Hypoalbuminemia in Jaundice Neonatorum among Term Newborns at a Tertiary Care Hospital

Background: Jaundice which occurs in about 60% term and more than 80 % preterm neonates. It remains on the most common morbidities observed in the first week of life of newborns and is most prevalent cause of re-hospitalization after their discharge from birth hospitalization. This study was conducted to document the frequency of hypoalbuminemia in neonatum jaundice as there is no such study conducted in Pakistan. Objective: To determine  the frequency of hypoalbuminemia in jaundice neonatorum in term infants. Material and methods: A total of 265 patients fulfilling the inclusion criteria from indoor department of pediatrics Nishtar hospital Multan were included in the study from May 2016 to May 2017. Demographic information of patients (gestational age, mode of delivery, gender, weight) was taken and recorded in study proforma. Three ml blood sample was collected from all participants for serum albumin levels and hypoalbuminemia was defined as serum albumin level of less than 2.5 g/dL by laboratory test. Data was analyzed with statistical analysis program (SPSS version11.5). Results: Of these 265 study cases, 150 (56.6%) were boys while 115 (43.4%) were girls. Mean gestational age of our study cases was 39.84 ± 1.67 weeks (with minimum gestational age was 37 weeks while maximum was 42 weeks). Mean gestational age of the boys was 40.41 ± 1.42 weeks while that of girls was 39.10 ± 1.69 weeks. Our study results have indicated that majority of our study cases i.e. 160 (60.4%) had gestational age ranging from  40- 42 weeks. Majority of these babies i.e. 222 (83.8%) were born through vaginal mode of delivery. Mean weight of our study cases was 3084.08 ± 344.422 grams (with minimum weight was 2550 grams while maximum weight was noted to be 3750 grams). Majority of our study cases i.e. 150 (56.6%) were from rural areas and 115 (43.3%) belonged to the urban areas. Of these 265 study cases, 104 (39.2%) were from poor socioeconomic background while 125 (47.2%) had middle income. Mean level of serum albumin was 2.55 ± 0.31 g/dl (with minimum albumin level was 2.2 and maximum was 3.6). Hypoalbuminemia was seen in 141 (53.2%) of our study cases.Conclusion: In our study, very high frequency of hypoalbuminemia has been noted in neonates presenting with jaundice. Neonatal jaundice was more prevalent in boys than girls. Hypoalbuminemia was significantly associated with rural residential status, vaginal mode of delivery and poor socioeconomic status. Keywords: Hyperbillirubinemia, hypoalbuminemia, jaundice

An Assessment of Knowledge, Attitude and Practices (KAP) towards Diabetes Mellitus and Diabetic Retinopathy among Patients of Nishter Medical University Hospital Multan, South-Punjab Pakistan

Objective: This study aimed to determine the Knowledge, Attitude and Practices (KAP) towards diabetes mellitus and diabetic retinopathy among the patients of a tertiary care hospital. Study design This study was an observational, cross-sectional study. Place and duration of study The current study was conducted at department of General Medicine, Nishtar Medical University Hospital Multan, Pakistan. The time span of the study was from March 2016 to February 2017. Method After taking approval from Ethical Review Committee, a questionnaire based descriptive study was conducted on 692 patients.  The technique of convenient sampling was used. All the gathered data were retrieved into MS Excel. The data were analyzed by using computer program SPSS 21 version. Results: Six hundred ninety two adults were interviewed. Of these, 271 (39.2%) were suffering from diabetes mellitus. Lowest mean knowledge score (5.28 ± 6.09) was seen in illiterate study population. Male’s Mean Knowledge score (5.61 ± 5.56) was better than female’s (4.46 ± 5.21). Over all mean score of Attitudes towards diabetes was 4.43 ± 2.37. It was higher (6.62 ± 2.03) in diabetic respondents as compared with non-diabetic respondents (4.70 ± 2.59) with p < 0.000. In Practice module majority of the respondents (69.9%) did not exercise, 49% took high caloric snacks between meals and 87% ate outside home once a month, 56.8% diabetics visited ophthalmologist for routine eye examination; but only 9.2% asked for retinal examination. Conclusion Poor knowledge of diabetes was found in the community. The problem was more marked in females, illiterate and the individuals not having diabetes mellitus. Key Words: Diabetes mellitus, Diabetic retinopathy, Diabetic Education Program, Knowledge, Attitude and Practices (KAP

