Sistema de informacion para el apoyo de la funcion lubricacion

140 p.A lo largo de este trabajo, se ha llevado a cabo el análisis, diseño e implementación de un Sistema de Información para el Apoyo de la Función de lubricación, destinado a servir tomo apoyo a las actividades diarias de lubricación que se realizan en los equipos de la industria nacional. Esto cumple con la finalidad de aumentar la eficiencia en cuanto al manejo de la información y al control de las tareas de lubricación. Con el uso de sistemas de esta naturaleza, se consigue captar y generar los datos pertinentes a las operaciones de lubricación, es decir, los datos necesarios para la toma de decisiones. Por otra parte, se consigue procesar los datos de una forma rápida y económica, utilizando al máximo los recursos que hoy en día están al altante en el área de la informática. Con esto, es posible producir información adecuada, precisa y oportuna, según sean los requerimientos de los usuarios

Cognition and its relationship with endogenous and exogenous factors in engineering students

In this research, a relational study was carried out between student cognition with endogenous factors (student attitude and age) and exogenous (collegiate origin) in engineering students of the University of Cartagena. The project was carried out in three (3) phases where the survey allowed the desired information to be obtained from an estimated nine hundred sixty (960) students between 2014 and 2016. In the second phase, the instrument was used to collect the information, which was constituted the cognitive scale of the Self-Regulation Inventory for Learning (SRLI) and in the third phase, the independent endogenous and exogenous variables were crossed with the dependent one (student cognition), constructing the bar diagram of the relationship analysis; being possible to determine statistical significance with the attitude of the student to a level of confidence of 95% while with the age and collegial origin was not relevant

Vibrational detection of acetaminophen in commercials tablets by ATR-FTIR spectroscopy and Chemometrics

Acetaminofén (AAP) es un ingrediente activo muy utilizado en muchas preparaciones farmacéuticas. AAP es un analgésico y un fármaco reductor de la fiebre. Generalmente, se utiliza para tratar muchas condiciones tales como dolor de cabeza, dolores musculares, artritis, dolor de espalda, dolores de muelas, resfriados y fiebres. Los métodos estándar más utilizados para la detección química de AAP se basan en técnicas de cromatografía y espectrofotometría, estos métodos generalmente implican una etapa de preparación de la muestra, mientras que los métodos basados en FTIR no. Por lo tanto, los métodos analíticos basados en espectroscopia IR (FTIR) son muy importantes para la industria farmacéutica y agencia policial, dado que permiten obtener de forma fácil y rápida información molecular de una compuesto químico que permite su detección. En un esfuerzo por lograr un procedimiento de identificación fiable para la determinación cualitativa de AAP en diferentes productos farmacéuticos, se propone un tratamiento quimiométrico adicional a los datos ATRFTIR. El método propuesto fue probado en muestras sólidas que contenían AAP. La estadística de rutina de análisis de componentes principales (PCA) produjo excelentes resultados. Los resultados muestran que el sensor multivariado es útil para la detección de AAP en los fármacos ensayados. El uso del método propuesto permite conocer si el fármaco está presente como producto deseado o si se trata de medicamentos falsificados.Acetaminophen (AAP) is active ingredient very used in many pharmaceutical preparations. AAP is a pain reliever and a fever reducer drug. Generally, it is used to treat many conditions such as headache, muscle aches, arthritis, backache, toothaches, colds, and fevers. Standard methods most used for AAP chemical detection are based on chromatography and spectrophotometry techniques, these methods generally imply a sample preparation step, while FTIR based methods do not. Hence, an analytical methods based on IR spectroscopy are very important for the pharmaceutical industry and law enforcement agency, given that allow obtain a way easy and fast molecular information for its detection. In effort for attaining a reliable identification procedure for qualitative determination of AAP in different pharmaceuticals product, an additional chemometrics treatment of ATR-FTIR data is proposed. The proposed method was tested on solid samples containing API. The statistical routine of principal component analysis (PCA) yielded excellent results. The results show that the multivariate sensor is useful for detection of AAP in the drugs tested. Using the proposed method allowed to know if drug is present as desired product or it is counterfeit drugs

Conditions of work and dermatitis in workers exposed to chemical risks by cement

This research was carried out in order to identify the working conditions in workers exposed to cement in a cement factory in the city of Cartagena. Through different tools it was possible to carry out the diagnosis of the working conditions and to identify the hazards to which the workers of the company are exposed when being in direct contact with the cement; in this way it was possible to know that the dermatitis that were manifesting the workers has its direct relation with this chemical and therefore to be able to establish those measures tending to ensure the complete state of health of the workers. The type of research carried out is descriptive-qualitative, the applied methodology used as a closed questions survey tool, it was obtained as a result that 70% of the respondents did not use personal protection elements when handling cement, so can say that there is a considerable number of people exposed, which increases the likelihood that they may suffer contact dermatitis, through this the different preventive measures for working and health conditions among the employees of the cement company were raised

