Dihadron fragmentation: in vacuum and in matter

Two particle correlations within a single jet produced in deeply inelastic scattering (DIS) off a large nucleus as well as in heavy-ion collisions are explored. This is performed within the framework of the medium modified dihadron fragmentation functions. The modification occurs due to gluon bremsstrahlung induced by multiple scattering. The modified fragmentation functions for dihadrons are found to follow closely that of single hadrons leading to a weak nuclear suppression of their ratios as measured by HERMES in DIS experiments. Meanwhile, a moderate medium enhancement of the near-side correlation of two high $p_T$ hadrons is found in central heavy-ion collisions, partially due to trigger bias caused by the competition between parton energy loss and the initial Cronin effect.Comment: 4 pages, 2 figures, LATEX, talk given at Hard Probes 200

Dirac Spinors and Flavor Oscillations

In the standard treatment of particle oscillations the mass eigenstates are implicitly assumed to be scalars and, consequently, the spinorial form of neutrino wave functions is not included in the calculations. To analyze this additional effect, we discuss the oscillation probability formula obtained by using the Dirac equation as evolution equation for the neutrino mass eigenstates. The initial localization of the spinor state also implies an interference between positive and negative energy components of mass eigenstate wave packets which modifies the standard oscillation probability.Comment: 14 pages, 1 figure, AMS-Te

Leading-particle suppression in high energy nucleus-nucleus collisions

Parton energy loss effects in heavy-ion collisions are studied with the Monte Carlo program PQM (Parton Quenching Model) constructed using the BDMPS quenching weights and a realistic collision geometry. The merit of the approach is that it contains only one free parameter that is tuned to the high-pt nuclear modification factor measured in central Au-Au collisions at sqrt{s_NN} = 200 GeV. Once tuned, the model is coherently applied to all the high-pt observables at 200 GeV: the centrality evolution of the nuclear modification factor, the suppression of the away-side jet-like correlations, and the azimuthal anisotropies for these observables. Predictions for the leading-particle suppression at nucleon-nucleon centre-of-mass energies of 62.4 and 5500 GeV are calculated. The limits of the eikonal approximation in the BDMPS approach, when applied to finite-energy partons, are discussed.Comment: 28 pages, 14 figures, final version, accepted by Eur. Phys. J.

Higher-Order Corrections to Instantons

The energy levels of the double-well potential receive, beyond perturbation theory, contributions which are non-analytic in the coupling strength; these are related to instanton effects. For example, the separation between the energies of odd- and even-parity states is given at leading order by the one-instanton contribution. However to determine the energies more accurately multi-instanton configurations have also to be taken into account. We investigate here the two-instanton contributions. First we calculate analytically higher-order corrections to multi-instanton effects. We then verify that the difference betweeen numerically determined energy eigenvalues, and the generalized Borel sum of the perturbation series can be described to very high accuracy by two-instanton contributions. We also calculate higher-order corrections to the leading factorial growth of the perturbative coefficients and show that these are consistent with analytic results for the two-instanton effect and with exact data for the first 200 perturbative coefficients.Comment: 7 pages, LaTe

S_3 Flavor Symmetry and Leptogenesis

We consider leptogenesis in a minimal S_3 extension of the standard model with an additional Z_2 symmetry in the leptonic sector. It is found that the CP phase appearing in the neutrino mixing is the same as that for the CP asymmetries responsible for leptogenesis. Because of the discrete S_3 x Z_2 flavor symmetries, the CP asymmetries are strongly suppressed. We therefore assume that the resonant enhancement of the CP asymmetries takes place to obtain a realistic size of baryon number asymmetry in theuniverse. Three degenerate right-handed neutrino masses of O(10) TeV are theoretically expected in this model.Comment: 25 pages, 3 figure

The BIN1 rs744373 SNP is associated with increased tau-PET levels and impaired memory

© 2019, The Author(s). The single nucleotide polymorphism (SNP) rs744373 in the bridging integrator-1 gene (BIN1) is a risk factor for Alzheimer’s disease (AD). In the brain, BIN1 is involved in endocytosis and sustaining cytoskeleton integrity. Post-mortem and in vitro studies suggest that BIN1-associated AD risk is mediated by increased tau pathology but whether rs744373 is associated with increased tau pathology in vivo is unknown. Here we find in 89 older individuals without dementia, that BIN1 rs744373 risk-allele carriers show higher AV1451 tau-PET across brain regions corresponding to Braak stages II–VI. In contrast, the BIN1 rs744373 SNP was not associated with AV45 amyloid-PET uptake. Furthermore, the rs744373 risk-allele was associated with worse memory performance, mediated by increased global tau levels. Together, our findings suggest that the BIN1 rs744373 SNP is associated with increased tau but not beta-amyloid pathology, suggesting that alterations in BIN1 may contribute to memory deficits via increased tau pathology

Management and 1-year outcomes of patients with newly diagnosed atrial fibrillation and chronic kidney disease: Results from the prospective garfield-af registry