Leveraging brain–computer interface for implementation of a bio-sensor controlled game for attention deficit people

In video games, neurofeedback via Electroencephalogram (EEG) has emerged as a method for treating attention deficit, alongside preventative measures such as behavioral therapy. By 2020–21, the Neuro-Gaming industry has reached USD 6.29 billion. As a remedy to attention deficit and to take advantage of the ever-growing EEG-based gaming industry, this research work presents the design and implementation of an EEG-controlled 2D game built in the Unity 3D game engine. Our research includes steps like dataset creation, training the learning algorithms, classification, and deciding on those results in the designed game whether to shoot a target or not. We read signals from the Neurosky sensor, user orientation, and linear acceleration. We pre-process them via transforms into a processed input for various learning algorithms. The results are then exported to the game engine and used in the game. In classification, we have achieved 89% accuracy and F1 score of 87% with LSTM

Assessment of medication adherence among patients with chronic diseases: a descriptive cross-sectional study

Background: Adherence is a key factor associated with effectiveness of all pharmacological therapies. Medication non-adherence is a significant barrier to achieve positive health outcomes especially for patients suffering from chronic diseases. Improving medication adherence is a public health priority and could reduce economic and health burdens. The aim of the present study was to assess medication adherence to some common chronic ailments.Methods: Pre-validated questionnaires were distributed among 300 patients suffering from chronic illnesses, by simple randomization out of which 240 patients returned completely filled questionnaires. The analysis was done by manual calculators, VassarStats, and SPSS V20. Results were calculated using univariate linear regression, with each patient’s adherence score as the dependent variable and each predictor as the independent variable. Results are expressed in frequencies and percentages.Results: In this study, 46.66% patients were males and 53.33% females. The mean age was 56.69 years ranging from 24 to 90 years.65.00% patients were uneducated.40.00% were taking one drug, 53.33% two to four drugs and 6.66% more than four drugs. 63.33% had low medication adherence, 35.00% medium and only 1.66% had high adherence. Compared to 14.28% men, 43.75% women were moderately adherent to medications. 41.02% uneducated patients had medium adherence as compared to 14.28% educated patients. 92.30% young patients had low adherence as compared to 53.25% in adults. 44.79% of patients receiving a single drug had medium adherence as compared to 25.00% in those receiving multiple drugs. Linear regression analysis demonstrated that the level of medication adherence was associated with patient gender, age, educational level, and number of prescribed drugs.Conclusions: There are many challenges in understanding the reasons for non-adherence. In this study medication adherence in chronic diseases was found suboptimal and associated with patient`s socio-demographic characteristics. Patient-tailored interventions are required to achieve sufficient adherence to therapeutic drug regimens

Chitosan nanoparticles: a versatile platform for biomedical applications

Chitosan is a biodegradable and biocompatible natural polymer that has been extensively explored in recent decades. The Food and Drug Administration has approved chitosan for wound treatment and nutritional use. Furthermore, chitosan has paved the way for advancements in different biomedical applications including as a nanocarrier and tissue-engineering scaffold. Its antibacterial, antioxidant, and haemostatic properties make it an excellent option for wound dressings. Because of its hydrophilic nature, chitosan is an ideal starting material for biocompatible and biodegradable hydrogels. To suit specific application demands, chitosan can be combined with fillers, such as hydroxyapatite, to modify the mechanical characteristics of pH-sensitive hydrogels. Furthermore, the cationic characteristics of chitosan have made it a popular choice for gene delivery and cancer therapy. Thus, the use of chitosan nanoparticles in developing novel drug delivery systems has received special attention. This review aims to provide an overview of chitosan-based nanoparticles, focusing on their versatile properties and different applications in biomedical sciences and engineering.info:eu-repo/semantics/publishedVersio

