Audio description and plurilingual competence: new allies in language learning?

The CEFR (Council of Europe, 2001) and its companion volumes (Council of Europe, 2018, 2020) highlight the development of plurilingual and pluricultural competence (PPC) as one of the main objectives of language teaching and learning. Within this context, the plurilingual approach in education has placed translation in a prominent situation, with authors such as Cummins (2007) observing how it promotes not only the acquisition of foreign languages (FL) and the consolidation of L1s, but also biliteracy development and identity affirmation. Within translation, audiovisual translation (AVT) has proven to be particularly effective in language learning (cf. Lertola, 2019). The polysemiotic nature of audiovisual texts incorporates elements that require the activation of specific forms of mediation that cannot always be found in general translation. This article sets out to reflect on the influence that linguistic and semiotic transfer in AVT can exert on PPC (Author, 2021), drawing on the results of a quasi-experimental research undertaken within the PluriTAV project (cf. Martínez-Sierra, 2021). This specific study was aimed at assessing the development of PPC through audio description (AD) in BA English undergraduate students, who were organised into an experimental and a control group, with only the former using AD as a didactic tool. Although results do not reveal a statistically significant improvement in PPC acquisition, they enable the formulation of hypotheses to be tested in further research. In addition, the experimental group showed some progress in the development of specific plurilingual and pluricultural skills, which suggests that the use of AD in the FL classroom can improve learners’ plurilingual and pluricultural repertoire.El MCER (Consejo de Europa, 2001) y sus volúmenes complementarios, Companion Volume with new descriptors (Consejo de Europa, 2018, 2020), destacan el desarrollo de la competencia plurilingüe y pluricultural (CPP) como uno de los principales objetivos de la enseñanza y el aprendizaje de lenguas. En este contexto, la presencia del enfoque plurilingüe en la educación ha situado a la traducción en una posición destacada. Así, autores como Cummins (2007) subrayan su papel no solo en la adquisición de lenguas extranjeras (LE) y la consolidación de las L1, sino también en el desarrollo de la biliteracidad y la afirmación de la identidad. Dentro del campo de la traducción, la traducción audiovisual (TAV) ha demostrado ser especialmente eficaz en la adquisición de lenguas (cf. Lertola, 2019). La naturaleza polisemiótica de los textos audiovisuales incorpora elementos que requieren la activación de formas específicas de mediación que no siempre se encuentran en la traducción general. En este artículo se reflexiona sobre la influencia que puede ejercer la transferencia lingüística y semiótica propia de la TAV sobre la CPP (Author, 2021), a partir de los resultados de una investigación cuasi-experimental llevada a cabo dentro del proyecto PluriTAV (cf. Martínez-Sierra, 2021). Este estudio específico tenía como objetivo evaluar el desarrollo de la CPP mediante la audiodescripción (AD) en estudiantes de filología inglesa divididos en un grupo experimental y otro de control, donde solo el primero utilizó la AD como herramienta didáctica. Aunque los resultados no revelan una mejora estadísticamente significativa en la adquisición de la CPP, permiten formular hipótesis a contrastar en futuras investigaciones. Además, el grupo experimental mostró ciertos progresos en el desarrollo de algunas habilidades plurilingües y pluriculturales específicas, lo que sugiere que el uso de la AD en el aula de LE puede enriquecer el repertorio plurilingüe y pluricultural del estudiantado

Audio description and plurilingual competence: new allies in language learning?

