The Turbulence Power Spectrum in Optically Thick Interstellar Clouds

The Fourier power spectrum is one of the most widely used statistical tools to analyze the nature of magnetohydrodynamic turbulence in the interstellar medium. Lazarian & Pogosyan (2004) predicted that the spectral slope should saturate to -3 for an optically thick medium and many observations exist in support of their prediction. However, there have not been any numerical studies to-date testing these results. We analyze the spatial power spectrum of MHD simulations with a wide range of sonic and Alfv\'enic Mach numbers, which include radiative transfer effects of the $^{13}$CO transition. We confirm numerically the predictions of Lazarian & Pogosyan (2004) that the spectral slope of line intensity maps of an optically thick medium saturates to -3. Furthermore, for very optically thin supersonic CO gas, where the density or CO abundance values are too low to excite emission in all but the densest shock compressed gas, we find that the spectral slope is shallower than expected from the column density. Finally, we find that mixed optically thin/thick CO gas, which has average optical depths on order of unity, shows mixed behavior: for super-Alfv\'enic turbulence, the integrated intensity power spectral slopes generally follow the same trend with sonic Mach number as the true column density power spectrum slopes. However, for sub-Alfv\'enic turbulence the spectral slopes are steeper with values near -3 which are similar to the very optically thick regime.Comment: accepted to Ap

HI Power Spectra and the Turbulent ISM of Dwarf Irregular Galaxies

HI spatial power spectra (PS) were determined for a sample of 24 nearby dwarf irregular galaxies selected from the LITTLE THINGS (Local Irregulars That Trace Luminosity Extremes - The HI Nearby Galaxy Survey) sample. The two-dimensional (2D) power spectral indices asymptotically become a constant for each galaxy when a significant part of the line profile is integrated. For narrow channel maps, the PS become shallower as the channel width decreases, and this shallowing trend continues to our single channel maps. This implies that even the highest velocity resolution of 1.8 km/s is not smaller than the thermal dispersion of the coolest, widespread HI component. The one-dimensional PS of azimuthal profiles at different radii suggest that the shallower PS for narrower channel width is mainly contributed by the inner disks, which indicates that the inner disks have proportionally more cooler HI than the outer disks. Galaxies with lower luminosity (M_B > -14.5 mag) and star formation rate (SFR, log(SFR (M\odot/yr)) < -2.1) tend to have steeper PS, which implies that the HI line-of-sight depths can be comparable with the radial length scales in low mass galaxies. A lack of a correlation between the inertial-range spectral indices and SFR surface density implies that either non-stellar power sources are playing a fundamental role in driving the interstellar medium (ISM) turbulent structure, or the nonlinear development of turbulent structures has little to do with the driving sources.Comment: 16 pages, 9 figures, 2 tables. Accepted by Ap

Changes in synaptic transmission and protein expression in the brains of adult offspring after prenatal inhibition of the kynurenine pathway

During early brain development, N-methyl-d-aspartate (NMDA) receptors are involved in cell migration, neuritogenesis, axon guidance and synapse formation, but the mechanisms which regulate NMDA receptor density and function remain unclear. The kynurenine pathway of tryptophan metabolism includes an agonist (quinolinic acid) and an antagonist (kynurenic acid) at NMDA receptors and we have previously shown that inhibition of the pathway using the kynurenine-3-monoxygenase inhibitor Ro61-8048 in late gestation produces rapid changes in protein expression in the embryos and effects on synaptic transmission lasting until postnatal day 21 (P21). The present study sought to determine whether any of these effects are maintained into adulthood. After prenatal injections of Ro61-8048 the litter was allowed to develop to P60 when some offspring were euthanized and the brains removed for examination. Analysis of protein expression by Western blotting revealed significantly reduced expression of the GluN2A subunit (32%) and the morphogenetic protein sonic hedgehog (31%), with a 29% increase in the expression of doublecortin, a protein associated with neurogenesis. No changes were seen in mRNA abundance using quantitative real-time polymerase chain reaction. Neuronal excitability was normal in the CA1 region of hippocampal slices but paired-pulse stimulation revealed less inhibition at short interpulse intervals. The amount of long-term potentiation was decreased by 49% in treated pups and recovery after low-frequency stimulation was delayed. The results not only strengthen the view that basal, constitutive kynurenine metabolism is involved in normal brain development, but also show that changes induced prenatally can affect the brains of adult offspring and those changes are quite different from those seen previously at weaning (P21). Those changes may be mediated by altered expression of NMDAR subunits and sonic hedgehog

Extending Velocity Channel Analysis for Studying Turbulence Anisotropies

We extend the velocity channel analysis (VCA), introduced by Lazarian & Pogosyan, of the intensity fluctuations in the velocity slices of position-position-velocity (PPV) spectroscopic data from Doppler broadened lines to study statistical anisotropy of the underlying velocity and density that arises in a turbulent medium from the presence of magnetic field. In particular, we study analytically how the anisotropy of the intensity correlation in the channel maps changes with the thickness of velocity channels. In agreement with the earlier VCA studies we find that the anisotropy in the thick channels reflects the anisotropy of the density field, while the relative contribution of density and velocity fluctuations to the thin velocity channels depends on the density spectral slope. We show that the anisotropies arising from Alfven, slow and fast magnetohydrodynamical modes are different, in particular, the anisotropy in PPV created by fast modes is opposite to that created by Alfven and slow modes, and this can be used to separate their contributions. We successfully compare our results with the recent numerical study of the PPV anisotropies measured with synthetic observations. We also extend our study to the medium with self-absorption as well as to the case of absorption lines. In addition, we demonstrate how the studies of anisotropy can be performed using interferometers.Comment: 36 pages, 16 figures, Accepted to MNRAS, minor changes to match the accepted versio

