Museos: la vitalidad del reducto, heteronomía y engramas

The Museum of Natural History of Rio Seco is a museum that works on the logic of displacement and differential work regarding what traditionally operates as a museum. It is outside the traditional logics of conservation and restoration, where conservation and restoration should do with the recombination of objects, rather than with a prophylactic operation on the object body preventing it from encoding the passage of time. An operation like the one mentioned is only possible, thanks to a notion of time that understands that the time is not linear, homogeneous and empty, but that it is plethora of all the possible times, must assume that the museum is not only a redoubt where to deposit objects Important, but it is a place with the capacity to generate narratives and speeches, on how to control, manage and act; last.El Museo de Historia Natural de Río Seco es un museo que funciona en la lógica del desplazamiento y el trabajo diferencial respecto de lo que tradicionalmente opera como museo se enmarca fuera de las lógicas tradicionales de la conservación y restauración, donde la conservación y restauración tiene que ver con la recombinación de objetos, más que con una operación profiláctica sobre el cuerpo de objeto evitando que cifre el paso del tiempo. Una operación como la mencionada solo es posible, merced a una noción de tiempo que entienda que el tiempo no es lineal, homogéneo y vacío, sino que es plétora de todos los tiempos posibles. Debe asumir que el museo no es solo un reducto donde depositar objetos importantes, sino que es un lugar con la capacidad de generar narrativas y discursos, sobre el cómo controlar, administrar y agenciar el pasado

Design of small CNC milling machine

Bakaláská práce se zabývá konstrukčním návrhem veteníku, vetena a vedením v ose Z malé CNC frézky. Nejprve je popsán současný stav a produkce malých CNC frézovacích stroj. Dále obsahuje systémový rozbor dané problematiky. Poté jsou zvoleny vstupní parametry, které se vyuijí k potebným výpočtm. Poslední část práce obsahuje konstrukční návrh veteníku a vetena s posuvem v ose Z, který je vytvoený v programu Autodesk Inventor. Součástí je 3D model, výkres sestavy a výrobní výkresy.The bachelor thesis deals with the design of headstock, spindle and Z axis of a small CNC milling machine. Firstly, the current state and production of small CNC milling machines is described. The other contains a system analysis of the given issue. Then input parameters are selected to be used for the necessary calculations. The last part of the thesis contains the structural design of the headstock and spindle with Z-axis feed, which is created in Autodesk Inventor. It includes a 3D model, assembly drawing, and production drawings.

Marketing analysis of regional sports klub in handball - TJ Sokol Vršovice

katedra: KTV

High loading shovel for loader

Tato diplomová práce se zabývá návrhem vysokovýklopné lopaty pro nakladač Komatsu WA380. Cílem je nalézt konstrukční řešení vysokovýklopné lopaty pro minimální výsypnou výšku 4 500 mm, šířku lopaty 3 000 mm a objem lopaty 5 m3. Práce obsahuje stručný popis vysokovýklopné lopaty, popis základních konstrukčních prvků a jejich volbu. Dále je provedena výpočtová část potřebné síly k vyklopení lopaty a statická analýza. V poslední části se práce zabývá pevnostní kontrolou čepů, lopaty a rámu. Práce je doplněna požadovanou výkresovou dokumentací.This diploma thesis deals with design of the high loading shovel for the loader Komatsu WA380. The aim is to find constructional solutions of the high loading shovel for a minimal dumping height of 4 500 mm, for the bucket width of 3 000 mm and for the bucket volume of 5 m3. The thesis contains a brief description of the high loading shovel and description of basic constructional components. It also contains choices of basic constructional components, a calculation of the necessary force to tilt the bucket and a static analysis. Stress control of the bucket, the frame and the pegs forms the final part of the thesis. The thesis is accompanied by the necessary technical drawings.

Belt conveyor for recycle aggregate

Tato bakalářská práce se zabývá pásovým dopravníkem pro dopravu recyklovatelného kameniva v šikmém směru. Cílem je nalézt konstrukční řešení pásového dopravníku pro zadaný dopravní výkon 85 000 kgh-1, zadanou osovou vzdálenost přesypů 49 metrů a výškový rozdíl 12 metrů. Práce obsahuje stručný popis pásového dopravníku, popis základních konstrukčních prvků a jejich volbu. Dále je provedena funkční výpočtová část výkonu a takových sil dle platné normy ČSN ISO 5048, stanovení základních rozměrů, návrh pohonu, návrh napínacího zařízení a pevnostní výpočet vybraných částí pásového dopravníku. Práce je doplněna požadovanou výkresovou dokumentací.This bachelor thesis deals with the belt conveyor for the transport of recycled aggregate in an oblique direction. The aim is to find constructional solutions to the belt conveyor for the assigned transport capacity of 95 000 kg per hour, and the assigned axial distance of 49 m and different height of 12 m. The thesis contains a brief description of the belt conveyor and a description of basic constructional components. It also contains a functional calculation of the capacity and forces according to the norm ČSN ISO 5048, a determination of main proportions of the belt conveyor, a conception and a design of the drive and of the tension system of the conveyor and a tensile strength calculation of some selected parts of the conveyor. The thesis is accompanied by the necessary technical drawings.

