Extremal Bounds for Three-Neighbour Bootstrap Percolation in Dimensions Two and Three

For $r\geq1$, the $r$-neighbour bootstrap process in a graph $G$ starts with a set of infected vertices and, in each time step, every vertex with at least $r$ infected neighbours becomes infected. The initial infection percolates if every vertex of $G$ is eventually infected. We exactly determine the minimum cardinality of a set that percolates for the $3$-neighbour bootstrap process when $G$ is a $3$-dimensional grid with minimum side-length at least $11$. We also characterize the integers $a$ and $b$ for which there is a set of cardinality $\frac{ab+a+b}{3}$ that percolates for the $3$-neighbour bootstrap process in the $a\times b$ grid; this solves a problem raised by Benevides, Bermond, Lesfari and Nisse [HAL Research Report 03161419v4, 2021].Comment: 45 page

Newcastle Disease Virus in Madagascar: Identification of an Original Genotype Possibly Deriving from a Died Out Ancestor of Genotype IV

In Madagascar, Newcastle disease (ND) has become enzootic after the first documented epizootics in 1946, with recurrent annual outbreaks causing mortality up to 40%. Four ND viruses recently isolated in Madagascar were genotypically and pathotypically characterised. By phylogenetic inference based on the F and HN genes, and also full-genome sequence analyses, the NDV Malagasy isolates form a cluster distant enough to constitute a new genotype hereby proposed as genotype XI. This new genotype is presumably deriving from an ancestor close to genotype IV introduced in the island probably more than 50 years ago. Our data show also that all the previously described neutralising epitopes are conserved between Malagasy and vaccine strains. However, the potential implication in vaccination failures of specific amino acid substitutions predominantly found on surface-exposed epitopes of F and HN proteins is discussed

How Status Concerns Can Make Us Rich and Happy

This paper considers an overlapping generations model of economic growth populated by two types of individuals. Competitive types compare future consumption (i.e. wealth) with the mean. Self-sufficient types derive utility simply from their own consumption and do not compare themselves with others. I derive a condition under which the utility (happiness) of both types increases when the economy is populated by a larger share of competitive types. In the long-run the condition is always fulfilled when the economy is capable of economic growth. The reason for this phenomenon is that competitive types generate higher savings and thus higher aggregate capital stock and income per capita, which raises utility of both types. I show that the result is robust to the consideration of endogenous work effort and that a sufficiently high share of competitive types in a society can be inevitable for long-run economic growth to exist

Circulating microRNAs in sera correlate with soluble biomarkers of immune activation but do not predict mortality in ART treated individuals with HIV-1 infection: A case control study

Introduction: The use of anti-retroviral therapy (ART) has dramatically reduced HIV-1 associated morbidity and mortality. However, HIV-1 infected individuals have increased rates of morbidity and mortality compared to the non-HIV-1 infected population and this appears to be related to end-organ diseases collectively referred to as Serious Non-AIDS Events (SNAEs). Circulating miRNAs are reported as promising biomarkers for a number of human disease conditions including those that constitute SNAEs. Our study sought to investigate the potential of selected miRNAs in predicting mortality in HIV-1 infected ART treated individuals. Materials and Methods: A set of miRNAs was chosen based on published associations with human disease conditions that constitute SNAEs. This case: control study compared 126 cases (individuals who died whilst on therapy), and 247 matched controls (individuals who remained alive). Cases and controls were ART treated participants of two pivotal HIV-1 trials. The relative abundance of each miRNA in serum was measured, by RTqPCR. Associations with mortality (all-cause, cardiovascular and malignancy) were assessed by logistic regression analysis. Correlations between miRNAs and CD4+ T cell count, hs-CRP, IL-6 and D-dimer were also assessed. Results: None of the selected miRNAs was associated with all-cause, cardiovascular or malignancy mortality. The levels of three miRNAs (miRs -21, -122 and -200a) correlated with IL-6 while miR-21 also correlated with D-dimer. Additionally, the abundance of miRs -31, -150 and -223, correlated with baseline CD4+ T cell count while the same three miRNAs plus miR- 145 correlated with nadir CD4+ T cell count. Discussion: No associations with mortality were found with any circulating miRNA studied. These results cast doubt onto the effectiveness of circulating miRNA as early predictors of mortality or the major underlying diseases that contribute to mortality in participants treated for HIV-1 infection

The Swiss Mass Immigration Initiative: The Impact of Increased Policy Uncertainty on Expected Firm Behaviour

