abualsel Abdulmenem
- Abuosba Abdelrahman
- Abusalem Osama
- Abusiam Wael
- Abutalib Raid Abdullah
- Abuzeid Mohamed Mostafa
- Addari Giulio
- Adebowale Yusuf
- Adejumo Adeyinka
- Adel Mohammed
- Adeoluwa Ojajuni
- Adeyeye Ademola
- Adly Ramy Magdy
- Adorisio Ottavio
- Agbonrofo Peter
- Agrawal Abhishek
- Ahmad Farooq
- Ahmad Misbahu Haruna
- Ahmad Mustafa
- Ahmad Sufian
- Ahmad Suhaib
- Ahmed Abeer Abdul Hameed
- Ahmed Arooj
- Ahmed Emad Ali
- Ahmed Hassan
- Ahmed Mohamed
- Ahmed Mostafa Mahmoud
- Aitali Abdelmounaim
- Akeel Nouf
- Akhtar Khalid
- Akin Furkan Atakan
- Akinmade Akinola
- Al Eisa Abdulmohsen
- Al Hassn Ibrahim
- Al Naeb Mohamed
- Al Turki Neamat Ahmed Ali
- Al-Bahrani Ahmed
- Al-Kubati Waheeb
- Al-Masari Hayder Makki
- Al-Sadery Humood
- Alaa Mohammed
- Alabbas Haytham
- Alafghani Haitham
- Alarabi Rayan
- Alawadhi Abdulbari Mohammed
- Alawady Mohammed
- Alawfi Homoud
- Alazzam Saleh
- Albadry Ali Almahdy Ali
- Albahooth Khalid
- Albalawi Ibrahim Altedlawi
- Albeshri Khalid A.
- Aleksandr Ogoreltsev
- Alfalah Haitham
- Algatanesh Nassib
- Alghamdi Faisal Saleh
- Alghamdi Saleh
- Alghuliga Abdullah
- Alhamdany Arkan Shubber
- Alharbi Abdulhamid
- Alhazmi Barrag
- Alhazmi Waleed
- Alhedaithy Alhanouf
- Alhendawey Moaaz
- Alhussaini Mohammed Khalid
- Alhussien Fade Ahmed
- Ali Ali Sayed
- Ali Bandar Idrees A.
- Ali Doaa
- Ali Mahmoud
- Ali Mohamed Anwar Abdel Razik
- Ali Muhammad Zulfiqar
- Ali Shabeer
- Ali Syed Muhammad
- Aliyu Yakubu
- Aljathlany Yousef
- Aljawhari Adel Ali
- Alkhalegy Ayman
- Alkhayat Ali
- Alkhayat Mohammed Amer
- Allaeys Mathias
- Almaghrabi Alhassan Hesham
- Almasri Mahmoud
- Almulhim Abdulrhman
- Alnabarawi Mahmoud
- Alnahas Yousef
- Alnashar Ahmed
- Alnoqaidan Emad
- Alomieri Adil
- Alotaibi Abdullah
- Alotaibi Abdulrahman
- Alotaibi Abdulrahman
- Alowairdhi Tumadher
- Alqarni Ahmed
- Alqasaby Abdallah
- Alqudaihi Heba
- Alrashidi Yousef
- Alsallum Ofays
- Alsawat Salem
- Alshabi Yaser Ahmad
- Alshehari Mohammed Mohammed Hasan
- Alshukr Sarah
- Alsuwaimel Munir A.
- Althobaiti Majid
- Althumali Abdullah
- Altomare Donato F.
- Alvarez Gallesio José Maria
- Alwan Ahmed
- Alwusaibie Ahmed
- Alyami Mohammad
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- Sherif Ahmed Elshawadfy
- Shetiwy Mosab
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- Shomoye El-Zaki
- Sibiany Abdulrahman
- Siboe Mark M. W.
- Sidorova Lyudmila
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- Sindy Abdullah
- Singh Baljit
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- Situ Oladele
- Skandalakis Georgios P.
