Line-of-Sight Reddening Predictions: Zero Points, Accuracies, the Interstellar Medium, and the Stellar Populations of Elliptical Galaxies

Revised (B-V)_0-Mg_2 data for 402 elliptical galaxies are given to test reddening predictions which can also tell us both what the intrinsic errors are in this relationship among gE galaxy stellar populations, as well as details of nearby structure in the interstellar medium (ISM) of our Galaxy and of the intrinsic errors in reddening predictions. Using least-squares fits, the explicit 1-sigma errors in the Burstein-Heiles (BH) and the Schlegel et al. (IR) predicted reddenings are calculated, as well as the 1-sigma observational error in the (B-V)_0-Mg_2 for gE galaxies. It is found that, in directions with E(B-V)<0.100 mag (where most of these galaxies lie), 1-sigma errors in the IR reddening predictions are 0.006 to 0.009 in E(B-V) mag, those for BH reddening prediction are 0.011 mag, and the 1-sigma agreement between the two reddening predictions is 0.007 mag. IR predictions have an accuracy of 0.010-0.011 mag in directions with E(B-V)>= 0.100 mag, significantly better than those of the BH predictions (0.024-0.025). Gas-to-dust variations that vary by a factor of 3, both high and low, exist along many lines-of-sight in our Galaxy. The approx 0.02 higher reddening zero point in E(B-V) previously determined by Schlegel et al. is confirmed, primarily at the Galactic poles. Despite this, both methods also predict many directions with E(B-V)<0.015 mag. Independent evidence of reddening at the North Galactic pole is reviewed, with the conclusion that there still exists directions at the NGP that have E(B-V)<<0.01. Two lines of evidence suggest that IR reddenings are overpredicted in directions with high gas-to-dust ratios. As high gas-to-dust directions in the ISM also include the Galactic poles, this overprediction is the likely cause of the E(B-V) = 0.02 mag larger IR reddening zero point.Comment: 5 figure

Supernova 1996L: evidence of a strong wind episode before the explosion

Observations of the type II SN 1996L reveal the presence of a slowly expanding (V~700$ km/s) shell at ~ 10^(16) cm from the exploding star. Narrow emission features are visible in the early spectra superposed on the normal SN spectrum. Within about two months these features develop narrow symmetric P-Cygni profiles. About 100 days after the explosion the light curve suddenly flattens, the spectral lines broaden and the Halpha flux becomes larger than what is expected from a purely radioactive model. These events are interpreted as signatures of the onset of the interaction between the fast moving ejecta and a slowly moving outer shell of matter ejected before the SN explosion. At about 300 days the narrow lines disappear and the flux drops until the SN fades away, suggesting that the interaction phase is over and that the shell has been swept away. Simple calculations show that the superwind episode started 9 yr before the SN explosion and lasted 6 yr, with an average dM/dt=10^(-3) M_solar/yr. Even at very late epochs (up to day 335) the typical forbidden lines of [OI], CaII], [FeII] remain undetected or very weak. Spectra after day 270 show relatively strong emission lines of HeI. These lines are narrower than other emission lines coming from the SN ejecta, but broader than those from the CSM. These high excitation lines are probably the result of non-thermal excitation and ionization caused by the deposition of the gamma-rays emitted in the decay of radioactive material mixed in the He layer.Comment: 8 pages, 6 figures, Latex, To appear in M.N.R.A.

Favorable outcome of early treatment of new onset child and adolescent migraine-implications for disease modification.

