Comparative study of ProSeal laryngeal mask airway and endotracheal tube in patients undergoing laparoscopic surgeries under general anaesthesia

Background: Supra glottic airway devices (SGAD) is integral to airway management during general anesthesia. PLMA, a second-generation SGAD with a gastric channel and an efficient seal, is an alternative for the COETT, which is the gold standard for securing the airway.SGAD has the advantage of lesser hemodynamic changes during insertion and removal. This study aimed to compare the hemodynamic and ventilatory changes between PLMA and the endotracheal tube (ETT).Methods: Prospective randomized study, conducted at Yenepoya medical college hospital on 90 patients undergoing elective laparoscopic surgeries under general Anaesthesia. The patients were divided into groups; group p=45 patients (PMLA) and E=45 patients (COETT). Heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), peripheral oxygen saturation (SpO2) and end-tidal carbon dioxide (EtCO2) were documented at baseline, at 1, 3, 5 and 8 minutes after placement of airway device. Results: Differences in vital parameters at baseline were statistically insignificant. HR, SBP, DBP and MAP were significantly higher in group E compared to group P at 1st, 3rd, 5th and 8 min after the insertion of the airway device. There was no statistically significant difference in SpO2 and EtCO2. Post-extubation laryngopharyngeal morbidity was noted in 5 patients with ETT compared to 1 patient with PMLA.Conclusions: PLMA provides better hemodynamic stability at insertion when compared to ETT. Both PLMA and ETT provide good oxygenation and ventilation during elective laparoscopic surgeries. Insertion at first attempt was more successful with PLMA when compared to ETT

Induced hypotension for functional endoscopic sinus surgery: comparison between dexmedetomidine and nitro-glycerine

Background: Functional endoscopic sinus surgery (FESS) is a minimally invasive technique used to restore sinus ventilation and normal function by opening sinus air cells and ostia. FESS requires bloodless field, several techniques and drugs have been used in the past for achieving controlled hypotension such as nitroglycerine, esmolol, remifentanil, dexmedetomidine, isoflurane, propofol. Therefore, this study was conducted to compare between dexmedetomidine and nitroglycerine for controlled hypotension for FESS. Primary aim to compare quality of surgical field using average category scale and surgeon satisfaction and secondary aim to compare arterial pressure and heart rate changes between dexmedetomidine and nitroglycerine when used to induce hypotension.Methods: This study was conducted in 40 consenting adult patients posted for FESS and were randomly divided into two groups, group D received dexmedetomidine 1 mcg/kg and group N received nitroglycerine 0.5 mcg/kg/min, both infusions started 10 min after induction. Parameters such as quality of surgical field by average category scale, heart rate and mean arterial pressure (MAP) recorded every 10 minutes.Results: Dexmedetomidine and nitroglycerine both had comparable quality of surgical field. ACS grading of 1 or 2 were found among both the groups. Dexmedetomidine group had better mean arterial pressure at 10th, 20th, 30th, 40th, 50th, 60th and 70th min and heart rate at 10th, 20th, 30th, 40th, 50th, 60th and 70th min when compared to nitroglycerine group.Conclusions: Dexmedetomidine and nitroglycerine both were found to be safe to use for controlled hypotension in functional endoscopic sinus surgeries

Measurements of branching fraction ratios and CP-asymmetries in suppressed B^- -> D(-> K^+ pi^-)K^- and B^- -> D(-> K^+ pi^-)pi^- decays

We report the first reconstruction in hadron collisions of the suppressed decays B^- -> D(-> K^+ pi^-)K^- and B^- -> D(-> K^+ pi^-)pi^-, sensitive to the CKM phase gamma, using data from 7 fb^-1 of integrated luminosity collected by the CDF II detector at the Tevatron collider. We reconstruct a signal for the B^- -> D(-> K^+ pi^-)K^- suppressed mode with a significance of 3.2 standard deviations, and measure the ratios of the suppressed to favored branching fractions R(K) = [22.0 \pm 8.6(stat)\pm 2.6(syst)]\times 10^-3, R^+(K) = [42.6\pm 13.7(stat)\pm 2.8(syst)]\times 10^-3, R^-(K)= [3.8\pm 10.3(stat)\pm 2.7(syst]\times 10^-3, as well as the direct CP-violating asymmetry A(K) = -0.82\pm 0.44(stat)\pm 0.09(syst) of this mode. Corresponding quantities for B^- -> D(-> K^+ pi^-)pi^- decay are also reported.Comment: 8 pages, 1 figure, accepted by Phys.Rev.D Rapid Communications for Publicatio