- Slavchev Mihail
- Sleilati Fadi
- Sobh Mohamed Ramadan
- Sofan Mostafa
- Soggiu Fiammetta
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- Soliman Ahmed
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- Stavrou George
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- Subramanian Sivaraman
- Suliman Omar AAbu
- Tabasi Hani
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- Tairab Elsanousi Ibrahim Sabir
- Taki-Eldin Ahmed
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- Taman Mohamed
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- Tamini Nicolò
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- Uggeri Fabio
- Uraiqat Ahmad
- Uranitsch Stefan
- Uslu Gülberk
- Valente Marina
- Valery Nekoval
- Van Daele Elke
- Van Praet Charles
- Van Ramshorst Gabrielle H.
- Vanlander Aude
- Vanommeslaeghe Hanne
- Varma Gopala Pillay
- Vázquez-Melero Alba
- Vella Ivan
- Veltri Marco
- Venturelli Paolina
- Vikrantmr Sharma
- Villwock Jennifer
- Visconti Diego
- Vishwakarma Kushagra
- Vosloo Susan
- W Njoroge P.
- Waleed Aasma
- Wali Zubair
- Waqar Shahzad Hussain
- Warusavitarne Janindra
- Waseem Talat
- Wexner Steven
- Wuraola Funmilola Olanike
- Yacir El Alami
- Yakar Fatih
- Yanaga Katsuhiko
- Yassin Nouf
- Yassine Wassim Abou
- Yeşilyurt Değercan
- Yildiz Alp
- Yousef Yousef Mohamed
- Youssef Mohamed
- Youssef Youssef Abdel Aziz
- Yves Van Nieuwenhove
- Zafar Noman
- Zahra Tarek
- Zaidi Mariam
- Zaieem Mohammad
- Zakaria Hazem M.
- Zakharenko Alexander
- Zancana Giuseppa
- Zentar Aziz
- Zese Monica
- Zewar Karem Shahin Mohamed
- Zidan Ahmed Azmy
- Zigiotto Daniele
- Zubayraeva Albina
- Zuhdy Mohammad
- Publication venue
- Publication date
- 01/01/2024
- Field of study
Get PDFBackground: SARS-CoV-2 pandemic has had many significant impacts within the surgical realm, and surgeons have been obligated to reconsider almost every aspect of daily clinical practice. Methods: This is a cross-sectional study reported in compliance with the CHERRIES guidelines and conducted through an online platform from June 14th to July 15th, 2020. The primary outcome was the burden of burnout during the pandemic indicated by the validated Shirom-Melamed Burnout Measure. Results: Nine hundred fifty-four surgeons completed the survey. The median length of practice was 10 years; 78.2% included were male with a median age of 37 years old, 39.5% were consultants, 68.9% were general surgeons, and 55.7% were affiliated with an academic institution. Overall, there was a significant increase in the mean burnout score during the pandemic; longer years of practice and older age were significantly associated with less burnout. There were significant reductions in the median number of outpatient visits, operated cases, on-call hours, emergency visits, and research work, so, 48.2% of respondents felt that the training resources were insufficient. The majority (81.3%) of respondents reported that their hospitals were included in the management of COVID-19, 66.5% felt their roles had been minimized; 41% were asked to assist in non-surgical medical practices, and 37.6% of respondents were included in COVID-19 management. Conclusions: There was a significant burnout among trainees. Almost all aspects of clinical and research activities were affected with a significant reduction in the volume of research, outpatient clinic visits, surgical procedures, on-call hours, and emergency cases hindering the training. Trial registration: The study was registered on clicaltrials.gov "NCT04433286" on 16/06/2020
