32 research outputs found

    Factors Related to Implementation and Reach of a Pragmatic Multisite Trial: The My Own Health Report (MOHR) Study

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    BACKGROUND: Contextual factors relevant to translating healthcare improvement interventions to different settings are rarely collected systematically. This study articulates a prospective method for assessing and describing contextual factors related to implementation and patient reach of a pragmatic trial in primary care. METHODS: In a qualitative case-series, contextual factors were assessed from the My Own Health Report (MOHR) study, focused on systematic health risk assessments and goal setting for unhealthy behaviors and behavioral health in nine primary care practices. Practice staff interviews and observations, guided by a context template were conducted prospectively at three time points. Patient reach was calculated as percentage of patients completing MOHR of those who were offered MOHR and themes describing contextual factors were summarized through an iterative, data immersion process.These included practice members' motivations towards MOHR, practice staff capacity for implementation, practice information system capacity, external resources to support quality improvement, community linkages, and implementation strategy fit with patient populations. CONCLUSIONS: Systematically assessing contextual factors prospectively throughout implementation of quality improvement initiatives helps translation to other health care settings. Knowledge of contextual factors is essential for scaling up of effective interventions

    Engaging stakeholders to inform national implementation of critical time intervention in a program serving homeless-experienced Veterans

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    The Veterans Affairs (VA) Grant and Per Diem Case Management “Aftercare” program provides 6 months of case management for homeless-experienced Veterans (HEVs) transitioning to permanent housing, with the aim of decreasing returns to homelessness. Implementing Critical Time Intervention (CTI)—an evidence-based case management practice—would standardize care across the 128 community-based agencies that provide Aftercare services. To prepare for national CTI implementation in Aftercare, guided by Replicating Effective Programs (REP), we conducted a four-site pilot in which we adapted a CTI implementation package (training, technical assistance, and external facilitation); characterized stakeholder perspectives regarding the acceptability and appropriateness of this package; and identified contextual factors that affected CTI implementation. We engaged a stakeholder workgroup to tailor existing CTI training and technical assistance materials for Aftercare. To provide tailored support for providers and leaders to adopt and incorporate evidence-based practices (EBPs) into routine care, we also developed external facilitation materials and processes. Over 9 months, we implemented this package at four sites. We conducted semi-structured interviews at pre-implementation, mid-implementation, and 6 months post-implementation, with HEVs (n = 37), case managers (n = 16), supervisors (n = 10), and VA leaders (n = 4); these data were integrated with templated reflection notes from the project facilitator. We used rapid qualitative analysis and targeted coding to assess the acceptability and appropriateness of CTI and our implementation package and identify factors influencing CTI implementation. Stakeholders generally found CTI acceptable and appropriate; there was consensus that components of CTI were useful and compatible for this setting. To adapt our implementation package for scale-up, this pilot highlighted the value of robust and tangible CTI training and technical assistance—grounded in real-world cases—that highlights the congruence of CTI with relevant performance metrics. Variations in agency-level contextual factors may necessitate more intense and tailored supports to implement and sustain complex EBPs like CTI. Processes used in this pilot are relevant for implementing other EBPs in organizations that serve vulnerable populations. EBP scale-up and sustainment can be enhanced by engaging stakeholders to tailor EBPs for specific contexts; pilot testing and refining implementation packages for scale-up; and using qualitative methods to characterize contextual factors that affect EBP implementation

    New genetic loci link adipose and insulin biology to body fat distribution.

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    Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms

    Delivering Preventing Health Services through Health Fairs: A Clinical-Community Partnership in Los Angeles County

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    Chronic diseases are the leading cause of poor health, disability, and death in the U.S. Efficient delivery of recommended preventive health services may significantly impact chronic disease burden, yet only a fraction of eligible adults receive preventive care. Therefore, innovative strategies are needed that extend the reach of the health care system into community venues, particularly for those with limited access to traditional health care settings. This dissertation examines how community health fairs organized through clinical-community partnerships can supplement the health care system in delivering preventive health services. Health fairs organized through the Faith Community Health Partnership (FCHP), a community benefit program of Providence Health and Services, were studied.The first study utilized administrative data from FCHP health fairs to construct a profile of participants (n=5,274), and the preventive health services they received including referrals for those with positive findings. Overall, screening rates for a standard battery of tests were high. FHCP health fairs served an at-risk population as evidenced by the large proportion of participants who screened positive on multiple tests.� Also reached were large numbers of uninsured and racial/ethnic minorities.The second study conducted a survey of 315 FCHP health fair participants to identify barriers to health care access, motivations for attending the health fairs, services received, and preferences for additional services. Common barriers to access included cost, lack of timely appointments, and long wait times in the doctor’s office. Free and convenient health fairs may address most identified barriers to care. Fewer than 33% of participants with positive screenings reported receiving referrals to follow-up care.The third study conducted qualitative interviews with FCHP partners (Providence, health ministries, and vendors), to identify the factors that underlie successful and sustainable collaboration in clinical-community partnerships. Perceived value, leadership buy-in, trust, and collaborative learning were key factors in promoting collaboration. The FCHP clinical-community partnership provided preventive health services to substantial numbers of health fair participants from populations of interest. However, for health fairs to serve as effective extenders of traditional primary care, the partners must also commit to providing linkages to primary care and adequate follow-up for participants with positive screenings
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