724 research outputs found

    La educación como determinante del salario: capital humano versus credencialismo

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    En este trabajo nos proponemos realizar un bosquejo de las dos grandes corrientes actuales de la economía de la educación. Inicialmente, describiremos los postulados básicos de la teoría del capital humano y, seguidamente, plantearemos las grandes líneas de la teoría del credencialismo. En ambas consideraciones nos referiremos, con particular énfasis, a la defendida relación entre educación e ingresos. Finalmente, expondremos las alternativas de política económica a las que nos conduce cada una de dichas escuelas

    Evaluation of Adipose Tissue Zinc-Alpha 2-Glycoprotein Gene Expression and Its Relationship with Metabolic Status and Bariatric Surgery Outcomes in Patients with Class III Obesity

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    Zinc-α2 glycoprotein (ZAG) is an adipokine involved in adipocyte metabolism with potential implications in the pathogenesis of metabolic disorders. Our aim was to evaluate the relationship between visceral (VAT) and subcutaneous adipose tissue (SAT) ZAG expression and metabolic parameters in patients with class III obesity, along with the impact of basal ZAG expression on short- and medium-term outcomes related to bariatric surgery. 41 patients with class III obesity who underwent bariatric surgery were included in this study. ZAG gene expression was quantified in SAT and VAT. Patients were classified into two groups according to SAT and VAT ZAG percentile. Anthropometric and biochemical variables were obtained before and 15 days, 45 days, and 1 year after surgery. The lower basal SAT ZAG expression percentile was associated with higher weight and waist circumference, while the lower basal VAT ZAG expression percentile was associated with higher weight, waist circumference, insulin, insulin resistance, and the presence of metabolic syndrome. Basal SAT ZAG expression was inversely related to weight loss at 45 days after surgery, whereas no associations were found between basal VAT ZAG expression and weight loss after surgery. Additionally, a negative association was observed between basal SAT and VAT ZAG expression and the decrease of gamma-glutamyl transferase after bariatric surgery. Therefore, lower SAT and VAT ZAG expression levels were associated with an adverse metabolic profile. However, this fact did not seem to confer worse bariatric surgery-related outcomes. Further research is needed to assess the clinical significance of the role of ZAG expression levels in the dynamics of hepatic enzymes after bariatric surgeryThis study has been co-funded by FEDER funds (“A way to make Europe”). M.M. and L.G.S. are also supported by UMA18-FEDERJA-285 and UMA20-FEDERJA-144, co-funded by Malaga University, Junta de Andalucía and FEDER funds, CB06/03/0018, PI-0297-2018 and PI-0194-2017, co-funded by FEDER funds and Consejería de Salud y Familias, Junta de Andalucía, and CP17/00133, Instituto de Salud Carlos III (ISCIII), Ministry of Science, Innovation and Universities, Spain Partial funding for open access charge: Universidad de Málag

    Expression of sterol regulatory element-binding proteins in epicardial adipose tissue in patients with coronary artery disease and diabetes mellitus: preliminary study

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    [Abstract] Objectives: Sterol regulatory element-binding proteins (SREBP) genes are crucial in lipid biosynthesis and cardiovascular homeostasis. Their expression in epicardial adipose tissue (EAT) and their influence in the development of coronary artery disease (CAD) and type-2 diabetes mellitus remain to be determined. The aim of our study was to evaluate the expression of SREBP genes in EAT in patients with CAD according to diabetes status and its association with clinical and biochemical data. Methods: SREBP-1 and SREBP-2 mRNA expression levels were measured in EAT from 49 patients with CAD (26 with diabetes) and 23 controls without CAD or diabetes. Results: Both SREBPs mRNA expression were significantly higher in patients with CAD and diabetes (p<0.001) and were identified as independent cardiovascular risk factor for coronary artery disease in patients with type-2 diabetes (SREBP-1: OR 1.7, 95%CI 1.1-2.5, p=0.02; SREBP-2: OR 1.6, 95%CI 1.2-3, p=0.02) and were independently associated with the presence of multivessel CAD, left main and anterior descending artery stenosis, and higher total and LDL cholesterol levels, and lower HDL cholesterol levels, in patients with CAD and diabetes. Conclusions: SREBP genes are expressed in EAT and were higher in CAD patients with diabetes than those patients without CAD or diabetes. SREBP expression was associated as cardiovascular risk factor for the severity of CAD and the poor lipid control. In this preliminary study we suggest the importance of EAT in the lipid metabolism and cardiovascular homeostasis for coronary atherosclerosis of patients with diabetes and highlight a future novel therapeutic target.Instituto de Salud Carlos III; PI13/02542Instituto de Salud Carlos III; PI11/01661Red de Investigación Cardiovascular; RD12/0042/003

