Modelos de estimación de componentes de (co)varianza en disciplinas equinas con fuerte influencia del jinete: la prueba de doma del ejercicio completo de equitación como ejemplo

La valoración genética para caracteres relacionados con la mayoría de las disciplinas ecuestres tiene el inconveniente de la fuerte influencia del factor humano en el desempeño del equino (generalmente la interacción entre el jinete y el caballo), lo cual puede determinar valoraciones muy sesgadas sino se tiene en cuenta este hecho. En este trabajo se comparan distintos modelos de evaluación genética en cuanto a la forma de incluir el jinete, utilizando para ello como ejemplo los resultados de la prueba de doma clásica en la disciplina de concurso completo de equitación con la finalidad de determinar el mejor modelo. Los datos se analizaron mediante modelo animal empleando el software ASREML. En total se evaluaron 8 modelos diferentes que diferían en la inclusión o no del entrenador (y si este se consideraba como efecto fijo o como aleatorio), así como la inclusión del jinete y/o la interacción jinete-animal en dicho modelo de evaluación. En todos los modelos se incluyeron como efectos fijos el concurso-juez, el nivel de estrés, la edad y el sexo del caballo participante. De acuerdo a los resultados obtenidos se considera que el modelo más adecuado a este tipo de datos es un modelo en que se tenga en cuenta como efectos aleatorios el animal, el jinete y la interacción entre ambos

Correlation between magnetic and transport properties in nanocrystalline Fe thin films: A grain-boundary magnetic disorder effect

We report on transport and magnetic measurements of islanded Fe(110) thin films. The electrical resistivity exhibits an anomalous increase at low temperatures, which disappears under the action of a magnetic field. Since such an anomaly completely disappears under the action of a magnetic field, it is inferred that it originates from spin-dependent scattering. We interpret the strong changes in the spin-dependent scattering in our films to be due to a low-temperature spin freezing of the island boundary magnetic regions that impedes ferromagnetic exchange between islands. A consequence of this magnetic behavior is the random arrangement of the individual magnetization, determined by the magnetocrystalline anisotropy of each island, resulting in an increase of the resistivity below the freezing temperature.Z.S. and J.L.M. acknowledge the Comunidad de Madrid for financial support. Work was performed under the financial support of the Comunidad de Madrid and the Spanish Commission of Science and Technology.Peer reviewe

Chagas disease in Latin American migrants: a Spanish challenge

AbstractChagas’ disease affects millions in Latin America and is the leading cause of cardiomyopathy and death due to cardiovascular disease in patients aged 30–50 years. As a consequence of immigration it has settled in several European countries, where besides imported cases, autochthonous infections arise through vertical transmission and blood/organ donation. All Latin American immigrants who attended our Unit were screened for T. cruzi infection (ELISA and IFAT ± PCR). An ECG and echocardiogram were requested for all positive patients, and oesophageal manometry, barium swallow and barium enema were requested according to patient symptoms. All patients under 50 years without severe cardiac involvement and who had not received correct treatment previously were treated with benznidazole 5 mg/kg/day for 60 days. Patients were followed-up with serology and PCR 1 month after treatment ended and every 6 months thereafter. A total of 1146 Latin Americans were screened for T. cruzi (357 positive serology results). The typical patient profile was a Bolivian female, of rural origin, in her fourth decade of life, without evidence of visceral involvement. Treatment tolerance was poor, with 29.7% discontinuing treatment due to adverse reactions. Among those with adverse reactions (52%), the most frequent were cutaneous hypersensitivity (68.7%), gastrointestinal upset (20%) and nervous system disturbances (16.2%). T. cruzi infection is no longer limited to Latin America. Poor treatment tolerance can limit current treatment options. More epidemiological data are necessary to estimate the magnitude of a problem of great relevance for public health and health resource planning

