The rad18 Gene of Schizosaccharomyces pombe Defines a New Subgroup of the SMC Superfamily Involved in DNA Repair

The rad18 mutant of Schizosaccharomyces pombe is very sensitive to killing by both UV and ¿ radiation. We have cloned and sequenced the rad18 gene and isolated and sequenced its homolog from Saccharomyces cerevisiae, designated RHC18. The predicted Rad18 protein has all the structural properties characteristic of the SMC family of proteins, suggesting a motor function- the first implicated in DNA repair. Gene deletion shows that both rad18 and RHC18 are essential for proliferation. Genetic and biochemical analyses suggest that the product of the rad18 gene acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair. This second repair pathway involves the products of the rhp51 gene (the homolog of the RAD51 gene of S. cerevisiae) and the rad2 gene

Structural Phase Transition and Superconductivity in 2H-BaGaGe with Buckled Honeycomb Layers

We report on the structural and superconducting properties of the intermetallic compound BaGaGe. We find that this material undergoes a structural second-order phase transition from the distorted AlB$_2$-type structure (1H, $a$ = 4.3254(2) \r{A}, $c$ = 5.1078(3) \r{A}, P6/mmm) into the CaIn$_2$-type structure (2H, $a$ = 4.3087(3) \r{A}, $c$ = 10.2117(6) \r{A}, P6$_3$/mmc) at a transition temperature of $T_{\rm S}$ = 253 K. We find that the structural phase-transition corresponds to a coherent buckling of the honeycomb layers, which we can interpret as a disorder-to-order transition of the atoms located within this layer. We show that the 2H-BaGaGe phase becomes superconducting at a critical temperature of $T_{\rm c}$ = 2.1 K. The bulk nature of the superconductivity in 2H-BaGaGe is confirmed by means of specific heat measurements, where we determine a value of $\Delta C$/$\gamma T_{\rm c}$ = 1.59, which is close to the expected BCS value in the weak coupling limit

Growth And The Growth Hormone-Insulin Like Growth Factor 1 Axis In Children With Chronic Inflammation:Current Evidence, Gaps In Knowledge And Future Directions

Growth failure is frequently encountered in children with chronic inflammatory conditions like juvenile idiopathic arthritis, inflammatory bowel disease and cystic fibrosis. Delayed puberty and attenuated pubertal growth spurt is often seen during adolescence. The underlying inflammatory state mediated by pro-inflammatory cytokines, prolonged use of glucocorticoid and suboptimal nutrition contribute to growth failure and pubertal abnormalities. These factors can impair growth by their effects on the growth hormone-insulin like growth factor axis and also directly at the level of the growth plate via alterations in chondrogenesis and local growth factor signaling. Recent studies on the impact of cytokines and glucocorticoid on the growth plate studies further advanced our understanding of growth failure in chronic disease and provided a biological rationale of growth promotion. Targeting cytokines using biologic therapy may lead to improvement of growth in some of these children but approximately one third continue to grow slowly. There is increasing evidence that the use of relatively high dose recombinant human growth hormone may lead to partial catch up growth in chronic inflammatory conditions, although long term follow-up data is currently limited. In this review, we comprehensively review the growth abnormalities in children with juvenile idiopathic arthritis, inflammatory bowel disease and cystic fibrosis, systemic abnormalities of the growth hormone-insulin like growth factor axis and growth plate perturbations. We also systematically reviewed all the current published studies of recombinant human growth hormone in these conditions and discuss the role of recombinant human insulin like growth factor-1

Basic Flows of Generalized Second Grade Fluids Based on a Sisko Model

The present investigation is concerned with basic flows of generalized second grade fluids based on a Sisko fluid. After formulation of the general equations of motion three simple flows of viscoplastic fluids of a Sisko type or fluids similar to them are considered. These flows are: Poiseuille flow in a plane channel, Poiseuille flow in a circular pipe and rotating Couette flow between two coaxial cylinders. After presentation the Sisko model one was presented some models of fluids similar to this model. Next it was given the solutions of equations of motion for three flows mentioned above

Simple Flows of Pseudoplastic Fluids Based on Dehaven Model

In this paper three simple flows of visco-plastic fluids of DeHaven type or fluids similar to them are considered. These flows are: Poiseuille flow in a plane channel, Poiseuille flow through a circular pipe and rotating Couette flow between two coaxial cylinders. After presentation DeHaven model it was presented some models of fluids similar to this model. Next it was given the solutions of equations of motion for three flows mentioned above

Flows of Newtonian and Power-Law Fluids in Symmetrically Corrugated Cappilary Fissures and Tubes

In this paper, an analytical method for deriving the relationships between the pressure drop and the volumetric flow rate in laminar flow regimes of Newtonian and power-law fluids through symmetrically corrugated capillary fissures and tubes is presented. This method, which is general with regard to fluid and capillary shape, can also be used as a foundation for different fluids, fissures and tubes. It can also be a good base for numerical integration when analytical expressions are hard to obtain due to mathematical complexities. Five converging-diverging or diverging-converging geometrics, viz. wedge and cone, parabolic, hyperbolic, hyperbolic cosine and cosine curve, are used as examples to illustrate the application of this method. For the wedge and cone geometry the present results for the power-law fluid were compared with the results obtained by another method; this comparison indicates a good compatibility between both the results

Basic Flows of Generalized Second Grade Fluids Based on a Sisko Model

The present investigation is concerned with basic flows of generalized second grade fluids based on a Sisko fluid. After formulation of the general equations of motion three simple flows of viscoplastic fluids of a Sisko type or fluids similar to them are considered. These flows are: Poiseuille flow in a plane channel, Poiseuille flow in a circular pipe and rotating Couette flow between two coaxial cylinders. After presentation the Sisko model one was presented some models of fluids similar to this model. Next it was given the solutions of equations of motion for three flows mentioned above

Simple Flows of Pseudoplastic Fluids Based on Dehaven Model

In this paper three simple flows of visco-plastic fluids of DeHaven type or fluids similar to them are considered. These flows are: Poiseuille flow in a plane channel, Poiseuille flow through a circular pipe and rotating Couette flow between two coaxial cylinders. After presentation DeHaven model it was presented some models of fluids similar to this model. Next it was given the solutions of equations of motion for three flows mentioned above

Simple flows of pseudoplastic fluids based on DeHaven model

In this paper three simple flows of visco-plastic fluids of DeHaven type or fluids similar to them are considered. These flows are: Poiseuille flow in a plane channel, Poiseuille flow through a circular pipe and rotating Couette flow between two coaxial cylinders. After presentation DeHaven model it was presented some models of fluids similar to this model. Next it was given the solutions of equations of motion for three flows mentioned above