    At the beginnings of the funerary Megalithism in Iberia at Campo de Hockey necropolis

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    [EN] The excavations undertaken at the Campo de Hockey site in 2008 led to the identification of a major Neolithic necropolis in the former Island of San Fernando (Bay of Cadiz). This work presents the results of the latest studies, which indicate that the site stands as one of the oldest megalithic necropolises in the Iberian Peninsula. The main aim of this work is to present with precision the chronology of this necropolis through a Bayesian statistical model that confirms that the necropolis was in use from c. 4300 to 3800 cal BC. The presence of prestige grave goods in the earliest and most monumental graves suggest that the Megalithism phenomenon emerged in relation to maritime routes linked to the distribution of exotic products. We also aim to examine funerary practices in these early megalithic communities, and especially their way of life and the social reproduction system. As such, in addition to the chronological information and the Bayesian statistics, we provide the results of a comprehensive interdisciplinary study, including anthropological, archaeometric and genetic data.We wish to express our gratitude to Antonio Saez Espligares (Historical Museum of San Fernando) and Lourdes Lorenzo (Figlina, s.l.) for their support during the archaeological excavation. This research was conducted in the framework of the following research projects: "Analysis of prehistoric societies from the Middle Palaeolithic to the Late Neolithic at both sides of the Strait of Gibraltar: relations and contacts", funded by the State Research Agency (SRA) and the European Regional Development Fund (ERDF). Ref.: HAR2017-87324-P. (2018-2021). "Analisis interdisciplinar para el conocimiento del poblamiento humano de la Bahia de Cadiz durante la Prehistoria Reciente (VI-II milenios a.n.e.)", funded by 2014-2020 ERDF Operational Programme and the Department of Economy, Knowledge, Business and University of the Regional Government of Andalusia. Ref.: FEDER-UCA18-106917 (2020-2023). "Analisis de los isotopos de oxigeno en conchas y de los isotopos estables de oxigeno y carbono en huesos humanos en el poblado neolitico insular de Campo de Hockey (San Fernando, Cadiz)", authorised and funded by CEIMAR. Ref.: CEIJ-015 (2018-2019). Eduardo Molina Piernas acknowledges co-funding from European Social Fund (D1113102E3) and Junta de Andalucia

    Inventariando la biodiversidad en el Parque Nacional de La Caldera de Taburiente (La Palma, Islas Canarias, España): novedades científicas

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    This paper is the first result of an agreement between the Organismo Autónomo Parques Nacionales and the Consejo Superior de Investigaciones Científicas, entitled “Inventory and study of the Invertebrate Fauna of the National Park of La Caldera de Taburiente”. A detailed account of the faunistic novelties found up to now among the specimens of terrestrial and freshwater invertebrates collected along the two years of sampling (July 1999 to July 2001), whose number is estimated in ca. 500,000, is given. A brief description of planning and of methodology applied to the inventory of the invertebrate fauna is made and a tabulated summary of novelties is presented. The list shows at present 284 families, 594 genera and 739 species. For the Canary Islands, the present record of new taxa is 29 families, 115 genera (1 of them confirmed as new to Science and 3 awaiting confirmation) and 187 species (24 new to Science). Moreover, 242 genera and 338 species are new to the fauna of La Palma I., being known from other islands of the archipelago. Other 47 taxa, still being studied, could be new to Science as well. These results have been reached with the study of just a minimal part of the whole material, which underlines the need for systematic, continued sampling to evaluate the faunistic richness of poorly explored areas and its possible necessity for protection. Therefore, one should expect more novelties and the inventory may increase significantly when all the material is revised.El presente artículo es el primer resultado de un convenio entre el Organismo Autónomo Parques Nacionales y el Consejo Superior de Investigaciones Científicas, denominado “Inventario y estudio de la Fauna Invertebrada del Parque Nacional de La Caldera de Taburiente”. Se detallan las novedades faunísticas encontradas hasta el momento entre los ejemplares de invertebrados terrestres y dulceacuícolas recogidos durante los dos años de muestreo (julio de 1999 a julio de 2001), cuyo número se estima en unos 500.000. Se hace una breve descripción de la planificación y la metodología aplicadas al inventario de la fauna invertebrada y se tabulan las novedades. En su estado actual el inventario arroja 284 familias, 594 géneros y 739 especies. Para la fauna de las Islas Canarias, el registro actual de táxones nuevos es de 29 familias, 115 géneros (de los cuales 1 género ha sido confirmado como nuevo para la Ciencia y otros 3 están pendientes de confirmación) y 187 especies (de las cuales 24 nuevas para la Ciencia). Además, 242 géneros y 338 especies son nuevas para la fauna de la isla de La Palma, conociéndose con anterioridad de otras islas del archipiélago. Otros 47 táxones aún en estudio, podrían resultar asimismo nuevos para la Ciencia. Estos resultados se han alcanzado tan sólo con el estudio de una parte mínima del material, lo que subraya la necesidad de muestreos continuados y sistemáticos para evaluar la riqueza faunística de áreas poco exploradas y su posible necesidad de protección. Por tanto, cabe esperar más novedades y el inventario puede quedar significativamente incrementado cuando se revise todo el material

