APEX observations of supernova remnants - I. Non-stationary MHD-shocks in W44

Aims. The interaction of supernova remnants (SNRs) with molecular clouds gives rise to strong molecular emission in the far-IR and sub-mm wavelength regimes. The application of MHD shock models in the interpretation of this line emission can yield valuable information on the energetic and chemical impact of supernova remnants. Methods. New mapping observations with the APEX telescope in CO (3-2), (4-3), (6-5), (7-6) and 13CO (3-2) towards two regions in the supernova remnant W44 are presented. Integrated intensities are extracted on five different positions, corresponding to local maxima of CO emission. The integrated intensities are compared to the outputs of a grid of models, which combine an MHD shock code with a radiative transfer module based on the large velocity gradient approximation. Results. All extracted spectra show ambient and line-of-sight components as well as blue- and red-shifted wings indicating the presence of shocked gas. Basing the shock model fits only on the highest-lying transitions that unambiguously trace the shock-heated gas, we find that the observed CO line emission is compatible with non-stationary shocks and a pre-shock density of 10^4 cm-3. The ages of the modelled shocks scatter between values of \sim1000 and \sim3000 years. The shock velocities in W44F are found to lie between 20 and 25 km/s, while in W44E fast shocks (30-35 km/s) as well as slower shocks (\sim20 km/s) are compatible with the observed spectral line energy diagrams. The pre-shock magnetic field strength components perpendicular to the line of sight in both regions have values between 100 and 200 \muG. Our best-fitting models allow us to predict the full ladder of CO transitions, the shocked gas mass in one beam as well as the momentum- and energy injection.Comment: 20 pages, 13 figures, 13 tables, accepted for publication in Astronomy and Astrophysic

SiO excitation from dense shocks in the earliest stages of massive star formation

Molecular outflows are a direct consequence of accretion, and therefore they represent one of the best tracers of accretion processes in the still poorly understood early phases of high-mass star formation. Previous studies suggested that the SiO abundance decreases with the evolution of a massive young stellar object probably because of a decay of jet activity, as witnessed in low-mass star-forming regions. We investigate the SiO excitation conditions and its abundance in outflows from a sample of massive young stellar objects through observations of the SiO(8-7) and CO(4-3) lines with the APEX telescope. Through a non-LTE analysis, we find that the excitation conditions of SiO increase with the velocity of the emitting gas. We also compute the SiO abundance through the SiO and CO integrated intensities at high velocities. For the sources in our sample we find no significant variation of the SiO abundance with evolution for a bolometric luminosity-to-mass ratio of between 4 and 50 $L_\odot/M_\odot$. We also find a weak increase of the SiO(8-7) luminosity with the bolometric luminosity-to-mass ratio. We speculate that this might be explained with an increase of density in the gas traced by SiO. We find that the densities constrained by the SiO observations require the use of shock models that include grain-grain processing. For the first time, such models are compared and found to be compatible with SiO observations. A pre-shock density of $10^5\,$cm$^{-3}$ is globally inferred from these comparisons. Shocks with a velocity higher than 25 km s$^{-1}$ are invoked for the objects in our sample where the SiO is observed with a corresponding velocity dispersion. Our comparison of shock models with observations suggests that sputtering of silicon-bearing material (corresponding to less than 10% of the total silicon abundance) from the grain mantles is occurring.Comment: Accepted for publication by A&

Glycolaldehyde in Perseus young solar analogs

Aims: In this paper we focus on the occurrence of glycolaldehyde (HCOCH2OH) in young solar analogs by performing the first homogeneous and unbiased study of this molecule in the Class 0 protostars of the nearby Perseus star forming region. Methods: We obtained sub-arcsec angular resolution maps at 1.3mm and 1.4mm of glycolaldehyde emission lines using the IRAM Plateau de Bure (PdB) interferometer in the framework of the CALYPSO IRAM large program. Results: Glycolaldehyde has been detected towards 3 Class 0 and 1 Class I protostars out of the 13 continuum sources targeted in Perseus: NGC1333-IRAS2A1, NGC1333-IRAS4A2, NGC1333-IRAS4B1, and SVS13-A. The NGC1333 star forming region looks particularly glycolaldehyde rich, with a rate of occurrence up to 60%. The glycolaldehyde spatial distribution overlaps with the continuum one, tracing the inner 100 au around the protostar. A large number of lines (up to 18), with upper-level energies Eu from 37 K up to 375 K has been detected. We derived column densities > 10^15 cm^-2 and rotational temperatures Trot between 115 K and 236 K, imaging for the first time hot-corinos around NGC1333-IRAS4B1 and SVS13-A. Conclusions: In multiple systems glycolaldehyde emission is detected only in one component. The case of the SVS13-A+B and IRAS4-A1+A2 systems support that the detection of glycolaldehyde (at least in the present Perseus sample) indicates older protostars (i.e. SVS13-A and IRAS4-A2), evolved enough to develop the hot-corino region (i.e. 100 K in the inner 100 au). However, only two systems do not allow us to firmly conclude whether the primary factor leading to the detection of glycolaldehyde emission is the environments hosting the protostars, evolution (e.g. low value of Lsubmm/Lint), or accretion luminosity (high Lint).Comment: A&A, in pres

