Characterization of Language Cortex Activity During Speech Production and Perception

Millions of people around the world suffer from severe neuromuscular disorders such as spinal cord injury, cerebral palsy, amyotrophic lateral sclerosis (ALS), and others. Many of these individuals cannot perform daily tasks without assistance and depend on caregivers, which adversely impacts their quality of life. A Brain-Computer Interface (BCI) is technology that aims to give these people the ability to interact with their environment and communicate with the outside world. Many recent studies have attempted to decode spoken and imagined speech directly from brain signals toward the development of a natural-speech BCI. However, the current progress has not reached practical application. An approach to improve the performance of this technology is to better understand the underlying speech processes in the brain for further optimization of existing models. In order to extend research in this direction, this thesis aims to characterize and decode the auditory and articulatory features from the motor cortex using the electrocorticogram (ECoG). Consonants were chosen as auditory representations, and both places of articulation and manners of articulation were chosen as articulatory representations. The auditory and articulatory representations were decoded at different time lags with respect to the speech onset to determine optimal temporal decoding parameters. In addition, this work explores the role of the temporal lobe during speech production directly from ECoG signals. A novel decoding model using temporal lobe activity was developed to predict a spectral representation of the speech envelope during speech production. This new knowledge may be used to enhance existing speech-based BCI systems, which will offer a more natural communication modality. In addition, the work contributes to the field of speech neurophysiology by providing a better understanding of speech processes in the brain

Characterization and Decoding of Speech Representations From the Electrocorticogram

Millions of people worldwide suffer from various neuromuscular disorders such as amyotrophic lateral sclerosis (ALS), brainstem stroke, muscular dystrophy, cerebral palsy, and others, which adversely affect the neural control of muscles or the muscles themselves. The patients who are the most severely affected lose all voluntary muscle control and are completely locked-in, i.e., they are unable to communicate with the outside world in any manner. In the direction of developing neuro-rehabilitation techniques for these patients, several studies have used brain signals related to mental imagery and attention in order to control an external device, a technology known as a brain-computer interface (BCI). Some recent studies have also attempted to decode various aspects of spoken language, imagined language, or perceived speech directly from brain signals. In order to extend research in this direction, this dissertation aims to characterize and decode various speech representations popularly used in speech recognition systems directly from brain activity, specifically the electrocorticogram (ECoG). The speech representations studied in this dissertation range from simple features such as the speech power and the fundamental frequency (pitch), to complex representations such as the linear prediction coding and mel frequency cepstral coefficients. These decoded speech representations may eventually be used to enhance existing speech recognition systems or to reconstruct intended or imagined speech directly from brain activity. This research will ultimately pave the way for an ECoG-based neural speech prosthesis, which will offer a more natural communication channel for individuals who have lost the ability to speak normally

Neurolinguistics Research Advancing Development of a Direct-Speech Brain-Computer Interface

A direct-speech brain-computer interface (DS-BCI) acquires neural signals corresponding to imagined speech, then processes and decodes these signals to produce a linguistic output in the form of phonemes, words, or sentences. Recent research has shown the potential of neurolinguistics to enhance decoding approaches to imagined speech with the inclusion of semantics and phonology in experimental procedures. As neurolinguistics research findings are beginning to be incorporated within the scope of DS-BCI research, it is our view that a thorough understanding of imagined speech, and its relationship with overt speech, must be considered an integral feature of research in this field. With a focus on imagined speech, we provide a review of the most important neurolinguistics research informing the field of DS-BCI and suggest how this research may be utilized to improve current experimental protocols and decoding techniques. Our review of the literature supports a cross-disciplinary approach to DS-BCI research, in which neurolinguistics concepts and methods are utilized to aid development of a naturalistic mode of communication. : Cognitive Neuroscience; Computer Science; Hardware Interface Subject Areas: Cognitive Neuroscience, Computer Science, Hardware Interfac

Real-Time Decoding of Brain Responses to Visuospatial Attention Using 7T fMRI

Brain-Computer interface technologies mean to create new communication channels between our mind and our environment, independent of the motor system, by detecting and classifying self regulation of local brain activity. BCIs can provide patients with severe paralysis a means to communicate and to live more independent lives. There has been a growing interest in using invasive recordings for BCI to improve the signal quality. This also potentially gives access to new control strategies previously inaccessible by non-invasive methods. However, before surgery, the best implantation site needs to be determined. The blood-oxygen-level dependent signal changes measured with fMRI have been shown to agree well spatially with those found with invasive electrodes, and are the best option for pre-surgical localization. We show, using real-time fMRI at 7T, that eye movement-independent visuospatial attention can be used as a reliable control strategy for BCIs. At this field strength even subtle signal changes can be detected in single trials thanks to the high contrast-to-noise ratio. A group of healthy subjects were instructed to move their attention between three (two peripheral and one central) spatial target regions while keeping their gaze fixated at the center. The activated regions were first located and thereafter the subjects were given real-time feedback based on the activity in these regions. All subjects managed to regulate local brain areas without training, which suggests that visuospatial attention is a promising new target for intracranial BCI. ECoG data recorded from one epilepsy patient showed that local changes in gamma-power can be used to separate the three classes

