LAND APPLICATION OF SWINE WASTE: REGULATION AND PRODUCER PRACTICES IN OKLAHOMA

Livestock Production/Industries,

Infectious Complications in Obese Patients Following Trauma

Background Obesity is a public health concern in the United States due to its increasing prevalence, especially in younger age groups. Trauma is the most common cause of death for people under aged 40 y. The purpose of this study is to determine the association between obesity and specific infectious complications after traumatic injury. Materials and methods A retrospective analysis was conducted using data from the 2012 National Trauma Data Bank. The National Trauma Data Bank defined obesity as having a body mass index of 30 or greater. Descriptive statistics were calculated and stratified by obesity status. A hierarchical regression model was used to determine the odds of experiencing an infectious complication in patients with obesity while controlling for age, gender, diabetes, number of comorbidities, injury severity, injury mechanism, head injury, and surgical procedure. Results Patients with a body mass index of 30 or greater compared with nonobese patients had increased odds of having an infectious complication (Odds Ratio, 1.59; 1.49-1.69). In addition to obesity, injury severity score greater than 29, age 40 y or older, diabetes, comorbid conditions, and having a surgical procedure were also predictive of an infectious complication. Conclusions Our results indicate that trauma patients with obesity are nearly 60% more likely to develop an infectious complication in the hospital. Infection prevention and control measures should be implemented soon after hospital arrival for patients with obesity, particularly those with operative trauma

Hypertension treatment intensification among stroke survivors with uncontrolled blood pressure

Objective The study objective was to evaluate a pharmacist hypertension care management program within the patient-centered medical home. Methods This was a retrospective case-control study. Cases included all patients with hypertension who were referred to the care management program, and controls included patients with hypertension who were not referred to the program during the same 1-year period. Each case was matched to a maximum of 3 controls on the basis of primary care physician, age ±5 years, gender, diagnoses of diabetes and kidney disease, baseline systolic blood pressure ±10 mm Hg, and number of unique antihypertensive medications. Pharmacists provided a hypertension care management program under an approved scope of practice that allowed pharmacists to meet individually with patients, adjust medications, and provide patient education. Primary outcomes were systolic blood pressure and diastolic blood pressure at 6 and 12 months. Multivariate regression models compared each blood pressure end point between cases and controls adjusting for age, comorbidities, baseline blood pressure, and baseline number of blood pressure medications. Results A total of 573 patients were referred to the hypertension program; 86% (465/543) had at least 1 matched control and were included as cases in the analyses; 3:1 matching was achieved in 90% (418/465) of cases. At baseline, cases and controls did not differ with respect to age, gender, race, or comorbidity; baseline blood pressure was higher (139.9/80.0 mm Hg vs 136.7/78.2 mm Hg, P ≤ .0002) in the cases compared with controls. Multivariate regression modeling identified significantly lower systolic blood pressure for the cases compared with controls at both 6 and 12 months (6-month risk ratio [RR], 9.7; 95% confidence interval [CI], 2.7-35.3; 12-month RR, 20.3; 95% CI, 4.1-99.2; P < .01 for both comparisons). Diastolic blood pressure was significantly lower at 12 months (RR, 2.9; 95% CI, 1.2-7.1; P < .01) but not at 6 months (RR, 1.0; 95% CI, 0.31-3.4; P = .9) for the cases compared with controls. Conclusions Patients who were referred to the pharmacist hypertension care management program had a significant improvement in most blood pressure outcomes. This program may be an effective method of improving blood pressure control among patients in a medical home model of primary care

Theory and Applications Surrounding Markov Chains

This capstone project explores the Markov Chain – a mathematical model used to describe systems that transition between states based on probabilities. It begins by introducing the fundamental concepts, including transition matrices, state classifications, and stationary distributions. The paper then applies Markov Chain theory to real-world scenarios, such as simulating Snakes and Ladders games, predicting soccer match outcomes for Manchester United, and generating texts from movie lines. Finally, it discusses key findings, challenges, and potential areas for future research in the field

TSPO: kaleidoscopic 18-kDa amid biochemical pharmacology, control and targeting of mitochondria

The 18-kDa translocator protein (TSPO) localizes in the outer mitochondrial membrane (OMM) of cells and is readily up-regulated under various pathological conditions such as cancer, inflammation, mechanical lesions and neurological diseases. Able to bind with high affinity synthetic and endogenous ligands, its core biochemical function resides in the translocation of cholesterol into the mitochondria influencing the subsequent steps of (neuro-)steroid synthesis and systemic endocrine regulation. Over the years, however, TSPO has also been linked to core cellular processes such as apoptosis and autophagy. It interacts and forms complexes with other mitochondrial proteins such as the voltage-dependent anion channel (VDAC) via which signalling and regulatory transduction of these core cellular events may be influenced. Despite nearly 40 years of study, the precise functional role of TSPO beyond cholesterol trafficking remains elusive even though the recent breakthroughs on its high-resolution crystal structure and contribution to quality-control signalling of mitochondria. All this along with a captivating pharmacological profile provides novel opportunities to investigate and understand the significance of this highly conserved protein as well as contribute the development of specific therapeutics as presented and discussed in the present review

