The siliciclastic Permian-Triassic deposits in Central and Northeastern Iberian Peninsula (Iberian, Ebro and Catalan Basins) : a proposal for correlation

The siliciclastic deposits of the Iberian, Ebro and Catalan Basins have been described for more than a century, but facies similarities and a lack of biostratigaphic data have difficulted the correlation of the local stratigraphic units in a general framework up to now. Combining pollen and spores data, the identification of the regional unconformities and hiatuses and the quantitative analysis of the subsidence by backstripping methods, a new correlation scheme for these facies is proposed

Estructura del sistema frontal de cabalgamientos en el Pirineo Oriental: control estratigráfico en la geometría y secuencia de emplazamiento de los cabalgamientos

El manto del Cadí, la unidad estructural más extensa del Pirineo Oriental meridional, involucra cerca de 5 km de sucesión paleógena depositada en una cuenca de antepaís. Esta secuencia constituye un sistema petrolífero que ha sido explorado desde el año 1960 y suprayace discordantemente un basamento Paleozoico involucrado en el apilamiento antiforme que caracteriza el centro de la cordillera. En el antepaís, la sucesión paleógena presenta un espesor menor y está constituida por un conjunto de facies diferente, en general más somera. La interpretación de datos sísmicos reprocesados recientemente y su integración con datos de superficie y de sondeos son la base de un nuevo modelo estructural del área. La presencia de un espesor anómalo de una serie de rocas evaporíticas por debajo del sinclinal de Ripoll (2000m perforados en el sondeo El Serrat-1) ha sido interpretada como asociada a un cambio lateral de facies entre una formación turbidítica (Campdevànol) septentrional, la formación evaporítica de Beuda y una formación carbonática meridional (Perafita) y a su apilamiento en un dúplex

The siliciclastic Permian-Triassic deposits in Central and Northeastern Iberian Peninsula (Iberian, Ebro and Catalan Basins): a proposal for correlation

The siliciclastic deposits of the Iberian, Ebro and Catalan Basins have been described for more than a century, but facies similarities and a lack of biostratigaphic data have difficulted the correlation of the local stratigraphic units in a general framework up to now. Combining pollen and spores data, the identification of the regional unconformities and hiatuses and the quantitative analysis of the subsidence by backstripping methods, a new correlation scheme for these facies is proposed

Are protected areas covering important biodiversity sites? An assessment of the nature protection network in Sicily (Italy)

GIS spatial analysis of three indicators (vegetation value, faunal richness and landscape heterogeneity) was used to detect and map High-Value Biodiversity Areas (HVBAs), estimate the coverage of biodiversity in the Sicilian protected areas network, and identify new priority areas that could improve long-term biodiversity conservation outcomes. Findings indicated that only 32% of HVBAs are currently covered by the protected areas network. Hotspot analysis revealed that a modest expansion (less than 1%) in the current extent of protected areas would include a disproportionate amount (56%) of biodiversity hotspots, and identified prioritized candidates HVBAs for designation of new protected areas. © 2018 Elsevier Lt

Relationships between Social Support, Self-Regulation

Neste estudo, investigaram-se as relações entre suporte social percebido, auto-regulação e comportamentos de consumo de álcool, tabaco e outras substâncias psicoactivas. A amostra foi constituída por 340 participantes. O suporte social correlacionou-se favoravelmente com a auto-regulação, mas somente na vertente de satisfação com o apoio social é que se observou esta tendência de forma evidente. O número de figuras de apoio diferenciou-se significativamente com o uso de tabaco, o que sugere o âmbito afiliativo de algumas substâncias psicoactivas. Nesse sentido, o uso de tabaco pode estar associado a uma rede social mais ampla, mas não com a qualidade do suporte social.In this study the relationships between perceived social support, self-regulation and consuming behaviors of tobacco and other psychoactive substances we investigated. The sample consisted of 340 adult participants. Social support correlated positively with self-regulation, but was solely in the aspect of satisfaction with social support that this trend was noted clearly. The number of support providers differed considerably with the use of tobacco, which suggests the affiliative scope of some psychoactive substances.info:eu-repo/semantics/publishedVersio

Increasing the Resolution and Spectral Range of Measured Direct Irradiance Spectra for PV Applications

