IV Seminario de Dramaturgia Puertorriqueña

IV Seminario de Dramaturgia Puertorriqueñ

Nueva dramaturgia puertorriqueña

Nueva dramaturgia puertorriqueñ

La creación del Archivo Nacional de Teatro y Cine como centro fundacional de la investigación teatral y cinematográfica puertorriqueña

The Archive Nacional de Teatro y Cine del Ateneo Puertorriqueño is the country's largest theatrical and cinematographic research and documentation center: its documentary collection serves researches, postgraduate and undergraduate students, scholars and creators of these two important branches of Puerto Rican culture. In the same way it generates proper investigations which redounds in important discoveries, such as the first literary piece published in Puerto Rico, by a puertorrican, ;Mucen o el triunfo del patriotismo ;, by Celedonio Luis Nebot, written and published in San Juan in the year 1833, ten years before ;Aguinaldo Puertorriqueño ;. Also preserves documents, moving images and paperwork of theater and cinema, as well as keeping important documents and works of the 19th Century. The Archivo stands as a center of documentation, not only of two national arts, but of all our national identity.El Archivo Nacional de Teatro y Cine del Ateneo Puertorriqueño es el centro de documentación e investigación teatral y cinematográfica más importante del país. Su acervo documental sirve a investigadores, tesistas, estudiantes, académicos y creadores de estas dos importantes ramas de la cultura puertorriqueña. De la misma forma genera investigaciones propias que redundan en importantes descubrimientos, como lo fue el hallazgo de la primera obra literaria publicada en Puerto Rico por un puertorriqueño, ;Mucen o el triunfo del patriotismo ;, de Celedonio Luis Nebot, escrita y publicada en San Juan en el año de 1833, diez años antes que el ;Aguinaldo Puertorriqueño ;. Adems conserva documentos, imágenes en movimiento y papelería de los más importantes dramaturgos y actores del teatro y el cine nacionales, así como reúne importantes documentos y obras del siglo XIX. Consolídase el Archivo en un centro de documentación no solo de dos artes nacionales, sino de toda nuestra identidad nacional

Safety and preliminary efficacy data of a novel Casein Kinase 2 (CK2) peptide inhibitor administered intralesionally at four dose levels in patients with cervical malignancies

<p>Abstract</p> <p>Background</p> <p>Cervical cancer is now considered the second leading cause of death among women worldwide, and its incidence has reached alarming levels, especially in developing countries. Similarly, high grade squamous intraepithelial lesion (HSIL), the precursor stage for cervical cancer, represents a growing health problem among younger women as the HSIL management regimes that have been developed are not fully effective. From the etiological point of view, the presence of Human Papillomavirus (HPV) has been demonstrated to play a crucial role for developing cervical malignancies, and viral DNA has been detected in 99.7% of cervical tumors at the later stages. CIGB-300 is a novel cyclic synthetic peptide that induces apoptosis in malignant cells and elicits antitumor activity in cancer animal models. CIGB-300 impairs the Casein Kinase (CK2) phosphorylation, by targeting the substrate's phosphoaceptor domain. Based on the perspectives of CIGB-300 to treat cancer, this "first-in-human" study investigated its safety and tolerability in patients with cervical malignancies.</p> <p>Methods</p> <p>Thirty-one women with colposcopically and histologically diagnosed microinvasive or pre-invasive cervical cancer were enrolled in a dose escalating study. CIGB-300 was administered sequentially at 14, 70, 245 and 490 mg by intralesional injections during 5 consecutive days to groups of 7 – 10 patients. Toxicity was monitored daily until fifteen days after the end of treatment, when patients underwent conization. Digital colposcopy, histology, and HPV status were also evaluated.</p> <p>Results</p> <p>No maximum-tolerated dose or dose-limiting toxicity was achieved. The most frequent local events were pain, bleeding, hematoma and erythema at the injection site. The systemic adverse events were rash, facial edema, itching, hot flashes, and localized cramps. 75% of the patients experienced a significant lesion reduction at colposcopy and 19% exhibited full histological regression. HPV DNA was negative in 48% of the previously positive patients. Long term follow-up did not reveal recurrences or adverse events.</p> <p>Conclusion</p> <p>CIGB 300 was safe and well tolerated. This is the first clinical trial where a drug has been used to target the CK2 phosphoaceptor domain providing an early proof-of-principle of a possible clinical benefit.</p

Measurement of the ratios of branching fractions R(D∗)\mathcal{R}(D^{*}) and R(D0)\mathcal{R}(D^{0})

The ratios of branching fractions $\mathcal{R}(D^{*})\equiv\mathcal{B}(\bar{B}\to D^{*}\tau^{-}\bar{\nu}_{\tau})/\mathcal{B}(\bar{B}\to D^{*}\mu^{-}\bar{\nu}_{\mu})$ and $\mathcal{R}(D^{0})\equiv\mathcal{B}(B^{-}\to D^{0}\tau^{-}\bar{\nu}_{\tau})/\mathcal{B}(B^{-}\to D^{0}\mu^{-}\bar{\nu}_{\mu})$ are measured, assuming isospin symmetry, using a sample of proton-proton collision data corresponding to 3.0 fb${ }^{-1}$ of integrated luminosity recorded by the LHCb experiment during 2011 and 2012. The tau lepton is identified in the decay mode $\tau^{-}\to\mu^{-}\nu_{\tau}\bar{\nu}_{\mu}$. The measured values are $\mathcal{R}(D^{*})=0.281\pm0.018\pm0.024$ and $\mathcal{R}(D^{0})=0.441\pm0.060\pm0.066$, where the first uncertainty is statistical and the second is systematic. The correlation between these measurements is $\rho=-0.43$. Results are consistent with the current average of these quantities and are at a combined 1.9 standard deviations from the predictions based on lepton flavor universality in the Standard Model.Comment: All figures and tables, along with any supplementary material and additional information, are available at https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-039.html (LHCb public pages