Design and Study of a Wide-Band Printed Circuit Board Near-Field Probe

Magnetic near-field probes (NFP) represent a suitable tool to measure the magnetic field level from a small electromagnetic interference (EMI) source. This kind of antenna is useful as a magnetic field probe for pre-compliance EMC measurements or debugging tasks since the user can scan a printed circuit board (PCB) looking for locations with strong magnetic fields. When a strong H-field point is found, the designer should check the PCB layout and components placement in that area to detect if this could result in an EMI source. This contribution focuses on analyzing the performance of an easy to build and low-cost H-field NFP designed and manufactured using a standard PCB stack-up. Thereby, the frequency range and sensitivity of the NFP-PCB are analyzed through a Finite Element Method (FEM) simulation model that makes it possible to evaluate its sensibility and effective frequency range. The numerical results obtained with the FEM models are validated against measurements to verify the design and performance of our NFP. The FEM model reproduces the experimental procedure, which is used to evaluate the performance of the NFP in terms of sensitivity by means of the simulated near-field distribution. The NFP-PCB has almost a flat response from 180 MHz to 6 GHz, with an almost perfect concordance between numerical and experimental S21 results. The numerical results show an average transmission loss of −27.9 dB by considering the flat response bandwidth, whereas the experimental one is −29.7 dB. Finally, the designed NFP is compared to two high-quality commercial probes in order to analyze its performance

Pleural cancer mortality in Spain: time-trends and updating of predictions up to 2020

Background A total of 2,514,346 metric tons (Mt) of asbestos were imported into Spain from 1906 until the ban on asbestos in 2002. Our objective was to study pleural cancer mortality trends as an indicator of mesothelioma mortality and update mortality predictions for the periods 2011–2015 and 2016–2020 in Spain.Methods Log-linear Poisson models were fitted to study the effect of age, period of death and birth cohort (APC) on mortality trends. Change points in cohort- and period-effect curvatures were assessed using segmented regression. Fractional power-link APC models were used to predict mortality until 2020. In addition, an alternative model based on national asbestos consumption figures was also used to perform long-term predictions.Results Pleural cancer deaths increased across the study period, rising from 491 in 1976–1980 to 1,249 in 2006–2010. Predictions for the five-year period 2016–2020 indicated a total of 1,319 pleural cancer deaths (264 deaths/year). Forecasts up to 2020 indicated that this increase would continue, though the age-adjusted rates showed a levelling-off in male mortality from 2001 to 2005, corresponding to the lower risk in post-1960 generations. Among women, rates were lower and the mortality trend was also different, indicating that occupational exposure was possibly the single factor having most influence on pleural cancer mortality.Conclusion The cancer mortality-related consequences of human exposure to asbestos are set to persist and remain in evidence until the last surviving members of the exposed cohorts have disappeared. It can thus be assumed that occupationally-related deaths due to pleural mesothelioma will continue to occur in Spain until at least 2040.The study was partially supported by a research grant from the Spanish Health Research Fund (FIS PI11/00871) and the HAR2009-07543 project of the Ministry of Science and Innovation. The Department of Labour of the Government of Catalonia provided the asbestos consumption data

Spectroscopy of luminous z>7 galaxy candidates and sources of contamination in z>7 galaxy searches

We present three bright z+ dropout candidates selected from deep Near-Infrared (NIR) imaging of the COSMOS 2 square degree field. All three objects match the 0.8-8um colors of other published z>7 candidates but are three magnitudes brighter, facilitating further study. Deep spectroscopy of two of the candidates covering 0.64-1.02um with Keck-DEIMOS and all three covering 0.94-1.10um and 1.52-1.80um with Keck-NIRSPEC detects weak spectral features tentatively identified as Ly-alpha at z=6.95 and z=7.69 in two of the objects. The third object is placed at z~1.6 based on a 24um and weak optical detection. A comparison with the spectral energy distributions of known z<7 galaxies, including objects with strong spectral lines, large extinction, and large systematic uncertainties in the photometry yields no objects with similar colors. However, the lambda>1um properties of all three objects can be matched to optically detected sources with photometric redshifts at z~1.8, so the non-detection in the i+ and z+ bands are the primary factors which favors a z>7 solution. If any of these objects are at z~7 the bright end of the luminosity function is significantly higher at z>7 than suggested by previous studies, but consistent within the statistical uncertainty and the dark matter halo distribution. If these objects are at low redshift, the Lyman-Break selection must be contaminated by a previously unknown population of low redshift objects with very strong breaks in their broad band spectral energy distributions and blue NIR colors. The implications of this result on luminosity function evolution at high redshift is discussed. We show that the primary limitation of z>7 galaxy searches with broad filters is the depth of the available optical data.Comment: 15 Pages, 15 figures, accepted to Ap

