Nutritivni i socioekonomski status slučajnog uzorka ispitanika koji žive u Jugoistočnoj Srbiji - u smeru strategija personalizovane ishrane

South-Eastern Serbia is with traditionally acknowledged intake of spicy and energy-dense food. For the purposes of this study we presented official socio-economic determinants for the three counties within South-Eastern Serbia: jablanički, niški and pirotski. The objective of this study was to assess nutritional status of randomly selected 40 subjects (11-74 years) residing in South Eastern Serbia within the counties. By means of validated food and dietary data methodology, we interviewed subjects and analyzed in a cross-sectional design. Our data indicate low-carbohydrate-high-fat like dietary pattern within the subjects, irrespective of age and gender in the region. Demonstrated likely improper nutritional status of sodium, calcium, vitamins A, C, D and B9 (folate) warrants public health initiatives towards optimization of the intake within the region. Our results indicate inadequate micronutrient intake within the adolescent group. Overall our results underline the necessity of raising education and awareness of healthy nutrition benefits and sustainable food choices within South Eastern Serbia and foster the necessity of implementation of an individualized approach in nutrition healthcare in this middle-income country.U jugoistočnoj Srbiji se tradicionalno konzumira začinjena i energetski bogata i jaka hrana. Za potrebe ove studije, prikazali smo zvanične socioekonomske pokazatelje kroz tri okruga jugoistočne Srbije: jablanički, niški i pirotski. Cilj ove studije bio je evaluacija nutritivnog statusa slučajnog uzorka 40 ispitanika (11-74 godine) koji žive unutar pomenuta tri regiona jugoistočne Srbije. Korišćenjem validiranih metodoloških alata o prikupljanju podataka o kvalitetu ishrane i učestalosti konzumiranja namirnica, intervjuisali smo ispitanike i analizirali metodama studije preseka. Naši podaci ukazuju na dijetarni obrazac u regionu koji teži nižem unosu ugljenih hidrata i povišenom unosu masti, nezavisno od pola i starosne dobi. U našem radu ukazano je i na mogući neadekvatan unos mikronutrijenata u regionu, uključujući natrijum, kalcijum, vitamine A, C, D i B9 (folat), podatak koji zahteva inicijative javnog zdravlja u regionu. Naši podaci ukazuju da je neadekvatan unos mikronutrijenata prvenstveno prisutan u grupi adolescenata. Uopšte uzev, naši rezultati ukazuju na neophodnost podsticanja obrazovanja i podizanja svesti o značaju zdrave, adekvatne i balansirane ishrane kao i održivih izbora hrane i grupa hrane u okviru jugoistočne Srbije. Naši podaci ističu neophodnost implementacije individualizovanog pristupa u nutritivnim i dijetarnim strategijama i dijetnim planovima zemlje u razvoju kakva je Srbija

Experiencia clínica con la utilización de nitratos vasodilatadores : Dinitrato de isosorbide y 5-mononitrato de isosorbide en el tratamiento de la insuficiencia cardíaca congestiva en 128 perros

En este trabajo estudiamos el uso de dos nitratos: dinitrato de isosorbide y su forma activa, el 5-mononitrato de isosorbide, vasodilatadores venosos, en 128 perros con insuficiencia cardíaca: congestiva describiendo su utilización, dosis empleadas, asociaciones con otros fármacos y evolución de los pacientes.In this paper we study the use of two nitrates: isosorbide dinitrate and its active metabolite the 5-isosorbide mononitrate, venodilators, in 128 dogs with congestive heart failure. We describe its utilization, doses, farmacology association with others cardiac drugs and the patients' evolution