Functional proteomics outlines the complexity of breast cancer molecular subtypes

Breast cancer is a heterogeneous disease comprising a variety of entities with various genetic backgrounds. Estrogen receptor-positive, human epidermal growth factor receptor 2-negative tumors typically have a favorable outcome; however, some patients eventually relapse, which suggests some heterogeneity within this category. In the present study, we used proteomics and miRNA profiling techniques to characterize a set of 102 either estrogen receptor-positive (ER+)/progesterone receptorpositive (PR+) or triple-negative formalin-fixed, paraffin-embedded breast tumors. Protein expressionbased probabilistic graphical models and flux balance analyses revealed that some ER+/PR+ samples had a protein expression profile similar to that of triple-negative samples and had a clinical outcome similar to those with triple-negative disease. This probabilistic graphical model-based classification had prognostic value in patients with luminal A breast cancer. This prognostic information was independent of that provided by standard genomic tests for breast cancer, such as MammaPrint, OncoType Dx and the 8-gene Score

Adjuvant dabrafenib and trametinib for patients with resected BRAF-mutated melanoma: DESCRIBE-AD real-world retrospective observational study

BRAF and MEK inhibitor, dabrafenib plus trametinib, adjuvant therapy is effective for high-risk resected melanoma patients with BRAF-V600 mutations. However, real-world evidence is limited. We aimed to determine the feasibility of this therapy in routine clinical practice. DESCRIBE-AD, a retrospective observational study, collected real-world data from 25 hospitals in Spain. Histologically confirmed and resected BRAF-mutated melanoma patients aged & GE;18 years who were previously treated with dabrafenib plus trametinib adjuvant therapy, were included. The primary objectives were treatment discontinuation rate and time to discontinuation. The secondary objectives included safety and efficacy. From October 2020 to March 2021, 65 patients were included. Dabrafenib and trametinib discontinuation rate due to treatment-related adverse events (TRAEs) of any grade was 9%. Other reasons for discontinuation included patients' decisions (6%), physician decisions (6%), unrelated adverse events (3%), disease progression (5%), and others (5%). The median time to treatment discontinuation was 9 months [95% confidence interval (CI), 5-11]. G3-4 TRAEs occurred in 21.5% of patients, the most common being pyrexia (3%), asthenia (3%), and diarrhoea (3%). Unscheduled hospitalisations and clinical tests occurred in 6 and 22% of patients, respectively. After 20-month median follow-up (95% CI, 18-22), 9% of patients had exitus due to disease progression, with a 12-month relapse-free survival and overall survival rates of 95.3% and 100%, respectively. Dabrafenib and trametinib adjuvant therapy proved effective for melanoma patients in a real-world setting, with a manageable toxicity profile. Toxicity frequencies were low leading to low incidence of unscheduled medical visits, tests, and treatment discontinuations

Effectiveness and safety of first-generation protease inhibitors in clinical practice: Hepatitis C virus patients with advanced fibrosis