The spectral distribution of the solar irradiance incident on photovoltaic (PV) modules is a key variable controlling their power production. It is required to properly simulate the production and performance of PV plants based on technologies with different spectral characteristics. Spectroradiometers can only sense the solar spectrum within a wavelength range that is usually too short compared to the actual spectral response of some PV technologies. In this work, a new methodology based on the Simple Model of the Atmospheric Radiative Transfer of Sunshine (SMARTS) spectral code is proposed to extend the spectral range of measured direct irradiance spectra and to increase the spectral resolution of such experimental measurements. Satisfactory results were obtained for both clear and hazy sky conditions at a radiometric station in southern Spain. This approach constitutes the starting point of a general methodology to obtain the instantaneous spectral irradiance incident on the plane of array of PV modules and its temporal variations, while evaluating the magnitude and variability of the abundance of atmospheric constituents with the most impact on surface irradiance, most particularly aerosols and water vapor

Biomonitoring of Mycotoxins in Plasma of Patients with Alzheimer's and Parkinson's Disease

Exposure to environmental contaminants might play an important role in neurodegenerative disease pathogenesis, such as Parkinson ' s disease (PD) and Alzheimer's disease (AD). For the first time in Spain, the plasmatic levels of 19 mycotoxins from patients diagnosed with a neurodegenerative disease (44 PD and 24 AD) and from their healthy companions (25) from La Rioja region were analyzed. The studied mycotoxins were aflatoxins B1, B2, G1, G2 and M1, T-2 and HT-2, ochratoxins A (OTA) and B (OTB), zearalenone, sterigmatocystin (STER), nivalenol, deoxynivalenol, 3-acetyldeoxynivalenol, 15-acetyldeoxynivalenol, deepoxy-deoxynivalenol, neosolaniol, diacetoxyscirpenol and fusarenon-X. Samples were analyzed by LC-MS/MS before and after treatment with beta-glucuronidase/arylsulfatase in order to detect potential metabolites. Only OTA, OTB and STER were detected in the samples. OTA was present before (77% of the samples) and after (89%) the enzymatic treatment, while OTB was only detectable before (13%). Statistically significant differences in OTA between healthy companions and patients were observed but the observed differences might seem more related to gender (OTA levels higher in men, p-value = 0.0014) than the disease itself. STER appeared only after enzymatic treatment (88%). Statistical analysis on STER, showed distributions always different between healthy controls and patients (patients' group > controls, p-value < 0.0001). Surprisingly, STER levels weakly correlated positively with age in women (rho = 0.3384), while OTA correlation showed a decrease of levels with age especially in the men with PD (rho = -0.4643)

Frequency and clinical impact of CDKN2A/ARF/CDKN2B gene deletions as assessed by in-depth genetic analyses in adult T cell acute lymphoblastic leukemia

© The Author(s).Recurrent deletions of the CDKN2A/ARF/CDKN2B genes encoded at chromosome 9p21 have been described in both pediatric and adult acute lymphoblastic leukemia (ALL), but their prognostic value remains controversial, with limited data on adult T-ALL. Here, we investigated the presence of homozygous and heterozygous deletions of the CDKN2A/ARF and CDKN2B genes in 64 adult T-ALL patients enrolled in two consecutive trials from the Spanish PETHEMA group. Alterations in CDKN2A/ARF/CDKN2B were detected in 35/64 patients (55%). Most of them consisted of 9p21 losses involving homozygous deletions of the CDKNA/ARF gene (26/64), as confirmed by single nucleotide polymorphism (SNP) arrays and interphase fluorescence in situ hybridization (iFISH). Deletions involving the CDKN2A/ARF/CDKN2B locus correlated with a higher frequency of cortical T cell phenotype and a better clearance of minimal residual disease (MRD) after induction therapy. Moreover, the combination of an altered copy-number-value (CNV) involving the CDKN2A/ARF/CDKN2B gene locus and undetectable MRD (≤ 0.01%) values allowed the identification of a subset of T-ALL with better overall survival in the absence of hematopoietic stem cell transplantation.This project was supported by the Asociación Española Contra el Cáncer, AECC (project ref.: GC16173697BIGA), by CERCA Program/Generalitat de Catalunya, the Catalan Government: 2014-SGR225 (GRE), Obra Social “La Caixa” and by Celgene Spain. E. Genescà is the recipient of agrant from the Spanish Health Ministry (ISCIII, CA12/00468) and an unrestricted grant from Gilead.A. Gonzalez-Perez is supported by a Ramon y Cajal fellowship (RYC-2013-14554) of the Educational Ministry (Madrid, Spain). This work was also partially supported by FEDER funds from the ISCIII (PT13/0010/0026, CIBERONC (CB16/12/00284 and CB16/12/00400), Madrid, Spain)

