The influence of South African mineral water on reduction of risk of calcium oxalate kidney stone formation

No Abstract

Protocol analysis data collection technique implemented for artificial intelligence design

This article suggests that artificial intelligence (AI) can automate protocol analysis, a form of data analysis in cognitive psychology for inferring the information processes used by individuals from their verbal behavior while solving a problem. We propose a framework to employ think-aloud protocols (TaP) and thematic analysis in qualitative accounting research. Specifically, we use the TaP methodology to explore the impact of legal conflict and the lack of international financial reporting standards (IFRS) knowledge on implementing these accounting standards in a developing country (i.e., Iraq). The article analyzes 32 semi-structured in-depth phone interviews with external auditors, preparers, the capital market, national professional accounting and auditing associations, and academics. The results indicate that the lack of an AI framework, IFRS knowledge, and legislation conflict may adversely interact with standard implementation. This article explores how protocol analysis can benefit from AI support and provide design features. Protocol analysis can provide opportunities for future article, design, and action

The parasitic worm-derived immunomodulator, ES-62 and its drug-like small molecule analogues exhibit therapeutic potential in a model of chronic asthma

Chronic asthma is associated with persistent lung inflammation and long-term remodelling of the airways that have proved refractory to conventional treatments such as steroids, despite their efficacy in controlling acute airway contraction and bronchial inflammation. As its recent dramatic increase in industrialised countries has not been mirrored in developing regions, it has been suggested that helminth infection may protect humans against developing asthma. Consistent with this, ES-62, an immunomodulator secreted by the parasitic worm Acanthocheilonema viteae, can prevent pathology associated with chronic asthma (cellular infiltration of the lungs, particularly neutrophils and mast cells, mucus hyper-production and airway thickening) in an experimental mouse model. Importantly, ES-62 can act even after airway remodelling has been established, arresting pathogenesis and ameliorating the inflammatory flares resulting from repeated exposure to allergen that are a debilitating feature of severe chronic asthma. Moreover, two chemical analogues of ES-62, 11a and 12b mimic its therapeutic actions in restoring levels of regulatory B cells and suppressing neutrophil and mast cell responses. These studies therefore provide a platform for developing ES-62-based drugs, with compounds 11a and 12b representing the first step in the development of a novel class of drugs to combat the hitherto intractable disorder of chronic asthma

Forecasting the Jordanian stock index: modelling asymmetric volatility and distribution effects within a GARCH framework

The modelling of market returns can be especially problematical in emerging and frontier financial markets given the propensity of their returns to exhibit significant non-normality and volatility asymmetries. This paper attempts to identify which representations within the GARCH family of models can most efficiently deal with these issues. A number of different distributions (normal, Student t, GED and skewed Student) and different volatility of returns asymmetry representations (EGARCH and GJR- -GARCH) are examined. Our data set consists of daily Jordanian stock market returns over the period January 2000 – November 2014. Using both the Superior Predicative Ability (SPA) and Model Confidence Set (MCS) testing frameworks it is found that using GJR-GARCH with a skewed Student distribution most accurately and efficiently forecasts Jordanian market movements. Our findings are consistent with similar research undertaken in respect to developed markets.</p

Protective effect of small molecule analogues of the Acanthocheilonema viteae secreted product ES-62 on oxazolone-induced ear inflammation

ES-62 is the major secreted protein of the rodent filarial nematode Acanthocheilonema viteae. The molecule contains covalently attached phosphorylcholine (PC) residues, which confer anti-inflammatory properties on ES-62, underpinning the idea that drugs based on this active moiety may have therapeutic potential in human diseases associated with aberrant inflammation. Here we demonstrate that two synthetic small molecule analogues (SMAs) of ES-62 termed SMA 11a and SMA 12b are protective in the oxazolone-induced acute allergic contact dermatitis mouse model of skin inflammation, as measured by a significant reduction in ear inflammation following their administration before oxazolone sensitisation and before oxazolone challenge. Furthermore, it was found that when tested, 12b was effective at reducing ear swelling even when first administered before challenge. Histological analysis of the ears showed elevated cellular infiltration and collagen deposition in oxazolone-treated mice both of which were reduced by treatment with the two SMAs. Likewise, the oxazolone-induced increase in IFNγ mRNA in the ears was reduced but no effect on other cytokines investigated was observed. Finally, no influence on the mast cell populations in the ear was observed

