Discordancia intra-Alcudiense en el anticlinal de Agudo (Ciudad Real-Badajoz)

The Proterozoic unconfomity, also known more to the East, is described in the Agudo Antic/ine at the base of the Upper Alcudian (Upper Vendian) and extended to the whole antic/inory. This allows the extension of the Intra-Alcudian unconformity to the W

BCI-Based Navigation in Virtual and Real Environments

A Brain-Computer Interface (BCI) is a system that enables people to control an external device with their brain activity, without the need of any muscular activity. Researchers in the BCI field aim to develop applications to improve the quality of life of severely disabled patients, for whom a BCI can be a useful channel for interaction with their environment. Some of these systems are intended to control a mobile device (e. g. a wheelchair). Virtual Reality is a powerful tool that can provide the subjects with an opportunity to train and to test different applications in a safe environment. This technical review will focus on systems aimed at navigation, both in virtual and real environments.This work was partially supported by the Innovation, Science and Enterprise Council of the Junta de Andalucía (Spain), project P07-TIC-03310, the Spanish Ministry of Science and Innovation, project TEC 2011-26395 and by the European fund ERDF

Evaluación de una interfaz cerebro-ordenador basada en potenciales relacionados con eventos para la detección de estímulos visuales en una tarea de vigilancia

Las interfaces cerebro-ordenador (BCI) permiten establecer un canal de comunicación entre un usuario y un dispositivo a través de su actividad cerebral. El presente trabajo explora el uso de una BCI basada en potenciales relacionados con eventos (ERP) para la detección automática de nuevos estímulos durante una tarea de vigilancia. La tarea de vigilancia consistió en detectar la presencia de nuevos aviones en un mapa. Asimismo, se estudio el impacto de las siguientes variables sobre el rendimiento: el tamaño de la superficie a vigilar, y la saliencia de la aparición de nuevos aviones manipulada a través del color. Para ello, 10 participantes controlaron tres condiciones: aparición de un avión rojo, diferente a los amarillos ya presentes, en un área pequeña a vigilar (RP); aparición de un avión amarillo, similar a los ya presentes, en un área pequeña a vigilar (AP); y aparición de un avión rojo, diferente a los amarillos ya presentes, en un área grande a vigilar (RG). La accuracy promedio de cada condición fue la siguiente: RP, 64.5%; AP, 67.5%; RG, 41%. Los resultados mostraron que el tamaño de la superficie a vigilar tenia un impacto negativo en el rendimiento del sistema, pero no la saliencia manipulada a través del color. Por tanto, futuros estudios podrían explorar cómo solucionar el problema del área a vigilar, o estudiar qué otras variables medien en el rendimiento de una BCI para la detección de estímulos en tareas de vigilancia.Esta investigación forma parte del proyecto SICODIS (PID2021-127261OB-I00), que ha sido financiado conjuntamente por el Ministerio de Ciencia, Innovación y Universidades (MCIU); la Agencia Estatal de Investigación (AEI); el Fondo Europeo de Desarrollo Regional (FEDER) y la Universidad de Málaga (UMA). Asimismo, los autores quieren agradecer la colaboración de todos los participantes durante las pruebas

Congenital ablation of Tacr2 reveals overlapping and redundant roles of NK2R signaling in the control of reproductive axis

peer reviewe

Wnt receptors, bone mass, and fractures: gene-wide association analysis of LRP5 and LRP6 polymorphisms with replication

Objectives. Genes explaining the susceptibility to osteoporosis have not been fully elucidated. Our objective was to explore the association of polymorphisms capturing common variations of the lipoprotein receptor related protein (LRP) 5 and 6 genes, encoding two Wnt receptors, with femoral neck bone mineral density (BMD) and osteoporotic fractures of the spine and the hip. Design. Cross-sectional, case-control and replication genetic association study. Methods. Thirty nine tagging and functional single nucleotide polymorphisms (SNP) were analyzed in a group of 1043 postmenopausal women and 394 women with hip fractures. The results were replicated in a different group of 342 women. Results. Three SNPs of the LRP6 gene were associated with BMD (nominal uncorrected pvalues< 0.05) in the discovery cohort. One showed a significant association after multiple test correction; two of them were also associated in the replication cohort, with a combined standardized mean difference of 0.51 (p=0.009) and 0.65 (p<0.0001) across rs11054704 and rs2302685 genotypes. In the discovery cohort, several LRP5 SNPs were associated with vertebral fractures (odds ratio 0.67; p=0.01), with hip fractures (unadjusted odds ratios between 0.59 and 1.21, p=0.005-0.033, but not significant after multiple test- or age-adjustment), and with height and the projected femoral neck area, but not with BMD. Transcripts of LRP5 and LRP6 were similarly abundant in bone samples. Conclusions. In this study we found common polymorphisms of LRP5 associated with osteoporotic fractures, and polymorphisms of the LRP6 gene associated with BMD, thus suggesting them as likely candidates to contribute explaining the hereditary influence on osteoporosis

Search for the standard model Higgs boson in the H to ZZ to 2l 2nu channel in pp collisions at sqrt(s) = 7 TeV

A search for the standard model Higgs boson in the H to ZZ to 2l 2nu decay channel, where l = e or mu, in pp collisions at a center-of-mass energy of 7 TeV is presented. The data were collected at the LHC, with the CMS detector, and correspond to an integrated luminosity of 4.6 inverse femtobarns. No significant excess is observed above the background expectation, and upper limits are set on the Higgs boson production cross section. The presence of the standard model Higgs boson with a mass in the 270-440 GeV range is excluded at 95% confidence level.Comment: Submitted to JHE

Constraints on the χ_(c1) versus χ_(c2) polarizations in proton-proton collisions at √s = 8 TeV

The polarizations of promptly produced χ_(c1) and χ_(c2) mesons are studied using data collected by the CMS experiment at the LHC, in proton-proton collisions at √s=8  TeV. The χ_c states are reconstructed via their radiative decays χ_c → J/ψγ, with the photons being measured through conversions to e⁺e⁻, which allows the two states to be well resolved. The polarizations are measured in the helicity frame, through the analysis of the χ_(c2) to χ_(c1) yield ratio as a function of the polar or azimuthal angle of the positive muon emitted in the J/ψ → μ⁺μ⁻ decay, in three bins of J/ψ transverse momentum. While no differences are seen between the two states in terms of azimuthal decay angle distributions, they are observed to have significantly different polar anisotropies. The measurement favors a scenario where at least one of the two states is strongly polarized along the helicity quantization axis, in agreement with nonrelativistic quantum chromodynamics predictions. This is the first measurement of significantly polarized quarkonia produced at high transverse momentum