© 2019 The Authors. Background-—Using data from the GARFIELD-AF (Global Anticoagulant Registry in the FIELD–Atrial Fibrillation), we evaluated the impact of chronic kidney disease (CKD) stage on clinical outcomes in patients with newly diagnosed atrial fibrillation (AF). Methods and Results-—GARFIELD-AF is a prospective registry of patients from 35 countries, including patients from Asia (China, India, Japan, Singapore, South Korea, and Thailand). Consecutive patients enrolled (2013–2016) were classified with no, mild, or moderate-to-severe CKD, based on the National Kidney Foundation’s Kidney Disease Outcomes Quality Initiative guidelines. Data on CKD status and outcomes were available for 33 024 of 34 854 patients (including 9491 patients from Asia); 10.9% (n=3613) had moderate-to-severe CKD, 16.9% (n=5595) mild CKD, and 72.1% (n=23 816) no CKD. The use of oral anticoagulants was influenced by stroke risk (ie, post hoc assessment of CHA2DS2-VASc score), but not by CKD stage. The quality of anticoagulant control with vitamin K antagonists did not differ with CKD stage. After adjusting for baseline characteristics and antithrombotic use, both mild and moderate-to-severe CKD were independent risk factors for all-cause mortality. Moderate-to-severe CKD was independently associated with a higher risk of stroke/systemic embolism, major bleeding, new-onset acute coronary syndrome, and new or worsening heart failure. The impact of moderate-to-severe CKD on mortality was significantly greater in patients from Asia than the rest of the world (P=0.001). Conclusions-—In GARFIELD-AF, moderate-to-severe CKD was independently associated with stroke/systemic embolism, major bleeding, and mortality. The effect of moderate-to-severe CKD on mortality was even greater in patients from Asia than the rest of the world

Equalization of four cardiovascular risk algorithms after systematic recalibration: Individual-participant meta-analysis of 86 prospective studies

© 2018 The Author(s). Published by Oxford University Press on behalf of the European Society of Cardiology. Aims There is debate about the optimum algorithm for cardiovascular disease (CVD) risk estimation. We conducted head-to-head comparisons of four algorithms recommended by primary prevention guidelines, before and after \u27recalibration\u27, a method that adapts risk algorithms to take account of differences in the risk characteristics of the populations being studied. Methods and results Using individual-participant data on 360 737 participants without CVD at baseline in 86 prospective studies from 22 countries, we compared the Framingham risk score (FRS), Systematic COronary Risk Evaluation (SCORE), pooled cohort equations (PCE), and Reynolds risk score (RRS). We calculated measures of risk discrimination and calibration, and modelled clinical implications of initiating statin therapy in people judged to be at \u27high\u27 10 year CVD risk. Original risk algorithms were recalibrated using the risk factor profile and CVD incidence of target populations. The four algorithms had similar risk discrimination. Before recalibration, FRS, SCORE, and PCE over-predicted CVD risk on average by 10%, 52%, and 41%, respectively, whereas RRS under-predicted by 10%. Original versions of algorithms classified 29-39% of individuals aged ≥40 years as high risk. By contrast, recalibration reduced this proportion to 22-24% for every algorithm. We estimated that to prevent one CVD event, it would be necessary to initiate statin therapy in 44-51 such individuals using original algorithms, in contrast to 37-39 individuals with recalibrated algorithms. Conclusion Before recalibration, the clinical performance of four widely used CVD risk algorithms varied substantially. By contrast, simple recalibration nearly equalized their performance and improved modelled targeting of preventive action to clinical need

Anisotropic field dependence of the magnetic transition in Cu2Te2O5Br2

We present the results of measurements of the thermal conductivity of Cu2Te2O5Br2, a compound where tetrahedra of Cu^{2+} ions carrying S=1/2 spins form chains along the c-axis of the tetragonal crystal structure. The thermal conductivity kappa was measured along both the c- and the a-direction as a function of temperature between 3 and 300 K and in external magnetic fields H up to 69 kOe, oriented both parallel and perpendicular to the c-axis. Distinct features of kappa(T) were observed in the vicinity of T_N=11.4 K in zero magnetic field. These features are unaltered in external fields which are parallel to the c-axis, but are more pronounced when a field is applied perpendicularly to the c-axis. The transition temperature increases upon enhancing the external field, but only if the field is oriented along the a-axis.Comment: 5 pages, 3 figure

Longitudinal Changes in Health-Related Quality of Life in Primary Glomerular Disease: Results From the CureGN Study

© 2020 Introduction: Prior cross-sectional studies suggest that health-related quality of life (HRQOL) worsens with more severe glomerular disease. This longitudinal analysis was conducted to assess changes in HRQOL with changing disease status. Methods: Cure Glomerulonephropathy (CureGN) is a cohort of patients with minimal change disease, focal seNorthwell Healthntal glomerulosclerosis, membranous nephropathy, IgA vasculitis, or IgA nephropathy. HRQOL was assessed at enrollment and follow-up visits 1 to 3 times annually for up to 5 years with the Patient-Reported Outcomes Measurement Information System (PROMIS). Global health, anxiety, and fatigue domains were measured in all; mobility was measured in children; and sleep-related impairment was measured in adults. Linear mixed effects models were used to evaluate HRQOL responsiveness to changes in disease status. Results: A total of 469 children and 1146 adults with PROMIS scores were included in the analysis. HRQOL improved over time in nearly all domains, though group-level changes were modest. Edema was most consistently associated with worse HRQOL across domains among children and adults. A greater number of symptoms also predicted worse HRQOL in all domains. Sex, age, obesity, and serum albumin were associated with some HRQOL domains. The estimated glomerular filtration rate (eGFR) was only associated with fatigue and adult physical health; proteinuria was not associated with any HRQOL domain in adjusted models. Conclusion: HRQOL measures were responsive to changes in disease activity, as indicated by edema. HRQOL over time was not predicted by laboratory-based markers of disease. Patient-reported edema and number of symptoms were the strongest predictors of HRQOL, highlighting the importance of the patient experience in glomerular disease. HRQOL outcomes inform understanding of the patient experience for children and adults with glomerular diseases