A coarse-to-fine approach to prostate boundary segmentation in ultrasound images

BACKGROUND: In this paper a novel method for prostate segmentation in transrectal ultrasound images is presented. METHODS: A segmentation procedure consisting of four main stages is proposed. In the first stage, a locally adaptive contrast enhancement method is used to generate a well-contrasted image. In the second stage, this enhanced image is thresholded to extract an area containing the prostate (or large portions of it). Morphological operators are then applied to obtain a point inside of this area. Afterwards, a Kalman estimator is employed to distinguish the boundary from irrelevant parts (usually caused by shadow) and generate a coarsely segmented version of the prostate. In the third stage, dilation and erosion operators are applied to extract outer and inner boundaries from the coarsely estimated version. Consequently, fuzzy membership functions describing regional and gray-level information are employed to selectively enhance the contrast within the prostate region. In the last stage, the prostate boundary is extracted using strong edges obtained from selectively enhanced image and information from the vicinity of the coarse estimation. RESULTS: A total average similarity of 98.76%(± 0.68) with gold standards was achieved. CONCLUSION: The proposed approach represents a robust and accurate approach to prostate segmentation

A survey on computational intelligence approaches for predictive modeling in prostate cancer

Predictive modeling in medicine involves the development of computational models which are capable of analysing large amounts of data in order to predict healthcare outcomes for individual patients. Computational intelligence approaches are suitable when the data to be modelled are too complex forconventional statistical techniques to process quickly and eciently. These advanced approaches are based on mathematical models that have been especially developed for dealing with the uncertainty and imprecision which is typically found in clinical and biological datasets. This paper provides a survey of recent work on computational intelligence approaches that have been applied to prostate cancer predictive modeling, and considers the challenges which need to be addressed. In particular, the paper considers a broad definition of computational intelligence which includes evolutionary algorithms (also known asmetaheuristic optimisation, nature inspired optimisation algorithms), Artificial Neural Networks, Deep Learning, Fuzzy based approaches, and hybrids of these,as well as Bayesian based approaches, and Markov models. Metaheuristic optimisation approaches, such as the Ant Colony Optimisation, Particle Swarm Optimisation, and Artificial Immune Network have been utilised for optimising the performance of prostate cancer predictive models, and the suitability of these approaches are discussed

Artificial Intelligence-based Motion Tracking in Cancer Radiotherapy: A Review

Radiotherapy aims to deliver a prescribed dose to the tumor while sparing neighboring organs at risk (OARs). Increasingly complex treatment techniques such as volumetric modulated arc therapy (VMAT), stereotactic radiosurgery (SRS), stereotactic body radiotherapy (SBRT), and proton therapy have been developed to deliver doses more precisely to the target. While such technologies have improved dose delivery, the implementation of intra-fraction motion management to verify tumor position at the time of treatment has become increasingly relevant. Recently, artificial intelligence (AI) has demonstrated great potential for real-time tracking of tumors during treatment. However, AI-based motion management faces several challenges including bias in training data, poor transparency, difficult data collection, complex workflows and quality assurance, and limited sample sizes. This review serves to present the AI algorithms used for chest, abdomen, and pelvic tumor motion management/tracking for radiotherapy and provide a literature summary on the topic. We will also discuss the limitations of these algorithms and propose potential improvements.Comment: 36 pages, 5 Figures, 4 Table

