Ttreating of idiopathic aseptic necrosis of the femoral head by intertrochanetric flexion osteotomy

U radu su prikazane indikacije, izbor operativne metode, operativna tehnika i prvi rezultati u liječenju aseptičnih nekroza fleksionom osteotomijom. Na osnovu praćenja 16 operiranih pacijenata, u toku 1983. i 1984. godine, možemo zaključiti da ta metoda ima svoje mjesto u liječenju idiopatskih nekroza glave bedrene kosti.The indications, operative method choice, operating technique and early results of treating aseptic necrosis by flexion osteotomy have been presented. 16 operated patients were checked during 1983 and 1984, and our conclusion is that this method has its place in treating idiopathic necrosis of femoral head

Kronična ruptura musculus pectoralis majora: Prikaz slučaja

Aim: To present a surgical technique and postoperative management of chronic pectoralis major rupture. Case report: We describe a male patient of 32 years after weight lifting injury. The MRI showed a rupture in the tendon with retraction to slightly laterally to the mid-axillary line. The patient was treated operatively and returned to non-restrictive way of life after six months. Conclusion: Chronic cases of pectoralis major rupture can be successfully treated. The present patient is fully recovered and he resumed activities (weightlifting) as before the injury. Non-surgical treatment is associated with a much more frequent loss of power and the inability to return to sports.Cilj: Predstaviti kiruršku tehniku i postoperativni tretman kronične rupture musculus pectoralis major. Prikaz slučaja: Prikazujemo pacijenta starog 32 godine, muškarca, nakon ozljede zadobivene tijekom dizanja utega. Magnetna rezonanca je pokazala rupturu tetive s retrakcijom lateralno od središnje aksilarne linije. Pacijent je operiran i nakon šest mjeseci nastavio je svoj prijašnji način života. Zaključak: Kronični slučajevi rupture m. pectoralis major mogu se uspješno liječiti. Naš pacijent se u potpunosti oporavio i nastavio baviti aktivnostima (dizanje utega) kao i prije ozljede. Nekirurško liječenje je povezano s mnogo češćim gubitkom snage i nemogućnošću ponovnog bavljenja sportom

BONE HEALING

Koštano cijeljenje složen je fiziološki proces koji podrazumijeva usklaðeno djelovanje većeg broja stanica i njihovih prekursora. Za razliku od mnogih drugih tkiva koja cijele ožiljkom, kost cijeli potpunom obnovom jednakovrijednog koštanog tkiva (restitutio ad integrum). Koštanu reakciju, histolški gledano, možemo podijeliti u primarno i sekundarno koštano cijeljenje. Primarno cijeljenje ili primarno kortikalno cijeljenje je premoštavanje prijeloma korteksa. Za razliku od toga, kod sekundarnog cijeljenja prijeloma dolazi do razvoja kalusa kao posljedice reakcije kosti, periosta i okolnoga mekog tkiva.Bone healing is a complex process which includes coordinated activity of several cell types and their precursors. Unlike many other tissues that heal by forming scar or cicatrice, bone heals by forming an equally valid bone tissue (restitutio ad integrum). From the histological point of view, bone reaction can de divided into primary and secondary bone healing. Primary or cortical healing comprehends bridging of cortex fracture. On the other hand, secondary healing refers to calus formation as a manifestation of bone, periosteum and surrounding soft tissue reaction

BONE HEALING

Koštano cijeljenje složen je fiziološki proces koji podrazumijeva usklaðeno djelovanje većeg broja stanica i njihovih prekursora. Za razliku od mnogih drugih tkiva koja cijele ožiljkom, kost cijeli potpunom obnovom jednakovrijednog koštanog tkiva (restitutio ad integrum). Koštanu reakciju, histolški gledano, možemo podijeliti u primarno i sekundarno koštano cijeljenje. Primarno cijeljenje ili primarno kortikalno cijeljenje je premoštavanje prijeloma korteksa. Za razliku od toga, kod sekundarnog cijeljenja prijeloma dolazi do razvoja kalusa kao posljedice reakcije kosti, periosta i okolnoga mekog tkiva.Bone healing is a complex process which includes coordinated activity of several cell types and their precursors. Unlike many other tissues that heal by forming scar or cicatrice, bone heals by forming an equally valid bone tissue (restitutio ad integrum). From the histological point of view, bone reaction can de divided into primary and secondary bone healing. Primary or cortical healing comprehends bridging of cortex fracture. On the other hand, secondary healing refers to calus formation as a manifestation of bone, periosteum and surrounding soft tissue reaction

Study of the healing process after transplantation of pasteurized bone grafts in rabbits.