The CEFR (Council of Europe, 2001) and its companion volumes (Council of Europe, 2018, 2020) highlight the development of plurilingual and pluricultural competence (PPC) as one of the main objectives of language teaching and learning. Within this context, the plurilingual approach in education has placed tran slation in a prominent situation, with authors such as Cummins (2007) observing how it promotes not only the acquisition of foreign languages (FL) and the consolidation of L1s, but also biliterac y development and identity affirmation. Within translation, a udiovisual translation (AVT) has proven to be particularly effective in language learning (cf. Lertola, 2019). The polysemiotic nature of audiovisual texts incorporates elements that require the ac tivation of specific forms of mediation that cannot always be found in general translation. This article sets out to reflect on the influence that linguistic and semiotic transfer in AVT can exert on PPC (Baños, Marzà, & Torralba, 2021), drawing on the results of a quasi - experimental research undertaken within the PluriTAV project (Martínez -Sierra, 2021). This specific study aimed to assess the development of PPC through audio description (AD) in Spanish undergraduates studying English Philology , who were organi sed into an experimental and a control group, with onl y the former using AD as a didactic tool. Although results do not reveal a statistically significant improvement in PPC acquisition, they enable hypotheses to be formulated that can then be tested in further research . In addition, the experimental group showed some progress in the development of specific plurilingual and pluricultural skills , which suggests that the use of AD in the FL classroom can improve learners’ plurilingual and pluricultural repertoire.El MCER (Consejo de Europa, 2001) y sus volúmenes complementarios, Companion Volume with new descriptors (Consejo de Europa, 2018, 2020), destacan el desarrollo de la competencia plurilingüe y pluricultural (CPP) como uno de los principales objetivos de la enseñanza y el aprendizaje de lenguas. En este contexto, la presencia del enfoque plurilingüe en la educación ha situado a la traducción en una posición destacada. Así, autores como Cummins (2007) subrayan su papel no solo en la adquisición de lenguas extranjeras (LE) y la consolidación de las L1, sino también en el desarrollo de la biliteracidad y la afirmación de la identidad. Dentro del campo de la traducción, la traducción audiovisual (TAV) ha demostrado ser especialmente eficaz en la adquisición de lenguas (cf. Lertola, 2019). La naturaleza polisemiótica de los textos audiovisuales incorpora elementos que requieren la activación de formas específicas de mediación que no siempre se encuentran en la traducción general. En este artículo se reflexiona sobre la influencia que puede ejercer la transferencia lingüística y semiótica propia de la TAV sobre la CPP (Author, 2021), a partir de los resultados de una investigación cuasi-experimental llevada a cabo dentro del proyecto PluriTAV (cf. Martínez-Sierra, 2021). Este estudio específico tenía como objetivo evaluar el desarrollo de la CPP mediante la audiodescripción (AD) en estudiantes de filología inglesa divididos en un grupo experimental y otro de control, donde solo el primero utilizó la AD como herramienta didáctica. Aunque los resultados no revelan una mejora estadísticamente significativa en la adquisición de la CPP, permiten formular hipótesis a contrastar en futuras investigaciones. Además, el grupo experimental mostró ciertos progresos en el desarrollo de algunas habilidades plurilingües y pluriculturales específicas, lo que sugiere que el uso de la AD en el aula de LE puede enriquecer el repertorio plurilingüe y pluricultural del estudiantado

Changes in and the mediating role of physical activity in relation to active school transport, fitness and adiposity among Spanish youth: the UP&DOWN longitudinal study

Background Longitudinal changes in child and adolescent active school transport (AST), and the mediating role of different intensities of daily physical activity (PA) levels in relation to AST and physical fitness and adiposity indicators is unclear. This study aimed to: 1) describe longitudinal changes in AST, light PA (LPA), moderate- to vigorous-intensity PA (MVPA), physical fitness and adiposity indicators over three time-points; and 2) investigate the mediating role of LPA and MVPA levels on associations between AST and physical fitness and adiposity indicators over three time-points among children and adolescents. Methods This longitudinal study comprised 1646 Spanish children and adolescents (48.8% girls, mean age 12.5 years +/- 2.5) at baseline, recruited from schools in Cadiz and Madrid. Mode of commuting to school was self-reported at baseline (T0, 2011-12), 1-year (T1) and 2-year follow-up (T2). PA was assessed using accelerometers. Handgrip strength, standing long jump and cardiorespiratory fitness (CRF) assessed physical fitness. Height, weight, body mass index, waist circumference, and triceps and subscapular skinfold thickness were measured. Multilevel linear regression analyses assessed changes in AST, PA levels, physical fitness and adiposity indicators over three time-points (T0-T1-T2). Additionally, longitudinal path analysis (n = 453; mean age [years] 12.6 +/- 2.4) was used to test the mediating effects of LPA and MVPA levels on the association between AST and physical fitness and adiposity indicators. Results Multilevel analyses observed decreases in LPA between T0-T1 (beta = - 11.27; p < 0.001) and T0-T2 (beta = - 16.27; p < 0.001) and decreases in MVPA between T0-T2 (beta = - 4.51; p = 0.011). Moreover, changes over time showed increases in handgrip between T0-T1 (beta = 0.78; p = 0.028) and T0-T2 (beta = 0.81; p = 0.046). Path analyses showed that AST was directly positively associated with MVPA at T1 (all, beta approximate to 0.33; p < 0.001). MVPA at T1 mediated associations between AST and CRF at T2 (beta = 0.20; p = 0.040), but not the other outcomes. LPA did not mediate any associations. Conclusions Results from longitudinal path analysis suggest that participation in more AST may help attenuate declines in MVPA that typically occur with age and improve CRF. Therefore, we encourage health authorities to promote AST, as a way to increase MVPA levels and CRF among youth