A Fully Automatic Segmentation Method for Breast Ultrasound Images

Breast cancer is the second leading cause of death of women worldwide. Accurate lesion boundary detection is important for breast cancer diagnosis. Since many crucial features for discriminating benign and malignant lesions are based on the contour, shape, and texture of the lesion, an accurate segmentation method is essential for a successful diagnosis. Ultrasound is an effective screening tool and primarily useful for differentiating benign and malignant lesions. However, due to inherent speckle noise and low contrast of breast ultrasound imaging, automatic lesion segmentation is still a challenging task. This research focuses on developing a novel, effective, and fully automatic lesion segmentation method for breast ultrasound images. By incorporating empirical domain knowledge of breast structure, a region of interest is generated. Then, a novel enhancement algorithm (using a novel phase feature) and a newly developed neutrosophic clustering method are developed to detect the precise lesion boundary. Neutrosophy is a recently introduced branch of philosophy that deals with paradoxes, contradictions, antitheses, and antinomies. When neutrosophy is used to segment images with vague boundaries, its unique ability to deal with uncertainty is brought to bear. In this work, we apply neutrosophy to breast ultrasound image segmentation and propose a new clustering method named neutrosophic l-means. We compare the proposed method with traditional fuzzy c-means clustering and three other well-developed segmentation methods for breast ultrasound images, using the same database. Both accuracy and time complexity are analyzed. The proposed method achieves the best accuracy (TP rate is 94.36%, FP rate is 8.08%, and similarity rate is 87.39%) with a fairly rapid processing speed (about 20 seconds). Sensitivity analysis shows the robustness of the proposed method as well. Cases with multiple-lesions and severe shadowing effect (shadow areas having similar intensity values of the lesion and tightly connected with the lesion) are not included in this study

Recent Advances in Machine Learning Applied to Ultrasound Imaging

Machine learning (ML) methods are pervading an increasing number of fields of application because of their capacity to effectively solve a wide variety of challenging problems. The employment of ML techniques in ultrasound imaging applications started several years ago but the scientific interest in this issue has increased exponentially in the last few years. The present work reviews the most recent (2019 onwards) implementations of machine learning techniques for two of the most popular ultrasound imaging fields, medical diagnostics and non-destructive evaluation. The former, which covers the major part of the review, was analyzed by classifying studies according to the human organ investigated and the methodology (e.g., detection, segmentation, and/or classification) adopted, while for the latter, some solutions to the detection/classification of material defects or particular patterns are reported. Finally, the main merits of machine learning that emerged from the study analysis are summarized and discussed. © 2022 by the authors. Licensee MDPI, Basel, Switzerland

Advancements and Breakthroughs in Ultrasound Imaging

Ultrasonic imaging is a powerful diagnostic tool available to medical practitioners, engineers and researchers today. Due to the relative safety, and the non-invasive nature, ultrasonic imaging has become one of the most rapidly advancing technologies. These rapid advances are directly related to the parallel advancements in electronics, computing, and transducer technology together with sophisticated signal processing techniques. This book focuses on state of the art developments in ultrasonic imaging applications and underlying technologies presented by leading practitioners and researchers from many parts of the world

Automated Resolution Selection for Image Segmentation

It is well known in image processing in general, and hence in image segmentation in particular, that computational cost increases rapidly with the number and dimensions of the images to be processed. Several fields, such as astronomy, remote sensing, and medical imaging, use very large images, which might also be 3D and/or captured at several frequency bands, all adding to the computational expense. Multiresolution analysis is one method of increasing the efficiency of the segmentation process. One multiresolution approach is the coarse-to-fine segmentation strategy, whereby the segmentation starts at a coarse resolution and is then fine-tuned during subsequent steps. Until now, the starting resolution for segmentation has been selected arbitrarily with no clear selection criteria. The research conducted for this thesis showed that starting from different resolutions for image segmentation results in different accuracies and speeds, even for images from the same dataset. An automated method for resolution selection for an input image would thus be beneficial. This thesis introduces a framework for the selection of the best resolution for image segmentation. First proposed is a measure for defining the best resolution based on user/system criteria, which offers a trade-off between accuracy and time. A learning approach is then described for the selection of the resolution, whereby extracted image features are mapped to the previously determined best resolution. In the learning process, class (i.e., resolution) distribution is imbalanced, making effective learning from the data difficult. A variant of AdaBoost, called RAMOBoost, is therefore used in this research for the learning-based selection of the best resolution for image segmentation. RAMOBoost is designed specifically for learning from imbalanced data. Two sets of features are used: Local Binary Patterns (LBP) and statistical features. Experiments conducted with four datasets using three different segmentation algorithms show that the resolutions selected through learning enable much faster segmentation than the original ones, while retaining at least the original accuracy. For three of the four datasets used, the segmentation results obtained with the proposed framework were significantly better than with the original resolution with respect to both accuracy and time