    Bosque de niebla. Gestión y educación ambiental como herramientas didácticas para su conservación

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    La investigación en estrategias de gestión en sistemas socioecológicos busca aportes al conocimiento para la protección de ecosistemas estratégicos como son los bosques de niebla y la comunicación que estos ejercen con la ciudad-región, como es el caso de bosque de niebla en el sector del Salto del Tequendama. Para ello se plantean diferentes miradas investigativas de diferentes profesionales que participaron en calidad de coinvestigadores, cuyos aportes significativos en las diferentes temáticas a los procesos investigativos, a través de diferentes aristas epistemológicas, se articulan alrededor de los siguientes ejes: ecología, ecopedagogía y recursos naturales, aulas ambientales, modelos pedagógicos en educación ambiental, didácticas ambientales y elementos de TIC. Todas estas son herramientas para desarrollar la educación ambiental y las experiencias pedagógicas por parte de algunos docentes en colegios del departamento de Cundinamarca, quienes dinamizaron proyectos Praes y experiencias educativas para la conservación de los recursos naturales. El elemento común en esto es conseguir que los actores de las comunidades educativas generaran procesos en los que la educación ambiental facilite y genere espacios participativos para el fomento de la protección y conservación de los recursos naturales, en especial de los bosques de niebla

    Contribution of cardio-vascular risk factors to depressive status in the PREDIMED-PLUS Trial. A cross-sectional and a 2-year longitudinal study

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    Background Cardio-vascular disease and depression are thought to be closely related, due to shared risk factors. The aim of the study was to determine the association between cardio-vascular risk (CVR) factors and depressive status in a population (55-75 years) with metabolic syndrome (MetS) from the PREDIMED-Plus trial. Methods and findings Participants were classified into three groups of CVR according to the Framingham-based REGICOR function: (1) low (LR), (2) medium (MR) or (3) high/very high (HR). The Beck Depression Inventory-II (BDI-II) was used to assess depressive symptoms at baseline and after 2 years. The association between CVR and depressive status at baseline (n = 6545), and their changes after 2 years (n = 4566) were evaluated through multivariable regression models (logistic and linear models). HR women showed higher odds of depressive status than LR [OR (95% CI) = 1.78 (1.26, 2.50)]. MR and HR participants with total cholesterol <160 mg/mL showed higher odds of depression than LR [OR (95% CI) = 1.77 (1.13, 2.77) and 2.83 (1.25, 6.42) respectively)] but those with total cholesterol ¿280 mg/mL showed lower odds of depression than LR [OR (95% CI) = 0.26 (0.07, 0.98) and 0.23 (0.05, 0.95), respectively]. All participants decreased their BDI-II score after 2 years, being the decrease smaller in MR and HR diabetic compared to LR [adjusted mean±SE = -0.52±0.20, -0.41 ±0.27 and -1.25±0.31 respectively). MR and HR participants with total cholesterol between 240-279 mg/mL showed greater decreases in the BDI-II score compared to LR (adjusted mean±SE = -0.83±0.37, -0.77±0.64 and 0.97±0.52 respectively). Conclusions Improving cardiovascular health could prevent the onset of depression in the elderly. Diabetes and total cholesterol in individuals at high CVR, may play a specific role in the precise response.The PREDIMED-Plus trial was supported by the European Research Council through a grant to MAM (Advanced Research Grant 2013-2018; 340918). The project was also supported by the official funding agency for biomedical research of the Spanish Government (ISCIII) through the Fondo de Investigación para la Salud (FIS), which is co-funded by the European Regional Development Fund (four coordinated FIS projects), who awarded grants to JS and JV (PI13/00673, PI13/00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/00728, PI13/01090, PI13/01056, PI14/01722, PI14/00636, PI14/00618, PI14/00696, PI14/01206, PI14/01919, PI14/00853, PI14/01374, PI16/00473, PI16/00662, PI16/01873, PI16/01094, PI16/00501, PI16/00533, PI16/00381, PI16/00366, PI16/01522, PI16/01120, PI17/00764, PI17/01183, PI17/00855, PI17/01347, PI17/00525, PI17/01827, PI17/00532, PI17/00215, PI17/01441, PI17/00508, PI17/01732 and PI17/00926). The International Nut&Dried Fruit Council-FESNAD also provided funding through a grant to MAM (201302), and Recercaixa also awarded a grant to JS (2013ACUP00194). The Department of Health, Generalitat de Cataluña by the calls 'Acció instrumental de programes de recerca orientats en lámbit de la recercaila innovació en salut' and 'Pla estrategic de recerca i innovació en salut (PERIS),' also awarded a grant to FF (SLT006/17/00246). This research was also partially funded by: Consejería de Salud de la Junta de Andalucía (PI0458/2013, PS0358/2016, PI0137/2018); Generalitat Valenciana (PROMETEO/2017/017); SEMERGEN, CIBEROBN, FEDER and ISCIII (CB06/03); EU-H2020 Grants (Eat2beNICE/h2020-sfs-2016-2, ref.728018; PRIME/h2020-SC1-BHC-2018-2020, ref: 847879)