Federated learning for performance prediction in multi-operator environments

Telecom vendors and operators deliver services with strict requirements on performance, over complex and sometimes partly shared network infrastructures. A key enabler for network and service management in such environments is knowledge sharing, and the use of data-driven models for performance prediction, forecasting, and troubleshooting. In this paper, we outline a multi-operator service metrics prediction framework using federated learning that allows privacy-preserved knowledge-sharing across operators for improved model performance, and also reduced requirements on data transfer within an operator network. Federated learning is compared against local and central learning strategies for multi-operator performance prediction, and it is shown to balance the requirements on data privacy, model performance, and the network overhead. Further, the paper provides insights on how data heterogeneity affects model performance, where the conclusion is that standard federated learning has certain robustness to data heterogeneity. Finally, we discuss the challenges related to training a federated learning model with a limited budget on the communication rounds. The evaluation is performed using a set of realistic publicly available data traces, that are adapted specifically for the purpose of studying multi-operator service performance prediction

Vitamin D Status and Its Correlation With Anthropometric and Biochemical Indicators of Cardiometabolic Risk in Serbian Underground Coal Miners in 2016

The status of vitamin D in underground working coal miners and its association with their cardiometabolic health is rarely studied. This study aimed to examine vitamin D (VitD) status in Serbian underground coal miners and to correlate it with anthropometric and laboratory indicators of cardiometabolic risk. Nutritional data (food frequency questionnaire, FFQ, and two times repeated 24 h recall), anthropometric data (including segmental analysis by bio-impedance analyzer TANITA BC-545N), arterial tension, and biochemical and hematological data of 103 coal miners (aged 22–63 years) were correlated with their late summer (early September) serum 25 (OH)D levels (measured by HPLC). 68.9% of the studied coal miners were overweight/obese, and 48.5% had metabolic syndrome. Their mean VitD nutritional intakes were low: 5.3 ± 3.8 μg/day (FFQ) and 4.9 ± 8 μg/day (24 h recalls), but their mean serum 25 (OH)D levels were surprisingly high (143.7 ± 41.4 nmol/L). Only 2.9% of the coal miners had 25(OH)D levels lower than 75 nmol/L (indicating an insufficient/deficient status), while 63.2% had values above 125 nmol/L (upper optimal limit), and even 10.7% had values above 200 nmol/L. There were no statistical differences in 25 (OH)D levels in the coal miners with or without metabolic syndrome (or overweight/obesity). Interestingly, 25(OH)D levels had significant positive correlations with body mass index (BMI), fat mass (FM), fat mass percentage (FM%), limbs FM%, serum triglycerides, GGT, AST, ALT, and ALT/AST ratio, and had significant negative correlations with serum HDL-cholesterol and age. All these correlations were lost after corrections for age, FM, FM%, and legs FM%. In Serbian coal miners, high levels of early September VitD levels were observed, indicating sufficient non-working-hour sun exposure during the summer period. Furthermore, the unexpected positive correlations of VitD levels with anthropometric and biochemical parameters indicative of obesity, metabolic syndrome, and fatty liver disease were found. More research is needed on the VitD status of coal miners (particularly in the winter period) and its relationship with their cardiometabolic status

Design, formulation and sensory evaluation of a polyphenol-rich food placebo: an example of aronia juice for food intervention studies

Products suitable for use as controls in food interventions designed to demonstrate the role of minor components are largely lacking. In the present study, we aimed to develop a formulation to be used as a placebo in a clinical trial designed to assess the effects of aronia juice polyphenols on platelet function. Three formulations with the same nutrient composition as aronia juice were prepared by mixing various nutrients, artificial colours and flavours with water. The similarity of formulations to aronia juice in terms of taste, colour, smell and texture was assessed by six food panellists. The final placebo was tested for its impact on platelet function, biochemical and anthropometric parameters in a 4-week long study. No significant changes in platelet function, or in several cardiovascular and safety markers were recorded. Formulation suitable for use as a placebo for dietary intervention studies using aronia juice has been developed and demonstrated to be well tolerated in humans

