The Stolen Children: Their Stories: Aboriginal Child Removal Policy and Consequences

From 1910 to 1970, the Australian government embarked on a policy of Aboriginal child removal which sought to acculturate Aborigine children of mixed descent into white Australian society. The 1997 report, Bringing Them Home, records the individual testimonies of hundreds of victims of child removal and argues that prolonged familial separation caused irreparable damage to native Australian communities. Carmel Bird’s edited version of the report, The Stolen Children: Their Stories, was published in 1998 to disseminate the report\u27s findings and advocate for legislative action. Her book includes the stories of seventeen individuals and responses to the original report from prominent politicians and historians

Molecular Imaging of Inflammation in Atherosclerosis

Acute rupture of vulnerable plaques frequently leads to myocardial infarction and stroke. Within the last decades, several cellular and molecular players have been identified that promote atherosclerotic lesion formation, maturation and plaque rupture. It is now widely recognized that inflammation of the vessel wall and distinct leukocyte subsets are involved throughout all phases of atherosclerotic lesion development. The mechanisms that render a stable plaque unstable and prone to rupture, however, remain unknown and the identification of the vulnerable plaque remains a major challenge in cardiovascular medicine. Imaging technologies used in the clinic offer minimal information about the underlying biology and potential risk for rupture. New imaging technologies are therefore being developed, and in the preclinical setting have enabled new and dynamic insights into the vessel wall for a better understanding of this complex disease. Molecular imaging has the potential to track biological processes, such as the activity of cellular and molecular biomarkers in vivo and over time. Similarly, novel imaging technologies specifically detect effects of therapies that aim to stabilize vulnerable plaques and silence vascular inflammation. Here we will review the potential of established and new molecular imaging technologies in the setting of atherosclerosis, and discuss the cumbersome steps required for translating molecular imaging approaches into the clinic

L’Imitation de Flaubert ou les Mystères de l’homme athée

L’homme authentiquement religieux, celui pour qui l’exemple du dieu ne survint jadis qu’à dessein protreptique, ne peut sans doute trouver satisfaction dans la seule foi. Son élément propre ne peut être que l’action : il excelle au faire. L’action par excellence qui relie l’homme à ce qui l’excède infiniment est l’imitation. Celui qui imite le dieu et qui s’engage dans la voie divine n’est ni celui qui seulement sait, fût-ce par science intime, ni celui qui croit pour ensuite transmettre à a..

L’Imitation de Flaubert ou les Mystères de l’homme athée

L’homme authentiquement religieux, celui pour qui l’exemple du dieu ne survint jadis qu’à dessein protreptique, ne peut sans doute trouver satisfaction dans la seule foi. Son élément propre ne peut être que l’action : il excelle au faire. L’action par excellence qui relie l’homme à ce qui l’excède infiniment est l’imitation. Celui qui imite le dieu et qui s’engage dans la voie divine n’est ni celui qui seulement sait, fût-ce par science intime, ni celui qui croit pour ensuite transmettre à a..

Using the intervention mapping protocol to reduce European preschoolers' sedentary behavior, an application to the ToyBox-study

Background: High levels of sedentary behavior are often measured in preschoolers, but only a few interventions have been developed to counteract this. Furthermore, detailed descriptions of interventions in preschoolers targeting different forms of sedentary behavior could not be located in the literature. The aim of the present paper was to describe the different steps of the Intervention Mapping Protocol used towards the development of an intervention component of the ToyBox-study focusing on decreasing preschoolers' sedentary behavior. The ToyBox-study focuses on the prevention of overweight in 4- to 6-year-old children by implementing a multi-component kindergarten-based intervention with family involvement in six different European countries. Methods: Applying the Intervention Mapping Protocol, six different steps were systematically completed for the structured planning and development of the intervention. A literature search and results from focus groups with parents/caregivers and kindergarten teachers were used as a guide during the development of the intervention and the intervention materials. Results: The application of the different steps in the Intervention Mapping Protocol resulted in the creation of matrices of change objectives, followed by the selection of practical applications for five different intervention tools that could be used at the individual level of the preschool child, at the interpersonal level (i.e., parents/caregivers) and at the organizational level (i.e., kindergarten teachers). No cultural differences regarding preschoolers' sedentary behavior were identified between the participating countries during the focus groups, so cultural and local adaptations of the intervention materials were not necessary to improve the adoption and implementation of the intervention. Conclusions: A systematic and evidence-based approach was used for the development of this kindergarten-based family-involved intervention targeting preschoolers, with the inclusion of parental involvement. The application of the Intervention Mapping Protocol may lead to the development of more effective interventions. The detailed intervention matrices that were developed as part of the ToyBox-study can be used by other researchers as an aid in order to avoid repetitive work for the design of similar interventions

Emotional Voice Areas: Anatomic Location, Functional Properties, and Structural Connections Revealed by Combined fMRI/DTI

We determined the location, functional response profile, and structural fiber connections of auditory areas with voice- and emotion-sensitive activity using functional magnetic resonance imaging (fMRI) and diffusion tensor imaging. Bilateral regions responding to emotional voices were consistently found in the superior temporal gyrus, posterolateral to the primary auditory cortex. Event-related fMRI showed stronger responses in these areas to voices-expressing anger, sadness, joy, and relief, relative to voices with neutral prosody. Their neural responses were primarily driven by prosodic arousal, irrespective of valence. Probabilistic fiber tracking revealed direct structural connections of these "emotional voice areas” (EVA) with ipsilateral medial geniculate body, which is the major input source of early auditory cortex, as well as with the ipsilateral inferior frontal gyrus (IFG) and inferior parietal lobe (IPL). In addition, vocal emotions (compared with neutral prosody) increased the functional coupling of EVA with the ipsilateral IFG but not IPL. These results provide new insights into the neural architecture of the human voice processing system and support a crucial involvement of IFG in the recognition of vocal emotions, whereas IPL may subserve distinct auditory spatial functions, consistent with distinct anatomical substrates for the processing of "how” and "where” information within the auditory pathway