Flicker of Modern Lighting Technologies Due to Rapid Voltage Changes

The purpose of the present paper is to evaluate the sensitivity of modern lighting technologies to different types of RVCs. In order to do that, 27 modern lampsmainly LEDhave been subjected to real RVCs and their response has been assessed. The detection of RVCs on the grid has been performed according to the IEC 61000-4-30 detection method, while the response of the lamps has been measured with a light flickermeter and characterized using the instantaneous flicker perception, as defined in IEC 61000-4-15. The obtained results show a high dispersion in the response of the modern lighting technologies and high values of flicker perception, although with a lower sensitivity than the incandescent lamp. The results led the authors to propose the definition of a new immunity test to be added to the lamp immunity protocol IEC TR-61547-1, to ensure that newly produced lamps cause limited irritation to grid users.This project has received funding from the European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 676042. This work also received financial support from the Spanish MINECO through the project DPI2014-53317-R (cofinanced with the European Regional Development Fund) and from the Basque Government (Basque Country, Spain) through the project IT1087-16

Technological potential of native lactic acid bacteria isolated from Swiss-type artisanal cheese (Ancash, Peru) for their application in food

Swiss-type artisanal cheese is highly appreciated sensorially, its flavor is often associated with the lactic acid bacteria involved in its production, which in many cases are indigenous. Three artisanal Swiss-type cheeses of greatest preference in the market of Huaraz (Ancash) were selected. The main LAB were isolated and identified and their safety properties and technological potential for their application in new cheeses were verified in vitro and evaluated by consumers. Eleven strains were confirmed as LAB by Gram-positive and catalase-negative biochemical tests; according to 16S rDNA, seven strains belonged to Lacticaseibacillus paracasei (KQ3, EQ1, CQ1, YQ1, LQ2, GQ2 and TQ1), three strains to Lentilactobacillus parabuchneri (BQ2, OQ2 and RQ3), and one to Lactiplantibacillus sp. (QQ3). In safety assays, LAB did not exhibit gelatinase or hemolytic activities. In addition, L. paracasei KQ3, GQ2 and L. parabuchneri BQ2 effectively inhibited pathogens such as S. aureus, E. coli and L. monocytogenes. Antibiotic susceptibility was variable among strains. L. paracasei CQ1, EQ1, KQ3, TQ1 and Lactiplantibacillus sp. QQ3 showed high milk acidification capacity (0.16-1.44%) and reduced pH from 6.6 to 3.5 after 72 h of incubation. L. paracasei CQ1, Lactiplantibacillus sp. QQ3 and L. paracasei KQ3 showed the highest casein degradation zones (20.8-11.5 mm). All strains showed lipolytic activity, with Lactiplantibacillus sp. QQ3, L. paracasei CQ1 and L. parabuchneri BQ2 standing out with halos of 30.8-36.3 mm. Lactiplantibacillus sp. QQ3 and L. paracasei TQ1 showed ability to produce diacetyl. The best strains were tested in cheese production where L. paracasei CQ1 showed the best sensory qualities. Finally, the native BAL strains showed a high potential for the production of natural, safe and sensorially acceptable dairy products

Malaria seroepidemiology in very low transmission settings in the Peruvian Amazon

Despite progress towards malaria reduction in Peru, measuring exposure in low transmission areas is crucial for achieving elimination. This study focuses on two very low transmission areas in Loreto (Peruvian Amazon) and aims to determine the relationship between malaria exposure and proximity to health facilities. Individual data was collected from 38 villages in Indiana and Belen, including geo-referenced households and blood samples for microscopy, PCR and serological analysis. A segmented linear regression model identified significant changes in seropositivity trends among different age groups. Local Getis-Ord Gi* statistic revealed clusters of households with high (hotspots) or low (coldspots) seropositivity rates. Findings from 4000 individuals showed a seropositivity level of 2.5% (95%CI: 2.0%-3.0%) for P. falciparum and 7.8% (95%CI: 7.0%-8.7%) for P. vivax, indicating recent or historical exposure. The segmented regression showed exposure reductions in the 40–50 age group (β1 = 0.043, p = 0.003) for P. vivax and the 50–60 age group (β1 = 0.005, p = 0.010) for P. falciparum. Long and extreme distance villages from Regional Hospital of Loreto exhibited higher malaria exposure compared to proximate and medium distance villages (p < 0.001). This study showed the seropositivity of malaria in two very low transmission areas and confirmed the spatial pattern of hotspots as villages become more distant

Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)

Objectives: The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters. Methods: A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs). Results: In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p < 0.001) for tocilizumab, 0.82 (0.71-1.30; p 0.82) for IHDC, 0.61 (0.43-0.86; p 0.006) for PDC, and 1.17 (0.86-1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02-0.17; p < 0.001). Conclusions: Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situatio

Programa Curricular de Educación Básica Alternativa. Ciclos Inicial - Intermedio 2019

El programa curricular de EBA forma parte del Currículo Nacional de Educación Básica y su finalidad es contribuir con orientaciones específicas que permitan concretar la propuesta pedagógica del CNEB. Además, se constituye como el documento orientador para la toma de decisiones pedagógicas a nivel regional, local e institucional. El programa curricular de EBA para los ciclos inicial e intermedio se ha estructurado en dos partes: la primera, contiene los aspectos generales como el perfil de egreso, las características de los estudiantes, las características de la modalidad, los enfoques transversales; asimismo, las orientaciones para la planificación y la evaluación, orientaciones para el desarrollo de los aprendizajes, la tutoría y orientación educativa, y los espacios educativos. En la segunda parte, se presentan las competencias organizadas en las áreas curriculares, así como, los desempeños que se alinean a los niveles de los estándares prescritos para los ciclos de la modalidad

Programa curricular de Educación Básica Alternativa : ciclos Inicial - Intermedio

La Constitución Política del Perú establece que la educación es un derecho fundamental de la persona y de la sociedad. El Estado garantiza el ejercicio del derecho a una educación integral y de calidad para todos y la universalización de la Educación Básica. La Ley General de Educación Nº 28044, en un esfuerzo de transformación estructural del sistema educativo nacional, institucionaliza la Educación Básica Alternativa (EBA) como modalidad equivalente a la Educación Básica Regular en calidad y logros de aprendizaje; enfatiza la preparación para el trabajo y el desarrollo de capacidades empresariales de los estudiantes. La EBA se organiza flexiblemente en función de las necesidades y demandas específicas de los estudiantes, que por diversas razones no accedieron o no culminaron la Educación Básica Regular y necesitan compatibilizar el trabajo con el estudio. Asimismo, admite el reconocimiento de sus trayectorias educativas y experiencias de vida. Así, como la existencia de otros espacios educativos en la comunidad, que fortalecen los aprendizajes de los estudiantes y son reconocidos a través de mecanismos adecuados de convalidación, revalidación o evaluación de ubicación, según normatividad vigente. El Currículo es la base de la política pedagógica nacional y es elaborada por el Ministerio de Educación (Minedu). Mediante Resolución Ministerial Nº 281-2016-MINEDU, modificada por Resolución Ministerial Nº 159-2017-MINEDU, se aprueba el Currículo Nacional de la Educación Básica (CNEB) que establece los aprendizajes que se espera logren los estudiantes como resultado de su formación básica en concordancia con los fines y principios de la Educación Peruana, el Proyecto Educativo Nacional y los objetivos de la Educación Básica

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality