43 research outputs found
Structure of a bacterial voltage-gated sodium channel pore reveals mechanisms of opening and closing
Voltage-gated sodium channels are vital membrane proteins essential for electrical signalling; in humans, they are key targets for the development of pharmaceutical drugs. Here we report the crystal structure of an open-channel conformation of NavMs, the bacterial channel pore from the marine bacterium Magnetococcus sp. (strain MC-1). It differs from the recently published crystal structure of a closed form of a related bacterial sodium channel (NavAb) by having its internal cavity accessible to the cytoplasmic surface as a result of a bend/rotation about a central residue in the carboxy-terminal transmembrane segment. This produces an open activation gate of sufficient diameter to allow hydrated sodium ions to pass through. Comparison of the open and closed structures provides new insight into the features of the functional states present in the activation cycles of sodium channels and the mechanism of channel opening and closing
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Diaprepes Root Weevil
Diaprepes root weevil is a serious pest of Florida citrus, sweet potatoes, papayas, and ornamental plants, and it threatens to become established in California as well. This publication gives guidelines for pest identification and control. 23 color photos
Recommended from our members
Diaprepes Root Weevil
Diaprepes root weevil is a serious pest of Florida citrus, sweet potatoes, papayas, and ornamental plants, and it threatens to become established in California as well. This publication gives guidelines for pest identification and control. 23 color photos