    Isotemporal substitution of inactive time with physical activity and time in bed: cross-sectional associations with cardiometabolic health in the PREDIMEDPlus study

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    Background: This study explored the association between inactive time and measures of adiposity, clinical parameters, obesity, type 2 diabetes and metabolic syndrome components. It further examined the impact of reallocating inactive time to time in bed, light physical activity (LPA) or moderate-to-vigorous physical activity (MVPA) on cardio-metabolic risk factors, including measures of adiposity and body composition, biochemical parameters and blood pressure in older adults. Methods: This is a cross-sectional analysis of baseline data from 2189 Caucasian men and women (age 55-75 years, BMI 27-40 Kg/m2) from the PREDIMED-Plus study (http://www.predimedplus.com/). All participants had ≥3 components of the metabolic syndrome. Inactive time, physical activity and time in bed were objectively determined using triaxial accelerometers GENEActiv during 7 days (ActivInsights Ltd., Kimbolton, United Kingdom). Multiple adjusted linear and logistic regression models were used. Isotemporal substitution regression modelling was performed to assess the relationship of replacing the amount of time spent in one activity for another, on each outcome, including measures of adiposity and body composition, biochemical parameters and blood pressure in older adults. Results: Inactive time was associated with indicators of obesity and the metabolic syndrome. Reallocating 30 min per day of inactive time to 30 min per day of time in bed was associated with lower BMI, waist circumference and glycated hemoglobin (HbA1c) (all p-values < 0.05). Reallocating 30 min per day of inactive time with 30 min per day of LPA or MVPA was associated with lower BMI, waist circumference, total fat, visceral adipose tissue, HbA1c, glucose, triglycerides, and higher body muscle mass and HDL cholesterol (all p-values < 0.05). Conclusions: Inactive time was associated with a poor cardio-metabolic profile. Isotemporal substitution of inactive time with MVPA and LPA or time in bed could have beneficial impact on cardio-metabolic health

    Aulas develadas 3: la práctica, con investigación, se cambia

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    Este tercer libro de la colección “Aulas develadas: La práctica, con investigación, se cambia”, producto de las investigaciones de aula adelantadas por docentes de la Universidad del Norte, con el apoyo del Centro para la Excelencia Docente (CEDU) en el programa Círculo de Escritura, lo componen seis capítulos que recopilan los resultados de trabajos realizados por docentes de las áreas Ciencia política y Relaciones internacionales, Matemáticas, Psicología e Ingeniería. Confiamos en que los hallazgos que aquí se presentan sean de interés para los lectores y puedan ser compartidos de manera amplia entre distintos públicos
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