There is evidence that the prevalence of migraine in children and adolescents may be increasing. Current theories of migraine pathophysiology in adults suggest activation of central cortical and brainstem pathways in conjunction with the peripheral trigeminovascular system, which ultimately results in release of neuropeptides, facilitation of central pain pathways, neurogenic inflammation surrounding peripheral vessels, and vasodilatation. Although several risk factors for frequent episodic, chronic, and refractory migraine have been identified, the causes of migraine progression are not known. Migraine pathophysiology has not been fully evaluated in children. In this review, we will first discuss the evidence that early therapeutic interventions in the child or adolescent new onset migraineur, may halt or limit progression and disability. We will then review the evidence suggesting that many adults with chronic or refractory migraine developed their migraine as children or adolescents and may not have been treated adequately with migraine-specific therapy. Finally, we will show that early, appropriate and optimal treatment of migraine during childhood and adolescence may result in disease modification and prevent progression of this disease

Biological and behavioral markers of pain following nerve injury in humans

The evolution of peripheral and central changes following a peripheral nerve injury imply the onset of afferent signals that affect the brain. Changes to inflammatory processes may contribute to peripheral and central alterations such as altered psychological state and are not well characterized in humans. We focused on four elements that change peripheral and central nervous systems following ankle injury in 24 adolescent patients and 12 age-sex matched controls. Findings include (a) Changes in tibial, fibular, and sciatic nerve divisions consistent with neurodegeneration; (b) Changes within the primary motor and somatosensory areas as well as higher order brain regions implicated in pain processing; (c) Increased expression of fear of pain and pain reporting; and (d) Significant changes in cytokine profiles relating to neuroinflammatory signaling pathways. Findings address how changes resulting from peripheral nerve injury may develop into chronic neuropathic pain through changes in the peripheral and central nervous system

The young stellar population at the center of NGC 205

Context. NGC 205 is a peculiar dwarf elliptical galaxy hosting in its center a population of young blue stars. Their origin is still matter of debate, the central fresh star formation activity possibly being related to dynamical interactions between NGC 205 and M31. Aims. The star formation history in the central 30\arcsec ($\sim$120 pc) around the NGC 205 central nucleus is investigated in order to obtain clues to the origin of the young stellar population. Methods. Deep HST/ACS CCD photometry is compared with theoretical isochrones and luminosity functions to characterize the stellar content of the region under study and compute the recent SF rate. Results. Our photometry reveals a previously undetected blue plume of young stars clearly distinguishable down to I$\simeq$26. Our analysis suggests that 1.9$\times10^5$ M$_\odot$ were produced between approximately 62 Myr and 335 Myr ago in the NGC 205 inner regions, with a latest minor episode occurring $\sim$25 Myr ago. This implies a star formation rate of $\sim7\times10^{-4}$ M$_\odot$/yr over this period. Conclusions. The excellent fit of the observed luminosity function of young main sequence stars obtained with a model having a constant star formation rate argues against a tidally triggered star formation activity over the last $\sim$300 Myr. Rather, a constant SF may be consistent with NGC 205 being on its first interaction with M 31.Comment: 5 pages, 2 figures, accepted for publication in A&A letter

Detection of diffuse interstellar bands in M31

We investigate the diffuse interstellar band (DIB) spectrum in the interstellar medium of M31. The DEIMOS spectrograph of the W. M. Keck observatory was used to make optical spectroscopic observations of two supergiant stars, MAG 63885 and MAG 70817, in the vicinity of the OB78 association in M31 where the metallicity is approximately equal to solar. The 5780, 5797, 6203, 6283 and 6613 DIBs are detected in both sightlines at velocities matching the M31 interstellar Na I absorption. The spectra are classified and interstellar reddenings are derived for both stars. Diffuse interstellar band (DIB) equivalent widths and radial velocities are presented. The spectrum of DIBs observed in M31 towards MAG 63885 is found to be similar to that observed in the Milky Way. Towards MAG 70817 the DIB equivalent widths per unit reddening are about three times the Galactic average. Compared to observations elsewhere in the Universe, relative to reddening the M31 ISM in the vicinity of OB78 is apparently a highly favourable environment for the formation of DIB carriers

Discovery of a Supernova Explosion at Half the Age of the Universe and its Cosmological Implications