Galaxy Zoo: The Environmental Dependence of Bars and Bulges in Disc Galaxies

We present an analysis of the environmental dependence of bars and bulges in disc galaxies, using a volume-limited catalogue of 15810 galaxies at z<0.06 from the Sloan Digital Sky Survey with visual morphologies from the Galaxy Zoo 2 project. We find that the likelihood of having a bar, or bulge, in disc galaxies increases when the galaxies have redder (optical) colours and larger stellar masses, and observe a transition in the bar and bulge likelihoods, such that massive disc galaxies are more likely to host bars and bulges. We use galaxy clustering methods to demonstrate statistically significant environmental correlations of barred, and bulge-dominated, galaxies, from projected separations of 150 kpc/h to 3 Mpc/h. These environmental correlations appear to be independent of each other: i.e., bulge-dominated disc galaxies exhibit a significant bar-environment correlation, and barred disc galaxies show a bulge-environment correlation. We demonstrate that approximately half (50 +/- 10%) of the bar-environment correlation can be explained by the fact that more massive dark matter haloes host redder disc galaxies, which are then more likely to have bars. Likewise, we show that the environmental dependence of stellar mass can only explain a small fraction (25 +/- 10%) of the bar-environment correlation. Therefore, a significant fraction of our observed environmental dependence of barred galaxies is not due to colour or stellar mass dependences, and hence could be due to another galaxy property. Finally, by analyzing the projected clustering of barred and unbarred disc galaxies with halo occupation models, we argue that barred galaxies are in slightly higher-mass haloes than unbarred ones, and some of them (approximately 25%) are satellite galaxies in groups. We also discuss implications about the effects of minor mergers and interactions on bar formation.Comment: 20 pages, 18 figures; references updated; published in MNRA

Mechanical stress confers nuclear and functional changes in derived leukemia cells from persistent confined migration

20 p.-8 fig.Nuclear deformability plays a critical role in cell migration. During this process, the remodeling of internal components of the nucleus has a direct impact on DNA damage and cell behavior; however, how persistent migration promotes nuclear changes leading to phenotypical and functional consequences remains poorly understood. Here, we described that the persistent migration through physical barriers was sufficient to promote permanent modifications in migratory-altered cells. We found that derived cells from confined migration showed changes in lamin B1 localization, cell morphology and transcription. Further analysis confirmed that migratory-altered cells showed functional differences in DNA repair, cell response to chemotherapy and cell migration in vivo homing experiments. Experimental modulation of actin polymerization affected the redistribution of lamin B1, and the basal levels of DNA damage in migratory-altered cells. Finally, since major nuclear changes were present in migratory-altered cells, we applied a multidisciplinary biochemical and biophysical approach to identify that confined conditions promoted a different biomechanical response of the nucleus in migratory-altered cells. Our observations suggest that mechanical compression during persistent cell migration has a role in stable nuclear and genomic alterations that might handle the genetic instability and cellular heterogeneity in aging diseases and cancer.Open Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature. This research was supported by a FPI Scholarship 2018 (Ministerio de Ciencia e Innovación/MICINN, Agencia Estatal de Investigación/AEI y Fondo Europeo de Desarrollo Regional/FEDER) to R.G.N.; JAE Intro 2022 (Agencia Estatal Consejo Superior de Investigaciones Científicas, Conexión CSIC Cancer, JAE-ICU-CC-34 and JAEINT22_EX_0263) to G.P.C. and M.P.C.R; grants from the Ministerio de Ciencia e Innovación (MICINN) Agencia Estatal de Investigación (AEI) (RTI2018-097267-B-I00), Asociación Española Contra el Cáncer (LAB AECC, LABAE211656TORR) and Beca FERO (BFERO2021.01) to V.T.; Comunidad de Madrid (Y2018/BIO-5207) and from the Ministerio de Ciencia e Innovación (MICINN) Agencia Estatal de Investigación (AEI) (PID2020-115444 GB-I00) to P.R.N; grants from the Ministerio de Ciencia e Innovación (MICINN) Agencia Estatal de Investigación (AEI) (TED2021-132296B-C52, PID2019-108391RB-100), and Comunidad de Madrid (Y2018/BIO-5207, S2018/NMT-4389 and REACT-EU program PR38-21–28 ANTICIPA-CM) to F.M.; and grants from 2020 Leonardo Grant for Researchers and Cultural Creators (BBVA Foundation), Ayuda de contratación de ayudante de investigación PEJ-2020-AI/BMD-19152 (Comunidad de Madrid), Comunidad de Madrid (Y2018/BIO-5207) and the Ministerio de Ciencia e Innovación (MICINN) Agencia Estatal de Investigación (AEI) (PID2020-118525RBI00, AEI/10.13039/501100011033) to J.R.M.Peer reviewe