Search for B_s --> mu+mu- and B_d --> mu+mu- Decays with CDF II

A search has been performed for B_s --> mu+mu- and B_d --> mu+mu- decays using 7/fb of integrated luminosity collected by the CDF II detector at the Fermilab Tevatron collider. The observed number of B_d candidates is consistent with background-only expectations and yields an upper limit on the branching fraction of BF(B_d-->mu+mu-) < 6.0E-9 at 95% confidence level. We observe an excess of B_s candidates. The probability that the background processes alone could produce such an excess or larger is 0.27%. The probability that the combination of background and the expected standard model rate of B_s --> mu+mu- could produce such an excess or larger is 1.9%. These data are used to determine BF(B_s-->mu+mu-) = (1.8^{+1.1}_{-0.9})E-8 and provide an upper limit of BF(B_s -->mu+mu-) < 4.0E-8 at 95% confidence level.Comment: 7 pages, 1 figure; version accepted by PR

Design and implementation of voice Command-Based robotic system

This project is designed to control a robotic vehicle by voice commands and manual control for remote operation. For detecting the signals provided through any mobile application, an ATMEGA32 microcontroller is employed in conjunction with a Bluetooth connection that is linked to a control module. The Bluetooth receiver connected to the Arduino receives serial data delivered from mobile application. We will deliberate how to control robot-controlled car using Wi-Fi module through android application of an android mobile. It provides control commands over Bluetooth that include managing the motor’s pace, detecting, and exchanging data with mobile regarding the robot’s direction as well as range from the closest barrier

Performance analysis of a FSO link considering different atmospheric turbulence

Free space optical (FSO) technology is a quick-to-deploy and economical way of getting access to the fiber optic network. FSO technology not only offers fiber-quality connections, but it also offers the sector’s cheapest transmission capacity. FSO systems complement legacy network commitments and function in harmony with any protocol, saving significant up-front investments as a completely protocol-independent broadband gateway. An FSO link may be purchased and deployed at a fraction of the cost of installing fiber cable and for roughly half the cost of equivalent microwave/RF wireless systems. With exception of RF wireless technologies, FSO does not need the purchase of expensive spectrum licenses or the fulfillment of additional regulatory criteria. The purpose of this study is to examine the performance of FSO-based optical access networks. Analysis of the performance in detail, with a focus on BER is also described

Table1_Identification of compelling inhibitors of human norovirus 3CL protease to combat gastroenteritis: A structure-based virtual screening and molecular dynamics study.docx

Human noroviruses (NV) are the most prevalent cause of sporadic and pandemic acute gastroenteritis. NV infections cause substantial morbidity and death globally, especially amongst the aged, immunocompromised individuals, and children. There are presently no authorized NV vaccines, small-molecule therapies, or prophylactics for humans. NV 3 C L protease (3CLP) has been identified as a promising therapeutic target for anti-NV drug development. Herein, we employed a structure-based virtual screening method to screen a library of 700 antiviral compounds against the active site residues of 3CLP. We report three compounds, Sorafenib, YM201636, and LDC4297, that were revealed to have a higher binding energy (BE) value with 3CLP than the control (Dipeptidyl inhibitor 7) following a sequential screening, in-depth molecular docking and visualization, physicochemical and pharmacological property analysis, and molecular dynamics (MD) study. Sorafenib, YM201636, and LDC4297 had BEs of -11.67, -10.34, and -9.78 kcal/mol with 3CLP, respectively, while control had a BE of -6.38 kcal/mol. Furthermore, MD simulations of the two best compounds and control were used to further optimize the interactions, and a 100 ns MD simulation revealed that they form stable complexes with 3CLP. The estimated physicochemical, drug-like, and ADMET properties of these hits suggest that they might be employed as 3CLP inhibitors in the management of gastroenteritis. However, wet lab tests are a prerequisite to optimize them as NV 3CLP inhibitors.</p

Accounting and Sustainable Development: A Case of Poverty Reduction in an Emerging Economy

Accounting has been widely used in both public and private sectors across the globe for the sustainable development of corporates as well as economies. However, in the recent past, there has been a wide discussion on poverty reduction and public sector accounting reforms especially in emerging economies in order to enhance the transparency in government expenditure, auditing and accountability as well. Since the governments are responsible on providing essential public services which have a greater impact on poverty, adequate measures in place to monitor the spending is vital for any country with an emerging economy. Moreover, according to the United Nations Millennium Development goals (MDGs) especially on reducing poverty, governments may require to recruit more employees for public sector to fill the gaps in the service in many essential areas such as education, health, and agriculture. Additionally, the recent past financial crisis and recession also have impacted on poverty reduction programs within emerging economies especially which are prone to corruption, fraud, and lack of transparency on government expenditures as well. Due to these various reasons, some emerging economies such as that of Sri Lanka are struggling to minimize the huge budget deficit of the government while leaving with less money for poverty reduction within the country as well. Therefore, unless these gaps are filled, many people in emerging economies will continue to live in poverty (Tridico 2009)