In Switzerland a sudden policy uncertainty shock happened in February 2014 with the close and largely unexpected acceptance of a referendum aiming at limiting free movement of persons. The referendum requires Switzerland to reintroduce annual quotas for immigrants within three years. The referendum is vaguely formulated and its actual consequences are largely unknown. Yet, the vote reduced the expected future availability of qualified labour, put at stake several economically important agreements between Switzerland and the European Union, and reduced expected future domestic demand for firms. This paper uses a special survey conducted by the KOF Swiss Economic Institute to analyse the short- to medium-run expected consequences of this substantial policy uncertainty shock on firms' private fixed investment and employment plans. We find that those firms that believe that potential growth in Switzerland will deteriorate and those that report that investment uncertainty has increased are also the ones that see a significant reduction in their future investment activities and their expected employment due to the vote, so that an uncertainty effect is present. We also provide evidence that the short-term effect of policy uncertainty on investment is economically significant.Die knappe Annahme der Initiative gegen Masseneinwanderung im Februar 2014 führte zu einem unerwarteten Anstieg der Unsicherheit über die zukünftigen politischen Rahmenbedingen in der Schweiz. Die Initiative verpflichtet den Bundesrat zur gesetzlichen Einführung fixer Kontingente innerhalb der nächsten drei Jahre. Die weit gefasste Formulierung des Initiativtextes verhindert jedoch das Vorhersehen der genauen Umsetzung und erhöht damit den Spielraum möglicher Auswirkungen, was letztlich in einem Anstieg der Unsicherheit resultiert. Die geforderten Kontingente beschränken den Zugang Schweizer Firmen zu ausländischen Arbeitskräften und erhöhen die Gefahr eines zukünftigen Mangels an Fachkräften. Zudem sind Kontingente mit dem bestehenden Vertrag der Personenfreizügigkeit unvereinbar, bei dessen Auflösung käme es zur Kündigung aller mit der Personenfreizügigkeit verbunden bilateralen Abkommen. Die Aussicht auf die Kündigung der bilateralen Verträge erhöht die Unsicherheit über den Zugang Schweizer Unternehmen zum Binnenmarkt der Europäischen Union und senkt letztlich die Erwartungen der zukünftigen Gesamtnachfrage. In diesem Artikel untersuchen wir die kurz- bis mittelfristigen Auswirkungen der Annahme der Initiative auf Beschäftigung und Investitionen. Unsere Analysen basieren auf einer Sonderumfrage der KOF Konjunkturforschungsstelle und zeigen, dass die gestiegene Unsicherheit bereits jetzt zu einer Reduktion der Investitionspläne und zukünftigen Beschäftigung führt

Development and Validation of a Risk Score for Chronic Kidney Disease in HIV Infection Using Prospective Cohort Data from the D:A:D Study

Ristola M. on työryhmien DAD Study Grp ; Royal Free Hosp Clin Cohort ; INSIGHT Study Grp ; SMART Study Grp ; ESPRIT Study Grp jäsen.Background Chronic kidney disease (CKD) is a major health issue for HIV-positive individuals, associated with increased morbidity and mortality. Development and implementation of a risk score model for CKD would allow comparison of the risks and benefits of adding potentially nephrotoxic antiretrovirals to a treatment regimen and would identify those at greatest risk of CKD. The aims of this study were to develop a simple, externally validated, and widely applicable long-term risk score model for CKD in HIV-positive individuals that can guide decision making in clinical practice. Methods and Findings A total of 17,954 HIV-positive individuals from the Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) study with >= 3 estimated glomerular filtration rate (eGFR) values after 1 January 2004 were included. Baseline was defined as the first eGFR > 60 ml/min/1.73 m2 after 1 January 2004; individuals with exposure to tenofovir, atazanavir, atazanavir/ritonavir, lopinavir/ritonavir, other boosted protease inhibitors before baseline were excluded. CKD was defined as confirmed (>3 mo apart) eGFR In the D:A:D study, 641 individuals developed CKD during 103,185 person-years of follow-up (PYFU; incidence 6.2/1,000 PYFU, 95% CI 5.7-6.7; median follow-up 6.1 y, range 0.3-9.1 y). Older age, intravenous drug use, hepatitis C coinfection, lower baseline eGFR, female gender, lower CD4 count nadir, hypertension, diabetes, and cardiovascular disease (CVD) predicted CKD. The adjusted incidence rate ratios of these nine categorical variables were scaled and summed to create the risk score. The median risk score at baseline was -2 (interquartile range -4 to 2). There was a 1: 393 chance of developing CKD in the next 5 y in the low risk group (risk score = 5, 505 events), respectively. Number needed to harm (NNTH) at 5 y when starting unboosted atazanavir or lopinavir/ritonavir among those with a low risk score was 1,702 (95% CI 1,166-3,367); NNTH was 202 (95% CI 159-278) and 21 (95% CI 19-23), respectively, for those with a medium and high risk score. NNTH was 739 (95% CI 506-1462), 88 (95% CI 69-121), and 9 (95% CI 8-10) for those with a low, medium, and high risk score, respectively, starting tenofovir, atazanavir/ritonavir, or another boosted protease inhibitor. The Royal Free Hospital Clinic Cohort included 2,548 individuals, of whom 94 individuals developed CKD (3.7%) during 18,376 PYFU (median follow-up 7.4 y, range 0.3-12.7 y). Of 2,013 individuals included from the SMART/ESPRIT control arms, 32 individuals developed CKD (1.6%) during 8,452 PYFU (median follow-up 4.1 y, range 0.6-8.1 y). External validation showed that the risk score predicted well in these cohorts. Limitations of this study included limited data on race and no information on proteinuria. Conclusions Both traditional and HIV-related risk factors were predictive of CKD. These factors were used to develop a risk score for CKD in HIV infection, externally validated, that has direct clinical relevance for patients and clinicians to weigh the benefits of certain antiretrovirals against the risk of CKD and to identify those at greatest risk of CKD.Peer reviewe