Abstracts from the 3rd International Genomic Medicine Conference (3rd IGMC 2015)
- Author
- Aadil Hussain
- Abbes Salem
- Abdelbaset Buhmaida
- Abdelbaset Buhmeida
- Abdelbaset Buhmeida
- Abdelbaset Buhmeida
- Abdelbaset Buhmeida
- Abdelbaset Buhmeida
- Abdelbaset Buhmeida
- Abdelbaset Buhmeida
- Abdelbaset Buhmeida
- Abdelbaset Buhmeida
- Abdelbaset Buhmeida
- Abdelbaset Buhmeida
- Abdelbaset Buhmeida
- Abdelbaset Buhmeida
- Abdelbasit Buhmeida
- Abdelbasit Buhmeida
- Abdellatif Bouazzaoui
- Abdelwahab Noorwali
- Abdulah E. A. Mathkoor
- Abdulazeez Sayyed
- Abdulla A. Alharthi
- Abdullah Al-Harbi
- Abdullah Alashwal
- Abdullah M. Gari
- Abdullraheem Rozi
- Abdulmonem Al-Mutawa
- Abdulmonem Al-Mutawa
- Abdulrahman M. S. Sibiani
- Abeer A. Al-refai
- Abid Qureshi
- Abrar Al Qahtani
- Adeel Chaudhary
- Adeel Chaudhary
- Adeel Chaudhary
- Adeel Chaudhary
- Adeel Chaudhary
- Adeel Chaudhary
- Adeel Chaudhary
- Adeel Chaudhary
- Adeel Chaudhary
- Adeel Chaudhary
- Adeel Chaudhary
- Adeel Chaudhary
- Adeel G. Chaudhary
- Adeel G. Chaudhary
- Adeel G. Chaudhary
- Adeel G. Chaudhary
- Adeel G. Chaudhary
- Adeel G. Chudhary
- Adel Abuzenada
- Adel Abuzenada
- Adel Abuzenadah
- Adel Abuzenadah
- Adel Abuzenadah
- Adel Abuzenadah
- Adel Abuzenadah
- Adel Abuzenadah
- Adel Abuzenadah
- Adel Abuzenadah
- Adel Abuzenadah
- Adel Abuzenadah
- Adel Abuzenadah
- Adel Abuzenadah
- Adel Al-Ammari
- Adel Al-Ammari
- Adel Al-Johari
- Adel Al-Johari
- Adel E. El-Tarras
- Adel Galal Ahmed El-Shemi
- Adel Galal Ahmed El-Shemi
- Adel Galal El-Shemi
- Adel M. Abu Zenadah
- Adel M. Abuzenadah
- Adel M. Abuzenadah
- Adel M. Abuzenadah
- Adel M. Abuzenadah
- Adel M. Abuzenadah
- Adel M. Abuzenadah
- Adel M. Abuzenadah
- Adel M. Abuzenadah
- Adel Mohammed Abuzenadah
- Adil Jamal
- Adnan Merdad
- Adnan Merdad
- Afnan Bahamaid
- Afnan Bandah
- Afnan Bandah
- Afnan Bandah
- Afnan O. Bahmaid
- Ahmad A. T. Naqvi
- Ahmad Ashshi
- Ahmad Ashshi
- Ahmad J. Al Sayyad
- Ahmad J. Al Sayyad
- Ahmed Al-Sayyad
- Ahmed Al-Sayyad
- Ahmed Ateya
- Ahmed M. Ashshi
- Ahmed M. Isa
- Ahmed M. Z. Darwish
- Ahmed Rebai
- Ahmed Rebai
- Ahmed Rebai
- Ahmed S. Masmoudi
- Aisha A. Alyamani
- Aisha Alyamani
- Aisha Hassan Elaimi
- Alaa A. Albogmi
- Alaa A. Albogmi
- Alaa A. Alboogmi
- Alaa Al-Ahmadi
- Alaa Al-Ahmadi
- Alaa Al-Ahmadi
- Alaa Alamandi
- Alaa K. Kamel
- Alaa O. Magrabi
- Alagiri Srinivasan
- Alastair D. Burt
- Albert J. Fornace
- Ali Al-Muraikhi
- Ali Al-Sahwan
- Ali Mobasheri
- Ali Sawan
- Alia M. Aldahlawi
- Alistair G. Rust
- Amal Awad
- Amal M. Mohamed
- Amal M. Nour
- Amanuel T. Gebreslasie
- Amein Al-Ali
- Ameur Cherif
- Ameur Cherif
- Amr Abdelfattah
- Anas M. M. Oun
- Andrey Ptitsyn
- Angel Carracedo
- Angel Carracedo
- Angie Ambers
- Anne Goodeve
- Areeg Faggad
- Asad M. Ilyas
- Asho Ali
- Ashok Agarwa
- Ashok Agarwal
- Ashok Agarwal
- Ashok Agarwal
- Ashok Agarwal
- Ashraf Ali
- Ashraf Ali
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- Susan Walker
- Syed A. Hassan
- Syed A. Hassan
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- Syed Hassan