Results from the first use of low radioactivity argon in a dark matter search

Liquid argon is a bright scintillator with potent particle identification properties, making it an attractive target for direct-detection dark matter searches. The DarkSide-50 dark matter search here reports the first WIMP search results obtained using a target of low-radioactivity argon. DarkSide-50 is a dark matter detector, using two-phase liquid argon time projection chamber, located at the Laboratori Nazionali del Gran Sasso. The underground argon is shown to contain Ar-39 at a level reduced by a factor (1.4 +- 0.2) x 10^3 relative to atmospheric argon. We report a background-free null result from (2616 +- 43) kg d of data, accumulated over 70.9 live-days. When combined with our previous search using an atmospheric argon, the 90 % C.L. upper limit on the WIMP-nucleon spin-independent cross section based on zero events found in the WIMP search regions, is 2.0 x 10^-44 cm^2 (8.6 x 10^-44 cm^2, 8.0 x 10^-43 cm^2) for a WIMP mass of 100 GeV/c^2 (1 TeV/c^2 , 10 TeV/c^2).Comment: Accepted by Phys. Rev.

Evaluation of CSF neurotransmitters and folate in 25 patients with Rett disorder and effects of treatment

Background: Rett disorder (RD) is a progressive neurodevelopmental entity caused by mutations in the MECP2 gene. It has been postulated that there are alterations in the levels of certain neurotransmitters and folate in the pathogenesis of this disease. Here we re-evaluated this hypothesis. Patients and methods: We evaluated CSF folate, biogenic amines and pterines in 25 RD patients. Treatment with oral folinic acid was started in those cases with low folate. Patients were clinically evaluated and videotaped up to 6 months after therapy. Results: CSF folate was below the reference values in 32% of the patients. Six months after treatment no clinical improvement was observed. Three of the four patients with the R294X mutation had increased levels of a dopamine metabolite associated to a particular phenotype. Three patients had low levels of a serotonin metabolite. Two of them were treated with fluoxetine and one showed clinical improvement. No association was observed between CSF folate and these metabolites, after adjusting for the patients age and neopterin levels. Conclusion: Our results support that folinic acid supplementation has no significant effects on the course of the disease. We report discrete and novel neurotransmitter abnormalities that may contribute to the pathogenesis of RD highlighting the need for further studies on CSF neurotransmitters in clinically and genetically well characterized patients.Research in Rett syndrome is supported by FSE/FEDER and Fundação para a Ciência e Tecnologia (FCT, Portugal), Grant No. POCTI 41416/2001

Measurement of the Generalized Polarizabilities of the Proton in Virtual Compton Scattering

We propose to conduct a measurement of the Virtual Compton Scattering reaction in Hall C that will allow the precise extraction of the two scalar Generalized Polarizabilities (GPs) of the proton in the region of $Q^2=0.05~(GeV/c)^2$ to $Q^2=0.50~(GeV/c)^2$. The Generalized Polarizabilities are fundamental properties of the proton, that characterize the system's response to an external electromagnetic (EM) field. They describe how easily the charge and magnetization distributions inside the system are distorted by the EM field, mapping out the resulting deformation of the densities in the proton. As such, they reveal unique information regarding the underlying system dynamics and provide a key for decoding the proton structure in terms of the theory of the strong interaction that binds its elementary quark and gluon constituents together. Recent measurements of the proton GPs have challenged the theoretical predictions, particularly in regard to the electric polarizability. The magnetic GP, on the other hand, can provide valuable insight to the competing paramagnetic and diamagnetic contributions in the proton, but it is poorly known within the region where the interplay of these processes is very dynamic and rapidly changing.The unique capabilities of Hall C, namely the high resolution of the spectrometers combined with the ability to place the spectrometers in small angles, will allow to pin down the dynamic signature of the GPs through high precision measurements combined with a fine mapping as a function of $Q^2$. The experimental setup utilizes standard Hall C equipment, as was previously employed in the VCS-I (E12-15-001) experiment, namely the HMS and SHMS spectrometers and a 10 cm liquid hydrogen target. A total of 59 days of unpolarized 75 $\mu A$ electron beam with energy of 1100 MeV (6 days) and 2200 MeV (53 days) is requested for this experiment