ECoG high gamma activity reveals distinct cortical representations of lyrics passages, harmonic and timbre-related changes in a rock song

Listening to music moves our minds and moods, stirring interest in its neural underpinnings. A multitude of compositional features drives the appeal of natural music. How such original music, where a composer's opus is not manipulated for experimental purposes, engages a listener's brain has not been studied until recently. Here, we report an in-depth analysis of two electrocorticographic (ECoG) data sets obtained over the left hemisphere in ten patients during presentation of either a rock song or a read-out narrative. First, the time courses of five acoustic features (intensity, presence/absence of vocals with lyrics, spectral centroid, harmonic change, and pulse clarity) were extracted from the audio tracks and found to be correlated with each other to varying degrees. In a second step, we uncovered the specific impact of each musical feature on ECoG high-gamma power (70–170 Hz) by calculating partial correlations to remove the influence of the other four features. In the music condition, the onset and offset of vocal lyrics in ongoing instrumental music was consistently identified within the group as the dominant driver for ECoG high-gamma power changes over temporal auditory areas, while concurrently subject-individual activation spots were identified for sound intensity, timbral, and harmonic features. The distinct cortical activations to vocal speech-related content embedded in instrumental music directly demonstrate that song integrated in instrumental music represents a distinct dimension in complex music. In contrast, in the speech condition, the full sound envelope was reflected in the high gamma response rather than the onset or offset of the vocal lyrics. This demonstrates how the contributions of stimulus features that modulate the brain response differ across the two examples of a full-length natural stimulus, which suggests a context-dependent feature selection in the processing of complex auditory stimuli

Brain-Computer Interfaces in Medicine

Brain-computer interfaces (BCIs) acquire brain signals, analyze them, and translate them into commands that are relayed to output devices that carry out desired actions. BCIs do not use normal neuromuscular output pathways. The main goal of BCI is to replace or restore useful function to people disabled by neuromuscular disorders such as amyotrophic lateral sclerosis, cerebral palsy, stroke, or spinal cord injury. From initial demonstrations of electroenceph-alography-based spelling and single-neuron-based device control, researchers have gone on to use electroenceph-alographic, intracortical, electrocorticographic, and other brain signals for increasingly complex control of cursors, robotic arms, prostheses, wheelchairs, and other devices. Brain-computer interfaces may also prove useful for rehabilitation after stroke and for other disorders. In the future, they might augment the performance of surgeons or other medical professionals. Brain-computer interface technology is the focus of a rapidly growing research and development enterprise that is greatly exciting scientists, engineers, clinicians, and the public in general. Its future achievements will depend on advances in 3 crucial areas. Brain-computer interfaces need signal-acquisition hardware that is convenient, portable, safe, and able to function in all environments. Brain-computer interface systems need to be validated in long-term studies of real-world use by people with severe disabilities, and effective and viable models for their widespread dissemination must be implemented. Finally, the day-to-day and moment-to-moment reliability of BCI performance must be improved so that it approaches the reliability of natural muscle-based function

Speech Processes for Brain-Computer Interfaces

Speech interfaces have become widely used and are integrated in many applications and devices. However, speech interfaces require the user to produce intelligible speech, which might be hindered by loud environments, concern to bother bystanders or the general in- ability to produce speech due to disabilities. Decoding a usera s imagined speech instead of actual speech would solve this problem. Such a Brain-Computer Interface (BCI) based on imagined speech would enable fast and natural communication without the need to actually speak out loud. These interfaces could provide a voice to otherwise mute people. This dissertation investigates BCIs based on speech processes using functional Near In- frared Spectroscopy (fNIRS) and Electrocorticography (ECoG), two brain activity imaging modalities on opposing ends of an invasiveness scale. Brain activity data have low signal- to-noise ratio and complex spatio-temporal and spectral coherence. To analyze these data, techniques from the areas of machine learning, neuroscience and Automatic Speech Recog- nition are combined in this dissertation to facilitate robust classification of detailed speech processes while simultaneously illustrating the underlying neural processes. fNIRS is an imaging modality based on cerebral blood flow. It only requires affordable hardware and can be set up within minutes in a day-to-day environment. Therefore, it is ideally suited for convenient user interfaces. However, the hemodynamic processes measured by fNIRS are slow in nature and the technology therefore offers poor temporal resolution. We investigate speech in fNIRS and demonstrate classification of speech processes for BCIs based on fNIRS. ECoG provides ideal signal properties by invasively measuring electrical potentials artifact- free directly on the brain surface. High spatial resolution and temporal resolution down to millisecond sampling provide localized information with accurate enough timing to capture the fast process underlying speech production. This dissertation presents the Brain-to- Text system, which harnesses automatic speech recognition technology to decode a textual representation of continuous speech from ECoG. This could allow to compose messages or to issue commands through a BCI. While the decoding of a textual representation is unparalleled for device control and typing, direct communication is even more natural if the full expressive power of speech - including emphasis and prosody - could be provided. For this purpose, a second system is presented, which directly synthesizes neural signals into audible speech, which could enable conversation with friends and family through a BCI. Up to now, both systems, the Brain-to-Text and synthesis system are operating on audibly produced speech. To bridge the gap to the final frontier of neural prostheses based on imagined speech processes, we investigate the differences between audibly produced and imagined speech and present first results towards BCI from imagined speech processes. This dissertation demonstrates the usage of speech processes as a paradigm for BCI for the first time. Speech processes offer a fast and natural interaction paradigm which will help patients and healthy users alike to communicate with computers and with friends and family efficiently through BCIs