The ultimate fate of the universe, infinite expansion or a big crunch, can be determined by measuring the redshifts, apparent brightnesses, and intrinsic luminosities of very distant supernovae. Recent developments have provided tools that make such a program practicable: (1) Studies of relatively nearby Type Ia supernovae (SNe Ia) have shown that their intrinsic luminosities can be accurately determined; (2) New research techniques have made it possible to schedule the discovery and follow-up observations of distant supernovae, producing well over 50 very distant (z = 0.3 -- 0.7) SNe Ia to date. These distant supernovae provide a record of changes in the expansion rate over the past several billion years. By making precise measurements of supernovae at still greater distances, and thus extending this expansion history back far enough in time, we can distinguish the slowing caused by the gravitational attraction of the universe's mass density Omega_M from the effect of a possibly inflationary pressure caused by a cosmological constant Lambda. We report here the first such measurements, with our discovery of a Type Ia supernova (SN 1997ap) at z = 0.83. Measurements at the Keck II 10-m telescope make this the most distant spectroscopically confirmed supernova. Over two months of photometry of SN 1997ap with the Hubble Space Telescope and ground-based telescopes, when combined with previous measurements of nearer SNe Ia, suggests that we may live in a low mass-density universe. Further supernovae at comparable distances are currently scheduled for ground and space-based observations.Comment: 12 pages and 4 figures (figure 4 is repeated in color and black and white) Nature, scheduled for publication in the 1 January, 1998 issue. Also available at http://www-supernova.lbl.go

The Legionella effector WipB is a translocated Ser/Thr phosphatase that targets the host lysosomal nutrient sensing machinery

Legionella pneumophila infects human alveolar macrophages and is responsible for Legionnaire’s disease, a severe form of pneumonia. L. pneumophila encodes more than 300 putative effectors, which are translocated into the host cell via the Dot/Icm type IV secretion system. These effectors highjack the host’s cellular processes to allow bacterial intracellular growth and replication. Here we adopted a multidisciplinary approach to investigate WipB, a Dot/Icm effector of unknown function. The crystal structure of the N-terminal domain at 1.7 Å resolution comprising residues 25 to 344 revealed that WipB harbours a Ser/Thr phosphatase domain related to the eukaryotic phospho-protein phosphatase (PPP) family. The C-terminal domain (residues 365–524) is sufficient to pilot the effector to acidified LAMP1-positive lysosomal compartments, where WipB interacts with the v-ATPase and the associated LAMTOR1 phosphoprotein, key components of the lysosomal nutrient sensing (LYNUS) apparatus that controls the mammalian target of rapamycin (mTORC1) kinase complex at the lysosomal surface. We propose that WipB is a lysosome-targeted phosphatase that modulates cellular nutrient sensing and the control of energy metabolism during Legionella infection

Radial kinematics of brightest cluster galaxies

This is the first of a series of papers devoted to the investigation of a large sample of brightest cluster galaxies (BCGs), their kinematic and stellar population properties, and the relationships between those and the properties of the cluster. We have obtained high signal-to-noise ratio, long-slit spectra of these galaxies with Gemini and William Herschel Telescope with the primary purpose of investigating their stellar population properties. This paper describes the selection methods and criteria used to compile a new sample of galaxies, concentrating on BCGs previously classified as containing a halo (cD galaxies), together with the observations and data reduction. Here, we present the full sample of galaxies, and the measurement and interpretation of the radial velocity and velocity dispersion profiles of 41 BCGs. We find clear rotation curves for a number of these giant galaxies. In particular, we find rapid rotation (>100 km s−1) for two BCGs, NGC 6034 and 7768, indicating that it is unlikely that they formed through dissipationless mergers. Velocity substructure in the form of kinematically decoupled cores is detected in 12 galaxies, and we find five galaxies with velocity dispersion increasing with radius. The amount of rotation, the velocity substructure and the position of BCGs on the anisotropy–luminosity diagram are very similar to those of ‘ordinary’ giant ellipticals in high-density environments