- Syed K. Zaidi
- Syed Kashif Zaidi
- Syed Kashif Zaidi
- Taha A. Abdel-Meguid
- Taha Abduallah Kumosani
- Taha Abduallah Kumosani
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- Taha Abo Almagd
- Taha Kumosani
- Takahiko Nishigaki
- Takis Athanasopoulos
- Taoufik Nedjadi
- Taoufik Nedjadi
- Tatsuhiro Shibata
- Tej P. Singh
- Tetsuji Naka
- Toshirou Nishida
- Touhami Mahjoub
- Touhami Mahjoub
- Touhami Mahjoub
- Tsuyoshi Takahashi
- Vera Chayeb
- Vikram Gopalakrishna Pillai
- Vladimir B. Bajic
- Wafaey Gomaa
- Waseem Ahmad
- Waseem Ahmad
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- Waseem Ahmad
- Wassim Almawi
- Wassim Y. Almawi
- Wejdan Al-Qahtani
- Wejdan Al-Qahtani
- Wejdan Al-Qahtani
- Wided Malah
- Yogesh S. Marfatia
- Yosr Z. Haffani
- Yosr Z. Haffani
- Youjin Na
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- Yousif A. Abutalib
- Youssri Ahmed
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- Zeenat Mirza
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- Zeenat Mirza
- Zeyad Al Yousef
- Zhihong Cui
- Zuhier A. Awan
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Get PDFReducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries
- Author
- Abad-Motos Ane
- Abbas Ahmed M.
- Abbas Mostafa
- Abbasi Mujeeb
- Abbott Tom
- Abd Karim Muhammad Fairuz Shah
- Abdalaal Ibrahim
- Abdel-Galil Khalid
- Abdelemam Rania
- Abdelgawad Abdalrahman
- Abdelkarim Maryam
- Abdelkhalek Mohamed
- Abdelmageed Abdelfatah
- Abdelmawgoud Sherif
- Abdelmohsen Sarah
- Abdelrahman Ahmed Saber
- Abdelrahman Mostafa
- Abdelwahab Khaled
- Abdou Hossam
- Abdulai Darling Ramatu
- Abdulkhaleq Marwa
- Abdullah Bahiyah
- Abdulsalam Khalifa
- Abdulsalam Shuaib
- Abdur-Rahman Lukman
- Abdus-Salam Rukiyat
- Abdussalam Hameedat Opeyemi
- Abebrese John Tabiri
- Abeldaño Ariel
- Abou-Khalil Jad
- Abou-Taleb Hisham
- Abozid Anwaar
- Abozied Hesham
- Abrate Alberto
- Abu-Zaid Ahmed
- Abubakar Mohammed Kabir
- Abud Burçin
- Abuzaid Mohammed
- Adam Albushra Altayeb
- Adamina Michel
- Adamou Harissou
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- Mahečić Tina Tomić
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- Martins Claudia Pinto
- Martins Paulo N.
- Martínez Daniel Fernández
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- McLeish Bethan
- McPherson Duncan
- Meara John G.
- Meead Adullah
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- Mengesha Mengistu G.
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- Méndez Patricia Serrano
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- Nacion Aeris Jane D.
- Nadi Khaldoun
- Naegele Felix
- Naga Hani
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- Naranjo Eddy P. Lincango
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- Narvaez-Rojas Alexis Rafael
- Nassar Mahmoud A.
- Nasser Sara
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- Natale Joseph
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- Nevins Edward J.
- Newman Samuel
- Ngaserin Sabrina
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- Niewiera Marc
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- Nitschke Christine
- Njokanma Iloba
- Noel Colin
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- Novysedlák René
- Ntalouka Maria P.