AIM: To evaluates the effectiveness and safety of the first generation, NS3/4A protease inhibitors (PIs) in clinical practice against chronic C virus, especially in patients with advanced fibrosis. METHODS: Prospective study and non-experimental analysis of a multicentre cohort of 38 Spanish hospitals that includes patients with chronic hepatitis C genotype 1, treatment-nai¨ve (TN) or treatment-experienced (TE), who underwent triple therapy with the first generation NS3/4A protease inhibitors, boceprevir (BOC) and telaprevir (TVR), in combination with pegylated interferon and ribavirin. The patients were treatment in routine practice settings. Data on the study population and on adverse clinical and virologic effects were compiled during the treatment period and during follow up. RESULTS: One thousand and fifty seven patients were included, 405 (38%) were treated with BOC and 652 (62%) with TVR. Of this total, 30% (n = 319) were TN and the remaining were TE: 28% (n = 298) relapsers, 12% (n = 123) partial responders (PR), 25% (n = 260) null-responders (NR) and for 5% (n = 57) with prior response unknown. The rate of sustained virologic response (SVR) by intention-to-treatment (ITT) was greater in those treated with TVR (65%) than in those treated with BOC (52%) (P < 0.0001), whereas by modified intention-to-treatment (mITT) no were found significant differences. By degree of fibrosis, 56% of patients were F4 and the highest SVR rates were recorded in the non-F4 patients, both TN and TE. In the analysis by groups, the TN patients treated with TVR by ITT showed a higher SVR (P = 0.005). However, by mITT there were no significant differences between BOC and TVR. In the multivariate analysis by mITT, the significant SVR factors were relapsers, IL28B CC and non-F4; the type of treatment (BOC or TVR) was not significant. The lowest SVR values were presented by the F4-NR patients, treated with BOC (46%) or with TVR (45%). 28% of the patients interrupted the treatment, mainly by non-viral response (51%): this outcome was more frequent in the TE than in the TN patients (57% vs 40%, P = 0.01). With respect to severe haematological disorders, neutropaenia was more likely to affect the patients treated with BOC (33% vs 20%, P = 0.0001), and thrombocytopaenia and anaemia, the F4 patients (P = 0.000, P = 0.025, respectively). CONCLUSION: In a real clinical practice setting with a high proportion of patients with advanced fibrosis, effectiveness of first-generation PIs was high except for NR patients, with similar SVR rates being achieved by BOC and TVR

Blazar spectral variability as explained by a twisted inhomogeneous jet

Blazars are active galactic nuclei, which are powerful sources of radiation whose central engine is located in the core of the host galaxy. Blazar emission is dominated by non-thermal radiation from a jet that moves relativistically towards us, and therefore undergoes Doppler beaming1. This beaming causes flux enhancement and contraction of the variability timescales, so that most blazars appear as luminous sources characterized by noticeable and fast changes in brightness at all frequencies. The mechanism that produces this unpredictable variability is under debate, but proposed mechanisms include injection, acceleration and cooling of particles2, with possible intervention of shock waves3,4 or turbulence5. Changes in the viewing angle of the observed emitting knots or jet regions have also been suggested as an explanation of flaring events6,7,8,9,10 and can also explain specific properties of blazar emission, such as intra-day variability11, quasi-periodicity12,13 and the delay of radio flux variations relative to optical changes14. Such a geometric interpretation, however, is not universally accepted because alternative explanations based on changes in physical conditions—such as the size and speed of the emitting zone, the magnetic field, the number of emitting particles and their energy distribution—can explain snapshots of the spectral behaviour of blazars in many cases15,16. Here we report the results of optical-to-radio-wavelength monitoring of the blazar CTA 102 and show that the observed long-term trends of the flux and spectral variability are best explained by an inhomogeneous, curved jet that undergoes changes in orientation over time. We propose that magnetohydrodynamic instabilities17 or rotation of the twisted jet6 cause different jet regions to change their orientation and hence their relative Doppler factors. In particular, the extreme optical outburst of 2016–2017 (brightness increase of six magnitudes) occurred when the corresponding emitting region had a small viewing angle. The agreement between observations and theoretical predictions can be seen as further validation of the relativistic beaming theory

Effect of the ultrastructure of chitosan nanoparticles in colloidal stability, quorum quenching and antibacterial activities

We have fabricated two types of crosslinked chitosan-based nanoparticles (NPs), namely (1) ionically crosslinked with tripolyphosphate (TPP), designated as IC-NPs and (2) dually co-crosslinked (ionically and covalently with TPP and genipin, respectively) termed CC-NPs. The two types of NPs were physichochemically characterized by means of DLS-NIBS, synchrotron SAXS and M3-PALS (zeta potential). First, we found that covalent co-crosslinking of ionically pre-crosslinked nanoparticles yielded monodisperse CC-NPs in the size range of ∼200 nm, whereas the parental IC-NPs remained highly polydisperse. While both types of chitosan nanoparticles displayed a core-shell structure, as determined by synchrotron SAXS, only the structure of CC-NPs remained stable at long incubation times. This enhanced structural robustness of CC-NPs was likely responsible of their superior colloidal stability even in biological medium. Second, we explored the antimicrobial and quorum sensing inhibition activity of both types of nanoparticles. We found that CC-NPs had lower long-term toxicity than IC-NPs. In contrast, sub-lethal doses of IC-NPs consistently displayed higher levels of quorum quenching activity than CC-NPs. Thus, this work underscores the influence of the NP’s ultrastructure on their colloidal and biological properties. While the cellular and molecular mechanisms at play are yet to be fully elucidated, our results broaden the spectrum of use of chitosan-based nanobiomaterialsin the development of antibiotic-free approaches against Gram-negative pathogenic bacteria