Toward the Integration of an Attract-and-Kill Approach with Entomopathogenic Nematodes to Control Multiple Life Stages of Plum Curculio (Coleoptera: Curculionidae)

Efforts to reduce insecticide inputs against plum curculio, Conotrachelus nenuphar, a key pest of apples in eastern North America, include perimeter-row insecticide sprays applied after the whole-orchard petal fall spray to manage dispersing adults and, more recently, insecticide sprays confined to odor-baited trap trees. Entomopathogenic nematodes (EPNs) are virulent to ground-dwelling stages of C. nenuphar, and may be applied to the ground underneath trap-tree canopies. Here, we (1) compared the efficacy of the odor-baited trap tree approach with grower-prescribed (=grower standard) sprays to manage C. nenuphar populations over a six-year period in seven commercial apple orchards in New England; and (2) assessed the performance of the EPN Steinernema riobrave at suppressing ground-dwelling stages of C. nenuphar. In addition, the performance of S. riobrave was compared against that of S. carpocapsae and S. feltiae in one year. Across the six years, percent fruit injury on trap tree plots averaged 11.3% on odor-baited trap trees and 1.4% on unbaited trees in grower standard plots, highlighting the ability of trap trees to aggregate C. nenuphar activity and subsequent injury. Mean percentage injury on fruit sampled from interior trees, the strongest measure of treatment performance, in trap tree plots did not differ significantly from that recorded on interior trees in grower standard spray plots (0.95 vs. 0.68%, respectively). Steinernema riobrave consistently reduced C. nenuphar populations as indicated by the significantly lower number of adult C. nenuphar that emerged from the soil, when compared to water control. Steinernema carpocapsae and S. riobrave performed similarly well, and both EPN species outperformed S. feltiae. Our combined findings indicate that an IPM approach that targets multiple life stages of C. nenuphar has the potential to manage this pest more sustainably in a reduced-spray environment

Validation of dynamic random dot stereotests in pediatric vision screening

Purpose: Stereo vision tests are widely used in the clinical practice for screening amblyopia and amblyogenic conditions. According to literature, none of these tests seems to be suitable to be used alone as a simple and reliable tool. There has been a growing interest in developing new types of stereo vision tests, with sufficient sensitivity to detect amblyopia. This new generation of assessment tools should be computer based, and their reliability must be statistically warranted. The present study reports the clinical evaluation of a screening system based on random dot stereograms using a tablet as display. Specifically, a dynamic random dot stereotest with binocularly detectable Snellen-E optotype (DRDSE) was used and compared with the Lang II stereotest. Methods: A total of 141 children (aged 4–14, mean age 8.9) were examined in a field study at the Department of Ophthalmology, Pécs, Hungary. Inclusion criteria consisted of diagnoses of amblyopia, anisometropia, convergent strabismus, and hyperopia. Children with no ophthalmic pathologies were also enrolled as controls. All subjects went through a regular pediatric ophthalmological examination before proceeding to the DRDSE and Lang II tests. Results: DRDSE and Lang II tests were compared in terms of sensitivity and specificity for different conditions. DRDSE had a 100% sensitivity both for amblyopia (n = 11) and convergent strabismus (n = 21), as well as a 75% sensitivity for hyperopia (n = 36). However, the performance of DRDSE was not statistically significant when screening for anisometropia. On the other hand, Lang II proved to have 81.8% sensitivity for amblyopia, 80.9% for strabismus, and only 52.8% for hyperopia. The specificity of DRDSE was 61.2% for amblyopia, 67.3% for strabismus, and 68.6% for hyperopia, respectively. Conversely, Lang II showed about 10% better specificity, 73.8% for amblyopia, 79.2% for strabismus, and 77.9% for hyperopia. Conclusions: The DRDSE test has a better sensitivity for the detection of conditions such as amblyopia or convergent strabismus compared with Lang II, although with slightly lower specificity. If the specificity could be further improved by optimization of the stimulus parameters, while keeping the sensitivity high, DRDSE would be a promising stereo vision test for screening of amblyopia.This study was supported by the EFOP-3.6.1.-16-2016-00004: Comprehensive Development for Implementing Smart Specialization Strategies at the University of Pécs and by the European Union, co-financed by the European Social Fund KTIA_NAP_13-1-2013-0001: Brain Research Program; 2017-1.2.1.-NKP-2017-00002: Brain Research Program 2.0; OTKA K108747, PTE ÁOK-KA-2017-06, EFOP-3.6.3-VEKOP-16-2017-00009, 20765-3/2018/FEKUTSTRAT “Central mechanisms of stereopsis”, National Excellence Program TÁMOP-4.2.4.A/ 2-11/1-2012-0001