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- Olori Samson
- Olson Kristofor A.
- Oludara Mobolaji
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- Othman Amani Alsayd Abdulsalam
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- Paraskevas Kosmas I.
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- Pettigrove K.L.
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- Pinkney Thomas
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- Piozzi Guglielmo Niccolò
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- Prodromidou Anastasia
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- Prusty Lydia
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- Punjabi Prakash P
- Puri Ajay
- Purich Kieran
- Pérez Beatriz Gómez
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- Rasheed Aqsa
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- Ravindra Raevin
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- Redondo Nuria Villacé
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- Ribeiro João
- Riccetti Camilla
- Richard H.
- Rickard Jennifer
- Rincón Natalia Andrea Rivera
- Ripollés-Melchor Javier
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- Rodrigues Sara Castanheira
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- Rodriguez Magdiel
- Rodriguez-Lopez Mario
- Rodríguez Lorena Varela
- Rokohl Alexander Christopher
- Roland Christina L
- Rolinger Jens
- Romano Angela
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- Ruggiero Silvia
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- Ryalino Christopher
- Ryan James
- Ryan Éanna
- Saad Rema
- Saaid Rahmah
- Sabbagh Abdulrahman J.
- Sabella Danielle
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- Santoshi John Ashutosh
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- Saracoglu Ayten
- Saracoglu Kemal
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- Sasireka Veerasamy
- Satchithanantham Vinojan
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- Sayyed Raza
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- Schmitt Françoise
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- Yeoh Tien
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- Yusefi Hossein
- Zabaleta Jon
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- Zahid Zahra
- Zaimis Tilemachos
- Zakaria Andee Dzulkarnaen
- Zambon Martina
- Zamora Lindsey
- Zampogna Biagio
- Zancana Giuseppa
- Zani Augusto
- Zanin Luca
- Zanini Nicola
- Zapardiel Ignacio
- Zapata Carlos Shiraishi
- Zarif Pierre
- Zaránd Attila
- Zehnder Philipp
- Zenger Serkan
- Zenha Horácio
- Zhu Michael Z. L.
- Ziemann Sebastian
- Zimak Danijela Mrazovac
- Zimak Zoran
- Zivkovic Dragana
- Zizzo Maurizio
- Zucker Benjamin
- Zwain Yasir
- Zyskowski Michael
- Ávila Clara Castro
- Älgå Andreas
- Çakici Mehmet Çaǧlar
- Çelik Enes
- Çelik Meryem Nur
- Özçay Necdet
- Şevik Hüsnü
- Šantak Goran
- Šimko Kristián
- Žatecký Jan
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2023
- Field of study
Get PDFAbstract
Background
Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres.
Methods
This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries.
Results
In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia.
Conclusion
This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries
Development and validation of Ran as a prognostic marker in stage I and stage II primary breast cancer.
- Author
- Publication venue
- Elsevier
- Publication date
- 15/09/2023
- Field of study
No full textPURPOSE
Existing prognostic biomarkers are inadequate for stratifying breast cancer patients with the highest risk of tumor progression at the time of diagnosis. Here, we demonstrate that the small GTPase Ran has predictive value for breast cancer (BC) patients as a whole, and for specific BC subtypes.
PATIENTS AND METHODS
Ran expression was quantified by immunohistochemistry in 263 patients with primary breast cancer diagnosed at the Breast Unit, Royal Liverpool Hospital. Additionally as an independent validation, we also analyzed the mRNA expressions of Ran, ER, PR, and Cerb-2, the triple-negative endocrine receptors, and their associations with patient survival in a combined patient cohorts of multiple public datasets (n = 1079). We analyzed the data with Spearman's rank correlation and Kaplan-Meier plots coupled with Wilcoxon-Gehan tests, respectively. All statistical tests were two-sided.
RESULTS
Ran nuclear, cytoplasmic, and total staining are substantially associated with poor survival, independent of conventional prognostic markers such as estrogen receptor (ER), human epidermal growth factor receptor 2 (HER2), and lymph node status. According to the datasets, Ran was significantly correlated with distant metastasis-free survival (DMFS) and relapse-free survival (RFS).
