The genetic architecture of the human cerebral cortex

The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder

Portland Farmer\u27s Market 2006 Site Plan Update

The team assisted the Portland Farmer\u27s Market in updating their 5 Year Site Plan and to make site-related recommendations for the 2010 Growth/Vision document. This project was conducted under the supervision of Sy Adler, Deborah Howe, Connie Ozawa, and Sumner Sharpe

Plexus 2007

Sponsors: School of Medicine Dean’s Office, Office of Educational Affairs, Office of AdmissionsThe PLEXUS staff wishes to recognize the hard work and support of the following individuals:Ellena Peterson, PhD, Gayle Pierce, Linda Hill, Carroll Rudy, Dale Fukuda from Printing Division.The Senior Editors also wish to thank Sarah Mourra and Boback Ziaeian for their endless guidance and encouragement.Co-Editors-in-Chief Jamie “Akiva” Kahn; Mariam NaqviManaging Editor: Pooya JavidanSenior EditorsAudio: Lauren CheungBeautification Project: Janet LimCreative Writing: Jamie “Akiva” KahnLayout & Design: Mariam NaqviMarketing & Outreach: Janet LimVisual Arts: Vicky MillayAssociate EditorsAudio: Wesley RyanBeautification Project: Christina UmberCreative Writing: Dana SteenhardLayout & Design: Rod MortazaviMarketing & Outreach: Julie HuiVisual Arts: Neera SodhiSelection Editors: Antony Hazel; Pooya Javidan; Jane LeeSelection Committee: Sarah Blaschko; Brian McMichael; Sarah Mourra; Manijeh Torki; Roya Saisan; Tracy Slone; Josh Waltzman; Randy Wei; Boback ZiaeianFaculty Advisors: Elizabeth Morrison, MD; Johanna Shapiro, PhDPlexus Audio provides audio artists with a way to showcase their talents. All of the work hasbeen created by affiliates of the UC Irvine School of Medicine and Medical Center. We hope that you enjoy the large variety of innovative and creative works and stay tuned for future developments from Plexus Audio.Senior Audio Editor: Lauren CheungAssociate Audio Editor: Wesley Ryan WWW.PLEXUSAUDIO.COM UCI School of Medicine  (c) 2007 PLEXUSPublished works were contributed by UCI School of Medicine students, faculty, staff, alumni, and patients