Relevance of d-D interactions on neutron and tritium production in IFMIF-EVEDA accelerator prototype

In the IFMIF-EVEDA accelerator prototype, deuterium is implanted in the components due to beam losses and in the beam dump, where the beam is stopped. The interaction of the deuterons with the deuterium previously implanted leads to the production of neutrons and tritium, which are important issues for radioprotection and safety analysis. A methodology to assess these production pathways in more realistic approach has been developed. The new tools and their main achievement are: (i) an “effective diffusivity coefficient” (deduced from available experimental data) that enables simulation of the diffusion phase, and (ii) the MCUNED code (able to handle deuteron transport libraries) allows to simulate the transport-slowdown of deuteron/tritium (to get the concentration profiles) and the neutron/tritium productions from d-Cu and d-D for up to 9 MeV incident deuteron. The results with/without theses tools are presented and their effect on the relevance of d-D sources versus d-Cu is evaluated

Star Forming Dense Cloud Cores in the TeV {\gamma}-ray SNR RX J1713.7-3946

RX J1713.7-3946 is one of the TeV {\gamma}-ray supernova remnants (SNRs) emitting synchrotron X rays. The SNR is associated with molecular gas located at ~1 kpc. We made new molecular observations toward the dense cloud cores, peaks A, C and D, in the SNR in the 12CO(J=2-1) and 13CO(J=2-1) transitions at angular resolution of 90". The most intense core in 13CO, peak C, was also mapped in the 12CO(J=4-3) transition at angular resolution of 38". Peak C shows strong signs of active star formation including bipolar outflow and a far-infrared protostellar source and has a steep gradient with a r^{-2.2$\pm$0.4} variation in the average density within radius r. Peak C and the other dense cloud cores are rim-brightened in synchrotron X rays, suggesting that the dense cloud cores are embedded within or on the outer boundary of the SNR shell. This confirms the earlier suggestion that the X rays are physically associated with the molecular gas (Fukui et al. 2003). We present a scenario where the densest molecular core, peak C, survived against the blast wave and is now embedded within the SNR. Numerical simulations of the shock-cloud interaction indicate that a dense clump can indeed survive shock erosion, since shock propagation speed is stalled in the dense clump. Additionally, the shock-cloud interaction induces turbulence and magnetic field amplification around the dense clump that may facilitate particle acceleration in the lower-density inter-clump space leading to the enhanced synchrotron X rays around dense cores.Comment: 22 pages, 7 figures, to accepted in The Astrophysical Journal. A full color version with higher resolution figures is available at http://www.a.phys.nagoya-u.ac.jp/~sano/ApJ10/ms_sano.pd

Probing MHD Shocks with high-J CO observations: W28F

Context. Observing supernova remnants (SNRs) and modelling the shocks they are associated with is the best way to quantify the energy SNRs re-distribute back into the Interstellar Medium (ISM). Aims. We present comparisons of shock models with CO observations in the F knot of the W28 supernova remnant. These comparisons constitute a valuable tool to constrain both the shock characteristics and pre-shock conditions. Methods. New CO observations from the shocked regions with the APEX and SOFIA telescopes are presented and combined. The integrated intensities are compared to the outputs of a grid of models, which were combined from an MHD shock code that calculates the dynamical and chemical structure of these regions, and a radiative transfer module based on the 'large velocity gradient' (LVG) approximation. Results. We base our modelling method on the higher J CO transitions, which unambiguously trace the passage of a shock wave. We provide fits for the blue- and red-lobe components of the observed shocks. We find that only stationary, C-type shock models can reproduce the observed levels of CO emission. Our best models are found for a pre-shock density of 104 cm-3, with the magnetic field strength varying between 45 and 100 {\mu}G, and a higher shock velocity for the so-called blue shock (\sim25 km s-1) than for the red one (\sim20 km s-1). Our models also satisfactorily account for the pure rotational H2 emission that is observed with Spitzer.Comment: 8 pages, 6 figures, 1 table, accepted for A&A SOFIA/GREAT Special Issu

Pittsburgh compound B imaging and cerebrospinal fluid amyloid-β in a multicentre European memory clinic study

