501 research outputs found
Space curves with the expected postulation
AbstractThe postulation of a space curve is a classifying invariant which computes for any integer n the dimension of the family of surfaces of degree n containing the curve. We prove that for any integers d and g satisfying d−3⩽g⩽2d−9, there exists a smooth connected curve of degree d and genus g with the minimal postulation expected by the Riemann–Roch theorem
Heterozygous Mutation of Drosophila Opa1 Causes the Development of Multiple Organ Abnormalities in an Age-Dependent and Organ-Specific Manner
Optic Atrophy 1 (OPA1) is a ubiquitously expressed dynamin-like GTPase in the inner mitochondrial membrane. It plays important roles in mitochondrial fusion, apoptosis, reactive oxygen species (ROS) and ATP production. Mutations of OPA1 result in autosomal dominant optic atrophy (DOA). The molecular mechanisms by which link OPA1 mutations and DOA are not fully understood. Recently, we created a Drosophila model to study the pathogenesis of optic atrophy. Heterozygous mutation of Drosophila OPA1 (dOpa1) by P-element insertion results in no obvious morphological abnormalities, whereas homozygous mutation is embryonic lethal. In eye-specific somatic clones, homozygous mutation of dOpa1 causes rough (mispatterning) and glossy (decreased lens deposition) eye phenotypes in adult Drosophila. In humans, heterozygous mutations in OPA1 have been associated with mitochondrial dysfunction, which is predicted to affect multiple organs. In this study, we demonstrated that heterozygous dOpa1 mutation perturbs the visual function and an ERG profile of the Drosophila compound eye. We independently showed that antioxidants delayed the onset of mutant phenotypes in ERG and improved larval vision function in phototaxis assay. Furthermore, heterozygous dOpa1 mutation also caused decreased heart rate, increased heart arrhythmia, and poor tolerance to stress induced by electrical pacing. However, antioxidants had no effects on the dysfunctional heart of heterozygous dOpa1 mutants. Under stress, heterozygous dOpa1 mutations caused reduced escape response, suggesting abnormal function of the skeletal muscles. Our results suggest that heterozygous mutation of dOpa1 shows organ-specific pathogenesis and is associated with multiple organ abnormalities in an age-dependent and organ-specific manner
LSST: from Science Drivers to Reference Design and Anticipated Data Products
(Abridged) We describe here the most ambitious survey currently planned in
the optical, the Large Synoptic Survey Telescope (LSST). A vast array of
science will be enabled by a single wide-deep-fast sky survey, and LSST will
have unique survey capability in the faint time domain. The LSST design is
driven by four main science themes: probing dark energy and dark matter, taking
an inventory of the Solar System, exploring the transient optical sky, and
mapping the Milky Way. LSST will be a wide-field ground-based system sited at
Cerro Pach\'{o}n in northern Chile. The telescope will have an 8.4 m (6.5 m
effective) primary mirror, a 9.6 deg field of view, and a 3.2 Gigapixel
camera. The standard observing sequence will consist of pairs of 15-second
exposures in a given field, with two such visits in each pointing in a given
night. With these repeats, the LSST system is capable of imaging about 10,000
square degrees of sky in a single filter in three nights. The typical 5
point-source depth in a single visit in will be (AB). The
project is in the construction phase and will begin regular survey operations
by 2022. The survey area will be contained within 30,000 deg with
, and will be imaged multiple times in six bands, ,
covering the wavelength range 320--1050 nm. About 90\% of the observing time
will be devoted to a deep-wide-fast survey mode which will uniformly observe a
18,000 deg region about 800 times (summed over all six bands) during the
anticipated 10 years of operations, and yield a coadded map to . The
remaining 10\% of the observing time will be allocated to projects such as a
Very Deep and Fast time domain survey. The goal is to make LSST data products,
including a relational database of about 32 trillion observations of 40 billion
objects, available to the public and scientists around the world.Comment: 57 pages, 32 color figures, version with high-resolution figures
available from https://www.lsst.org/overvie
Influence of single and binary doping of strontium and lithium on in vivo biological properties of bioactive glass scaffolds
Effects of strontium and lithium ion doping on the biological properties of bioactive glass (BAG) porous
scaffolds have been checked in vitro and in vivo. BAG scaffolds were prepared by conventional glass melting route and subsequently, scaffolds were produced by evaporation of fugitive pore formers. After thorough physico-chemical and in vitro cell characterization, scaffolds were used for pre-clinical study. Soft and hard tissue formation in a rabbit femoral defect model after 2 and 4 months, were assessed using different tools. Histological observations showed excellent osseous tissue formation in Sr and Li + Sr scaffolds and moderate bone regeneration in Li scaffolds. Fluorochrome labeling studies showed wide regions of new bone formation in Sr and Li + Sr doped samples as compared to Li doped samples. SEM revealed abundant collagenous network and minimal or no interfacial gap between bone
and implant in Sr and Li + Sr doped samples compared to Li doped samples. Micro CT of Li + Sr samples showed highest degree of peripheral cancellous tissue formation on periphery and cortical tissues inside implanted samples and vascularity among four compositions. Our findings suggest that addition of Sr and/or Li alters physico-chemical properties of BAG and promotes early stage in vivo osseointegration and bone remodeling that may offer new insight in bone tissue engineering
The POLARBEAR-2 and Simons Array Focal Plane Fabrication Status
We present on the status of POLARBEAR-2 A (PB2-A) focal plane fabrication.