Different bone allografts (pasteurized, autoclaved, and frozen) were compared based on their osteoinductive properties. Our primary purpose was to examine the biologic qualities of pasteurized allografts, as pasteurization inactivates most viruses transmitted by transplantation. Frozen, pasteurized, and autoclaved allografts were packed into a standard defect of rabbit ulna. The animals were sacrificed at 2 and 4 weeks after surgery. The parts of bones with experimental defects were explored en bloc, and a roentgenogram was carried out. Ulna bone samples were then embedded in methyl-methacrylate. Roentgenograms showed that after 2 weeks, calluses were well-formed, but irregular in shape in all 3 types of allografts. After 4 weeks, the calluses were regular in shape in all but the autoclaved grafts. After 2 weeks, the healing processes had begun in the frozen and pasteurized grafts, with the reaching approximately the same stage, while in the autoclaved grafts these processes were not seen and the bone particles were surrounded by connective tissue without any changes. After 4 weeks, osteoinductive processes were very strong, with the first signs of complete bone remodeling at the bone edges of the defect in pasteurized and frozen allografts. The osteoinductive values of these 2 types were very high and similar. Autoclaved allografts, on the other hand, had very low osteoinductive values, as they were still at the very beginning of the healing process. Histomorphometric analysis revealed a significant difference in both newly formed osteoid thickness and osteoblast number per microm of bone surface in all experimental groups (P &#60; 0.005). Values of osteoid thickness and osteoblast number were significantly higher in both frozen and pasteurized grafts when compared with the autoclaved ones (P &#60; 0.005). Osteogenic properties of pasteurized bone allografts were preserved, and the allografts have been gradually replaced with newly formed bone. As such, pasteurized bone grafts from a bone bank have approximately the same biologic validity as frozen grafts, while autoclaved grafts impair bone healing.</p

Muscle fiber type distribution in multifidus muscle in cases of lumbar disc herniation.

A study was conducted to analyze the distribution and diameter of muscle fiber types in samples of the medial paravertebral lumbar muscle, i.e., multifidus muscle, obtained from 76 patients who underwent surgery for disc herniation. The samples were compared with 41 control samples of corresponding muscle tissue taken from 41 young healthy subjects who had died a sudden death. Histochemical analysis of fibers associated with myofibrillar adenosine triphosphatase (ATPase) revealed the presence of Type I fibers (slow-twitch fibers) and of Type IIA and IIB fibers (fast-twitch fibers) in both the experimental and control samples. The respective percentage of muscle fibers was calculated and their diameters were measured. Type I fibers predominated in both groups and were significantly larger in diameter than Type IIA and IIB fibers. Both fast-twitch fiber types were distributed in almost equal proportions in the healthy women. In the healthy men, Type IIA fibers prevailed. In the healthy females, the percentage of Type I fibers was found to be slightly higher than in the males, but the diameter of all fiber types was respectively smaller. In the females who had undergone surgery, Type I fibers were significantly larger in diameter than those of the healthy subjects. On the other hand, the diameters of all muscle fiber types were significantly larger, and the percentage of both fast-twitch fibers were Idwer in the samples from men who underwent surgery, as compared to the healthy tissue samples. The morphometric changes in the multifidus muscle at the level of the protruded disc observed by the histochemical method for demonstration of myofibrillar ATPase could not be related to the compressed nerve root in the majority of cases in our study.</p

The genetic architecture of the human cerebral cortex

The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder

Osteoindukcijska vrijednost pasteriziranog alogenog transplantata iz koštane banke kunića : doktorska disertacija

Sažetak disertacije "Osteoindukcijska vrijednost pasteriziranog alogenog transplantata iz koštane banke kunića" nije dostupan

Ttreating of idiopathic aseptic necrosis of the femoral head by intertrochanetric flexion osteotomy

U radu su prikazane indikacije, izbor operativne metode, operativna tehnika i prvi rezultati u liječenju aseptičnih nekroza fleksionom osteotomijom. Na osnovu praćenja 16 operiranih pacijenata, u toku 1983. i 1984. godine, možemo zaključiti da ta metoda ima svoje mjesto u liječenju idiopatskih nekroza glave bedrene kosti.The indications, operative method choice, operating technique and early results of treating aseptic necrosis by flexion osteotomy have been presented. 16 operated patients were checked during 1983 and 1984, and our conclusion is that this method has its place in treating idiopathic necrosis of femoral head