A survey on computational intelligence approaches for predictive modeling in prostate cancer

Predictive modeling in medicine involves the development of computational models which are capable of analysing large amounts of data in order to predict healthcare outcomes for individual patients. Computational intelligence approaches are suitable when the data to be modelled are too complex forconventional statistical techniques to process quickly and eciently. These advanced approaches are based on mathematical models that have been especially developed for dealing with the uncertainty and imprecision which is typically found in clinical and biological datasets. This paper provides a survey of recent work on computational intelligence approaches that have been applied to prostate cancer predictive modeling, and considers the challenges which need to be addressed. In particular, the paper considers a broad definition of computational intelligence which includes evolutionary algorithms (also known asmetaheuristic optimisation, nature inspired optimisation algorithms), Artificial Neural Networks, Deep Learning, Fuzzy based approaches, and hybrids of these,as well as Bayesian based approaches, and Markov models. Metaheuristic optimisation approaches, such as the Ant Colony Optimisation, Particle Swarm Optimisation, and Artificial Immune Network have been utilised for optimising the performance of prostate cancer predictive models, and the suitability of these approaches are discussed

Preferences in Case-Based Reasoning

Case-based reasoning (CBR) is a well-established problem solving paradigm that has been used in a wide range of real-world applications. Despite its great practical success, work on the theoretical foundations of CBR is still under way, and a coherent and universally applicable methodological framework is yet missing. The absence of such a framework inspired the motivation for the work developed in this thesis. Drawing on recent research on preference handling in Artificial Intelligence and related fields, the goal of this work is to develop a well theoretically-founded framework on the basis of formal concepts and methods for knowledge representation and reasoning with preferences

Generalized Probabilistic Reasoning and Empirical Studies on Computational Efficiency and Scalability

Expert Systems are tools that can be very useful for diagnostic purposes, however current methods of storing and reasoning with knowledge have significant limitations. One set of limitations involves how to store and manipulate uncertain knowledge: much of the knowledge we are dealing with has some degree of uncertainty. These limitations include lack of complete information, not being able to model cyclic information and limitations on the size and complexity of the problems to be solved. If expert systems are ever going to be able to tackle significant real world problems then these deficiencies must be corrected. This paper describes a new method of reasoning with uncertain knowledge which improves the computational efficiency as well as scalability over current methods. The cornerstone of this method involves incorporating and exploiting information about the structure of the knowledge representation to reduce the problem size and complexity. Additionally, a new knowledge representation is discussed that will further increase the capability of expert systems to model a wider variety of real world problems. Finally, benchmarking studies of the new algorithm against the old have led to insights into the graph structure of very large knowledge bases