Análisis de la composición mineral en alimentos congelados precocinados de consumo habitual

La realización del presente estudio analítico ha tenido como principal objetivo ampliar y mejorar los datos queactualmente vienen reflejados en las tablas de composición de alimentos españoles, aportando datos que, además depropios, corresponden a alimentos ampliamente distribuidos en el mercado español y son consumidos de formahabitual en nuestro país. El análisis de los diferentes minerales se ha realizado en 28 alimentos precocinados congelados,previamente seleccionados, entre los que se incluyen pastas, pizzas, arroces y fritos de mayor consumo. Estetipo de alimentos son susceptibles de sufrir pérdidas en minerales debido a los procesos de elaboración, congelacióny pretratamiento culinario a que son sometidos antes de su consumo, por lo que es de gran interés el conocimientode su composición mineral, dando respuesta a las exigencias de un amplio grupo de profesionales y consumidoresque requieren de esta información nutricional

Els conflictes entre alumnes: una proposta d'intervenció des de la teràpia breu d’orientació sistèmica

Abstract not availabl

Changes in surface solar radiation in Northeastern Spain over the past six centuries recorded by tree-ring δ13C.

Although solar radiation at the surface plays a determinant role in carbon discrimination in tree rings, stable carbon isotope chronologies (δ13C) have often been interpreted as a temperature proxy due to the co-variability of temperature and surface solar radiation. Furthermore, even when surface solar radiation is assumed to be the main driver of 13C discrimination in tree rings, δ13C records have been calibrated against sunshine duration or cloud cover series for which longer observational records exists. In this study, we use different instrumental and satellite data over northeast Spain (southern Europe) to identify the main driver of tree-ring 13C discrimination in this region. Special attention is paid to periods in which the co-variability of those climate variables may have been weaker, such as years after large volcanic eruptions. The analysis identified surface solar radiation as the main driver of tree-ring δ13C changes in this region, although the influence of other climatic factors may not be negligible. Accordingly, we suggest that a reconstruction of SSR over the last 600 years is possible. The relation between multidecadal variations of an independent temperature reconstruction and surface solar radiation in this region shows no clear sign, and warmer (colder) periods may be accompanied by both higher and lower surface solar radiation. However, our reconstructed records of surface solar radiation reveals a sunnier Little Ice Age in agreement with other δ13C tree-ring series used to reconstruct sunshine duration in central and northern Europe

Importancia del lugar de elaboración de un producto de bollería de alto consumo sobre su composición grasa

Many epidemiologic studies show the relationship between the amount and the quality of the fat in the diet and the incidence of some patologies such as cardiovasculardiseases, cancer, etc. These data, adicionally to the fat that in later years the industrialized bakery food high in fat, are becoming a very important part of the children and adolescents diet, have motivated us to study the fat cuality of a industrialized bakery named "bollo relleno al cacao", Knowing the diferences product widely knowledge of elaboration of the same product but in differentnational factories.Numerosos estudios epidemiológicos ponen de manifiesto la relación entre la cantidad y calidad de la grasa ingerida en la dieta y la incidencia de determinadas patologías como enfermedades cardiovasculares, cáncer, etc. Estos datos sumados al hecho de que en la dieta del niño y del adolescente, en los últimos años, han adquirido una gran importancia los productos de bollería industriales, productos con alto contenido en grasas, nos ha motivado a realizar el análisis de la calidad de la grasa de un tipo de producto de bollería ampliamente consumido, denominado bollo relleno al cacao, teniendo en cuenta las diferencias de elaboración de este mismo producto en distintas fabricas a nivel nacional

P2X7 receptor is essential for cross-dressing of bone marrow-derived dendritic cells