Efficacy and safety of autologous platelet rich plasma for the treatment of vascular ulcers in primary care: Phase III study

Background: Vascular ulcers are commonly seen in daily practice at all levels of care and have great impact at personal, professional and social levels with a high cost in terms of human and material resources. Given that the application of autologous platelet rich plasma has been shown to decrease healing times in various different studies in the hospital setting, we considered that it would be interesting to assess the efficacy and feasibility of this treatment in primary care. The objectives of this study are to assess the potential efficacy and safety of autologous platelet rich plasma for the treatment of venous ulcers compared to the conventional treatment (moist wound care) in primary care patients with chronic venous insufficiency (C, clinical class, E, aetiology, A, anatomy and P, pathophysiology classification C6). Design: We will conduct a phase III, open-label, parallel-group, multicentre, randomized study. The subjects will be 150 patients aged between 40 and 100 years of age with an at least 2-month history of a vascular venous ulcer assigned to ten primary care centres. For the treatment with autologous platelet rich plasma, all the following tasks will be performed in the primary care setting: blood collection, centrifugation, separation of platelet rich plasma, activation of coagulation adding calcium chloride and application of the PRP topically after gelification. The control group will receive standard moist wound care. The outcome variables to be measured at baseline, and at weeks 5 and 9 later include: reduction in the ulcer area, Chronic Venous Insufficiency Quality of Life Questionnaire score, and percentage of patients who require wound care only once a week. Discussion: The results of this study will be useful to improve the protocol for using platelet rich plasma in chronic vascular ulcers and to favour wider use of this treatment in primary care.This study can be undertaken thanks to the financial support of the Spanish Carlos III Health Institute. We are grateful for funding from the Department of Health and Consumer Affairs of the Government of the Basque Country, the Basque Health Service (Osakidetza) for the pilot support and the Ezkerraldea Enkarterri health region

Association of blood-based biomarkers with radiologic markers and cognitive decline in atrial fibrillation patients

[Background] Atrial fibrillation (AF) has been associated with an increased risk of silent brain infarcts (SBI) and cognitive impairment, even in patients with low embolic risk. We aimed to test the association between 11 blood-biomarkers representing different AF-related pathways, and SBI, white matter hyperintensities (WMH), and cognitive decline in patients with AF and low embolic risk.[Methods] The present study followed a cross-sectional design. 70 patients with a history of AF and CHADS2 score ≤1, and 10 controls with neither AF nor SBI were included. All patients underwent a 3T brain MRI. Cortical and large subcortical ischemic lesions were considered presumed embolic origin lesions. White matter hyperintensities (WMH) were measured according to the Fazekas scale. A subset of patients underwent cognitive evaluation with the MoCA test. Circulating proteins were measured under blind conditions in a laboratory at Roche Diagnostics, Germany.[Results] 45 patients presented SBI in the MRI, and 25 did not. Ang-2, FGF-23, and BMP-10 were increased in patients with SBI. Ang-2 was elevated only in patients with embolic infarcts, whereas FGF-23 and BMP-10 tended to be elevated in patients with both types of infarcts. Ang-2 (OR = 1.56 [0.94-2.59], p = 0.087), and BMP-10 (OR = 4.83 [0.99–23.60], p = 0.052) were the biomarkers that showed the highest association with SBI when entered in a multivariable logistic regression model corrected by age. No biomarker was found associated with WMH or mild cognitive impairment.[Conclusions] BMP-10, and Ang-2 were increased in patients with SBI. Its usefulness to detect SBI in AF patients should be further explored.A Junta de Andalucía grant (PIN-0144-2016) supported partially the study. The Fundación Cajasol contributed to the study. Neurovascular Research Groups at Seville and Barcelona are part of the Spanish Neurovascular Disease Research Network (RICORS-ICTUS, RD21/0006/0007).Peer reviewe