The PB2-A is the first of three telescopes in the Simon Array (SA), which is an
array of three cosmic microwave background (CMB) polarization sensitive
telescopes located at the POLARBEAR (PB) site in Northern Chile. As the
successor to the PB experiment, each telescope and receiver combination is
named as PB2-A, PB2-B, and PB2-C. PB2-A and -B will have nearly identical
receivers operating at 90 and 150 GHz while PB2-C will house a receiver
operating at 220 and 270 GHz. Each receiver contains a focal plane consisting
of seven close-hex packed lenslet coupled sinuous antenna transition edge
sensor bolometer arrays. Each array contains 271 di-chroic optical pixels each
of which have four TES bolometers for a total of 7588 detectors per receiver.
We have produced a set of two types of candidate arrays for PB2-A. The first we
call Version 11 (V11) and uses a silicon oxide (SiOx) for the transmission
lines and cross-over process for orthogonal polarizations. The second we call
Version 13 (V13) and uses silicon nitride (SiNx) for the transmission lines and
cross-under process for orthogonal polarizations. We have produced enough of
each type of array to fully populate the focal plane of the PB2-A receiver. The
average wirebond yield for V11 and V13 arrays is 93.2% and 95.6% respectively.
The V11 arrays had a superconducting transition temperature (Tc) of 452 +/- 15
mK, a normal resistance (Rn) of 1.25 +/- 0.20 Ohms, and saturations powers of
5.2 +/- 1.0 pW and 13 +/- 1.2 pW for the 90 and 150 GHz bands respectively. The
V13 arrays had a superconducting transition temperature (Tc) of 456 +/-6 mK, a
normal resistance (Rn) of 1.1 +/- 0.2 Ohms, and saturations powers of 10.8 +/-
1.8 pW and 22.9 +/- 2.6 pW for the 90 and 150 GHz bands respectively
Observation of the Decay Λ0b→Λ+cτ−¯ν
The first observation of the semileptonic b-baryon decay Λb0→Λc+τ-ν¯τ, with a significance of 6.1σ, is reported using a data sample corresponding to 3 fb-1 of integrated luminosity, collected by the LHCb experiment at center-of-mass energies of 7 and 8 TeV at the LHC. The τ- lepton is reconstructed in the hadronic decay to three charged pions. The ratio K=B(Λb0→Λc+τ-ν¯τ)/B(Λb0→Λc+π-π+π-) is measured to be 2.46±0.27±0.40, where the first uncertainty is statistical and the second systematic. The branching fraction B(Λb0→Λc+τ-ν¯τ)=(1.50±0.16±0.25±0.23)% is obtained, where the third uncertainty is from the external branching fraction of the normalization channel Λb0→Λc+π-π+π-. The ratio of semileptonic branching fractions R(Λc+)B(Λb0→Λc+τ-ν¯τ)/B(Λb0→Λc+μ-ν¯μ) is derived to be 0.242±0.026±0.040±0.059, where the external branching fraction uncertainty from the channel Λb0→Λc+μ-ν¯μ contributes to the last term. This result is in agreement with the standard model prediction
Measurement of the photon polarization in decays
The photon polarization in transitions is measured for the
first time in radiative b-baryon decays exploiting the unique spin structure of
decays. A data sample corresponding to an
integrated luminosity of collected by the LHCb experiment in
collisions at a center-of-mass energy of is used. The photon
polarization is measured to be , where the first uncertainty is
statistical and the second systematic. This result is in agreement with the
Standard Model prediction and previous measurements in b-meson decays.
Charge-parity breaking effects are studied for the first time in this
observable and found to be consistent with symmetry.Comment: All figures and tables, along with machine-readable versions and any
supplementary material and additional information, are available at
https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2021-030.html (LHCb
public pages
Angular analysis of and decays and search for violation
The first full angular analysis and an updated measurement of the decay-rate
asymmetry of the and decays are reported. The analysis uses proton-proton
collision data collected with the LHCb detector at centre-of-mass energies of
7, 8 and 13 TeV. The data set corresponds to an integrated luminosity of 9
fb. The full set of -averaged angular observables and their
asymmetries are measured as a function of the dimuon invariant mass. The
results are consistent with expectations from the standard model and with
symmetry.Comment: All figures and tables, along with any supplementary material and
additional information, are available at
https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2021-035.html (LHCb
public pages
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