Molecular Evidence of High Proportion of Plasmodium vivax

Plasmodium falciparum is a predominant malaria species that infects humans in the African continent. A recent WHO report estimated 95% and 5% of P. falciparum and P. vivax malaria cases, respectively, in Sudan. However many laboratory reports from different areas in Sudan indicated otherwise. In order to verify, we selected four hundred suspected malaria cases from Aljabalain area located in the White Nile state, central Sudan, and diagnosed them with quality insured microscopy and species-specific nested PCR. Our results indicated that the proportion of P. vivax infections among suspected malaria cases was high. We found that on average 20% and 36.5% of malaria infections in both study areas were caused by P. vivax using both microscopy and PCR, respectively. This change in pattern is likely due to the recent demographic changes and high rate of immigration from neighbouring countries in the recent years. This is the first extensive clinical study of its kind that shows rising trend in P. vivax malaria cases in White Nile area, Sudan

Measurement of t(t)over-bar normalised multi-differential cross sections in pp collisions at root s=13 TeV, and simultaneous determination of the strong coupling strength, top quark pole mass, and parton distribution functions

Peer reviewe

Measurement of the top quark forward-backward production asymmetry and the anomalous chromoelectric and chromomagnetic moments in pp collisions at √s = 13 TeV

Abstract The parton-level top quark (t) forward-backward asymmetry and the anomalous chromoelectric (d̂ t) and chromomagnetic (μ̂ t) moments have been measured using LHC pp collisions at a center-of-mass energy of 13 TeV, collected in the CMS detector in a data sample corresponding to an integrated luminosity of 35.9 fb−1. The linearized variable AFB(1) is used to approximate the asymmetry. Candidate t t ¯ events decaying to a muon or electron and jets in final states with low and high Lorentz boosts are selected and reconstructed using a fit of the kinematic distributions of the decay products to those expected for t t ¯ final states. The values found for the parameters are AFB(1)=0.048−0.087+0.095(stat)−0.029+0.020(syst),μ̂t=−0.024−0.009+0.013(stat)−0.011+0.016(syst), and a limit is placed on the magnitude of | d̂ t| < 0.03 at 95% confidence level. [Figure not available: see fulltext.

MUSiC : a model-unspecific search for new physics in proton-proton collisions at root s=13TeV

Results of the Model Unspecific Search in CMS (MUSiC), using proton-proton collision data recorded at the LHC at a centre-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 35.9 fb(-1), are presented. The MUSiC analysis searches for anomalies that could be signatures of physics beyond the standard model. The analysis is based on the comparison of observed data with the standard model prediction, as determined from simulation, in several hundred final states and multiple kinematic distributions. Events containing at least one electron or muon are classified based on their final state topology, and an automated search algorithm surveys the observed data for deviations from the prediction. The sensitivity of the search is validated using multiple methods. No significant deviations from the predictions have been observed. For a wide range of final state topologies, agreement is found between the data and the standard model simulation. This analysis complements dedicated search analyses by significantly expanding the range of final states covered using a model independent approach with the largest data set to date to probe phase space regions beyond the reach of previous general searches.Peer reviewe

Measurement of prompt open-charm production cross sections in proton-proton collisions at root s=13 TeV

The production cross sections for prompt open-charm mesons in proton-proton collisions at a center-of-mass energy of 13TeV are reported. The measurement is performed using a data sample collected by the CMS experiment corresponding to an integrated luminosity of 29 nb(-1). The differential production cross sections of the D*(+/-), D-+/-, and D-0 ((D) over bar (0)) mesons are presented in ranges of transverse momentum and pseudorapidity 4 < p(T) < 100 GeV and vertical bar eta vertical bar < 2.1, respectively. The results are compared to several theoretical calculations and to previous measurements.Peer reviewe