Structure of the Lithosphere and Upper Mantle Across the Arabian Peninsula

Analysis of modern broadband (BB) waveform data allows for the inference of seismic velocity structure of the crust and upper mantle using a variety of techniques. This presentation will report inferences of seismic structure of the Arabian Plate using BB data from various networks. Most data were recorded by the Saudi Arabian National Digital Seismic Network (SANDSN) which consists of 38 (26 BB, 11 SP) stations, mostly located on the Arabian Shield. Additional data were taken from the 1995-7 Saudi Arabian IRIS-PASSCAL Deployment (9 BB stations) and other stations across the Peninsula. Crustal structure, inferred from teleseismic P-wave receiver functions, reveals thicker crust in the Arabian Platform (40-45 km) and the interior of the Arabian Shield (35-40 km) and thinner crust along the Red Sea coast. Lithospheric thickness inferred from teleseismic S-wave receiver functions reveals very thin lithosphere (40-80 km) along the Red Sea coast which thickens rapidly toward the interior of the Arabian Shield (100-120 km). We also observe a step of 20-40 km in lithospheric thickness across the Shield-Platform boundary. Seismic velocity structure of the upper mantle inferred from teleseismic P- and S-wave travel time tomography reveals large differences between the Shield and Platform, with the Shield being underlain by slower velocities, {+-}3% for P-waves and {+-}6% for S-waves. Seismic anisotropy was inferred from shear-wave splitting, using teleseismic SKS waveforms. Results reveal a splitting time of approximately 1.4 seconds, with the fast axis slightly east of north. The shear-wave splitting results are consistent across the Peninsula, with a slight clockwise rotation parallel for stations near the Gulf of Aqaba. In summary, these results allow us to make several conclusions about the tectonic evolution and current state of the Arabian Plate. Lithospheric thickness implies that thinning near the Red Sea has accompanied the rupturing of the Arabian-Nubian continental lithosphere. The step in the lithospheric thickness across the Shield-Platform boundary likely reveals a pre-existing difference in the lithospheric structure prior to accretion of the terranes composing the eastern Arabian Shield. Tomographic imaging of upper mantle velocities implies a single large-scale thermal anomaly underlies the Arabian Shield and is associated with Cenozoic uplift and volcanism

The March 11, 2002 Masafi, United Arab Emirates Earthquake: Insights into the Seismotectonics of the Northern Oman Mountains

A moderate (M{approx}5) earthquake struck the northeastern United Arab Emirates (UAE) and northern Oman on March 11, 2002. The event was felt over a wide area of the northern Emirates and was accompanied by smaller (felt) events before and after the March 11 main shock. The event was large enough to be detected and located by global networks at teleseismic distances. We estimated focal mechanism and depth from broadband complete regional waveform modeling. We report a normal mechanism with a slight right-lateral strike-slip component consistent with the large-scale tectonics. The normal component suggests relaxation of obducted crust of the Semail Ophilite (specifically, the Khor Fakkan Block) while the right-lateral strike-slip component of the mechanism is consistent with shear across the Oman Line. Felt earthquakes are rare in the region, however no regional seismic network exists in the UAE to determine local seismicity. This event offers a unique opportunity to study the active tectonics of the region as well as inform future studies of seismic hazard in the UAE and northern Oman

Observations of chemical differentiation in clumpy molecular clouds

We have extensively mapped a sample of dense molecular clouds (L1512, TMC-1C, L1262, Per 7, L1389, L1251E) in lines of HC3N, CH3OH, SO and C^{18}O. We demonstrate that a high degree of chemical differentiation is present in all of the observed clouds. We analyse the molecular maps for each cloud, demonstrating a systematic chemical differentiation across the sample, which we relate to the evolutionary state of the cloud. We relate our observations to the cloud physical, kinematical and evolutionary properties, and also compare them to the predictions of simple chemical models. The implications of this work for understanding the origin of the clumpy structures and chemical differentiation observed in dense clouds are discussed.Comment: 20 pages, 7 figures. Higher quality figures appear in the published journal articl

The parasitic worm-derived immunomodulator, ES-62 and its drug-like small molecule analogues exhibit therapeutic potential in a model of chronic asthma

Chronic asthma is associated with persistent lung inflammation and long-term remodelling of the airways that have proved refractory to conventional treatments such as steroids, despite their efficacy in controlling acute airway contraction and bronchial inflammation. As its recent dramatic increase in industrialised countries has not been mirrored in developing regions, it has been suggested that helminth infection may protect humans against developing asthma. Consistent with this, ES-62, an immunomodulator secreted by the parasitic worm Acanthocheilonema viteae, can prevent pathology associated with chronic asthma (cellular infiltration of the lungs, particularly neutrophils and mast cells, mucus hyper-production and airway thickening) in an experimental mouse model. Importantly, ES-62 can act even after airway remodelling has been established, arresting pathogenesis and ameliorating the inflammatory flares resulting from repeated exposure to allergen that are a debilitating feature of severe chronic asthma. Moreover, two chemical analogues of ES-62, 11a and 12b mimic its therapeutic actions in restoring levels of regulatory B cells and suppressing neutrophil and mast cell responses. These studies therefore provide a platform for developing ES-62-based drugs, with compounds 11a and 12b representing the first step in the development of a novel class of drugs to combat the hitherto intractable disorder of chronic asthma

Protective effect of small molecule analogues of the Acanthocheilonema viteae secreted product ES-62 on oxazolone-induced ear inflammation

ES-62 is the major secreted protein of the rodent filarial nematode Acanthocheilonema viteae. The molecule contains covalently attached phosphorylcholine (PC) residues, which confer anti-inflammatory properties on ES-62, underpinning the idea that drugs based on this active moiety may have therapeutic potential in human diseases associated with aberrant inflammation. Here we demonstrate that two synthetic small molecule analogues (SMAs) of ES-62 termed SMA 11a and SMA 12b are protective in the oxazolone-induced acute allergic contact dermatitis mouse model of skin inflammation, as measured by a significant reduction in ear inflammation following their administration before oxazolone sensitisation and before oxazolone challenge. Furthermore, it was found that when tested, 12b was effective at reducing ear swelling even when first administered before challenge. Histological analysis of the ears showed elevated cellular infiltration and collagen deposition in oxazolone-treated mice both of which were reduced by treatment with the two SMAs. Likewise, the oxazolone-induced increase in IFNγ mRNA in the ears was reduced but no effect on other cytokines investigated was observed. Finally, no influence on the mast cell populations in the ear was observed