Bulletin No. 97 - Report on the Southern Utah Experiment Station

When, in the early part of the year 1905 , the management of the Southern Utah Experiment Farm was turned over to the officials of the Utah Agricultural Experiment Station, in compliance with an act of the legislature of that year a number of experiments were under way, principally variety tests with orchard and small fruit. The State Board of Horticulture had been in charge of this farm since its establishment in 1899, and had succeeded in making out of it not only a place that will indicate the varieties of fruits adapted to that climate and soil , but also a farm that in neatness and careful arrangement can be an instructive model to anyone contemplating engaging in that industry. The new management decided not to make any radical change in the tests that were under way , but to continue them to such a conclusion a will yield the valuable results that were to come out of them. New tests or investigations are to be started with the same crop without interfering with them as variety tests, and upon the ground still available or which has not yet been set out into orchard, vineyard, or other permanent crops. Such it is planned to do as the problems suggest themselves, and as means are available

Seedling Johnsongrass Growth in Sugarcane as Affected by Time of Emergence (Agroecology, Sorha, Weed Potential).

Field studies were conducted to document seedling johnsongrass Sorghum halepense (L.) Pers. growth as influenced by date of emergence in sugarcane (Saccharum interspecific hybrids, cultivar \u27CP 65-357\u27). The crop was in the plant cane year of growth in 1982 and 1983, and the first stubble year in 1984. The experiments were randomized complete block designs. Johnsongrass seedling emergence days were approximately three weeks apart, from April or early May through mid-July for a total of five emergence days each year. There were 36, 60, and 72 replicates for emergence days numbered 1 to 3, 4, and 5, respectively, over three years. Individual johnsongrass plants were established in the center of the plot and plants were a minimum of 2 m apart. Seedling johnsongrass physical characteristics were measured and recorded weekly until mid-July. After this time, sampling was at 2 to 3 wk intervals. Johnsongrass survival, culm height, canopy diameter, stems/plant, seedheads/plant were measured across time. In the fall prior to first frost, standing biomass was harvested and recorded after drying for 96 hr at 80(DEGREES)C. Survival analysis gave a X(\u272) = 1.85 (3 df, P = 0.6) and described a negative linear relationship with later emergence in sugarcane. Plants from emergence days 1, 2, 3, 4, and 5 survived until end-of-season 83, 64, 47, 20, and 10% of the time, respectively. These surviving plants overwintered to produce rhizome johnsongrass plants the next spring 47, 25, 17, 3, and 0% of the time, respectively. Negative linear relationships with later emergences were observed for height of tallest johnsongrass culms, canopy diameter, and seedheads/plant at end-of-season (Sum of Squares Regression/Sum of Squares Treatments, or Q(\u272), = 0.97, 0.91, and 0.76, respectively). Stems/plant showed a negative exponential relationship with time of emergence at end-of-season (Q(\u272) = 0.99). Johnsongrass height and canopy diameter growth rates also declined linearly with time of emergence in sugarcane (Q(\u272) = 0.83 and 0.76, respectively). Surviving johnsongrass plants from emergence day 1 attained a mean height and canopy diameter of 209 and 176 cm, respectively, at end-of-season. Plants from emergence day 5 produced less than 1% of the biomass produced by emergence day 1 plants. Cumulative distribution analysis indicated that a sugarcane canopy radius of 75 to 80 cm would control subsequent johnsongrass emergences and as such, marked the end of the period for required control of seedling johnsongrass in sugarcane

Over-reaction to the CALPERS focus list?

The California Public Employees Retirement System (CalPERS) has over $ 200 billion in assets. Over the years it has gained an activist reputation. The size of investment provides it with a strong voice and the incentive to incur monitoring costs. CalPERS nudges the management and the board to act in the best interest of the shareholders. CalPERS regularly examines its portfolio and seeks change in firms that can potentially perform better. Some firms heed to this attention while those that ignore the attention end up on the focus list. This study examines the reaction of the market to the publishing of the CalPERS focus list. On one hand, an investor could interpret this news positively: A large shareholder is actively pushing management and the board, to improve operations. In the remaining sections, the literature is reviewed, we present our results and the paper ends with a discussion

Deletion of airway cilia results in noninflammatory bronchiectasis and hyperreactive airways

The mechanisms for the development of bronchiectasis and airway hyperreactivity have not been fully elucidated. Although genetic, acquired diseases and environmental influences may play a role, it is also possible that motile cilia can influence this disease process. We hypothesized that deletion of a key intraflagellar transport molecule, IFT88, in mature mice causes loss of cilia, resulting in airway remodeling. Airway cilia were deleted by knockout of IFT88, and airway remodeling and pulmonary function were evaluated. In IFT88− mice there was a substantial loss of airway cilia on respiratory epithelium. Three months after the deletion of cilia, there was clear evidence for bronchial remodeling that was not associated with inflammation or apparent defects in mucus clearance. There was evidence for airway epithelial cell hypertrophy and hyperplasia. IFT88− mice exhibited increased airway reactivity to a methacholine challenge and decreased ciliary beat frequency in the few remaining cells that possessed cilia. With deletion of respiratory cilia there was a marked increase in the number of club cells as seen by scanning electron microscopy. We suggest that airway remodeling may be exacerbated by the presence of club cells, since these cells are involved in airway repair. Club cells may be prevented from differentiating into respiratory epithelial cells because of a lack of IFT88 protein that is necessary to form a single nonmotile cilium. This monocilium is a prerequisite for these progenitor cells to transition into respiratory epithelial cells. In conclusion, motile cilia may play an important role in controlling airway structure and function