CONCLUSION
We found that Ran expression is a unique predictive biomarker for patient survival, metastasis, and tumor relapse. This biomarker could be used for diagnostic purposes, using formalin-fixed, paraffin-embedded tumor biopsy samples from breast cancer patients in the early stages
Epitope-Based Peptide Vaccine against Glycoprotein G of Nipah Henipavirus Using Immunoinformatics Approaches
- Author
- Publication venue
- 'Hindawi Limited'
- Publication date
- 01/01/2020
- Field of study
No full textBackground. Nipah belongs to the genusHenipavirusand theParamyxoviridae family. It is an endemic most commonly foundat South Asia and hasfirst emerged in Malaysia in 1998. Bats are found to be the main reservoir for this virus, causing disease inboth humans and animals. The last outbreak has occurred in May 2018 in Kerala. It is characterized by high pathogenicity andfatality rates which varies from 40% to 70% depending on the severity of the disease and on the availability of adequatehealthcare facilities. Currently, there are no antiviral drugs available for NiV disease and the treatment is just supportive.Clinical presentations for this virus range from asymptomatic infection to fatal encephalitis.Objective. This study is aimed atpredicting an effective epitope-based vaccine against glycoprotein G of Nipah henipavirus, using immunoinformaticsapproaches.Methods and Materials. Glycoprotein G of the Nipah virus sequence was retrieved from NCBI. Differentprediction tools were used to analyze the epitopes, namely, BepiPred-2.0: Sequential B Cell Epitope Predictor for B cell andT cell MHC classes II and I. Then, the proposed peptides were docked using Autodock 4.0 software program.Results andConclusions. The two peptides TVYHCSAVY and FLIDRINWI have showed a very strong binding affinity to MHC class Iand MHC class II alleles. Furthermore, considering the conservancy, the affinity, and the population coverage, the peptideFLIDRINWIT is highly suitable to be utilized to formulate a new vaccine against glycoprotein G of Nipah henipavirus. Anin vivo study for the proposed peptides is also highly recommended
Epitope-Based Peptide Vaccine against Glycoprotein G of Nipah Henipavirus Using Immunoinformatics Approaches
- Author
- Publication venue
- 'Hindawi Limited'
- Publication date
- 01/01/2020
- Field of study
No full textBackground. Nipah belongs to the genus Henipavirus and the Paramyxoviridae family. It is an endemic most commonly found at South Asia and has first emerged in Malaysia in 1998. Bats are found to be the main reservoir for this virus, causing disease in both humans and animals. The last outbreak has occurred in May 2018 in Kerala. It is characterized by high pathogenicity and fatality rates which varies from 40% to 70% depending on the severity of the disease and on the availability of adequate healthcare facilities. Currently, there are no antiviral drugs available for NiV disease and the treatment is just supportive. Clinical presentations for this virus range from asymptomatic infection to fatal encephalitis. Objective. This study is aimed at predicting an effective epitope-based vaccine against glycoprotein G of Nipah henipavirus, using immunoinformatics approaches. Methods and Materials. Glycoprotein G of the Nipah virus sequence was retrieved from NCBI. Different prediction tools were used to analyze the epitopes, namely, BepiPred-2.0: Sequential B Cell Epitope Predictor for B cell and T cell MHC classes II and I. Then, the proposed peptides were docked using Autodock 4.0 software program. Results and Conclusions. The two peptides TVYHCSAVY and FLIDRINWI have showed a very strong binding affinity to MHC class I and MHC class II alleles. Furthermore, considering the conservancy, the affinity, and the population coverage, the peptide FLIDRINWIT is highly suitable to be utilized to formulate a new vaccine against glycoprotein G of Nipah henipavirus. An in vivo study for the proposed peptides is also highly recommended
REACTIONS WITH 6-METHYL-2-THIOURACIL SYNTHESIS OF DIPYRIMIDINO[2,1-b:1′,2′-c]THIAZINE. A NEW RING SYSTEM
- Author
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
No full text