Neural correlates of visual–spatial attention in electrocorticographic signals in humans

Attention is a cognitive selection mechanism that allocates the limited processing resources of the brain to the sensory streams most relevant to our immediate goals, thereby enhancing responsiveness and behavioral performance. The underlying neural mechanisms of orienting attention are distributed across a widespread cortical network. While aspects of this network have been extensively studied, details about the electrophysiological dynamics of this network are scarce. In this study, we investigated attentional networks using electrocorticographic (ECoG) recordings from the surface of the brain, which combine broad spatial coverage with high temporal resolution, in five human subjects. ECoG was recorded when subjects covertly attended to a spatial location and responded to contrast changes in the presence of distractors in a modified Posner cueing task. ECoG amplitudes in the alpha, beta, and gamma bands identified neural changes associated with covert attention and motor preparation/execution in the different stages of the task. The results show that attentional engagement was primarily associated with ECoG activity in the visual, prefrontal, premotor, and parietal cortices. Motor preparation/execution was associated with ECoG activity in premotor/sensorimotor cortices. In summary, our results illustrate rich and distributed cortical dynamics that are associated with orienting attention and the subsequent motor preparation and execution. These findings are largely consistent with and expand on primate studies using intracortical recordings and human functional neuroimaging studies

Understanding and Decoding Imagined Speech using Electrocorticographic Recordings in Humans

Certain brain disorders, resulting from brainstem infarcts, traumatic brain injury, stroke and amyotrophic lateral sclerosis, limit verbal communication despite the patient being fully aware. People that cannot communicate due to neurological disorders would benefit from a system that can infer internal speech directly from brain signals. Investigating how the human cortex encodes imagined speech remains a difficult challenge, due to the lack of behavioral and observable measures. As a consequence, the fine temporal properties of speech cannot be synchronized precisely with brain signals during internal subjective experiences, like imagined speech. This thesis aims at understanding and decoding the neural correlates of imagined speech (also called internal speech or covert speech), for targeting speech neuroprostheses. In this exploratory work, various imagined speech features, such as acoustic sound features, phonetic representations, and individual words were investigated and decoded from electrocorticographic signals recorded in epileptic patients in three different studies. This recording technique provides high spatiotemporal resolution, via electrodes placed beneath the skull, but without penetrating the cortex In the first study, we reconstructed continuous spectrotemporal acoustic features from brain signals recorded during imagined speech using cross-condition linear regression. Using this technique, we showed that significant acoustic features of imagined speech could be reconstructed in seven patients. In the second study, we decoded continuous phoneme sequences from brain signals recorded during imagined speech using hidden Markov models. This technique allowed incorporating a language model that defined phoneme transitions probabilities. In this preliminary study, decoding accuracy was significant across eight phonemes in one patients. In the third study, we classified individual words from brain signals recorded during an imagined speech word repetition task, using support-vector machines. To account for temporal irregularities during speech production, we introduced a non-linear time alignment into the classification framework. Classification accuracy was significant across five patients. In order to compare speech representations across conditions and integrate imagined speech into the general speech network, we investigated imagined speech in parallel with overt speech production and/or speech perception. Results shared across the three studies showed partial overlapping between imagined speech and speech perception/production in speech areas, such as superior temporal lobe, anterior frontal gyrus and sensorimotor cortex. In an attempt to understanding higher-level cognitive processing of auditory processes, we also investigated the neural encoding of acoustic features during music imagery using linear regression. Despite this study was not directly related to speech representations, it provided a unique opportunity to quantitatively study features of inner subjective experiences, similar to speech imagery. These studies demonstrated the potential of using predictive models for basic decoding of speech features. Despite low performance, results show the feasibility for direct decoding of natural speech. In this respect, we highlighted numerous challenges that were encountered, and suggested new avenues to improve performances