T cell activation requires the processing and presentation of antigenic peptides in the context of a major histocompatibility complex (MHC complex). Cross-dressing is a non-conventional antigen presentation mechanism, involving the transfer of preformed peptide/MHC complexes from whole cells, such as apoptotic cells (ACs) to the cell membrane of professional antigen-presenting cells (APCs), such as dendritic cells (DCs). This is an essential mechanism for the induction of immune response against viral antigens, tumors, and graft rejection, which until now has not been clarified. Here we show for first time that the P2X7 receptor (P2X7R) is crucial to induce cross-dressing between ACs and Bone-Marrow DCs (BMDCs). In controlled ex vivo assays, we found that the P2X7R in both ACs and BMDCs is required to induce membrane and fully functional peptide/MHC complex transfer to BMDCs. These findings show that acquisition of ACs-derived preformed antigen/MHC-I complexes by BMDCs requires P2X7R expression.Fil: Barrera Avalos, Carlos. Universidad de Santiago de Chile; ChileFil: Briceño, Pedro. Universidad de Chile; ChileFil: Valdés, Daniel. Universidad de Santiago de Chile; ChileFil: Imarai, Mónica. Universidad de Santiago de Chile; ChileFil: Leiva Salcedo, Elías. Universidad de Santiago de Chile; ChileFil: Rojo, Leonel E.. Universidad de Santiago de Chile; ChileFil: Milla, Luis A.. Universidad de Santiago de Chile; ChileFil: Huidobro Toro, Juan Pablo. Universidad de Santiago de Chile; ChileFil: Robles Planells, Claudia. Universidad de Santiago de Chile; ChileFil: Escobar, Alejandro. Universidad de Chile; ChileFil: Di Virgilio, Francesco. Università di Ferrara; ItaliaFil: Moron, Victor Gabriel. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFil: Sauma, Daniela. Universidad de Chile; ChileFil: Acuña Castillo, Claudio. Universidad de Santiago de Chile; Chil

Comparative study on the clinical-nutritional status of obese postmenopausal women on a weight loss programme based on prepared dishes

