The effectiveness of rape interventions

This paper examines research into the effectiveness of rape law education in schools and Universities on attitudes and behaviour

Two strategies for implementing outcome-based learning

This paper will be delivered in two parts. Part one addresses the importance of adopting a standardised assessment and feedback framework, which reflects outcome-based learning objectives that can be adapted for individual assessments. Part two will address the conundrum of finding the space in an already packed curriculum to bridge the gap between legal theory and practice

Effective strategies for teaching and learning law: an analysis of student experience and perception

This paper seeks to assess the most effective methods in teaching law as identified by law students studying at the University of Greenwich. The paper is based on a student questionnaire completed by over 300 students studying law at levels one, two and three. The questionnaire contained 20 questions designed to assess the student perspective on effective learning strategies in relation to lectures, seminars and other learning forums. The questions were primarily presented in a multiple choice format. They provided students with answer options designed to obtain constructive feedback on a wide range of teaching styles and support structures for student learning. At one end of the spectrum, students’ views were sought on the traditional expectation that undergraduates should be responsible managing their own learning, with limited contact time with tutors (“hands off” learning). At the other extreme, students were asked to consider the approach deemed as increasingly necessary by some legal academics whereby students are given the kind of direction and assistance usually seen in schools (“hands on” learning). The paper will briefly assess some of the teaching methods currently used in legal education and then assess them in the context of the feedback and analysis gained from the student survey. The limitations regarding this research are recognised, given that the student cohort at the University of Greenwich may differ from the student cohort in law schools nationally. Nonetheless, the author considers that the results may be useful in the wider context of the issues arising in legal education nationally

The Intriguing Effects of Substituents in the N-Phenethyl Moiety of Norhydromorphone: A Bifunctional Opioid from a Set of “Tail Wags Dog” Experiments

This work is licensed under a Creative Commons Attribution 4.0 International License.(−)-N-Phenethyl analogs of optically pure N-norhydromorphone were synthesized and pharmacologically evaluated in several in vitro assays (opioid receptor binding, stimulation of [35S]GTPγS binding, forskolin-induced cAMP accumulation assay, and MOR-mediated β-arrestin recruitment assays). “Body” and “tail” interactions with opioid receptors (a subset of Portoghese’s message-address theory) were used for molecular modeling and simulations, where the “address” can be considered the “body” of the hydromorphone molecule and the “message” delivered by the substituent (tail) on the aromatic ring of the N-phenethyl moiety. One compound, N-p-chloro-phenethynorhydromorphone ((7aR,12bS)-3-(4-chlorophenethyl)-9-hydroxy-2,3,4,4a,5,6-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7(7aH)-one, 2i), was found to have nanomolar binding affinity at MOR and DOR. It was a potent partial agonist at MOR and a full potent agonist at DOR with a δ/μ potency ratio of 1.2 in the ([35S]GTPγS) assay. Bifunctional opioids that interact with MOR and DOR, the latter as agonists or antagonists, have been reported to have fewer side-effects than MOR agonists. The p-chlorophenethyl compound 2i was evaluated for its effect on respiration in both mice and squirrel monkeys. Compound 2i did not depress respiration (using normal air) in mice or squirrel monkeys. However, under conditions of hypercapnia (using air mixed with 5% CO2), respiration was depressed in squirrel monkeys.NIDA grant P30 DA13429NIDA grant DA039997NIDA grant DA018151NIDA grant DA035857NIDA grant DA047574NIH Intramural Research Programs of the National Institute on Drug AbuseNational Institute of Alcohol Abuse and AlcoholismNIH Intramural Research Programs of the National Institute on Drug AbuseNIH Intramural Research Program through the Center for Information TechnologyNIH Intramural Research Programs of the National Institute on Drug Abus

Changing portrayals of medicine and patients in eighteenth-century medical writing : Lexical bundles in Public Health, Methods, and case studies

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Towards new knowledge : The corpus of Late Modern English Medical Texts

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Scientific Periodicals : The Philosophical Transactions and the Edinburgh Medical Journal

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Sociohistorical and cultural context of Late Modern English Medical Texts

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Manual to the LMEMT corpus

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