Effects of a New Triple-alpha Reaction on X-ray Bursts of a Helium Accreting Neutron Star

The effects of a new triple-$\alpha$ reaction rate (OKK rate) on the helium flash of a helium accreting neutron star in a binary system have been investigated. Since the ignition points determine the properties of a thermonuclear flash of type I X-ray bursts, we examine the cases of different accretion rates, $dM/dt (\dot{M})$, of helium from $3\times10^{-10} M_{\odot} \rm yr^{-1}$ to $3\times10^{-8} M_{\odot} \rm yr^{-1}$, which could cover the observed accretion rates. We find that for the cases of low accretion rates, nuclear burnings are ignited at the helium layers of rather low densities. As a consequence, helium deflagration would be triggered for all cases of lower accretion rate than $\dot{M}\simeq 3\times10^{-8} M_{\odot} \rm yr^{-1}$. We find that OKK rate could be barely consistent with the available observations of the X-ray bursts on the helium accreting neutron star. However this coincidence is found to depend on the properties of crustal heating and the neutron star model.We suggest that OKK rate would be reduced by a factor of $10^{2-3}$ for $10^8$ K in the range of the observational errors.Comment: 10 pages, 4 figure

Experimental investigation of the impact of optical injection on vital parameters of a gain-switched pulse source

An analysis of optical injection on a gain-switched distributed feedback (DFB) laser and its impact on pulse parameters that influence the performance of the pulse source in high-speed optical communication systems is presented in this paper. A range of 10 GHz in detuning and 5 dB in injected power has been experimentally identified to attain pulses, from an optically injected gain-switched DFB laser, with durations below 10 ps and pedestal suppression higher than 35 dB. These pulse features are associated with a side mode suppression ratio of about 30 dB and a timing jitter of less than 1 ps. This demonstrates the feasibility of using optical injection in conjunction with appropriate pulse compression schemes for developing an optimized and cost-efficient pulse source, based on a gain-switched DFB laser, for high-speed photonic systems

An adaptive stereo basis method for convolutive blind audio source separation

NOTICE: this is the author’s version of a work that was accepted for publication in Neurocomputing. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in PUBLICATION, [71, 10-12, June 2008] DOI:neucom.2007.08.02

Multi-Modal Analysis of Vibration and Meteorological Data for Structures on the World Heritage Site “Battleship Island”

This paper reports the results of vibration and meteorological observations of a buildng built on Hashima, Nagasaki, southern part of Japan, which was registered as a World Heritage Site in 2015 [1], and analyzes its dynamic characteristics. Hashima is called "Battleship Island" because its appearance resembles a battleship due to the many buildings standing upon it. The structure contributing most to the battleship appearance is No. 3 Building. An accelerometer and a weather sensor have been installed in No. 3 Building for long-term measurements. Multi-modal analysis of vibration and meteorological data was performed for 5 months, and the dynamic characteristics of No. 3 Building were examined

Medical Care Capacity for Influenza Outbreaks, Los Angeles

In December 1997, media reported hospital overcrowding and “the worst [flu epidemic] in the past two decades” in Los Angeles County (LAC). We found that rates of pneumonia and influenza deaths, hospitalizations, and claims were substantially higher for the 1997–98 influenza season than the previous six seasons. Hours of emergency medical services (EMS) diversion (when emergency departments could not receive incoming patients) peaked during the influenza seasons studied; the number of EMS diversion hours per season also increased during the seasons 1993–94 to 1997–98, suggesting a decrease in medical care capacity during influenza seasons. Over the seven influenza seasons studied, the number of licensed beds decreased 12%, while the LAC population increased 5%. Our findings suggest that the capacity of health-care systems to handle patient visits during influenza seasons is diminishing

Erythropoietic protoporphyria

Erythropoietic protoporphyria (EPP) is an inherited disorder of the haem metabolic pathway characterised by accumulation of protoporphyrin in blood, erythrocytes and tissues, and cutaneous manifestations of photosensitivity. EPP has been reported worldwide, with prevalence between 1:75,000 and 1:200,000. It usually manifests in early infancy upon the first sun exposures. EPP is characterised by cutaneous manifestations of acute painful photosensitivity with erythema and oedema, sometimes with petechiae, together with stinging and burning sensations upon exposure to sunlight, without blisters. These episodes have a variable severity depending on the exposure duration and may result in chronic permanent lesions on exposed skin. As protoporphyrin is a lipophilic molecule that is excreted by the liver, EPP patients are at risk of cholelithiasis with obstructive episodes, and chronic liver disease that might evolve to rapid acute liver failure. In most patients, EPP results from a partial deficiency of the last enzyme of the haem biosynthetic pathway, ferrochelatase, EC 4.99.1.1/FECH (encoded by the FECH gene). EPP appears to be inherited as an autosomal dominant disease, the clinical expression of which is modulated by the presence of the hypomorphic FECH IVS3-48C allele trans, but recessive inheritance with two mutated FECH alleles has also been described. In about 2% of patients, overt disease was recently shown to be caused by gain-of-function mutations in the erythroid-specific aminolevulinic acid synthase 2 (ALAS2/ALAS, EC 2.3.1.27) gene and named X-linked dominant protoporphyria. Diagnosis is established by finding increased levels of protoporphyrin in plasma and red blood cells, and detection of a plasma fluorescence peak at 634 nm. Investigations for hepatic involvement, ferrochelatase activity level, genetic analysis (FECH mutations, presence of the hypomorphic FECH IVS3-48C allele trans and ALAS2 mutations) and family studies are advisable. Differential diagnosis includes phototoxic drug reactions, hydroa vacciniforme, solar urticaria, contact dermatitis, angio-oedema and, in some cases, other types of porphyria. Management includes avoidance of exposure to light, reduction of protoporphyrin levels and prevention of progression of possible liver disease to liver failure. As the major risk in EPP patients is liver disease, a regular follow-up of hepatic involvement is essential. Sequential hepatic and bone marrow transplantation should be considered as a suitable treatment for most severe cases of EPP with hepatic involvement. EPP is a lifelong disorder whose prognosis depends on the evolution of the hepatic disease. However, photosensitivity may have a significant impact on quality of life of EPP patients

Rational design of an orthogonal tryptophanyl nonsense suppressor tRNA

While a number of aminoacyl tRNA synthetase (aaRS):tRNA pairs have been engineered to alter or expand the genetic code, only the Methanococcus jannaschii tyrosyl tRNA synthetase and tRNA have been used extensively in bacteria, limiting the types and numbers of unnatural amino acids that can be utilized at any one time to expand the genetic code. In order to expand the number and type of aaRS/tRNA pairs available for engineering bacterial genetic codes, we have developed an orthogonal tryptophanyl tRNA synthetase and tRNA pair, derived from Saccharomyces cerevisiae. In the process of developing an amber suppressor tRNA, we discovered that the Escherichia coli lysyl tRNA synthetase was responsible for misacylating the initial amber suppressor version of the yeast tryptophanyl tRNA. It was discovered that modification of the G:C content of the anticodon stem and therefore reducing the structural flexibility of this stem eliminated misacylation by the E. coli lysyl tRNA synthetase, and led to the development of a functional, orthogonal suppressor pair that should prove useful for the incorporation of bulky, unnatural amino acids into the genetic code. Our results provide insight into the role of tRNA flexibility in molecular recognition and the engineering and evolution of tRNA specificity