The aim of this study was to assess the agreement between data on cerebral amyloidosis, derived using Pittsburgh compound B positron emission tomography and (i) multi-laboratory INNOTEST enzyme linked immunosorbent assay derived cerebrospinal fluid concentrations of amyloid-β 42 ; (ii) centrally measured cerebrospinal fluid amyloid-β 42 using a Meso Scale Discovery enzyme linked immunosorbent assay; and (iii) cerebrospinal fluid amyloid-β 42 centrally measured using an antibody-independent mass spectrometry-based reference method. Moreover, we examined the hypothesis that discordance between amyloid biomarker measurements may be due to interindividual differences in total amyloid-β production, by using the ratio of amyloid-β 42 to amyloid-β 40 . Our study population consisted of 243 subjects from seven centres belonging to the Biomarkers for Alzheimer’s and Parkinson’s Disease Initiative, and included subjects with normal cognition and patients with mild cognitive impairment, Alzheimer’s disease dementia, frontotemporal dementia, and vascular dementia. All had Pittsburgh compound B positron emission tomography data, cerebrospinal fluid INNOTEST amyloid-β 42 values, and cerebrospinal fluid samples available for reanalysis. Cerebrospinal fluid samples were reanalysed (amyloid-β 42 and amyloid-β 40 ) using Meso Scale Discovery electrochemiluminescence enzyme linked immunosorbent assay technology, and a novel, antibody-independent, mass spectrometry reference method. Pittsburgh compound B standardized uptake value ratio results were scaled using the Centiloid method. Concordance between Meso Scale Discovery/mass spectrometry reference measurement procedure findings and Pittsburgh compound B was high in subjects with mild cognitive impairment and Alzheimer’s disease, while more variable results were observed for cognitively normal and non-Alzheimer’s disease groups. Agreement between Pittsburgh compound B classification and Meso Scale Discovery/mass spectrometry reference measurement procedure findings was further improved when using amyloid-β 42/40 . Agreement between Pittsburgh compound B visual ratings and Centiloids was near complete. Despite improved agreement between Pittsburgh compound B and centrally analysed cerebrospinal fluid, a minority of subjects showed discordant findings. While future studies are needed, our results suggest that amyloid biomarker results may not be interchangeable in some individuals

PACS and SPIRE photometer maps of M33: First results of the Herschel M33 extended survey (HERM33ES)

Within the framework of the HERM33ES key project, we are studying the star forming interstellar medium in the nearby, metal-poor spiral galaxy M33, exploiting the high resolution and sensitivity of Herschel. We use PACS and SPIRE maps at 100, 160, 250, 350, and 500 micron wavelength, to study the variation of the spectral energy distributions (SEDs) with galacto-centric distance. Detailed SED modeling is performed using azimuthally averaged fluxes in elliptical rings of 2 kpc width, out to 8 kpc galacto-centric distance. Simple isothermal and two-component grey body models, with fixed dust emissivity index, are fitted to the SEDs between 24 and 500 micron using also MIPS/Spitzer data, to derive first estimates of the dust physical conditions. The far-infrared and submillimeter maps reveal the branched, knotted spiral structure of M33. An underlying diffuse disk is seen in all SPIRE maps (250-500 micron). Two component fits to the SEDs agree better than isothermal models with the observed, total and radially averaged flux densities. The two component model, with beta fixed at 1.5, best fits the global and the radial SEDs. The cold dust component clearly dominates; the relative mass of the warm component is less than 0.3% for all the fits. The temperature of the warm component is not well constrained and is found to be about 60K plus/minus 10K. The temperature of the cold component drops significantly from about 24K in the inner 2 kpc radius to 13K beyond 6 kpc radial distance, for the best fitting model. The gas-to-dust ratio for beta=1.5, averaged over the galaxy, is higher than the solar value by a factor of 1.5 and is roughly in agreement with the subsolar metallicity of M33.Comment: 5 pages, 3 figures, accepted for publication in the A&A Herschel Special Issu

Caveolin-1 protects B6129 mice against Helicobacter pylori gastritis.

Caveolin-1 (Cav1) is a scaffold protein and pathogen receptor in the mucosa of the gastrointestinal tract. Chronic infection of gastric epithelial cells by Helicobacter pylori (H. pylori) is a major risk factor for human gastric cancer (GC) where Cav1 is frequently down-regulated. However, the function of Cav1 in H. pylori infection and pathogenesis of GC remained unknown. We show here that Cav1-deficient mice, infected for 11 months with the CagA-delivery deficient H. pylori strain SS1, developed more severe gastritis and tissue damage, including loss of parietal cells and foveolar hyperplasia, and displayed lower colonisation of the gastric mucosa than wild-type B6129 littermates. Cav1-null mice showed enhanced infiltration of macrophages and B-cells and secretion of chemokines (RANTES) but had reduced levels of CD25+ regulatory T-cells. Cav1-deficient human GC cells (AGS), infected with the CagA-delivery proficient H. pylori strain G27, were more sensitive to CagA-related cytoskeletal stress morphologies ("humming bird") compared to AGS cells stably transfected with Cav1 (AGS/Cav1). Infection of AGS/Cav1 cells triggered the recruitment of p120 RhoGTPase-activating protein/deleted in liver cancer-1 (p120RhoGAP/DLC1) to Cav1 and counteracted CagA-induced cytoskeletal rearrangements. In human GC cell lines (MKN45, N87) and mouse stomach tissue, H. pylori down-regulated endogenous expression of Cav1 independently of CagA. Mechanistically, H. pylori activated sterol-responsive element-binding protein-1 (SREBP1) to repress transcription of the human Cav1 gene from sterol-responsive elements (SREs) in the proximal Cav1 promoter. These data suggested a protective role of Cav1 against H. pylori-induced inflammation and tissue damage. We propose that H. pylori exploits down-regulation of Cav1 to subvert the host's immune response and to promote signalling of its virulence factors in host cells