Structural and non-coding variants increase the diagnostic yield of clinical whole genome sequencing for rare diseases

Background Whole genome sequencing is increasingly being used for the diagnosis of patients with rare diseases. However, the diagnostic yields of many studies, particularly those conducted in a healthcare setting, are often disappointingly low, at 25–30%. This is in part because although entire genomes are sequenced, analysis is often confined to in silico gene panels or coding regions of the genome. Methods We undertook WGS on a cohort of 122 unrelated rare disease patients and their relatives (300 genomes) who had been pre-screened by gene panels or arrays. Patients were recruited from a broad spectrum of clinical specialties. We applied a bioinformatics pipeline that would allow comprehensive analysis of all variant types. We combined established bioinformatics tools for phenotypic and genomic analysis with our novel algorithms (SVRare, ALTSPLICE and GREEN-DB) to detect and annotate structural, splice site and non-coding variants. Results Our diagnostic yield was 43/122 cases (35%), although 47/122 cases (39%) were considered solved when considering novel candidate genes with supporting functional data into account. Structural, splice site and deep intronic variants contributed to 20/47 (43%) of our solved cases. Five genes that are novel, or were novel at the time of discovery, were identified, whilst a further three genes are putative novel disease genes with evidence of causality. We identified variants of uncertain significance in a further fourteen candidate genes. The phenotypic spectrum associated with RMND1 was expanded to include polymicrogyria. Two patients with secondary findings in FBN1 and KCNQ1 were confirmed to have previously unidentified Marfan and long QT syndromes, respectively, and were referred for further clinical interventions. Clinical diagnoses were changed in six patients and treatment adjustments made for eight individuals, which for five patients was considered life-saving. Conclusions Genome sequencing is increasingly being considered as a first-line genetic test in routine clinical settings and can make a substantial contribution to rapidly identifying a causal aetiology for many patients, shortening their diagnostic odyssey. We have demonstrated that structural, splice site and intronic variants make a significant contribution to diagnostic yield and that comprehensive analysis of the entire genome is essential to maximise the value of clinical genome sequencing

Automatic Filtering and Substantiation of Drug Safety Signals

Drug safety issues pose serious health threats to the population and constitute a major cause of mortality worldwide. Due to the prominent implications to both public health and the pharmaceutical industry, it is of great importance to unravel the molecular mechanisms by which an adverse drug reaction can be potentially elicited. These mechanisms can be investigated by placing the pharmaco-epidemiologically detected adverse drug reaction in an information-rich context and by exploiting all currently available biomedical knowledge to substantiate it. We present a computational framework for the biological annotation of potential adverse drug reactions. First, the proposed framework investigates previous evidences on the drug-event association in the context of biomedical literature (signal filtering). Then, it seeks to provide a biological explanation (signal substantiation) by exploring mechanistic connections that might explain why a drug produces a specific adverse reaction. The mechanistic connections include the activity of the drug, related compounds and drug metabolites on protein targets, the association of protein targets to clinical events, and the annotation of proteins (both protein targets and proteins associated with clinical events) to biological pathways. Hence, the workflows for signal filtering and substantiation integrate modules for literature and database mining, in silico drug-target profiling, and analyses based on gene-disease networks and biological pathways. Application examples of these workflows carried out on selected cases of drug safety signals are discussed. The methodology and workflows presented offer a novel approach to explore the molecular mechanisms underlying adverse drug reactions