Algunas cuestiones sobre el origen oriental de la fíbula de codo tipo Huelva

A partir de un análisis tipológico y cronológico de las fíbulas de codo tipo Huelva, se estudian algunos ejemplares que tradicionalmente se han considerado, en orden a sus orígenes, como sus inmediatos prototipos orientales. Comprobándose lo inadecuado de esta consideración en el registro arqueológico actual y apreciándose que la fíbula de codo tipo Huelva es un producto local antiguo y genuino de la Península Ibérica, sin aparentes débitos exógenos.Several examples of elbow fibulae traditionally considered as them inmediate oriental prototypes will be analysed from a typological and chronological analysis of type Huelva’s fibulae. In order to test the inadequate consideration in the current archaeological record and taking into account the type Huelva’s fibulae is a local, genuine and ancient product of Iberian Peninsula, without any exogenous origins

Fíbulas de codo tipo Huelva de Montejícar, Granada

They are made known two fíbulas of elbow protohistorics, originating from the deposit of the Allozos, in Montejícar, of the didn't exist concrete referring of township prior to the iberians. This contribution extends the evidence of these fíndings metall in the southeast peninsular, supporting the hypothesis of a mining of transformation local, to the rnargin of the developments of the Baja Andalucía, in what were Tartessos. The analysis of composition of the fíbulas, of type Huelva, show the survival of a tradition craft that sinks their origins in the Late/Middle Bronze, with the maintenance of sorne developments technicals that have been known lost from the apparent argaric crisis. The novelty of the discovery explains the deceit on such crisis, outlining by against the evolution of the substratum toward developments economics and, perhaps social, that explain the Final Bronze and his real importance.Se dan a conocer dos fíbulas de codo protohistóricas, procedentes del yacimiento de Los Allozos, en Montejícar, del que no había evidencias concretas de poblamiento anteriores a lo ibérico. Esta aportación amplía el referente de estos hallazgos metálicos en el sureste peninsular, apoyando la hipótesis de una minería de transformación local, al margen de los desarrollos de la Baja Andalucía, en lo que fuera Tartessos. Los análisis compositivos de las fíbulas, de tipo Huelva, muestran la pervivencia de una tradición artesana que hunde sus raíces en el Bronce Tardío/Medio, con el mantenimiento de unos caracteres técnicos que se creían perdidos desde la aparente crisis argárica. La novedad del descubrimiento ilustraría la falacia sobre tal crisis, planteando por contra la evolución del sustrato hacia desenvolvimientos económicos y, quizá sociales, que explican el Bronce Final y su verdadera importancia

Clasificación secuencial tecno-tipológica de las fíbulas de codo de la Península Ibérica.

Sin resume

Peninsular fibulae: elbow «sículas» or type «Monachil»? News and revision

Se estudia un amplio conjunto de fibulas de codo de las tradicionalmente denominadas «sículas», bajo nuestra nomenclatura de tipo «Monachil», que vienen a completar el panorama cada vez más conocido de este tipo de artilugios problemáticos y paradigmáticos del Bronce Final en la Península Ibérica. De nuevo, se profundiza en sus diferentes tipologías y cronologías, así como en su dispersión regional y posible autoctonía o aloctonía, con el fin de seguir incidiendo en la elaboración de un factible marco crono-cultural, en el que encuadrar mínimamente sus mal definidas formas y desarrollos. Con los datos actuales no es factible mantener un origen sículo para estas fíbulas en la Península Ibérica.We study a wide range of elbow fibulae, traditionally referred to as «sículas» in our Monachil nomenclature. This study will fulfill our knowledge of these problematic and paradigmatic devices in the Late Bronze in the Iberian Peninsula. The different typologies and chronologies are deeply analyzed, as well as their regional distribution, focusing on their native or foreign origin. Our aim is to build a chrono-cultural framework incorporating these fibulae. With the current information available, we cannot conclude that these Iberian fibulae have a Sicilian origin

Nuevos datos para el estudio de representaciones zoomorfas en el arte esquemático de Andalucía

Se estudia un soporte-mueble cerámico, para la comprensión estilística y cronológica de la capra pyrenaica, bien representada entre los esquemas iconográficos del discurso esquemático peninsular. En los últimos años, este tipo de referentes muebles ha constituido el paradigma en donde se han articulado hipótesis y cronologías. Desde ese punto de vista, esta aportación adquiere un carácter excepcional.Capra Pyrenaica have been very well represented in the schematic iconographical discourse of the Iberian Peninsula, in order understand in chronological and stylistically, a representation made on pottery will be analyzed. During the last years this sort of portable representation has been the base for chronologies and hypothesis and, from this point of view, this find has an exceptional importance

SARS-CoV-2 viral load in nasopharyngeal swabs is not an independent predictor of unfavorable outcome