False positive result of human chorionic gonadotropin caused by human anti-mouse antibodies

Immunochemical reactions are fast, can be automated, and generally do not require pretreatment of biological material. Based on these advantages, they are widely used. On the other hand, they are susceptible to analytical interference that can lead to inaccurate results. These factors include the presence of anti-mouse antibodies, causing false positive (or sometimes false negative) results. Although the anti-mouse antibodies over many decades have been repeatedly identified to be the causative source but due to the rarity of such encounters they remain insufficiently considered. Here we show a case, a 45 year-old female who was mis-diagnosed with pregnancy due to falsely elevated human chorionic gonadotropin (hCG) due to anti-mouse antibodies. This led to the patient undergoing two ultrasound examinations and laparoscopy before the hCG was repeated on alternative assays which showed negative results, preventing the patient from methotrexate treatment. Here we describe the details of the case, outline the assay principal, supporting the finding from literature and outlining a process on how to identify such interferences in timely manner

Digital competence in laboratory medicine

Objectives: Even though most physicians and professionals in laboratory medicine have received basic training in statistics, experience shows that a general understanding of data analysis is not yet available on a broad scale. Therefore, data literacy, data-driven decision making, and computational thinking should be implemented in future educational training. To evaluate the state of digital competence among young scientists (YS) in laboratory medicine, we launched a worldwide online survey. Methods: A global online survey was conducted from 25/05/2022 to 26/06/2022 and was disseminated to YS who are listed in three large networks: YS of the DGKL, the EFLM Task Group-YS, and IFCC Task Force-YS and its corresponding members, covering a base of 53 countries. Results: A total of 119 young scientists from 40 countries participated in this survey. 80% did not learn digital skills in their academic education but 96% felt they needed to. Digital literacy was associated with terms such as programming, artificial intelligence and machine learning, statistics, communication, Big Data and data analytics. Conclusions: The results of our survey show that more knowledge and training in the area of digital skills is not just necessary, but also wanted by young scientists. A varied learning environment consisting of tutorial articles, videos, exercises, technical articles, collection of helpful links, online meetings and in person bootcamps is crucial to meet the challenges of an international project with different languages, health systems and time zones

High-sensitivity troponin assays for the early rule-out or diagnosis of acute myocardial infarction in people with acute chest pain: a systematic review and cost-effectiveness analysis.

BACKGROUND: Early diagnosis of acute myocardial infarction (AMI) can ensure quick and effective treatment but only 20% of adults with emergency admissions for chest pain have an AMI. High-sensitivity cardiac troponin (hs-cTn) assays may allow rapid rule-out of AMI and avoidance of unnecessary hospital admissions and anxiety. OBJECTIVE: To assess the clinical effectiveness and cost-effectiveness of hs-cTn assays for the early (within 4 hours of presentation) rule-out of AMI in adults with acute chest pain. METHODS: Sixteen databases, including MEDLINE and EMBASE, research registers and conference proceedings, were searched to October 2013. Study quality was assessed using QUADAS-2. The bivariate model was used to estimate summary sensitivity and specificity for meta-analyses involving four or more studies, otherwise random-effects logistic regression was used. The health-economic analysis considered the long-term costs and quality-adjusted life-years (QALYs) associated with different troponin (Tn) testing methods. The de novo model consisted of a decision tree and Markov model. A lifetime time horizon (60 years) was used. RESULTS: Eighteen studies were included in the clinical effectiveness review. The optimum strategy, based on the Roche assay, used a limit of blank (LoB) threshold in a presentation sample to rule out AMI [negative likelihood ratio (LR-) 0.10, 95% confidence interval (CI) 0.05 to 0.18]. Patients testing positive could then have a further test at 2 hours; a result above the 99th centile on either sample and a delta (Δ) of ≥ 20% has some potential for ruling in an AMI [positive likelihood ratio (LR+) 8.42, 95% CI 6.11 to 11.60], whereas a result below the 99th centile on both samples and a Δ of < 20% can be used to rule out an AMI (LR- 0.04, 95% CI 0.02 to 0.10). The optimum strategy, based on the Abbott assay, used a limit of detection (LoD) threshold in a presentation sample to rule out AMI (LR- 0.01, 95% CI 0.00 to 0.08). Patients testing positive could then have a further test at 3 hours; a result above the 99th centile on this sample has some potential for ruling in an AMI (LR+ 10.16, 95% CI 8.38 to 12.31), whereas a result below the 99th centile can be used to rule out an AMI (LR- 0.02, 95% CI 0.01 to 0.05). In the base-case analysis, standard Tn testing was both most effective and most costly. Strategies considered cost-effective depending upon incremental cost-effectiveness ratio thresholds were Abbott 99th centile (thresholds of < £6597), Beckman 99th centile (thresholds between £6597 and £30,042), Abbott optimal strategy (LoD threshold at presentation, followed by 99th centile threshold at 3 hours) (thresholds between £30,042 and £103,194) and the standard Tn test (thresholds over £103,194). The Roche 99th centile and the Roche optimal strategy [LoB threshold at presentation followed by 99th centile threshold and/or Δ20% (compared with presentation test) at 1-3 hours] were extendedly dominated in this analysis. CONCLUSIONS: There is some evidence to suggest that hs-CTn testing may provide an effective and cost-effective approach to early rule-out of AMI. Further research is needed to clarify optimal diagnostic thresholds and testing strategies. STUDY REGISTRATION: This study is registered as PROSPERO CRD42013005939. FUNDING: The National Institute for Health Research Health Technology Assessment programme