Induction of sustained clinical remission in early axial spondyloarthritis following certolizumab pegol treatment: 48-week outcomes from C-OPTIMISE

INTRODUCTION: Achievement of remission is a key treatment goal for patients with axial spondyloarthritis (axSpA). C-OPTIMISE assessed achievement of sustained clinical remission in patients with axSpA, including radiographic (r) and non-radiographic (nr) axSpA, during certolizumab pegol (CZP) treatment, and subsequent maintenance of remission following CZP dose continuation, dose reduction or withdrawal. Here, we report outcomes from the first 48 weeks (induction period) of C-OPTIMISE, during which patients received open-label CZP. METHODS: C-OPTIMISE (NCT02505542) was a two-part, multicenter, phase 3b study in adult patients with early axSpA (r-/nr-axSpA), including a 48-week open-label induction period followed by a 48-week maintenance period. Patients with active adult-onset axSpA, < 5 years' symptom duration, and fulfilling Assessment of SpondyloArthritis international Society classification criteria, were included. During the induction period, patients received a loading dose of CZP 400 mg at weeks 0, 2, and 4, followed by CZP 200 mg every 2 weeks (Q2W) up to week 48. The main outcome of the 48-week induction period was the achievement of sustained clinical remission (defined as an Ankylosing Spondylitis Disease Activity Score [ASDAS] < 1.3 at week 32 and < 2.1 at week 36 [or vice versa], and < 1.3 at week 48). RESULTS: In total, 736 patients (407 with r-axSpA, 329 with nr-axSpA) were enrolled into the study. At week 48, 43.9% (323/736) of patients achieved sustained remission, including 42.8% (174/407) of patients with r-axSpA and 45.3% (149/329) with nr-axSpA. Patients also demonstrated substantial improvements in axSpA symptoms, MRI outcomes and quality of life measures. Adverse events occurred in 67.9% (500/736) of patients, of which 6.0% (44/736) were serious. CONCLUSIONS: Over 40% of patients with early axSpA achieved sustained remission during 48 weeks of open-label CZP treatment. Additionally, patients across the axSpA spectrum demonstrated substantial improvements in imaging outcomes and quality of life following treatment. No new safety signals were identified. TRIAL REGISTRATION: NCT02505542

Genetic polymorphisms of RANTES, IL1-A, MCP-1 and TNF-A genes in patients with prostate cancer

<p>Abstract</p> <p>Background</p> <p>Inflammation has been implicated as an etiological factor in several human cancers, including prostate cancer. Allelic variants of the genes involved in inflammatory pathways are logical candidates as genetic determinants of prostate cancer risk. The purpose of this study was to investigate whether single nucleotide polymorphisms of genes that lead to increased levels of pro-inflammatory cytokines and chemokines are associated with an increased prostate cancer risk.</p> <p>Methods</p> <p>A case-control study design was used to test the association between prostate cancer risk and the polymorphisms <it>TNF-A</it>-308 A/G (rs 1800629), <it>RANTES</it>-403 G/A (rs 2107538), <it>IL1-A</it>-889 C/T (rs 1800587) and <it>MCP-1 </it>2518 G/A (rs 1024611) in 296 patients diagnosed with prostate cancer and in 311 healthy controls from the same area.</p> <p>Results</p> <p>Diagnosis of prostate cancer was significantly associated with <it>TNF-A </it>GA + AA genotype (OR, 1.61; 95% CI, 1.09–2.64) and <it>RANTES </it>GA + AA genotype (OR, 1.44; 95% CI, 1.09–2.38). A alleles in <it>TNF-A </it>and <it>RANTES </it>influenced prostate cancer susceptibility and acted independently of each other in these subjects. No epistatic effect was found for the combination of different polymorphisms studied. Finally, no overall association was found between prostate cancer risk and <it>IL1-A </it>or <it>MCP-1 </it>polymorphisms.</p> <p>Conclusion</p> <p>Our results and previously published findings on genes associated with innate immunity support the hypothesis that polymorphisms in proinflammatory genes may be important in prostate cancer development.</p