Identification of genetic variants associated with Huntington's disease progression: a genome-wide association study

Background Huntington's disease is caused by a CAG repeat expansion in the huntingtin gene, HTT. Age at onset has been used as a quantitative phenotype in genetic analysis looking for Huntington's disease modifiers, but is hard to define and not always available. Therefore, we aimed to generate a novel measure of disease progression and to identify genetic markers associated with this progression measure. Methods We generated a progression score on the basis of principal component analysis of prospectively acquired longitudinal changes in motor, cognitive, and imaging measures in the 218 indivduals in the TRACK-HD cohort of Huntington's disease gene mutation carriers (data collected 2008–11). We generated a parallel progression score using data from 1773 previously genotyped participants from the European Huntington's Disease Network REGISTRY study of Huntington's disease mutation carriers (data collected 2003–13). We did a genome-wide association analyses in terms of progression for 216 TRACK-HD participants and 1773 REGISTRY participants, then a meta-analysis of these results was undertaken. Findings Longitudinal motor, cognitive, and imaging scores were correlated with each other in TRACK-HD participants, justifying use of a single, cross-domain measure of disease progression in both studies. The TRACK-HD and REGISTRY progression measures were correlated with each other (r=0·674), and with age at onset (TRACK-HD, r=0·315; REGISTRY, r=0·234). The meta-analysis of progression in TRACK-HD and REGISTRY gave a genome-wide significant signal (p=1·12 × 10−10) on chromosome 5 spanning three genes: MSH3, DHFR, and MTRNR2L2. The genes in this locus were associated with progression in TRACK-HD (MSH3 p=2·94 × 10−8 DHFR p=8·37 × 10−7 MTRNR2L2 p=2·15 × 10−9) and to a lesser extent in REGISTRY (MSH3 p=9·36 × 10−4 DHFR p=8·45 × 10−4 MTRNR2L2 p=1·20 × 10−3). The lead single nucleotide polymorphism (SNP) in TRACK-HD (rs557874766) was genome-wide significant in the meta-analysis (p=1·58 × 10−8), and encodes an aminoacid change (Pro67Ala) in MSH3. In TRACK-HD, each copy of the minor allele at this SNP was associated with a 0·4 units per year (95% CI 0·16–0·66) reduction in the rate of change of the Unified Huntington's Disease Rating Scale (UHDRS) Total Motor Score, and a reduction of 0·12 units per year (95% CI 0·06–0·18) in the rate of change of UHDRS Total Functional Capacity score. These associations remained significant after adjusting for age of onset. Interpretation The multidomain progression measure in TRACK-HD was associated with a functional variant that was genome-wide significant in our meta-analysis. The association in only 216 participants implies that the progression measure is a sensitive reflection of disease burden, that the effect size at this locus is large, or both. Knockout of Msh3 reduces somatic expansion in Huntington's disease mouse models, suggesting this mechanism as an area for future therapeutic investigation

. 40 Año 16 (2017) enero-junio. Señales de humo

- Editorial por José Luis Perea González. - La antropología y el patrimonio cultural por Patricia Olga Hernández Espinoza. - Talleres para la conservación y divulgacion de los caminos reales México-Estados Unidops por Esperanza Donjuan Espinoza. - Restauración de San Ignacio de Loyola de Bacanora, Sonora por Rodolfo del Castillo López. - El proyecto Sahuaripa y la Sierra Central. Resultados prelimilares 2014-2016 por John Carpenter y Guadalupe Sánchez. - Tierra. Diálogos con el patrimonio cultural de Trincheras por Julio Guillén. - Cristina Killoste Yowe por Raquel Padilla Ramos. - Cataloga INAH riqueza histórica del Templo del Barrio del Konti en Cócorit, Sonora por Martha Olivia Solís Zataraín. - Vida académica por Cristina García Moreno. - Colecciones arqueológicas del Museo de Sonora por Adriana Hinojo Hinojo y Zenón H. Tribucio Robles

. 41 Año 16 (2017) julio-diciembre. Señales de humo

- Editorial por José Luis Perea González. - Imágenes y devociones por Esperanza Donjuan Espinoza. - Oniame Tamó Nonó Nawesame Akichí. Peregrinación Macurawe por el Río Mayo por Alejandro Aguilar Zeleny y Roberto Ramírez Méndez. - Entre Comcaac, Pimas y Cahitas: Estudio Paleotnobotánico en la Costa Central de Sonora por Guadalupe Sánchez Miranda y Claudia León. - La cuaresma en el Noroeste de México por Jose Luis Moctezuma Zamarrón. - La tercera reunión anual de Seminario Ales Hrdlicka por Patricia Olga Hernández Espinoza. - Entre nómadas y rancheros, arqueología en ela cuenca del arroyo la poza por Tomás Pérez-Reyes. - Compartiendo el patrimonio por Martha Oliva Solís Zataraín. - Un breve repaso por la historia del internado Corl. J. Cruz Gálvez por Raquel Padilla Ramos. - La protección técnica y legal de los Sitios Arqueológicos del Estado de Sonora por Gristina García Moreno y Dai E. Blanquel García