Altered hippocampal plasticity by prenatal kynurenine administration, kynurenine-3-monoxygenase (KMO) deletion or galantamine

Glutamate receptors sensitive to N-methyl-d-aspartate (NMDA) are involved in embryonic brain development but their activity may be modulated by the kynurenine pathway of tryptophan metabolism which includes an agonist (quinolinic acid) and an antagonist (kynurenic acid) at these receptors. Our previous work has shown that prenatal inhibition of the pathway produces abnormalities of brain development. In the present study kynurenine and probenecid (both 100 mg/kg, doses known to increase kynurenic acid levels in the brain) were administered to female Wistar rats on embryonic days E14, E16 and E18 of gestation and the litter was allowed to develop to post-natal day P60. Western blotting revealed no changes in hippocampal expression of several proteins previously found to be altered by inhibition of the kynurenine pathway including the NMDA receptor subunits GluN1, GluN2A and GluN2B, as well as doublecortin, Proliferating Cell Nuclear Antigen (PCNA), sonic hedgehog and unco-ordinated (unc)-5H1 and 5H3. Mice lacking the enzyme kynurenine-3-monoxygenase (KMO) also showed no changes in hippocampal expression of several of these proteins or the 70-kDa and 100-kDa variants of Disrupted in Schizophrenia-1 (DISC1). Electrical excitability of pyramidal neurons in the CA1 region of hippocampal slices was unchanged, as was paired-pulse facilitation and inhibition. Long-term potentiation was decreased in the kynurenine-treated rats and in the KMO(−/−) mice, but galantamine reversed this effect in the presence of nicotinic receptor antagonists, consistent with evidence that it can potentiate glutamate at NMDA receptors. It is concluded that interference with the kynurenine pathway in utero can have lasting effects on brain function of the offspring, implying that the kynurenine pathway is involved in the regulation of early brain development

Integrated Ocean Drilling Program Expedition 317/319 Scientific Prospectus: Pacific Equatorial Age Transect

As the world's largest ocean, the Pacific is intricately linked to major changes in the global climate system. Throughout the Cenozoic, Pacific plate motion has had a northward component. Thus, the Pacific is unique in that the thick sediment bulge of biogenic-rich deposits from the currently narrowly focused zone of equatorial upwelling is slowly moving away from the Equator. Hence, older sections are not deeply buried and can be recovered by drilling. Previous drilling in this area during Ocean Drilling Program (ODP) Legs 138 and 199 was remarkably successful in giving us new insights into the workings of the climate and carbon system, productivity changes across the zone of divergence, time-dependent calcium carbonate dissolution, bio- and magnetostratigraphy, the location of the Intertropical Convergence Zone (ITCZ), and evolutionary patterns for times of climatic change and upheaval. Together with older Deep Sea Drilling Project drilling in the eastern equatorial Pacific, both legs also helped to delineate the position of the paleoequator and variations in sediment thickness from ~150°W to 110°W.The Pacific equatorial age transect (PEAT) science program is based on Integrated Ocean Drilling Program (IODP) Proposal 626 and consists of Expeditions 317 and 319, grouped into one science program. The goal is to recover a continuous Cenozoic record of the equatorial Pacific by drilling at the paleoposition of the Equator at successive crustal ages on the Pacific plate. Records collected from Expeditions 317 and 319 are to be joined with records of previous drilling during ODP Legs 138 and 199 to make a complete equatorial Pacific record from 0 to 55 Ma. Previously, ODP Legs 138 and 199 were designed as transects across the paleoequator in order to study the changing patterns of sediment deposition across equatorial regions at critical time intervals. As we have gained more information about the past movement of plates and when in Earth's history "critical" climate events took place, it becomes possible to drill an age transect ("flow-line") along the position of the Pacific paleoequator. The goal of this transect is to target important time slices where calcareous sediments have been best preserved and the sedimentary archive will allow us to reconstruct past climatic and tectonic conditions. Leg 199 enhanced our understanding of extreme changes of the calcium carbonate compensation depth (CCD) across major geological boundaries during the last 55 m.y. A very shallow CCD during most of the Paleogene makes it difficult to obtain well-preserved sediments during these stratigraphic intervals, but the strategy of site locations for the current two expeditions is designed to occupy the most promising sites and to obtain a unique sedimentary biogenic sediment archive for time periods just after the Paleocene/Eocene boundary event, Eocene cooling, the Eocene–Oligocene transition, the "one cold pole" Oligocene, the Oligocene–Miocene transition, and the Miocene. These new cores and data will significantly contribute to the objectives of the IODP Extreme Climates Initiative and will provide material that the previous legs were not able to recover.For logistical reasons, the PEAT science program is composed of two expeditions but is being implemented as a single science program to best achieve the overall objectives of Proposal 626. Participants on both expeditions (as well as approved shore-based scientists) will comprise a single science party with equal access to data and materials from both cruises. Sampling aboard the ship will be minimal, and the bulk of the sampling will be completed postcruise.The operational plan is to occupy eight sites along the age transect with the goal of recovering as complete a sedimentary succession as possible. This will probably require three holes to be cored at each site with wireline logging operations in one hole. Basement will be tagged in at least one of the holes. Expedition 317 will be directed primarily to sample the Neogene sites (proposed Sites PEAT-2C, 6C, and 7C, in priority order). The second expedition (319) will primarily sample the Paleogene sites (proposed Sites PEAT-1C, 3C, 4C, and possibly 5C, in priority order)