The aim was to assess the ability of nasopharyngeal SARS-CoV-2 viral load at first patient’s hospital evaluation to predict unfavorable outcomes. We conducted a prospective cohort study including 321 adult patients with confirmed COVID-19 through RT-PCR in nasopharyngeal swabs. Quantitative Synthetic SARS-CoV-2 RNA cycle threshold values were used to calculate the viral load in log10 copies/mL. Disease severity at the end of follow up was categorized into mild, moderate, and severe. Primary endpoint was a composite of intensive care unit (ICU) admission and/or death (n = 85, 26.4%). Univariable and multivariable logistic regression analyses were performed. Nasopharyngeal SARS-CoV-2 viral load over the second quartile (≥ 7.35 log10 copies/mL, p = 0.003) and second tertile (≥ 8.27 log10 copies/mL, p = 0.01) were associated to unfavorable outcome in the unadjusted logistic regression analysis. However, in the final multivariable analysis, viral load was not independently associated with an unfavorable outcome. Five predictors were independently associated with increased odds of ICU admission and/or death: age ≥ 70 years, SpO2, neutrophils > 7.5 × 103/µL, lactate dehydrogenase ≥ 300 U/L, and C-reactive protein ≥ 100 mg/L. In summary, nasopharyngeal SARS-CoV-2 viral load on admission is generally high in patients with COVID-19, regardless of illness severity, but it cannot be used as an independent predictor of unfavorable clinical outcome

Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection

Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components. Dendritic cells (DCs) play a key role in the defense against viral infections, for instance plasmacytoid DCs (pDCs), have the capacity to produce vast amounts of interferon-alpha (IFN-α). In COVID-19 there is a deficit in DC numbers and IFN-α production, which has been associated with disease severity. In this work, we described that in addition to the DC deficiency, several DC activation and homing markers were altered in acute COVID-19 patients, which were associated with multiple inflammatory markers. Remarkably, previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+ myeloid DCs and pDCs seven months after SARS-CoV-2 infection. Moreover, the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients, while no restoration of integrin β7 and indoleamine 2,3-dyoxigenase (IDO) levels were observed. These findings contribute to a better understanding of the immunological sequelae of COVID-19

Clinical and Ecological Impact of an Educational Program to Optimize Antibiotic Treatments in Nursing Homes (PROA-SENIOR): A Cluster, Randomized, Controlled Trial and Interrupted Time-Series Analysis

[Background] Antimicrobial stewardship programs (ASPs) are recommended in nursing homes (NHs), although data are limited. We aimed to determine the clinical and ecological impact of an ASP for NHs.[Methods] We performed a cluster, randomized, controlled trial and a before–after study with interrupted time-series analyses in 14 NHs for 30 consecutive months from July 2018 to December 2020 in Andalusia, Spain. Seven facilities implemented an ASP with a bundle of 5 educational measures (general ASP) and 7 added 1-to-1 educational interviews (experimental ASP). The primary outcome was the overall use of antimicrobials, calculated monthly as defined daily doses (DDD) per 1000 resident days (DRD).[Results] The total mean antimicrobial consumption decreased by 31.2% (−16.72 DRD; P = .045) with respect to the preintervention period; the overall use of quinolones and amoxicillin–clavulanic acid dropped by 52.2% (P = .001) and 42.5% (P = .006), respectively; and the overall prevalence of multidrug-resistant organisms (MDROs) decreased from 24.7% to 17.4% (P = .012). During the intervention period, 12.5 educational interviews per doctor were performed in the experimental ASP group; no differences were found in the total mean antimicrobial use between groups (−14.62 DRD; P = .25). Two unexpected coronavirus disease 2019 waves affected the centers increasing the overall mean use of antimicrobials by 40% (51.56 DRD; P < .0001).[Conclusions] This study suggests that an ASP for NHs appears to be associated with a decrease in total consumption of antimicrobials and prevalence of MDROs. This trial did not find benefits associated with educational interviews, probably due to the coronavirus disease 2019 pandemic.[Clinical Trials Registration] NCT03543605.Peer reviewe

Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)

Objectives: The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters. Methods: A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs). Results: In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p < 0.001) for tocilizumab, 0.82 (0.71-1.30; p 0.82) for IHDC, 0.61 (0.43-0.86; p 0.006) for PDC, and 1.17 (0.86-1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02-0.17; p < 0.001). Conclusions: Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situatio

Quorum sensing network in clinical strains of A. baumannii : AidA is a new quorum quenching enzyme

Acinetobacter baumannii is an important pathogen that causes nosocomial infections generally associated with high mortality and morbidity in Intensive Care Units (ICUs). Currently, little is known about the Quorum Sensing (QS)/Quorum Quenching (QQ) systems of this pathogen. We analyzed these mechanisms in seven clinical isolates of A. baumannii. Microarray analysis of one of these clinical isolates, Ab1 (A. baumannii ST-2-clon-2010), previously cultured in the presence of 3-oxo-C12-HSL (a QS signalling molecule) revealed a putative QQ enzyme (α/β hydrolase gene, AidA). This QQ enzyme was present in all nonmotile clinical isolates (67% of which were isolated from the respiratory tract) cultured in nutrient depleted LB medium. Interestingly, this gene was not located in the genome of the only motile clinical strain growing in this medium (A. baumannii strain Ab421-GEIH-2010 [Ab7], isolated from a blood sample). The AidA protein expressed in E. coli showed QQ activity. Finally, we observed downregulation of the AidA protein (QQ system attenuation) in the presence of HO (ROS stress). In conclusion, most of the A. baumannii clinical strains were not surface motile (84%) and were of respiratory origin (67%). Only the pilT gene was involved in surface motility and related to the QS system. Finally, a new QQ enzyme (α/β hydrolase gene, AidA protein) was detected in these strains