Comparative Study; English Abstract; Journal Article;INTRODUCTION Few studies have evaluated the efficacy and reliability of weight loss-focussed prepared food dishes in obese post-menopausal women. OBJECTIVE To compare the efficacy of a weight loss programme based on a balanced hypocaloric diet using prepared dishes* with that of a similar programme based on standard commercially available foods and with a non-intervened control group. A further aim was to evaluate the subjectivity of participants in the preparation of the diet-adjusted dishes based on usually consumed products. SUBJECTS Obese post-menopausal women aged between 55 and 65 years. DESIGN Controlled longitudinal interventional study. METHOD The sample of 75 female volunteers were divided into three groups of 25 women: a control group, who continued to consume their usual non-dietary adjusted meals (CG), an intervened group, treated with a diet adjusted to their individual requirements and based on standard commercially available food (SG), and another intervened group, treated with a similarly adjusted diet but based on prepared dishes (PG). Data were gathered on anthropometric variables, consumption habits and physical activity levels, and clinical-nutritional controls were conducted at the start and every two weeks to the end of the 8-week study in order to evaluate biochemical changes. RESULTS The weight loss was slightly higher in the prepared-dishes group (PG) than in the standard food diet group (SG), but the difference was not statistically significant, whereas it was considerably higher in both groups than in the non-dietary adjusted control group (CG) and this difference was highly significant (losses of 7.60 kg in PG and 7.01 kg in SG versus 2.10 kg in CG (p < 0.01). However, the PG showed a significantly higher (p < 0.01) loss of fatty mass and abdominal circumference versus the SG women. CONCLUSION More weight was lost by the two groups treated with a diet based on prepared dishes or usual food items in comparison to untreated controls, but the diet based on prepared dishes obtained more reliable and higher quality outcomes, achieving a positive change at fatty compartment level and in the abdominal circumference.El presente proyecto ha sido financiado por la empresa Deliline® S. A.YesIntroducción: Son escasos los estudios que hayan evaluado la eficacia y la fiabilidad de los platos de comidas preparadas* enfocadas a la pérdida de peso en la mujer posmenopáusica obesa. Objetivo: Evaluar la eficiencia de un programa de pérdida de peso basado en una ingesta hipocalórica equilibrada, a partir de platos preparados* comparando con otra basada en alimentos de consumo habitual en el mercado y con un grupo control no intervenido. En el presente estudio se pretende, además, valorar la subjetividad de la participante a la hora de preparar los platos ajustados a la dieta de restricción basada en productos de consumo habitual. Sujetos de estudio: mujeres posmenopáusicas obesas, con edad comprendida entre 55-65 años. Diseño del estudio: Estudio longitudinal de intervención y controlado. Metodología: La muestra de 75 mujeres voluntarias se divide en tres grupos de 25 mujeres; uno con alimentación habitual, sin dieta ajustada (GC), otro intervenido mediante tratamiento con una dieta ajustada a los requerimientos individuales, pero con productos de consumo habitual en mercado (GE) y un tercero intervenido con dieta ajustada del mismo modo al anterior, pero con platos preparados (GD). Se registraron datos antropométricos, hábitos de consumo y nivel de actividad física. También se realizaron controles clínico-nutricionales para evaluar cambios bioquímicos al inicio del estudio, cada 2 semanas y al final del estudio, durante 8 semanas. Resultados: El grupo basado en platos preparados GD muestra resultados de pérdida de peso ligeramente mayores, aunque no estadísticamente significativos, al grupo de dieta estándar GE, mostrando, sin embargo, ambos, descensos muy significativos respecto al grupo no ajustado GC (con una pérdida de 7,60 kg en GD, 7,01 kg en el grupo GE y 2,10 kg en GC). Sin embargo, éste grupo de mujeres alimentadas con dieta hipocalórica basada en platos preparados GD, presenta (p < 0,01) una mayor pérdida significativa, tanto de masa grasa como de perímetro abdominal. Conclusión: Las mujeres tratadas con dieta basada en platos preparados GD y las tratadas con dieta ajustada habitual GE presentan una mayor pérdida de peso, pero el grupo GD mostró unos resultados más fiables y de calidad, dado el cambio positivo encontrado a nivel de compartimento graso y en el perímetro abdominal de las participantes del grupo objeto del estudio

Hipomineralización incisivo molar: su importancia en odontopediatría

Los defectos de estructura del esmalte pueden ser de origen hereditario o bien de origen ambiental, sean de causa sistémica o local. Estudios recientes muestran la prevalencia de un tipo de alteraciones del esmalte en los primeros molares e incisivos permanentes con características peculiares, y cuya etiología no está completamente esclarecida. El objetivo de esta revisión es actualizar los conocimientos acerca de los defectos por hipomineralización de incisivos y primeros molares permanentes, así como, conocer los posibles factores etiológicos, la prevalencia, las características clínicas y las posibilidades de tratamiento que enmarcan la situación clínica de hipomineralización incisivo molar

Magnesium reduces calcification in bovine vascular smooth muscle cells in a dose-dependent manner

WOS: 000300421300010PubMed ID: 21750166Vascular calcification (VC), mainly due to elevated phosphate levels, is one major problem in patients suffering from chronic kidney disease. In clinical studies, an inverse relationship between serum magnesium and VC has been reported. However, there is only few information about the influence of magnesium on calcification on a cellular level available. Therefore, we investigated the effect of magnesium on calcification induced by beta-glycerophosphate (BGP) in bovine vascular smooth muscle cells (BVSMCs). BVSMCs were incubated with calcification media for 14 days while simultaneously increasing the magnesium concentration. Calcium deposition, transdifferentiation of cells and apoptosis were measured applying quantification of calcium, von Kossa and Alizarin red staining, real-time reverse transcription-polymerase chain reaction and annexin V staining, respectively. Calcium deposition in the cells dramatically increased with addition of BGP and could be mostly prevented by co-incubation with magnesium. Higher magnesium levels led to inhibition of BGP-induced alkaline phosphatase activity as well as to a decreased expression of genes associated with the process of transdifferentiation of BVSMCs into osteoblast-like cells. Furthermore, estimated calcium entry into the cells decreased with increasing magnesium concentrations in the media. In addition, higher magnesium concentrations prevented cell damage (apoptosis) induced by BGP as well as progression of already established calcification. Higher magnesium levels prevented BVSMC calcification, inhibited expression of osteogenic proteins, apoptosis and further progression of already established calcification. Thus, magnesium is influencing molecular processes associated with VC and may have the potential to play a role for VC also in clinical situations.Fresenius Medical Care Deutschland GmbH, GermanyThis study was supported by Fresenius Medical Care Deutschland GmbH, Germany