Neutro-Connectedness Theory, Algorithms and Applications

Connectedness is an important topological property and has been widely studied in digital topology. However, three main challenges exist in applying connectedness to solve real world problems: (1) the definitions of connectedness based on the classic and fuzzy logic cannot model the “hidden factors” that could influence our decision-making; (2) these definitions are too general to be applied to solve complex problem; and (4) many measurements of connectedness are heavily dependent on the shape (spatial distribution of vertices) of the graph and violate the intuitive idea of connectedness. This research focused on solving these challenges by redesigning the connectedness theory, developing fast algorithms for connectedness computation, and applying the newly proposed theory and algorithms to solve challenges in real problems. The newly proposed Neutro-Connectedness (NC) generalizes the conventional definitions of connectedness and can model uncertainty and describe the part and the whole relationship. By applying the dynamic programming strategy, a fast algorithm was proposed to calculate NC for general dataset. It is not just calculating NC map, and the output NC forest can discover a dataset’s topological structure regarding connectedness. In the first application, interactive image segmentation, two approaches were proposed to solve the two most difficult challenges: user interaction-dependence and intense interaction. The first approach, named NC-Cut, models global topologic property among image regions and reduces the dependence of segmentation performance on the appearance models generated by user interactions. It is less sensitive to the initial region of interest (ROI) than four state-of-the-art ROI-based methods. The second approach, named EISeg, provides user with visual clues to guide the interacting process based on NC. It reduces user interaction greatly by guiding user to where interacting can produce the best segmentation results. In the second application, NC was utilized to solve the challenge of weak boundary problem in breast ultrasound image segmentation. The approach can model the indeterminacy resulted from weak boundaries better than fuzzy connectedness, and achieved more accurate and robust result on our dataset with 131 breast tumor cases

IMAGE UNDERSTANDING OF MOLAR PREGNANCY BASED ON ANOMALIES DETECTION

Cancer occurs when normal cells grow and multiply without normal control. As the cells multiply, they form an area of abnormal cells, known as a tumour. Many tumours exhibit abnormal chromosomal segregation at cell division. These anomalies play an important role in detecting molar pregnancy cancer. Molar pregnancy, also known as hydatidiform mole, can be categorised into partial (PHM) and complete (CHM) mole, persistent gestational trophoblastic and choriocarcinoma. Hydatidiform moles are most commonly found in women under the age of 17 or over the age of 35. Hydatidiform moles can be detected by morphological and histopathological examination. Even experienced pathologists cannot easily classify between complete and partial hydatidiform moles. However, the distinction between complete and partial hydatidiform moles is important in order to recommend the appropriate treatment method. Therefore, research into molar pregnancy image analysis and understanding is critical. The hypothesis of this research project is that an anomaly detection approach to analyse molar pregnancy images can improve image analysis and classification of normal PHM and CHM villi. The primary aim of this research project is to develop a novel method, based on anomaly detection, to identify and classify anomalous villi in molar pregnancy stained images. The novel method is developed to simulate expert pathologists’ approach in diagnosis of anomalous villi. The knowledge and heuristics elicited from two expert pathologists are combined with the morphological domain knowledge of molar pregnancy, to develop a heuristic multi-neural network architecture designed to classify the villi into their appropriated anomalous types. This study confirmed that a single feature cannot give enough discriminative power for villi classification. Whereas expert pathologists consider the size and shape before textural features, this thesis demonstrated that the textural feature has a higher discriminative power than size and shape. The first heuristic-based multi-neural network, which was based on 15 elicited features, achieved an improved average accuracy of 81.2%, compared to the traditional multi-layer perceptron (80.5%); however, the recall of CHM villi class was still low (64.3%). Two further textural features, which were elicited and added to the second heuristic-based multi-neural network, have improved the average accuracy from 81.2% to 86.1% and the recall of CHM villi class from 64.3% to 73.5%. The precision of the multi-neural network II has also increased from 82.7% to 89.5% for normal villi class, from 81.3% to 84.7% for PHM villi class and from 80.8% to 86% for CHM villi class. To support pathologists to visualise the results of the segmentation, a software tool, Hydatidiform Mole Analysis Tool (HYMAT), was developed compiling the morphological and pathological data for each villus analysis