Spatio‐temporal patterns of tree growth as related to carbon isotope fractionation in European forests under changing climate

Aim To decipher Europe-wide spatiotemporal patterns of forest growth dynamics and their associations with carbon isotope fractionation processes inferred from tree rings as modulated by climate warming. Location Europe and North Africa (30‒70°N, 10°W‒35°E). Time period 1901‒2003. Major taxa studied Temperate and Euro-Siberian trees. Methods We characterize changes in the relationship between tree growth and carbon isotope fractionation over the 20th century using a European network consisting of 20 site chronologies. Using indexed tree-ring widths (TRWi), we assess shifts in the temporal coherence of radial growth across sites (synchrony) for five forest ecosystems (Atlantic, Boreal, cold continental, Mediterranean and temperate). We also examine whether TRWi shows variable coupling with leaf-level gas exchange, inferred from indexed carbon isotope discrimination of tree-ring cellulose (Δ13Ci). Results We find spatial autocorrelation for TRWi and Δ13Ci extending over up to 1,000 km among forest stands. However, growth synchrony is not uniform across Europe, but increases along a latitudinal gradient concurrent with decreasing temperature and evapotranspiration. Latitudinal relationships between TRWi and Δ13Ci (changing from negative to positive southwards) point to drought impairing carbon uptake via stomatal regulation for water saving occurring at forests below 60°N in continental Europe. A rise in forest growth synchrony over the 20th century together with increasingly positive relationships between TRWi and Δ13Ci indicate intensifying drought impacts on tree performance. These effects are noticeable in drought-prone biomes (Mediterranean, temperate and cold continental). Main conclusions At the turn of this century, convergence in growth synchrony across European forest ecosystems is coupled with coordinated warming-induced drought effects on leaf physiology and tree growth spreading northwards. Such a tendency towards exacerbated moisture-sensitive growth and physiology could override positive effects of enhanced leaf intercellular CO2 concentrations, possibly resulting in Europe-wide declines of forest carbon gain in the coming decades

Sodium channel gene family: epilepsy mutations, gene interactions and modifier effects

The human sodium channel family includes seven neuronal channels that are essential for the initiation and propagation of action potentials in the CNS and PNS. In view of their critical role in neuronal firing and their strong sequence conservation during evolution, it is not surprising that mutations in the sodium channel genes are responsible for a growing spectrum of channelopathies. Nearly 700 mutations of the SCN1A gene have been identified in patients with Dravet's syndrome (severe myoclonic epilepsy of infancy), making this the most commonly mutated gene in human epilepsy. A small number of mutations have been found in SCN2A , SCN3A and SCN9A , and studies in the mouse suggest that SCN8A may also contribute to seizure disorders. Interactions between genetic variants of SCN2A and KCNQ2 in the mouse and variants of SCN1A and SCN9A in patients provide models of potential genetic modifier effects in the more common human polygenic epilepsies. New methods for generating induced pluripotent stem cells and neurons from patients will facilitate functional analysis of amino acid substitutions in channel proteins. Whole genome sequencing and exome sequencing in patients with epilepsy will soon make it possible to detect multiple variants and their interactions in the genomes of patients with seizure disorders.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/79388/1/jphysiol.2010.188482.pd